NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

Pyrrhonian; You weren't talking to me. So pardon that... but the issue of early progression and cd4 counts is interesting.

True early progressors would correlate with exceptionally low cd4 counts.
Pseudo early progressors would correlate with exceptionally high cd4 counts.

Not saying there is a direct correspondence. But correlating does not require that. This damage to the immune system is just one factor. But when you separate it out, you would certainly see the above relationship.

Another primary determinate for progression would be the methylation issue. I speak indirectly about it because the methylation is a tad hard to remember for me. There is the methylation of the DNA repair enzyme which prevents that enzyme from functioning properly. Then there is the damage to the DNA that Temador does as it's normal function. It damages the DNA by methylating it. So their are two aspects of methylation.

At any rate, the patients with the damaged / methylated repair enzyme would correlate with pseudo early progression. I think it is correct to say that patients with the healthy repair enzyme would correlate with true early progression.

Although there are many other variables, as you say, I think these two parameters probably do a pretty good job of explaining most of the observed response behavior. And these two variables are the ones Bosch talked about as significant.