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good luck to cor longs
i've been out of cor for about 2 years.
i lost $150,000 on cor. i'm not blaming anyone but myself for my substantial loss. i drank the cool-aid. i listened to the many voices promoting cor. and i believed ampakine was the cure for a multitude of aliments from head to toe.
after the pps fell overnight to $1 on fda rejection, there was a never ending stream of would-a, could-a, should-a and new indications and trials. and if i remember correctly Rod. & Renshaw stating the pps could be $0.35 received a lot of criticism.
it was always one more indication and one more trial that would put cor back on an upward path.
every once in a while i check the posts. in some ways there the same thing over and over, except that the pps was $0.60 when i got out and now it's $0.20. there seems less discussion about amakine indications and on-going trials, and more about the mismanagement of the company and share dilution.
speaking of dilution, well actually more like "delusion", the reason i check in every now and then is because i want to find a reason to justify getting back in so a can recoup some of my losses. yes, i know that not very realistic, but it's hard to accept that i lost so very much money on cor.
what's the latest and greatest with ampakine drugs/trials. judging by the pps, it doesn't look like there's anyone that thinks it has promse for any indication. and as i stated, the last 75 or so post i read are mostly about management, pipes and additional share authorizations, and not about the science of ampakines.
i hope cor makes big come back.
gook luck
rectal??
yes i agree; cortex has a lot of experience with rectal.
they have been sticking it rectally to their share holders for quite some time now.
"One way around that problem might be to first run the entire cohort of patients through an opioid-only regimen to identify which patients experience significant RD and at what doses. Then on another day these same patients could be run through the same opioid dosing regimen but get CX-717 first."
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hopefully those that experience significant rd will still be alive the following day.
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"...it's a shame we don't have an IV formulation so we could run a true "rescue" type trial."
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why is that. why can't they make an iv formulation for the trial?? what did the researchers in alberta use in their trials??? oral, injection, iv -- ????
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what is the greater likely use, prevention or rescue of rd??
perhaps one of our posters that communicate with dr stoll via email could ask him WHY they will be using an oral formulation of cx717 instead of an iv formulation which would seem to be a superior delivery method, at least for the initial testing.
are you buying today because you think we'll get some upward price movement after dr stoll speaks???
good luck with the new stuff (ad/spinal').
neuro -- just before dr stoll spoke at R & R on nov 1 the pps had a slight gain. then a slow and painful journey back to $0.48.
are we about to do an instant replay??
re:ad pet --If companies take an early peek at results, there is usually some statistical penalty involved, but that might not matter that much to a BP in this case since it's just a small proof of concept type trial. (per gfp to me)
so why aren't they peeking??
re:rd. do we know any details of how paitents will be tested??
fred
to the board --
is there any reason to think we're going to hear something new/different on dec 5th from what stoll told us on nov 1 at R & R.?? do you think dr stoll will anounce that cx701 ind was filed??
fred
is there any reason to think we're going to hear something new/different on dec 5th from what stoll told us on nov 1 at R & R.?? do you think dr stoll will anounce that cx701 ind was filed??
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"We do not think that we will have to worry about our stock price being at this very low level later next year because we have several opportunities to show good progress with the AMPAKINE® technology and believe we can therefore improve our stock price. Roger <<<"
well roger's statement is vague as usual. a .65 cents shareprice next december would make roger correct, but do little for sharesholders.
