Innovation Pharmaceuticals Inc (IPIX)

[mdphd2008]

Your point is well received, and I would agree that daptomycin is not often used in the Perioperative period, as it's use is often reserved for the sickest of patients with pathogens that are resistant to multiple antibiotics. Vancomycin, is more typically used when indicated in the Perioperative period.

Orthopedic surgery as you mentioned, and I would add cardiac surgery with prosthetic valves, implantable pacemakers or any similarly implantable devices may certainly benefit from a superior antibiotic offering prophylactic antibiotic coverage.

However, cefazolin (as you correctly mentioned a first generation cephalosporin) and others noted requires redosing at 4 hour intervals, perhaps one day be better replaced by a drug such as Brilacidin if it truly is able to be instituted as a single dose offering better compliance, less drug resistance, wider antibiotic coverage (gram positive as well as gram negative microbes), and safe side effect profile.