Provectus Biopharmaceuticals Inc (PVCT)

[vorlon1966]

Breaking tolerance


Why does the immune system sometimes doesn't see the cancer.... Part of that is tolerance. When a person is allergic to something a doctor will give the patient low dose shots of the antigen to put the immune system to sleep. It becomes tolerant to the allergens. The immune system keeps seeing the antigens and no longer sees them as threats. Cancer is a cell of the body which in many cases looks enough like a normal cell to put the immune system to sleep. The difference of the surface antigens might not be high enough for the immune system to react. How do you awaken the immune system.... You break the tolerance with a massive dose to get the immune systems attention. You increase the odds that the immune system sees a difference. In the bystander effect it is thought that massive exposure to cancer antigens in context breaks the immune system tolerance. The more tumors you treat at the same time increases the odds of breaking tolerance.... i.e...more of a chance for dc and apc cells to see intact dead cancer cells.