NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

Mol, it would be helpful in the future if you named the quotes as it could be misconstrued that some were mine that were not, and others were someone else's and were instead mine.

1. You said

With regard to the systemic response vs. systemic immunity, although one doesn’t always equal the other, in most cases I would say they do.

Triozzi defines patients 6 and 8 as having responses in other non-injected tumors, then immediately afterwards states there was no systemic anti-tumor activity specifically in other patients with Lung and Liver tumors. Patient 8, in my understanding, had a systemic anti-tumor response, where systemic means the non-injected tumors were eradicated. I think Triozzi inferred the same, but later considered why this did not occur in some other patients.

2. You said:

A complete response by one tumor or a partial response by another tumor is not a complete systemic response. There was absolutely no evidence whatsoever that there was a systemic response immune or otherwise in any of the patients.

Mol, I was not saying it was a "complete response by one tumor" only, as you contend. Instead, as restated below, complete response of the injected tumorand eight other 0.5–1.0 cm satellite lesions….

Triozzi said:

Regressions of noninjected tumors were observed in two patients. One patient (Patient 8) with melanoma manifested a complete response of the injected tumor and eight other 0.5–1.0 cm satellite lesions within a 6-cm radius of the injected tumor. Another patient with breast carcinoma (Patient 6) manifested a minor regression, i.e., a 25% reduction in the sum of the products of the longest perpendicular dimensions of the injected tumor and of a noninjected tumor that was located within 5 cm of the injected tumor. There was no clinical evidence of systemic antitumor activity in metastatic lung or liver tumors present in the patients enrolled.

In other words, you can keep calling it one tumor each for patients 6 and 8, but those are not the facts.

I'll try to address some of your further discussion later today or tomorrow.