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do you think any of the scheduled upcommings trials (rd q4-07) or filings (ind701) will give us some upward shareprice movement pre positive results??
thanks
well as a non medical person, it seems to me that once rd has ensued, rd is something that needs immediate intervention; therefore iv would provied the fastest means to deliver the needed dose levels to overcome rd, as opposed to ingesting a pill, which in many or most cases would not be possible, and waiting 20 to 30 min for the drug to enter the patients system. unless of course we're targeting prevention of rd then a pill form would seem ok.
does this make sence?
will the rd trial address both response to rd onset and also prevention?
did cor give any details on how the trial will actually be done??
current ad pet -- is this blind until completed?? or does cor get to peek?
rd - scheduled to start pending trial approval or it will start?? what the 2nd trial for?? to confirm first or different end point??
cx701 -- ind filing, for which indication??
is cor going to have the $$ for all those trials??
what's the scuttlebutt on partnering?
re: stoll's email response -- "...irons in the fire...", i've heard it before. i want to believe. but you know how the saying goes, "when you play with fire you get burned."
thanks
Hi All
it's been awhile.
(i would appreciate all responses to the questions below. thanks)
i sold all of my 62k of cor in oct. post fda rejection. bought some back before the r&r conference on nov 1 at .69. then feeling uneasy, sold it all again at .69 just before dr stoll spoke.
after loosing about $110,000 on cor i just can't let go and forget about cor. i think i just can't admit i let myself buy into all the hype, going all into cor instead of a small to moderate position. but as we all know greed is a strong force. and yes i know i have no one but myself to blame.
i'm thinking of getting back into cor to a lesser degree, but before i do i was hoping our cor family could get me up to speed.
so what's the latest on --
1)ad pet (it's been a while since the trial resumed),
2)rd ind submission, when?
3)did the fda give any informal (wink, wink) on rd
4)what use is cor planning for cx701.
5)also, gfp's list of insiders doesn't include the new guy Tran, did he buy any shares?
6)initially when Tran joined cor immediately after the fda rejection of cx717 for adhd there was a lot of speculation as to why he accepted the position. what's the latest on him??
7)any recent email responses form dr stoll.
8)did cor ever get a formal response from the fda?
thanks
fred
ps -- it seems odd, for lack of a better word, that i, and many others here, owned a lot more shares than the cor biggies gfp listed.
"I need COR to get back to $3.00 to break even, which doesn't seem like such an unreachable number should things go right in 2008."
no, $3 doesn't seem like an unreachable number; it's the "should things go right..." part that seems to be the problem for cortex, who is the murphy's law academy award winner.
fred
what's your pps estimate post cc??
per the "Modernization Act" --
the 30-day Response Clock: FDA is required by the Modernization Act to respond in writing to
an IND sponsor within 30 calendar days.
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i'm sure the FDA responded in writing within the 30 days; it's just that the letter sent via pony express, no, make that donkey express, hasn't yet made it to cortex's mailbox.
"government gone wild". it's a reality show and a horror show all in one.
buying back in, probably the second biggest mistake of my life.
fred
have you heard from those in the know: has psychiatry's decission caused a rift with neurology??
fred
" I think there's a 75% chance of a bounce as soon as Stoll gets around to addressing shareholders. Who knows, if the plan is decent couldn't there shares rise again?"
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yes, we could see .63, maybe even .65.
maybe rod. and ren.'s price prediction of .35 is not that far off from where cor's will be at year end (i hope not).
i sold 58k of my 61k, lost $105,000.
cortex is the worst mistake of my life.
fred
have you heard if the Psychiatric decision has caused a rift with Neurology??
"The second possibility is that there was something wrong with the tissue, some occult cellular weakness caused by the drug or some harmful residue, invisible even to the electron microscope examination, that in combination with the fixative produced the troubling result."
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POSSIBLE?? YES.
BUT HOW COULD THEY MAKE SUCH A DECISION??
THEY'RE LOOKING AT COR's TEST RESULTS. THEY'RE LOOK AT THE IMAGES OF THE ELECTRON MICROSCOPE cor PROVIDED.
if there was a problem "invisible even to the electron microscope examination", how would they (the fda) know??
fred
YES, BUT AT 75 X (IF I REMEMBER CORRECTLY) THE EFFECTIVR DOSE.
