Tuesday, September 09, 2014 9:47:11 AM
http://sttp.healthsciences.ucla.edu/abstract/sttp-abstract-current?abstract_id=2455
states the substance injected into the tumor microenvironment as "bacillus Calmette Guerin (BCG) and interferon (IFN)-gamma" mixed with DCs.
BCG has been used to treat cancer for some time now. Studies have shown its effectiveness is enhanced by interferon gamma:
http://www.hindawi.com/journals/au/2012/181987/
Studies have also shown that these can cause ideal maturation of DCs such that they can stimulate higher proportions of specific T cells as well as IFN-y secretion by these T cells:
http://www.translational-medicine.com/content/1/1/7
The question left to answer is, will BCG and IFN-y mixed with DCs produce a stronger effect than BCG + IFN-y alone? Or BCG + IFN-y + IL-2 (or IL-10, or 12)? The answer will take time. BCG + IFN-y alone has produced strong anti-tumor effects (as noted above), and especially when combined with IL. Time and additional studies will answer questions. All the better if through the Adaptive Licensing pathway.
The conclusion is especially appropriate:
Time will tell.
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