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TET...
Yeah...Cancer is a real disease and CVD is even more real...This virus is pure bull shit which will go nowhere..Its not going to kill the doctors and nurses..Its going to level out right now 95% at least of the infected are only experiencing a mild to moderate Upper Respiratory Infection.. and they are not going die...
Yes an outbreak in a nursing home would be serious..but these would be isolated situations..
the more young people who get the disease and survive the smaller the pool for new cases..That and the fact this is a retrovirus..and they all tend to lose their potency over time and replications...And there are drugs which will effectively cure the disease...Like Chloroquine...
":>) JL
biotechtrader'''
You don't know shit...Its virtually impossible for someone to sneeze and pass on the disease to a whole room full of people..
You or nobody else can say what the death rate will be or how fast it will increase..You are just a fear monger..This virus has been going on for months and we are only up to 122 deaths..as far as it doubling...Everybody with an IQ over 90 (except you) understands the disease is spread by droplets which land on surfaces or if with six feet by direct contact...and to contract the disease you need to expose mucous membranes. to direct contact..And if you are in a crowded room and some carrier sneezes the correct thing to do is to avoid putting your hand in your mouth or in your eyes..and then when you leave the room get to a bathroom..Wash your hands with soap..or take a shower if you are really worried...Ie use some common sense...Also if you are not over 60 or have serious heart disease or diabetes you are very unlikely to die from the contagion...
Trump is not an epidemiologist and he is getting some very bad advice. Of course I think CVD is more dangerous than this virus..I am an Harvard Med School grad..How about you...CVD kills more people every 20 seconds in the USA than this virus has killed in the USA...
":>) JL
jf....
You need a history lesson...
Quote: "A Covid 19 sufferer walks in and is admitted and given a bed. He goes south with a successive and ever worsening deterioration in his condition. He ultimately may require greater and greater efforts and resources and ultimately, a piece of equipment that is unavailable. And he could turn one or more healthy caregivers into doppelgangers requiring the same resources he does, to everyone's detriment."
This was actually what happened in the 1918...Its not what is happening in the USA in this recent virus. and is exactly the reason why we should not be panicking and inventing scenarios like you are dreaming up..We know fatalities in those under 60 without severe health issues are virtually unheard of...So we need to use younger and healthier care givers..and we don't want 80 year old diabetics with heart disease taking care of the virus patients..In the 1918 pandemic (a real pandemic) doctors and nurses young and healthy died like flies..
122 deaths in the USA after several months is not a crisis 1600 cancer patients die every hour in the USA..Why don't we shut down the country for them..And more die of heart disease..How bout we close down all the fast food joints and put everyone in the country on a strict diet till they reach their optimal weight..That would save more lives than this panic program...and would improve the scenery...Why are cigarettes still being sold...And how about booze and auto accidents..Look up the number of drunk driver related death...its way more than these virus deaths..
Why do we let people ride motorcycles?? We end up paying for their injuries..The most expensive injury case I ever took care of in my residency was a 23 yo motor cyclist who got drunk and ran his bike off the road and was found with one leg on one side of a tree and the other leg on the other side ..His pelvic xrays looked like a box of Kellogg's Cornflakes..He started uncontrollable bleeding which caused the hospital to put out an APB for whole blood as he went through the entire Boston blood supply..He remained in the Surgical ICU for almost four months until he contacted a pseudomonas infection in his pelvic region...This led to meningitis because he had a unrecognised communication with his spinal column which was in contact with the pelvic injuries...
":>) JL
lb...
Good luck..I am currently house shopping in the Orlando area...and am awaiting Judge Du's decision...
Best of luck....":>) JL
Cmon Debbie...
Pepsi did never put Coke out of business..We don't even know how long it would take these generics to ramp up and how cheap they can can sell it for..
That is in the very unlikely possibility they win the court case...
":>) JL
During the 1918 pandemic appearing in public without wearing a mask was a crime...
