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Originally, dosage was supposed to be selected at 210. But since no one from the 100mg or 200mg group was hospitalized, dosage was selected at 400, perhaps after someone from the 100mg group was hospitalized. After that, according to everyone's favorite options receiver, they call him BMT, the trial actually went to 1:1.
Now if you play around with:
https://clincalc.com/stats/samplesize.aspx
With whatever %'s or ratios you want, you will find a certain number of participants is needed to prove significance. Which is how efficacy is analyzed by the regulatory types.
All speculation. The point being, a certain number of participants is required even if Bucillamine has 100% efficacy.
What we know is, that even with 0% Bucillamine hospitalizations and even 4% hospitalization of placebo, requires about 200 participants per arm to prove statistical significance.
NAC trial dosage
4000mg NAC at first dose, 1200mg/day for 14 days.
https://clinicaltrials.gov/ct2/show/NCT05074121#outcomemeasures
Phone glitched before and posted too early.
Get NAC off Amazon. Available in Canada. A bottle is under $40. 1200 mg/day. And 500mg/day glutathione.
$1.10 for 10 days and $.70 warrants forced to market.
The covid treatment market is expected to be 25 billion soon. If we are one of the few treatments that could be 5-10billion. Multiply by 5, 25-50 billion market cap. Possible with amazing results.
It takes a messed up person to wish or rejoice in harm on another. If you believe in Karma, you're putting out some bad energy.
Tgitm.... The FDA has declared NAC a pharmaceutical, not a supplement, as it was first tried as a drug in the 50's. Amazon can't sell pharmaceuticals. eBay is selling it illegally and saying it's a supplement still.
We can leave the rest alone.
How about honesty from governments?! I never said anything about anarchy. The government is you and me in theory. So you are lying to yourself! Go watch Oliver Stone's untold history of the United States, then come back and tell me you completely trust the government!
Anyone can make NAC. There is not just one manufacturer. Now let's say you hold A patent for COVID-19 treatment utilizing NAC. But anyone can buy a bottle for $30 and treat themselves at home. Maybe even have a few bottles in the cupboard. How will that company utilize their patent unless it can only be prescribed? The only chance for a market share is to have doctors prescribe your NAC.
And the USA government does not want people to be healthy.
Look at patent 6630507 -Cannabinoids as antioxidants and neuroprotectants.
Filed in 1999 by.... The United States of America as represented by the Department of Health and Human Services (Washington, DC)
Read that again... The US government had a medical patent for Cannabis while they were saying it was a schedule 1 drug with no medical value. As well as putting people in jail for promoting the medical uses and helping people get access to that medicine.
Governments SUCK!
Available in Canada on Amazon.ca, it's the American government that has banned the sale of NAC, not Amazon. They don't want people to be healthy there, well not for cheap. Works everytime for me with the standard cold rhinovirus. Pop some NAC and back to 100% the next day.
Classic warrior, big pharma could buy just Bucillamine IP, but commercialization payments will forever fund the research of all our other IP with no more share dilution (public/private share offerings). We can even have them pay for all future Bucillamine research and reformulation.
P.s. big pharma won't buy mushrooms just yet.
P.P.S. Future Dividend payments of a $1 per share per quarter.... ;)
Stop thinking buy out and start thinking commercialization Rights. If we are bought, the Supriya deal is void.
I would prefer constant income of hundreds of millions per deal from commercialization Rights for the next 10 years over a buy out. Cash, cash, cash, cash..... Or we sell once.
I think the FDA know this Revive team member:
Dr. Onesmo Mpanju, PhD has over 28 years of experience in biopharmaceutical R&D, including 18 years as a regulatory scientist. Previously, Dr. Mpanju was a Reviewer at the U.S. FDA, Center for Biologics Evaluation & Research. His consulting experience includes non-commercial entities such as the U.S. National Institutes of Health, US Army Medical Materiel Development Activity (USAMMDA), the Bill & Melinda Gates Foundation, and others. Dr. Mpanju holds a Ph.D. in Experimental Medicine (Infectious Diseases) from the University of British Columbia, Vancouver, Canada.
Patients swallow pills crushed up through a feeding tube. I believe it's "pre-clinical" but also mentioned designing protocol for severe.That's all I know.
Commercialization Rights:
From Revive's MD & A:
Worldwide, except
for Japan, South Korea and Taiwan
Maybe we pay Joe Rogan $$$ to do the EAP?
Buy out? Do people even read!?
Commercialization Rights!
MF said it. "The Company is in discussions with reputable international pharmaceutical companies seeking to obtain commercial rights to Bucillamine as a treatment for COVID-19 in various countries in Europe, India and Asia"
I don't know what the deals, $ or % numbers, will be but I would expect a similar format to this:
US$20 million on signing. 50 percent on the first US$200 million in annual net sales, then 40 percent on the next US$200 million, then 35 percent on net sales greater than US$400 million. This would be about $250mill per year per deal. Add a few deals and we'd be a multi-billion $ company in no time.
That is just the format. Not the numbers to expect.
I'm sure they'll find out Cannabinoids will kill it. Kills resistant Bacteria too.
46 Presidents not $46 dollars. That's a joke prediction from around the election.
MD&A page 8
Perhaps he should hire someone other than his daughter to do PR and media:
Alexandra Frank
Vice President of Marketing at Dominion Water Reserves Corp.
Experience
Summer Marketing Associate
Revive Therapeutics Ltd. (CSE: RVV)
Apr 2020 - Present11 mos
Toronto, Ontario, Canada
Research And Development Specialist
Revive Therapeutics Ltd. (TSXV: RVV) (OTCQB: RVVTF)
May 2018 - Sep 20185 mos
Toronto, Ontario, Canada
SP gain of vaxart of 1.7 billion on phase 1 results. That's $6.60 if we have a small phase 3 run
Enrolling by invitation: The study is selecting its participants from a population, or group of people, decided on by the researchers in advance. These studies are not open to everyone who meets the eligibility criteria but only to people in that particular population, who are specifically invited to participate.
They are hand picking patients to have the best range of patients. If you fill up with 80 year olds you don't know what it does for 20 year olds. Add in race, age, sex... Excellent data set!
FDA may give final approval but the DSMB has all power over the trial. They have the power to declare "Suspension or early termination of the study or of one or more study arms because study objectives have been obtained according to pre-established statistical guidelines;"
Maybe the 46th president will make it $46
It missed the pivot yesterday which was important. Today's miss does not matter as much, as 90% of the time that trend will continue for 12-72 hours after the first missed pivot.
Data goes to DSMB continuously... but from the study description starting 28 days after first pill taken. 14 days treatment, 14 days follow up. So interm data from first patient started arriving Christmas day.
"Following completion of the treatment course, follow up assessments will be performed by a study nurse 14, 28, 42, and 60 days following the end of treatment."
Each one of those companies now owes the government royalties for funding their research. