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Street was gone last september and I can say, it was not something done other than to scrape away expense. I think it was very difficult given his contribution.
my understanding was that Street was given his termination last year during the cost cutting and employee releases, purely a move at attaining solvency. I don't think it was an easy thing to do but his contribution was clearly enormous in scope for the franchise.
Before the $2 million came in, it was a concern that this would prevent Servier from taking the US rights, per conversations.
Alpha Lipoic Acid. A-LA
I mix that concoction in a gallon of fresh well water and drink throughout the day, each day. Cost effective as well as all can be bought cheaply online. I can feel a cold virus enter ( I live with 2 boys who attend public schools) and gestate wondering if I can kill it's ass in 24 hours or less. Most times this is the case FWIW.
I take A-LA as a supplement alongside L-glutamine and Spirulina I get from nutritiongeeks.com. It works for me in muscle recovery from a lot of exercise and general health. I swear up and down, the illness in the nation would get clocked if all did as well. When I was in college I had a bout with acne, my Mom sent me to a derm who prescribed tetrapsychline (sp?) bad f...ing move as it butt slammed my immune system, the zits went away at a high long term cost. I had to take ammoxycyline for little colds which turned bacterial every year thereafter (25 years) until about 7 years ago when I discovered the above cocktail. No anti-biotics since.
I watched a Phil Dick video and that just hit me when I saw your post. I am going to try to reach MV this week. I have to believe something is moving in the right direction.
Bladerunner, I have one question...do Android's dream about electric sheep?
Go back and read this post if you will, the one I responded to. I said, " we won't really know if anything is going on until we see some life in the stock." I haven't spoken to Mark but I will try again. I am guessing this movement ( however small ) is not random. Just a guess but maybe after all the horror and all the losses, the end of the disaster has already happened. We'll see.
Servier spent the money for a reason. My understanding is that Servier has enough problems surrounding a mishap ( past) and costs associated that for them to cough up the last $2 million this early meant it was a priority. I didn't know the MJF animal work was in primates, I thought it was a mouse model. I don't know enough to say that even matters but I find it interesting.
5 years ago, there would have been 20-50 posts in the time that has elapsed since your inquisitive post, roughly 45 minutes ago. I am going to try to speak with Mark but my gut feeling is that nothing much has changed in the past 2 months. I have told people I know in the stock that we won't know something is up until we see the stock start moving and there is life again for CORX. That could happen. You wonder with all the hype of Whitney Houston, following Michael Jackson why the pharma biz wouldn't spend a dime in RD with us to see where it goes, hail Mary. I guess like so many multi nationals they are so focused on hitting Wall Street numbers that nothing else really matters. I see it somewhat first hand as a giant domestic tobacco business nearby Altria, business is weak admittedly --the Co. lays off 15% off it's workforce in December, cuts benefits by 30% for the remaining employees in January, but stock makes an all time high. I then read both P&G and Pepsico have plans to do the same.
I can remember back in around 2000 when there really were few reasonable opportunities not getting some funding. In fact so much money was sloshing around the Abgenix's of the world were sloshing it into little private start-ups looking to a target to aim a MAB at, it was as insane then as it is now, in reverse. By the way, I see more of these report and announce layoffs going on, Pepsico just recently, Altria just dumped nearly 20% of it's domestic salaried workforce. You hear a little of it in the banks and obviously a bunch in the pharma world. I think sans Apple this is driving the corporate numbers that are driving the market, well and Fed 0% FF.
You are dead right enemem. I meant the psychology, the breadth in trading, the lack of capital investment, the general malaise was spot on between refining and developmental biotech, the industry groups are night and day apart. Capacity being taken out and shot....need for new products ( eventual capacity) maybe....The link between SA and AD written about recently has me curious, and the weakened oxygen flow to the brain would clearly make sense as a catalyst of sort. At 6 cents I mean anything positive is hopeful.
Based on what I read in the "mainstream" press, I think there is a rhyme to things that come out of research aimed at understanding neuro diseases and the potential of Ampakines. There is a link up there, maybe a big one..maybe Servier is the only willing gambler left. Years back, (15-17) I was obsessed with the opportunity to invest in refining here in the USA. The valuations were unbelievable to the low side, way below the cost to replace and the returns in the 1-2-3 Crack spread were the reason, they sucked. The weird thing was, every summer the supply tracked near demand way too closely. The average auto MPG was declining faster than well, our own stock....reaally fast. Nothing happened, for maybe another 6 years. A lot of refineries were "shut in"...retired, too unprofitable. Valero and others saw what I saw and bought everything they could like KKR going after ( everything under the sun). The crack spread went from 2 or 3 to 4 to about 15.....starting in 2001 to 2007. It was tough along the way, 1992-1999 Hell then 2001-2007 Nirvanna....This reminds me of the conditions in R&D in Biopharma..... Valuation is non-existent or defunct, will somebody will be a Valero and go up 75 fold? Could Cortex do this? I don't know obviously. The Opiate RD to me is the most logical possibility. I like the attention SA is getting. I like that Servier is moving into phase 2. I hope something comes from Fox PD. But it's grim, just like it was in 1996 in refining.