":>) JL
I have gone over to pattern trading...
What is obvious about the stock is we are seeing a fairly consistent PPS pattern developing and trading the pattern with a small portion of your position is a no brainer...
":.) JL
jasbg
Very good post...Agree Trump has to operate under constraints and must give the appearance of treating a full out catastrophic event regardless of whether he believes it or not...And there is of course the possibility it might actually turn out to be one...Viruses can and do mutate and they can mutate into very deadly vectors..and that would completely change the situation...This is not very likely: but not impossible..So being prepared make sense at this point...
Most likely however a mutation will not occur..We will see a mitigation of the virus over time, we will begin to fight the disease with drugs like Chloroquine or Hydroxychloroquine...and it will fade like a bad dream...And that most likely will come before we need hundred of thousands of respirators on twice the number of hospitals..Remember respirators will not save you if your lungs are filled with fluid..Respirators are only effective if you have some lung function...
Treating at home makes a lot of sense. As most cases are mild...At present the mortality rate is very low...except for elderly with CVD, DM or other risks..
A couple of months and I believe we will be back to normal..or should be..We will still have the fear mongers and the panic bomb throwers.
I have read extensively of the 1918 pandemic...it actually briefly returned in 1919 and 1920...
This current virus is nothing like the "Spanish Flu"...
The 1918 flu hit areas and killed most of the susceptible individuals and killed them quickly and that included the medical personnel taking care of them..It was sudden ...With lung damage that combat doctors noted was comparable to poison gas..Death was sudden and violent usually occurring within hours of the first symptoms.The lungs just turned to hamburger..No one was really safe...Colonies of people on pacific Atolls contracted the contagion and it would kill 80% of the isolated population..But this was different Virus (influenza) not a Corona Virus..
":>) JL
Temper, temper little accountant..
":>) JL
LOL....
":>) JL
jasbg...
This is just another case of caving in to hysteria...This disease is not airborn and it is susceptible to several forms of therapies and drugs...
I'm predicting the end of the hysteria and the so called "pandemic" in less than 6 weeks...(and its outa here)..I repeat and call this the virus that could not shoot straight..
":>) JL
On the lighter side...
I would rather we have Judge Du...than Judge Don't....
">) JL
KIWI...
Must you put your BS slant on everything you post...You are frequently wrong...but never in doubt..
This is not a 1918 influenza issue...not even close..Not an influenza virus..If it was 1918 and we were on the second or third wave we would have over a million deaths already...A lot of them dead nurses and doctors...
":>) JL
invest...
Thanks so much for posting this...I think the fact the government might have an anti viral and is actually using it would make a lot of people feel better nd offer some hope...
Good luck in getting your hands on some...Hopefully they are ramping up production..
":>) JL
duke....
Since the Virus is known to enter the host cell via the ACE-2 receptors it would make sense that ACE inhibitors like lisinopril should help stop the entry, but for some reason (I don't know) that may not be the case and ACE inhibitors could actually aid the virus...Please do not make decision based on my comments...
We do klow that Chloriquine in addition to interfering with the production of the virus also blocks entry of the virus from the ACE-2 cell membrane receptors...
":>) JL
Zebra...
The pandemic just petered out..Most viruses and certainly retro viruses tend to lose potency as they create new generations...getting weaker and weaker..That is why the Ebola epidemic did not get too far...
Measles which is airborne is really deadly in populations which have no natural immunity...But remains highly contagious, but not lethal..in populations that have developed immunity..
":>) JL
jasbg...
I appreciate your confidence..but the chances of Trump contacting me and asking my advice would be only slightly better than getting a call from Abe Lincoln...
Our hope really lies in people way down the food chain from Trump..(Who e-mails) me for contributions dailly...There are already Doctors in Australia who are very aware of the promise of Chloroquine and Hyroxy-Chloroquine and its potential to kill the COVID virus..Why are we not seeing a pandemic in Africa...We know the virus travels better in cool climates...But as far as I can tell the virus is skipping Africa...Could it be the anti-malarials are knocking it off..
":>) JL
Would be nice if some of these Amarin management guys bought some stock here to show us we are not completely insane for holding our shares...
It would be nice and if they used some of that $650 mil to buy back some would be even nicer..C'mon guys show us that you all are not just a greedy bunch of assholes that don't give a damn about your shareholders..who are swaying in the wind...
":>) JL
The Trouble with Regulatory Agencies...
"There are more tears shed in heaven for wishes granted"...
Most of us are familiar with the history of the FDA...Chartered initially to combat the flood of Patent Medicines in the early twentieth century. In the early 1900s the vast majority of advertisements were for patent medicines..For the most these nostrums were ineffective but some were down right dangerous...The book "Charlaton" is an excellent read on the subject...
This lead to the formation of the FDA...The FDA scored a major victory in the 1950s by banning the drug thalidomide from use in the USA..Thalidomide was very effective at minimising the effects of "morning sickness" and was taken by many pregnant women in Europe..Thalidomide caused birth defects namely a condition called Phocomelia (seal arm) which led to loss of arms or legs in newborns..This one major victory put FDA into the untouchable status..
FDA embraces the prime doctrine..."First do no harm"..But the FDA has morphed into a sprawling bureaucracy that operates a "marketing process" that delays drugs and other devices years before they are available for therapies..and adds billions of dollars to the cost of an already out of control medical system..This combined with Malpractice suits is leading to a state we will no longer be able to afford..And one where most of the doctors are very unhappy with their career choices of going into medicine..Regulations and legal issues are making clinical practice close to unbearable..
And now we face a new challenge..a potential pandemic. In this the FDA stands like a coral shelf in the midst of a calm ocean and politicians are running the show rather than the doctors..The President is a very good business man (although his father was rich),and a savvy politician, But he is not a clinician and should step aside..What he should be doing is putting the clamps on the FDA and let the clinicians do their job..Right now this is not a problem created by a bad drug...It's about contagion and do we have the drugs which can stop the vector (the virus) and we can not worry about adverse events or side effects in a situation where there are lives in the balance...
We need to be running real trials using Chloroquine , the GILD drug and any other drug which has a plausible chance of killing the virus. FDA needs to get out of the way...I am a fan of Trump up to a point..He is still too worried about whether he will getting his share of the credit when he needs to be more like FDR...More "We have nothing to fear, but fear itself"..He should not be pandering to the wishes of the Democrats. Time he ceases being a politician and starts being a Statesman..We need a leader...He should recant his July to August estimate..which is based on nothing and is tanking an already jittery market...This whole thing can be over by May Day if it is done correctly...
":>) JL
Chloroquine for cure of the COVID-19 virus....
A must read.....
https://medium.com/@savesightmd/an-old-drug-for-the-new-virus-a6fd6a0843bc
":>) JL
Jas...
Forget GILD...they will not be able to meet the demand and their drug will be too expensive...and will not be as effective as Chloroquine...
As I have posted and the world and Elon Musk is beginning to become aware of is there is already a cheap very effective cure for the COVID-19 virus and it is CHloroquine...An old anti malaria drug that changes the PH of cytoplasmic membranes which are the production and construction sites for the COVID-19 RNA virus...
Anyone notice there is not a lot of COVID news coming out of Africa..That is because so many people are on Chloroquine or Hydroxy Chloroquine where the falciperine (malaria) has become resistant to Chloroquine..
Chloroquine is widely available and very cheap...We need to get the CDC and FDA off their fat asses and start the Chloroquine trials.. and stop Trump (I am a Republican) from scaring the shit out of the American public..And spooking the Stock Market..
We need to concentrate on our mental power over life form that has no IQ. If we can not control a vector that has no real strategy then we do not deserve to be the species that controls the planet..
