![](http://investorshub.advfn.com/images/default_ih_profile2_4848.jpg?cb=0)
Wednesday, May 14, 2014 1:00:23 PM
However, a statistically significant positive correlation was observed between the CD3+CD8+pSTAT5+% and MFI (post DCVax/pre DCVax ratio) after a single dose of IL-2 stimulation and overall patient survival (Figure 3A-B; hazard ratio = 0.1834; 95% CI = 0.045, 0.749; p = 0.018). As is apparent in Figure 3, CD3 + CD8+ T cells whose
responsiveness to IL-2 was elevated after DC vaccination compared with before DC vaccination (Figure 3B) had signficantly longer overall survival than patients whose CD3 + CD8+ T cell responsiveness to IL-2 did not change (Figure 3A). Based on this correlation, a one unit increase in the ratio of the pSTAT-5 ratio (post to pre DC vaccination) from IL-2- stimulated cytotoxic T-cells following DC vaccination reduces the risk of death in vaccinated
patients by 5.45 times.
Our findings provide evidence that alterations in cytokine responsiveness of PBLs from glioblastoma patients treated with dendritic cell vaccination are associated with overall
survival and may be reflective of vaccine efficacy. We measured STAT phosphorylation in the PBLs of glioblastoma patients enrolled in clinical trials of autologous tumor lysate loaded
or tumor antigen associated peptide pulsed dendritic cell vaccine. Initial measurements were taken from PBLs before the patient had received the DC vaccine. Comparison measurements
were made on PBL from patients after three biweekly DC vaccinations were given. When ratios of cytokine responsiveness were compared in an individual pre- and post-vaccination,
we found a strong correlation that enhanced responsiveness of CD8+ T lymphocytes to IL-2 was associated with long-term survival of greater than 2 years. DC vaccination reproducibly
induced elevated IL-2 (pSTAT-5) responsiveness, the magnitude of which was also directly associated with survival.
Recent NWBO News
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/13/2024 08:01:24 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/09/2024 09:06:07 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/08/2024 08:30:09 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/02/2024 02:42:28 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/30/2024 11:49:38 PM
- Biophma Announces Exclusive In License for Dendritic Cell Technology, Sending Shares Higher • AllPennyStocks.com • 06/17/2024 04:40:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/04/2024 09:11:16 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 06/03/2024 09:22:55 PM
- Form PRE 14A - Other preliminary proxy statements • Edgar (US Regulatory) • 05/22/2024 08:13:36 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/10/2024 09:04:57 PM
- Form NT 10-K - Notification of inability to timely file Form 10-K 405, 10-K, 10-KSB 405, 10-KSB, 10-KT, or 10-KT405 • Edgar (US Regulatory) • 03/01/2024 10:04:38 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 12/02/2023 01:31:35 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/16/2023 10:11:54 PM
- Epazz, Inc. (OTC Pink: EPAZ) ZenaDrone Demonstration to Defense Departments of UAE and Saudi Arabia • InvestorsHub NewsWire • 11/15/2023 12:19:31 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/09/2023 09:30:39 PM
- Epazz, Inc. (OTC Pink: EPAZ) US Navy Collaboration ZenaDrone 1000 • InvestorsHub NewsWire • 11/09/2023 01:00:34 PM
- Epazz, Inc. (OTC Pink: EPAZ) US Navy Collaboration ZenaDrone 1000 Extreme Weather Demo • InvestorsHub NewsWire • 11/07/2023 12:29:43 PM
FEATURED Element79 Gold Corp Provides Update on Nevada Portfolio • Aug 23, 2024 8:00 AM
PickleJar Unveils Latest Venue Managed Services Innovations in Upcoming Webinar • PKLE • Aug 23, 2024 1:11 PM
Maybacks Adds Award Winning Show to Its Lineup Discusses Maybacks Opportunity • AHRO • Aug 22, 2024 11:30 AM
North Bay Resources Announces First Gold Concentrate at Mt. Vernon Gold Mine, Assays 12 oz/ton Gold, 17.5 oz/ton Platinum, and 8 oz./ton Silver, Sierra County, California • NBRI • Aug 22, 2024 10:28 AM
All Things Mobile Analytic, Inc. Reports Major Growth with Over $11 Million in Revenue • ATMH • Aug 22, 2024 7:19 AM
Unitronix Announces Strategic Entry into Cryptocurrency Space • UTRX • Aug 21, 2024 10:00 AM