75 X. -- THERE'S PROBABLY NOT ONE DURG ON THE MARKET THAT WOULDN'T KILL YOU TAKEN AT 75 X THE EFFECTIVE/APPROVED DOSAGE.
"There was clear PET evidence in primates given CX-717, so it's likely the metabolic brain activity will increase similarly in humans."
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but do we know if metabolic brain activity result in benefit to the paitents. a car spinning its wheels in mud has activity, but the activity is useless/worthless.
did the primates show some improved cognitive abitity as a result of the increased brain activity?
fred
"patients receive a single dose of CX-717, then the PET scan is done, looking for increases in glucose metabolism in brain areas involved in memory/cognition."
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Ok. has cor seen any of the results of the paitents tested thus far?? do we know if all, most, some or none tested thus far show increased glucose metabolism??
is there anything more than an assumption (any proof) that if there is an increase in glucose metabolism that it results in a benefit to the paitent??
and thanks for your previous reply.
fred
re: current ad trial
gfp927z
could you breifly outline the 5 'w' of the current ad trial.
does cor get to see the data as the trial progresses or only after the trial is completed??
"Tran is taking on a serious amount of risk by jumping on board with COR. Risk in lost wages, risk in damage to his resume.."
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but why?? yes, cor has compounds that look promising (for ad, rd). BUT other than efficancy with cx717 in adhd which is now dead what hard cold facts would dr tran have to base his decission on?? something that goes beyond promise; some solid evidence that convinced him to join cor.
fred
two things--
roger may be in denial, but is dr tran delusional?? you would think he would be looking at all aspects of cor with a very realistic eye before deciding to come aboard.
is he an idiot? was he blinded by greed like (me) most of us.
other than cx717 for adhd which is dead, which cor ampakines have shown statistically significant efficacy in human trials??
fred
did cor receive the formal rejection letter from the fda yet???
thank god we didn't have to file the application with the department of education. to them, within 30 calendar day of sept 11th, 2007 is feb 29th, 2008. and that's only because 2008 is leap year, or we'd really be in big trouble.
fred
well maybe the govt. doesn't use the base 10 counting method. so you may be correct in that according to the fda tomorrow is the 30th day.
just a fine point for everyone/anyone who cares --
per the "Modernization Act" --
the 30-day Response Clock: FDA is required by the Modernization Act to respond in writing to
an IND sponsor within 30 calendar days.
"CDER will review all initial INDs and, within 30 calendar days of receipt of the original IND..."
note "calendar days". to me that means if the application was received on sept 11th, that's the 1st calendar day, so today would be the 30th day. (of course we're not 100% sure that the fda actually did receive the ind app on sep 11. hopefully cortex had it sent next day delivery and didn't try to save $20 and sent it "ground" which takes from 5 to 7 days. (just kidding))
per a literal reading of the guideline, the fda actually has until 11:59:59 pm tonight to "respond in writing."
anyway, one day more or less shouldn't make a difference. i think we're in good shape.
fred
but just in case, i'll be sure to say my prayers tonight.
5 posts so far today. the 30th day post ind reciept at the fda. "D" day. remember the no news is good news.
is everybody celebrating at their local bar. is that why there's no one posting.
does the rest of the world know something that i don't know??
fred
"I am not willing to loose my money..."
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then why did you buy cor instead of getting a cd at your bank?
why buy it and then think about the risk; maybe the thinking part should have come first.
anyway, don't worry. there's 100% chance that the pps will be higher in about 1 week, and there's a 100% chance that my forecast will be correct if not erroneous. the probability is + or - 37.8% most times, except of course when the parabolic mean is above normal, in which case there is a 79.3% chance of statistical pps divergence in either direction.
i hope this helps, and good luck with your investment.
fred
at an italian restaurant when i ordered sushi. the waiter said, "i curry right back with your order."
curry favor, to seek to advance oneself through flattery or fawning: His fellow workers despised him for currying favor with the boss.
