Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Can somebody post the JP Morgan bio conference web link?
Guesses, Guesses, Guesses, ...
Super immunity. What if someone was NOT vcxx and twice got Covid, does it lead to super-immunity?
My answer: who knows?
Fin Market speculations and science are different things.
From practical point of view, monthly vaccinations (assuming there are zero AE) are not acceptable. But there are AE we just started to learn specifically cardiovascular.
I will not be surprise seeing Molnupiravir approved by FDA regardless of its efficacy and AE. I hope PFE data are more solid
So far, COVID vaccination did not stop the pandemics either.
PS
With such rapid COVID virus mutations, the present vaccine approach was a failure.
Personally, the Covid virus identification and treatment are only ways to stop the pandemics.
PFE COVID treatment looks god.
But what are side-effects?
As for ENTA, they need a partner.
Lately, Florida is extensively using antibodies to treat COVID infected pts. FL Covid related death rate is very small.
Just my observation.
AZD7442 PROVENT Phase III prophylaxis trial met primary endpoint in preventing COVID-19
https://www.astrazeneca.com/media-centre/press-releases/2021/azd7442-prophylaxis-trial-met-primary-endpoint.html
AZD7442 is very much welcome.
vinmantoo,
If a vaccine is effective and you are vaccinated then you have nothing to worry about. You are protected regardless whether you are in contact with a vaccinated or not or infected person.
In a vaccine is not effective then there is no difference whether you are in contact with a vaccinated or not vaccinated person. It does not protect you any how.
Presently, Covid-19 vaccines are not properly tested for effectiveness, durability, and adverse-effects. It took plenty of time to learn that asbestos is very harmful to humans.
Any arguments?
I am vaccinated with PFE mRNA.
However, I 100% support people who against being forced to be enjected with anything.
This is how communist and/or fascist societies subjugate its citizens. Do we really want a Cultural Revolution here in the USA? Like any revolution or war, it is easy to start it but it is very hard to stop it or predict the consequences and it is always very bloody.
It appears, PFA wants the Delta booster jab approval before having any supporting data.
Thank you. Not for me.
Well,
1. Not everybody intends to be vaccinated with today COVID-19 vaccines.
2. Safety and durability of today COVID-19 vaccines are not known as well as their effectiveness against future COVID variants.
3. New coronaviruses pill treatments and vaccinations are much more desirable than ones manufactured today.
<The European Union cemented its support for Pfizer-BioNTech and its novel COVID-19 vaccine technology Saturday by agreeing to a massive contract extension for a potential 1.8 billion doses through 2023.>
It is 1.8 billion doses just from Pfizer-BioNTech not counting the flood of COVID-19 vaccines from others (AZN, JNJ, NVAX, etc.,)
The question? What for does EU (with ~450M people) procure many Billions of COVID-19 vaccines?
PS
Will China benefit from Biden's IP waiver? No doubts, they will. They are not very creative but are very smart. In the last 20 years, China has made a gigantic intellectual advancement.
"Capitalists will sell us a rope we will hang them with" V. Lenin
Thanks Due
New COVID-19 variants are multiplying exponentially.
Questions:
- What are the mechanisms responsible for COVID virus mutations? In other words, what are the primary differences between the mutated Covid-19 viruses?
- What treatments and vaccines technologies are most promising being "Universal" treatment for different Covir-19 mutations?
Thanks in advance.
It appears that ENTA completely missed the COVID-19 train due to its management inflexibility.
No even a close comparison with ATEA activities.
Indeed, it is a very bad news:
* coronavirus mutation velocity is very rapid and
* immunity developed to one Covid variant provides very marginal if any protection against other evolving variants
It appears that we are losing the race to develop effective vaccine against coronavirus infection. It puts into a question (as miljenko rightfully said) the entire present understanding of COVID-19 and vaccine development approach.
Effective COVID treatment becomes even more important.
Did you watch BB?
Taking into account ENTA's development speed, COVID pandemics will be over before they start PhII.
ENTA needs a partner like Abbvie to make things moving.
Thank you Due.
This is not exactly true.
I remember to read German publication reporting heart MRI tests for people recovered from COVID.
