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I agree the data looks good enough for EUA. My only concern is that they reported reduction in median values only. On a relatively small dataset the median could be quite misleading. I thought about adding yesterday but just holding for now. If the data on ICU and hospital stay reduction is truly representative, I see no reason why we wouldn't get EUA in the next few weeks.
Please re-read it yourself. Again, nowhere does it say EUA was denied. It says that FDA would not grant it based on EAP data. We have to wait for unblinding of data from full trial.
If you were expecting EUA before data from controlled trial then certainly this might be disappointing, but the writing has been on the wall for quite some role that EUA would not be granted based on uncontrolled EAP data.
The fact that they won’t grant EUA does not reflect negatively on our data. If they agreed to use EAP data then it would have been granted because EAP data looks really really good. They simply want data from full trial, which is still blinded so they can’t make a decision yet.
Waiting for data from full trial does not equal denial. At this point I think everybody already assumed we were waiting on full data before EUA.
If they were going to grant based on EAP data it would have been done long time ago. Nothing new here.
NeuroRX has always been listed as the sponsor because they are running the trials in US. Relief also hasn’t been listed as a collaborator for the past 7-8 months.
Pretty sure they are both referring to the same trial.
You also need to consider dilution when determining the point at which BRPAW returns will outpace BRPAR. BRPA will suffer dilution as rights are automatically converted at merger.
Less risk in the warrants if the merger falls through and much higher reward if stock does well long term.
However, vast majority of SPAC lose money after merger. If you bought at today’s price, if merger went through tomorrow your rights would be converted to BRPA at 29.63 (not accounting for dilution) when you effectively paid 13.40. Effective cost from warrants are 17.19 but you can’t exercise right away anyways. You’d need BRPA to go up another ~4 to $33 to get the same return (per share) but you could buy ~twice as many warrants due to leverage. You can also be forced to exercise the warrants sooner than you’d like if it is trading consistently high.
Basically I agree with everything you said but there is lots of minutiae to consider when comparing the rights vs warrants.
Julie, below is my understanding. Just information not investing advice. Please see link to BRPA 8k filing below and do your own DD before investing. I’m no expert and SPAC are high risk investments.
BRPA will become 1 common share of NeuroRX after merger with BRPA completed. If merger falls through you will get $10 per share from trust and lose the rest.
BRPAW are warrants. Each warrants gives you the right to buy 1 shares of common stock in post-merger company for 11.50. There are additional limitations as to cooling period after merger before you can exercise, and company can force to exercise if stock runs too high for too long. These become worthless if merger falls through.
BRPAR is right to 1/10 of a common share of post merger company. Automatically converted post merger but worthless if falls through.
BRPAU is 1 common stock, 1 rights, and 1/2 a warrant.
IMO BRPAR is where it’s at right now given price point of BRPA and BRPAW, but I wouldn’t hold on to any of them for too long if they really run.
https://www.sec.gov/Archives/edgar/data/1719406/000165495420013700/brpa_8k.htm
There are no goal posts being moved. It’s completely normal for clinical trial to continue enrollment beyond target while awaiting approval. What else would they do, stop treating people for several months in the meantime?
This is good news that enrollment moving along so quickly. IF it turns out that expansion is needed, we’ll be in good position to reach that target with minimal delay, but just the fact that enrollment is continuing is not at all indicative that expansion WILL be needed for approval.
I’m curious why you are using the 165 number in regards to EAP patients? 165 enrollment is for the full trial. Why would they give any update specifically at 165 patients from EAP?
I’m not saying there won’t be an update from EAP, but could be any number greater than 90 patients from the last update. Could be more or less than 165. Though to be honest I don’t expect anything before results from the real trial since it’s almost January and I think more good results from EAP won’t mean much. I’d actually be concerned with release of more EAP data this close to the finish line as it would seem like a pump before poor trial results.
They were clearly talking about both, spreading misinformation in the process, and were justifiably corrected.
Looks like it’s been fixed now. I can confirm on first reading the article this morning that they referred to it as a vaccine not just once, but many times.
Dr. J said a long time ago that patients in the inhaled trial would use a portable nebulizer at home. It’s well known that majority of people who use inhalers to treat asthma use the inhaler incorrectly. Nebulizers are much more effective at getting medicine into the lungs. Given that it’s already outpatient, and the serious consequences of the progression of Covid19, I don’t see why they would move to inhaler. There has also been no indication from Relief or NeuroRX that they will, but who knows. I don’t think it changes anything one way or the other tbh.
This is definitely good news, but it’s pretty clear from the release that this is not interim trial data. It’s based on patients who received through EAP only.
Quit believing garbage clickbait news.
https://www.factcheck.org/2020/11/fabricated-claim-of-biden-campaign-officials-arrest/
Very interesting. It appears they will be interviewing Dr.J after the conference in addition to him being a panelist.
Dude, all you have to do is look at success of Japan or South Korea. Japan has like half the population of US in a country the size of California. The difference is they actually wear masks. If US had their population density we’d be F’d.
Also when you say “ask any medical expert” what you really mean is all of the YouTube videos/Facebook posts or whatever you’ve seen tell you that, but the reality is the other 99.9% of medical experts disagree.