"...first hear the phrase "currying favor"...
are you pulling my leg?? if you are, pull the right one; it's shorter than the left one.
i don't remember what i had for diner 30 minutes ago, but it had kind of a curry flavor.
maybe if cortex ever get a drug to market, i'll be able to recall.
fred
well, whose favor do we want to curry most?
that's why good friday is closed.
just a few more days.
fred
the odds are overwhelmingly in our favor. of course once the decision is rendered, the odds are meaningless; it is what it is. but we all know it looks pretty good. a lot better odds than you'll get in las vegas.
i'll go with the general consensus that in a few weeks (6 to 8) the pps will be close to $4. for those who have held on, the miserable recent pps will, other than the stomach cramps it caused, be almost meaningless. actually, as note by several of our mb posters, the recent price gave us yet another chance to buy on the cheap. i bought a few more shares. i wish i could have bought more.
the opportunity to buy under $3 will soon be coming to an end.
good luck
fred
ps -- may i suggest you say your prayers before bedtime, do a good deed every day, and make a charitable contribution to the "better living for fred" fund (tax deductable, of course).
the only thing we have to fear, is fear itself.
these memorable and poignant words were spoken by slick willy to monica lewinsky when monica asked, "that's not a cuban cigar is it?"
monica and cortex shareholders keep a stiff upper lip. while nothing is guaranteed, based on the info we do know, the odds are overwhelmingly in our favor.
fred
and don't forget global warming.
just bought another 1100 @ 1.659.
better odds than las vegas. although some would say that's a lot of craps.
fred
I am SCARED what they will do in the future..
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THEN WHY ARE YOU INVESTED IN CORTEX.
buy microsoft and avoid all the 'SCARED' feelings.
good luck
fred
well, i'm also loosing almost as much, on paper, as you, so i'm not happy. regarding your criticism of the company, and it's management, you can't compare a cortex to a walmart.
when walmart sales decline the share price might decline 5%; when the fda places a clinical trials on hold or when a drug does not meet it's primary end point, like sonus recently, the share price might drop 80% or more.
but the reverse it true when positive results are achieved. i'm sure i'm not telling you anything you don't already know.
big upside potential comes with big(er) downside risk. the best management in the world can't overcome the whims of the fda, drug trial short-comings, nor a monkey that was up late partying the night before it was ..., well you know.
fred
$3/share, post 30-day IND approval, why or why not?
put me in the "WHY" column.
1)cause bp deal will be sure to follow.
2)cause after bp deal the pps will be $6 or maybe more.
3)cause many people will board cor post ind approval hoping to enjoy the ride to 1 & 2, rather than be left standing at the station.
All Aboard!
fred
"This will/should not be a "sealed bid public opening" of a one time shot at being the high bidder..."
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thanks for your reply.
i understand that it's not a seal bid type of transaction. what i was trying to do was to compair one extreme(secret bid), to what i understood you post to state, " everyone will know everyone elses offer."
then stating, "it doesn't sound right. there must be some confidentiality in the process. please enlighten me."
which you have now done, and i thank you.
fred
"It isn't as if every "player" won't know what the high bid was/is before a deal is consummated. Everyone will have an opportunity to match or exceed the high bid."
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i work for gov agency. so i'm used to the 'sealed bid' kind of thing. no one knows what the other guys bid is, highest bid wins.
you stated that every "player" will know everyone elses offer.
is that really the way it goes down? every offer submitted is available for review by every other company??
it doesn't sound right. there must be some confidentiality in the process. please enlighten me.
good question (good question because i asked something similar a while back).
basically, the responses were -
it's not how its done. it's easer to deal with one firm who gives you a chech than dealing with 40 million shareholders.
pearks, benefits go the firms fronting the money so that they do in fact put together others to committ the money.
no rewards for them, no money for us (cortex).
i'm a novis. others here are much more savy with understanding the ins and outs of the money/inverstig/financing stuff.
fred