The BP's have acquired every source of stable revenue at any price and cut costs. That is the business model and what seems evident to me is the markups that disappear in terms of branded price falling still offer decent margins in generic environment if there is enough cost cutting. It's self-canibalistic but it is working better than I ever thought it might have in 2005. That is the tough part of it and they are all taking part in the model.
I have lurked here for a while and without having anything to say, appropriately said nothing. I did happen to speak to Mark for a few minutes, he was at JP Morgan's conference. A few quick thoughts: RD is less dead as in I believe they are approaching the generic opiate manufacturers with at least a quiver of interest, they historically avoid R&D but I think there may be something here, MAY be. The results @ FOX relatively soon, I am guessing first quarter, I guess you know the trial was fumbled a bit by the 3rd party extending the timeline. SA cued up and more or less ready to go, obviously in the need of funds, probably 100% up front these days. The balance sheet is OK for now in regard to operations, which ($COSTS) will likely get trimmed some more this year cutting burn rate. Servier headed for phase 2 in AD. It sounds like things are still extremely difficult, the pharmas are using funds to find projects trying to ( cover butts) spread risk. I have to hand it to him that we are still in the game, Neuro might agree as well.
Well, I am back. I have taken a sabatical with the knowledge not much was likely to happen. I spoke to Mark today, not much new...you know what I know concerning the public releases. They want to run the central SA trial, I think it hinges on Servier but there are irons in the fire for participation as well. He spoke of CNS and pharma as well in the throws of a depression and getting worse with plenty of talented folks watching from home. My impression is that Fox has been delayed because of issues @ the CRO and the trial design itself but this has seemingly been righted and seems to be moving forward now. I won't go into why but it seemed to me like bad luck-
I had a conversation, I really did. My take is that Central Sleep Apnea, related to in all likelihood -Congestive Heart Failure-but potentially a bigger population. This is where things are headed with low impacts before anything happens with ADHD. My take. I understand this has some real potential as there is a big population CHF and apneas are prevalent - there is very little that can be done. Perhaps someone else can comment further. The feeling is the inventory of high impacts is a strong beneficiary of some good news at Servier and it was timely though had been in discussion for a while. Nothing new at Fox but things surely are getting close to some resolution or completion.
the last conversation I had surrounded creating an entity to finance , CO -OWN and co-develop ADHD
I have been watching and having nothing to say, not posting. I did try to connect with Mark and traded messages, no conversation. I am happier to see this than not-I believe it does offer that Servier is seeing something good-Parkinsons mice are likely up for some news, but I don't know this-it's a guess because it has been a year or so....should I connect, I'll detail.
I have been watching and having nothing to say, not posting. I did try to connect with Mark and traded messages, no conversation. I am happier to see this than not-I believe it does offer that Servier is seeing something good-Parkinsons mice are likely up for some news, but I don't know this-it's a guess because it has been a year or so....should I connect, I'll detail.
yep prolly all-the-above but maybe they have a Mob connection with an interest....
holeinonestocks...I have absolutely no clue as to whether they are good bad or anything.....
I like Alex Jones, I love his rants knowing every thing he says isn't necessarily true-he does make a ton of good points. Charlie Sheen? Seems bipolar and delusional to me, he has outlived Belushi somehow. That said I spoke to MV: I think the money thing is still challenging. From the conversation, I believe they have new ideas on raising it that may translate into things working out. I think the older methods, secondary offerings and warrants just won't work. I think ADHD IND is ready to go if(when) the funding comes in...I believe Servier is coming long as is Fox.....Servier farther than I had thought. I asked how morale was and he implied that the feeling about the tech and opportunity is very strong but the realism about money generally is frustrating. He sounded pretty optimistic overall but chasing financing is very draining, he felt optimistic on RD prospects, CX-2076 as a backup.....a friend of mine who gets low priced stock services said he got a recommendation on CORX saying it was supposed to go up a bunch in a month's time.....who knows what that means.....
First, I heard him about 3 weeks ago-maybe he's right the Middle East seems surreal to me like Iran 1978. I feel like there is a western hand in undoing the puppet dictators. I am going to point you in the directi0n of Clif High who I have listened to for years, he is a sharp guy- whether he can predict from web bot technology who knows but I have heard him hit some accurate calls. You can youtube webbot. I think the big deal is the earth's movement-as big as the middle east, finance and then some, his work makes a great deal of sense to me.