Fuck the COVID-19 virus..Get off my planet...
":>) JL
ggwpq...
The new COVID-19 Virus is not spread airborne..It is spread by contact. The source you are using is speculating it might be able to remain airborne for a short period of time..If this virus was spread airborn rather than by contact that would be a total disaster...The current situation is nothing compared to what it would be if the vector was spread airborne. You could pick it up virtually everywhere you went..and would not not be safe anywhere.
":>) JL
Montana...
Kiwi keeps his own count..look up the word estimate...
":>) JL
KIWI...
Quote: "a Stanford paper estimating 600 infected about 3 days ago.
3 days from now that will be 1,200 estimated cases in the Bay Area
It’s exponential growth."
I'm guessing you were not a math major..but is English your second language..
Estimate means it is an approximation...600 infected "about 3 days ago" three days from now that will be 1200 estimated cases (how do you know that) 1200 is just double 600 and is not exponential...to be exponential you need another time interval in this case you would need six more days and 2,400 cases...
":>) JL
Sluicebox.....
Yes Chloroquine seems like it is made to order for this vector...
I could see possible similaries with malaria..even though the two disease have important differences...It appeared to me they were using a lot of the same intercellular processes to replicate..Get rid of the intracellular membranes or disable them and you should be able to shut down the virus production..
Chloroquine is very cheap unless Shkreli has hiked up the cost of the drug.
I vaguely remember this drug went off patent....
":>) JL
Albino2...
I am not an authority on ACE2 receptors...If I get this right ACE2 receptors are located on the cell membrane and the prevalence is greater in individuals with high blood pressure and diabetes...Apparently the COVID-19 virus (native to bats) Uses these ACE2 receptors to gain entry into the cell..This is confusing because women have more ACE2 receptors but the Virus is more serious in men..
In clinical medicine drugs like lisinopril block or inhibit the ACE2 receptors and that would seem to be a good thing if you wanted to cut the
spread of the disease...But the results are confusing and there is currently no opinion on whether ACE inhibitors are a good thing or a bad thing...
":>) JL
ranjo...
Completely agree...Blood in the streets..best time to buy..The bad news is baked in...The smart money (the real smart money) is buying today...
":>) JL
KIWI...
If you bought back...when it was cheaper then hats off to you..I don't as a rule like to buy in at prices much above 5$...but Tdoc has been a hell of a stock..
":>) JL
You buy it KIWI...Its way out of my range...If you have any money left you should be buying Amarin...
":>) JL
Just saying..This would be a perfect time for J.T. to use some of that 650 mil $ and buyback some stock...That would show some real savy...
":>) JL
raist...
Agree. With the sales reps move..
":>) JL
TWIMC....
Just bought some more Amarin...10.55.....Just could not help myself...
":>) jl
Amarin apparently put its drug reps on inactive status...Circut breaker for 15 minutes...
":>) JL
TET...
What is irrational is the fear..and the fear is of dying..not of something you don't understand..Who understands dying...Only one guy ever came back and he did not have very much to say about the experience..
Regardless of all the hand wringing and scare tactics...IMO (just MO) I don't put this up there with the big ones ..Plague in the thirteenth century or the 1918 Great Influenza...This plague just doesn't make the grade..
Scott Adams..Evokes "The Law of Slow Moving Disasters"...Slow moving disasters (ie this COVID-19 pandemic) always turn out to be imposters as there is too much brain power being directed to corralling it..Stay home, wash your hands..Don't go on commercial airlines or cruise ships...don't French Kiss a Cobra...Or get into an argument with a witch doctor...and last but not least do not drive on I-4 in Florida..
So I am calling BS on this "pandemic"...Hell even Hungary has this thing under control. G. Is on the case...
":>) JL
invest...
"Dr. Faust"..too funny...
I feel your pain and agree.. Nation wide (like on this board we have the "bomb throwers" trying to scare the crap out of everyone...and in the meantime we have FDA putting up roadblocks on the road to recovery...
