Provectus Biopharmaceuticals Inc (PVCT)

[vorlon1966]

How the drug works

A repost of mine

Cancer cells never get the signal to die like normal cells do...they just keep multiplying......something they do at a faster rate than normal cells which makes them starved for oxygen. Oxygen starved cells become anaerobic and thus puts them into acidosis (acidic). They change to live like this...makes them a mean tough cell. So their ph is below 7 while normal cells are around 7.2

The PVCT group decided to try to target cancer to take advantage of this difference. Why not others? For years we had squeeze bottle mustard but glass bottle ketchup until someone saw the answer that was right under their nose....But I digress...

For whatever reason the targeting of cancer was under everybody's nose. Then PVCT had a "Ureka!" moment....target the ph difference and so they set to work. They set down to design a small molecule to bounce off normal cells and go into the lower ph cancer cells. They put together different atoms on the computer and ran simulations based on the ionic properties that should work. When they found a candidate that worked in the simulation they realized it already existed as an eye dye...Rose Bengal. They filed the patents the very next day.

Now why does pv-10 kill cancer? Well, in every cell there is a sub cell that is called a lysosome. It is very acidic. It's normal job is to chop up bits food for the cell to use...like a stomach. When a cell had divided enough times the nucleus sends a signal out and tells the lysosome to self destruct...thus spilling out its very acidic contents and killing the cell from the inside out. Cancer cells never give that signal for self destruction. Here is where pv-10 comes in. Due to the molecule's design it is attracted to acidic (negative charge) cells. Once in the cell it gets absorbed into the lysosome to the point of rupture. Thus causing cell death. Since most cancers are acidic....pv-10 will work on most cancers while sparing normal cells.
In fact any excess is processed out of the body and into the bile in about an hour.

The very nature of how it targets and why its safe is basic chemistry. Other drugs are trying to induce the cell death signal or target single antigens found on the cancer cells surface. None have done so without damaging some normal tissue.....thus side effects.

The bystander effect works because the cell dies from the inside out leaving the outside antigen markers intact. The immune system does not recognize bad cells or foreign invaders...too complicated.... But rather it recognizes what is not self. Everybody has cancer but in most cases the immune system uses dendritic cells and apc cells to identify those cells which have changed enough to no longer resemble a normal cell. Some cancers develop a cloaking mechanism that keeps the dc and apc cells from reading the change in antigens on the cell surface. When Pv-10 kills the cancer cells from the inside out it stops the cloaking mechanism and allows the immune system to read the difference in self on the surface. The immune system then picks out the strange antigen markers and tells the T cells to go looking for those cells who have that difference. T cells are not fooled by cloaking tricks and go hunting that type of cancer and kill it.

Single antigen targeting is tricky. It's like going into a room with people wearing a red bandana and saying your going to target red bandanas wearers. Sometimes good and bad people wear red bandanas so your targeting is incomplete. But if you know by experience that if good people wear red bandanas around their necks and bad people wear then around their head you have a context to determine good and bad. So by letting the immune system read the antigens in context of where they are placed you allow it to zero in on just bad cells.
Pv-10 does not target antigens but rather allows the immune system pick the antigens it finds as being different in context of the cell surface. Mother Nature knows better than we do on targeting once giving the chance.

PV-10 kills cancer and spares normal tissue by a very simple process. The fact it is also a dye has nothing to do with nothing. Many other drugs came from dyes....look that up.