Additionally, being a nurse, doctor, brain surgeon etc. does not make you any more of an expert on infectious diseases than anybody else. We should be listening to infectious disease experts who dedicate their lives to this stuff, not some dude with a sports medicine degree. Basically all of the actual experts say masks work.
I’m not sure what facts you expect? You are asking for proof that NeuroRX merging with another company won’t effect the OS or possibility of a R/S for Relief, a completely separate company not involved in said merger?
It’s common sense.
NeuroRX has plans to merge and list with a NYSE company in the next 3-6 months, not Relief.
From other board. Fox News Doctor mentioned Aviptadil after question about what’s the strongest Covid drug out there right now. He said they are using all over Europe. Mispronounced name as Adiptivir.
Started like 20min late last time.
Chill out. FDA approvals take time, with good reason. It would normally take many years to go through clinical trials you can only speed these things up so much without compromising the integrity of the science. Things are moving very fast. If it’s not fast enough for you that’s totally understandable but you should consider investing in a different space.
All the results for this drug look really great so far but you can’t rush the science. Blinded study results in the next few weeks will tell us where this is going. There is absolutely nothing that could make me part with my shares before then.
Because there weren’t 9 more?...
Yes, very shocking indeed that markets fluctuate and sometimes go up and sometimes down. What’s not shocking is that you post the same exact crap every day then disappear when it’s green and return like a floater from last nights burrito whenever it’s red and try to act like you nailed it.
I understand that. I was referring to people’s assumptions about the 21 patients and claims that there can be no placebo effect if patients were unconscious.
Yes placebo effect does not require the patient to be conscious. If a patient is given an ineffective treatment/drug but they still get better (due to their own immune system, or some other factor ) that is a placebo effect, conscious or not. If doctors think or know that a specific treatment was given it can effect how they treat the patient or assess their status, that is a placebo effect.
Do you know what it means? Might want to double check because I think you are confusing it with “in vivo”. His point is that it hasn’t been tested on an actual living organism and based on that link it hasn’t.
It’s not necessarily a bad thing. Companies that are bleeding out tend to do a RS to buoy the price and maintain listing status or keep from falling off investor radar. In Pennies for instance many investors won’t touch trip zero stocks, but a RS can keep the stock alive.
However, this is only one reason for a RS. Many people here are perpetuating the idea that RS leads to decline in value, when it is the other way around (a loss in value precedes the RS). A company doing a RS to keep from being delisted is is not comparable in any way to a company doing a RS to uplift for the first time. Their trajectories are completely different. Don’t worry about a RS unless we’re already talking.
According to Johns Hopkins, current case fatality rate for a Covid19 is 3.1%. Average case fatality rate for influenza most years is 0.1%. Obviously these numbers will change and you have to look at ALL data and interpret it very carefully but just comparing the yearly death toll of flu to current death t total from covid is misleading. WAAAY more people get the flu each year than have gotten Covid, so far as we know right now, in part due to lockdowns, masks, etc. The overwhelming majority of scientific community agrees covid is much worse than the flu. I trust that over anecdotes.
I think this whole plasma thing was a typically stupid political stunt, but to be fair he said 35% reduction in mortality rate. That is very much different than 35% survival rate.
Wrong, where did you even get that idea? Her didn’t discover VIP, and he is the Founder of NeuroRX, not Relief Therapeutics who has the patent on Aviptadil.
The 18 dollar figure is from the seekingalpha pump article not some completely speculative calculation by “Prof Jarvitt” bruh. Pretty sure he has better things to do.
Tommy Searcy update: 8/22 PM
X-Rays show signs of slight improvement. The vent is currently at 80% and ECMO is at 100%. Blood pressure has been stable today with no additional meds needed. The 5th dose of RFL-100 is currently being administered.
Would be great but speculation, and a bit of a stretch based on a GIF.
Even if you believe Dr. Yo has some inside information, he mentioned another drug and another pharmacy at the same time...
I don’t buy it
The PI in that study is Houston doctor, not Javitt. He corrected Dr.Yo several times when he tried to attribute the study to him..
Yeah I don’t think it’s real at all. If it was why in the world would it be only on FB haha? At best somebody got ahold of an early draft or something. I’d be happy to be proven wrong. That being said I think the actual report will be as good if not better results.
Doesn’t sound like BS and sorry I obviously misspoke in glossing over the fact that people can in fact have an allergic reaction in very rare cases. Mostly just tired of people latching onto the mercury thing like they’re going to get mercury poisoning or something which just isn’t true. I think most Thimerosal will be completely phased out in not too distant future anyways though.
I know it’s off topic but this is just not true... Some vaccines contain thimerosal which prevents bacteria from growing in the vaccine. Thimerosal contains ethylmercury, which is NOT the same as mercury that is in fish, etc. Thimerosal is very safe and has been studied many many times and the only known side effect is swelling and redness.
Just because a molecule or compound has some element in it doesn’t mean it has the properties of any other compound with that element. People don’t avoid eating table salt even though it contains much more chlorine by weight than bleach or mustard gas...
That being said, I guess I should be less annoyed about the spread uninformed antivaxx garbage now that I’m holding all this RLFTF!