Chloroquine is an FDA approved drug and has been shown to be effective in stopping the virus in cell culture...There is no good reason to believe it will not work in Vivo (patients)...We know it can stop malaria plasmids which are synthesised in the cytoplasm...
We should be seeing a trial right now...
":>) JL
North...
IMO..the USA should concentrate on using Chloroquine before they go over to the GILD drug...Chloroquine showed at least as much antiviral effect as the GILD drug and is going to be much much cheaper...I know the side effects seem bad...But keep in mind the only real clinical experience for Americans using Choroquine was in the Vietnam war..That was to combat Malaria...
A good deal of the so called side effects have to be weighed against the fact that many of the combat troops actually wanted to contract Malaria because it was a ticket to getting out of country..A ticket back to "The World"...Infantry officers were actually graded on getting their troops to take the anti malaria drug...
Chloroquine acts by changing the pH of some of the cytoplasmic membranes where the RNA sequences of the virus are fabricated..That stopped the production of the malarial particles and seems to stop the production of the virus..The GILD drug uses substitution of the nucleotides to create sequences that stop the production of the virus..It is unclear as to how long this will continue to block the viral production...I like the idea that Chloroquine interrupts the machinery that that synthesises the virus..
":>) JL
TET...
..You and Gabor...You both need to stick to what you know best,,Gabor to being an accountant and you being a comedian...Its like dumb and dumber..
So people are scared of dying from something they don't understand..but dying from something they do understand is OK? They are not scared of that. I am scared of dying from anything..That includes cancer, heart disease, auto accidents or falling off a horse...Or anything that can kill you.
Gabor has an ego the size of Milwaukee...And if he knew one quarter of what he thinks he does he would be smarter than Einstein.
Gabor.. Sorry I am a real MD and you are not and never will be, live with it..Sorry but there were lessons learned in Viet Nam..Which you also will never know..You are just some Hungarian want to be...live with it..I'm sure you can correct somebody's clerical error..and add some of your strange sarcasm which you find so amusing...Stick to being an accountant..
":>) JL
HDG...
My point is a mask will not protect you from getting the disease because the disease is not spread airborne..It will however help preventing you from spreading disease..
But of course you know everything...
FYI..the current thinking is a very high percent of new cases are contracted from people that are asymptomatic..And they don't know they should be locked up in a room.Sitting on their asses.
":>) JL
Bill B....
I would not be surprised to find out Chloroquine is more effective than GILD's drug...and will be lot cheaper..
":>) JL
TET...
Sorry I don't buy the pathos.This whole (Much to do mania) will blow over in couple of months...I call this "The Pandemic that can not shoot straight"...
It's a shake hands plague...And we are not in the Age of Cholera..All the great plagues have Three components which this one lacks.
1) Mystery.. When I was kid a long time ago in the age of Polio the problem was very little was known about the transmission of the disease..It was rumored to be caused by swimming pools..but no body really knew for sure..We know practically everything about this virus..Makes you kind of feel sorry for it..
2)Really bad plagues are usually very deadly and act quickly...This is the true of the Plagues caused by Pasteurella Pesti...The Black Death..The 1918 Great Influenza...
3) the vector is airborne..This is a contact virus..a little bit like Herpes Simplex in the way it is transmitted...Old People get very sick and die from this virus. but so far the young seem to have a remarkable resistance. That was not the case on with the great plagues. Right now I immagine that Colonel Sanders might be causing more deaths than this virus..
I think the logical action to take in this latest contagion are to avoid crowded places, avoid contact..Stay at home if you can...and don't go on plane rides or ship cruises..
I think Chloroquine might be very effective at treating this disease as the condition has a lot of similarities to Malaria...
PS..Malaria is one of the worlds most prevalent conditions...It is not transferred by contact, but by mosquitoes but the symptoms are eerily
similar
":>) JL