Few thousands pts were tested:
* ~25% of all pts had heart muscles inflammation
* 15% of young sport athletes had the same problems few months after recovery
"Coronavirus Moderna Vaccine Has Side Effects
Side effects were higher in participants who hadn't previously contracted Covid-19 than those who did.
After either shot, 9.1% and 16.5% of participants, respectively, reported severe injection site pain or systemic side effects.
Up to 28 days after either injection, 21.9% of participants reported at least one side effect. Severe side effects occurred in 1.2% of participants."
Patients who previously had Covid-19 were included in the MDRN trial!
Why? These people are naturally immune against Covid-19. This complicates the entire purpose of the trial and potentially makes the entire vaccine effectiveness numbers bogus!?
Am I wrong?
“Tamiflu & influenza vaccines: more harm than good?
TAMIFLU & INFLUENZA VACCINES: MORE HARM THAN GOOD?
Owen Dyer reminds us that we have spent billions on a drug that possibly does more harm than good. (BMJ 2020;368:m626—February 19) The same thing can be said about influenza vaccines.
We hear so much about the vital importance of flu shots that it will come as a nasty surprise to learn that they increase the risk of illness from noninfluenza virus infections such as rhinoviruses, coronaviruses, RS viruses, parainfluenza viruses, adenoviruses, HMP viruses and enteroviruses. This has been shown in at least two studies that have received little attention from public health authorities:
A prospective case-control study in healthy young Australian children found that seasonal flu shots doubled their risk of illness from noninfluenza virus infections (unadjusted OR 2.13, CI 1.20—3.79).
Overall, the vaccine increased the risk of virus-associated acute respiratory illness, including influenza, by 73% (OR 1.73, CI 0.99—3.03). (Table 2 in Kelly et al, Pediatr Infect Dis J 2011;30:107)
….A randomized placebo-controlled trial in Hong Kong children found that flu shots increased the risk of noninfluenza viral ARIs fivefold (OR 4.91,CI 1.04—8.14) and, including influenza, tripled the overall viral ARI risk (OR 3.17, CI 1.04—9.83). (Table 3 in Cowling et al, Clin Infect Dis 2012;54:1778)”
The discussion about this study here: https://www.bmj.com/content/368/bmj.m626/rr
Biowatch@
Thank you for sharing with us your view.
Unfortunately, we still must learn a lot about coronavirus infection before declaring a victory.
https://www.cdc.gov/flu/about/burden
While the impact of flu varies, it places a substantial burden on the health of people in the United States each year. CDC estimates that influenza has resulted in between 9 million – 45 million illnesses, between 140,000 – 810,000 hospitalizations and between 12,000 – 61,000 deaths annually since 2010.
Biowatch @
If one was exposed (positive antibody test) or recovered from COVID, do they need vaccine right away?
So far, COVID clinical trials were designed for "approval" since asymptotic pts were not tested or followed.
People under 40s has almost zero chance to die. Do they need to be vaccinated? After all, durability of natural immune system or due to vaccination are unknown.
In my book, so far, the Covid response was a failure world-around.
Look at Vietnam:
Total cases: 1,341
Total Deaths: 35
Population: 97.3 million (just 3.5 times less than the USA)
Vietnam is an active participant in the World trade with many visiting Chinese.
The secret? Vigorous tracing all potentially exposed contacts and quarantining them.
Puzzling higher AstraZeneca vaccine efficacy for smaller dosage explained: It was reportedly tested on people only under 56
A larger dosage usually produces a stronger immune response, so the discrepancy made some experts wonder. Apparently, AstraZeneca omitted a key detail of their study that explains the results, Bloomberg reported on Tuesday citing Moncef Slaou, the head of the US Operation Warp Speed program.
PS
I never trusted either to AZN or its products
IMHO, lately, ENTA was a big disapointment
Well,
asymptomatic did not get a Covid test. At least asymptomatic pts are not seriously ill. It is good for them but it will not stop Covid-19.
From the trial design is not clear whether we got a vaccine or a treatment?
Are they Covid-19 free and are not spreaders?
Still too many questions remain.
"Pfizer said there were 170 cases of COVID-19 in its trial of more than 43,000 volunteers and only eight people with the disease had been given the shot rather than a placebo, meaning the vaccine had a 95% efficacy rate. Of the 10 people who developed severe COVID-19, one had received the vaccine."