First, I heard him about 3 weeks ago-maybe he's right the Middle East seems surreal to me like Iran 1978. I feel like there is a western hand in undoing the puppet dictators. I am going to point you in the directing of Clif High who I have listened to for years, he is a sharp guy- whether he can predict from web bot technology who knows but I have heard him hit some accurate calls. You can youtube webbot. I think the big deal is the earth's movement-as big as the middle east, finance and then some, his work makes a great deal of sense to me.
A couple of thoughts that are OT but relevant as humans: The S&P has a reverse cup and handle with all the relative shifts in volume (downside) and money flow (negative) to identify the real move seems down and the trend at least short term is down. Cortex money flow is positive which might be meaningless, might not be meaningless- I am hopeful but still sit with Athero that the macro micro BP thing is dead. See CSCO price, think they are fired up about AT&T and T-Mobile? Another cost shifting deal ( Merck/SGP PFE/WYE) that benefits no one but senior management, lawyers and investment bankers. There are a cluster of earthquakes near Puerto Rico about 26 in the last week. There was a 6.0 in the middle of the Atlantic between Africa and South America, it seems there is a pickup in activity in the western hemisphere, the New Madrid and Atlantic.
why would biovail sell back the rights so cheaply if Cortex could not imply that it was in a position to defensibly prove it was going to do something with them...all the upside is in the back end.
In a conversation about a month ago, I got the feeling there are decent prospects to partner RD. decent.....not slam dunk or to the moon. You have to give Mark credit for pulling it back in. Biovail and it's new owner just don't want to expense the capital, they don't probably because THEIR nut, the contract that pays their ASSES, says this or that about EPS or cash flow. Interesting, the GE ceo Immelt ( and his top dogs), was being paid by increases in EBITDA as was Jack Welch, this is why they continued to ram GE finance harder and harder, it paid them a huge cash payout without developing anything else. It worked in reverse and may not be finished, they even lent DSCO money back then-obviously not too much relatively.
I think this event will be like a dagger into the yen. There is a major geophysical event taking place over there. http://earthquake.usgs.gov/earthquakes/recenteqsww/Maps/10/145_35.php These things are never like this, they are pretty centralized to a square or 2 with aftershocks. It is like the Pacific plate is expanding right at northeast Japan.
Unfortunately, right now the "market's" overall interest in Cortex is non-existent. This was true of junior Gold miners, oil tanker stocks and refiners in 1999 as well. I was getting out of them because they were killing me, I was early. Could this be said of Cortex one day? possibly. Changing gears a bit-- The yen is blowing my mind in that it has risen since the quake. Talk of free markets? with Tokyo within hours drive of the mess and quakes just blowing out daily over 600 square miles to the NE.....not.
I believe all @ Biovail....I mean Cortex.
I have traded calls with MV about 2 weeks ago, but not spoken-I chose to give it a rest. I only call when I feel it is appropriate, (I am waiting for the conference call/Roth) and space things out. I try not to call when I am sure they are in some deliberation, which I am sure they are regarding RD.
You are using your treasure trove of humor with ferocious abandon, you are aware you have yet to exploit the " squirt of juice" DARPA monkeys yet? Watching and lurking, I remain, I know nothing new but I am hopeful.
Hypocratically yes, but a major or MAJORLY minor part of the US economy dies too. I think CORX can do something but it requires creativity now.....that is a new mindset to the old call Rodman and Renshaw. DSCO did a capital raise undoubtedly in reverse split land but they got $23 million, why anyone would bother in such a small market? Who knows but it is a good sign.
I agree with you about where new drugs are likely to come from, but the BP's have already adjusted business models, and spending to account for making, marketing and living off generics to a large degree. This includes the R&D meltdown and helps to ex[plain all the mergers several years back.
welcome to my ignore list.
I don't have anything new, just watching honestly and hopeful RD comes back.
I certainly feel as crummy as anyone at the turn of events. I think the company and their management ( with their share of dropped balls) are just ten years maybe 12 years late to the party, I do feel things can improve-but though it is an awful situation and we are in good enough shape, scientifically, to advance dramatically. CX-516 was a weak drug with some evidence and it was the only dog till 2003. Roger did alot to get that momentum shifted to 717 and unfortunately we all know how it ended. In a perfect world we'd be riding some wall street mojo and hiring back Pierre Tran types but we aren't, and it isn't 1999 or 2003 or 2006. I do hold out hope but with all this bullsh$t about recovery and zero rates (continued bailouts) for depositors at banks to reboot the banking system, we are in a tough spot with few options monetarily, plenty of shots on goal.
Pfizer bought a million companies big and small and saw no increase in value, just shares outstanding. No Cortex comparisons because I am aware of what went "down" there. Pfizer has eliminated most of it's value beyond it's transactions for Wyeth and WLA and Upjohn and whatever else.....the deals do not increase value. Merck/SGP will experience the same. One could argue that absent deals the shares would have gotten clocked faster.