These numbers do not make sense: out of 43,000 volunteers only 170 got COVID-19 or just one in ~250 in a 4 months trial? Are these people were quarantined?
Thank you again.
anesthesia doc,
Thank you very much.
One more question: Are there any potential interferences with patient Normal DNA functions?
Thanks in advance.
Please somebody help me.
I still feel very uneasy regarding to RNA induced immunity, specifically
* Safety
* Immune response durability
What are wrongs to watch for and how soon?
Regeneron to exclude severely/critically ill COVID-19 patients from antibody cocktail study.
There is potentially another bad news: not all antibodies are the 'right" ones.
Potentially, an elevated level of some antibodies indicates undesirable inflammatory processes in progress and/or processes previously took place rather than treatment effectiveness & progress. This also will greatly complicate COVID-19 vaccine development.
Singapore Has Stopped Using Two Flu Vaccines after an Large Number of Deaths in South Korea
Singapore has temporarily pulled its backing for SK Bioscience’s SKYCellflu Quadrivalent and Sanofi Pasteur’s VaxigripTetra, the Ministry of Health said Sunday (October 25). Among the seven brands administered to people who died in South Korea, these two are the only ones also available in Singapore.
The Ministry of Health (MOH) and the Health Sciences Authority (HSA) are monitoring the situation closely.
HSA is in touch with the South Korean authorities for further information as they investigate to determine if the deaths are related to influenza vaccinations. Based on information released by the South Korean health authorities, seven brands of influenza vaccines were administered to the individuals involved in the deaths reported in South Korea. Of the seven brands, two are available in Singapore. They are SKYCellflu Quadrivalent, manufactured by SK Bioscience and locally distributed by AJ Biologics, and VaxigripTetra, manufactured by Sanofi Pasteur and locally distributed by Sanofi Aventis.
The U.S. Food and Drug Administration is pathetic.
Hospitalized COVID-19 patients who were taking a daily low-dose aspirin to protect against cardiovascular disease had a significantly lower risk of complications and death compared to those who were not taking aspirin, according to a new study.
The researchers found aspirin use was associated with a 44 percent reduction in the risk of being put on a mechanical ventilator, a 43 percent decrease in the risk of ICU admission and – most importantly – a 47 percent decrease in the risk of dying in the hospital compared to those who were not taking aspirin. The patients in the aspirin group did not experience a significant increase in adverse events such as major bleeding while hospitalised.
https://journals.lww.com/anesthesia-analgesia/Abstract/9000/Aspirin_Use_is_Associated_with_Decreased.95423.aspx
Atea Pharmaceuticals Announces Strategic Collaboration with Roche to Develop and Distribute AT-527 for Patients with COVID-19
Roche Obtains Exclusive Right to Develop and Distribute AT-527 Outside the United States
BOSTON, Mass., October 22, 2020 – Atea Pharmaceuticals, Inc., a clinical stage biopharmaceutical company focused on discovering, developing and commercializing antiviral therapeutics to improve the lives of patients suffering from life-threatening viral infections, today announces that the company has entered into an agreement with Roche (SIX: RO, ROG; OTCQX: RHHBY) for the exclusive rights to research, develop and distribute AT-527 as an oral antiviral treatment for COVID-19 in territories outside of the United States. Under the terms of the agreement, Atea will receive an upfront payment of $350 million in cash from Roche with the potential for future milestone payments and royalties.
Jean-Pierre is currently the Founder, Chairman and CEO of Atea Pharmaceuticals
Previously Jean-Pierre was the Principal Founder of Idenix Pharmaceuticals, Inc. (NASDAQ: IDIX) and a Co-Founder of Pharmasset, Inc. (NASDAQ: VRUS). Both of these companies were acquired; Idenix by Merck for $3.85 billion in 2014 and Pharmasset by Gilead for $11 billion in 2012.
PS
So far ENTA did not do too well in Covid-19.
One more simple question.
Why some people get viral infection and others don't? Is it a function of a person immune system or is there also a threshold level a person must be exposed to in a combination with immune system potency?
Thanks to all.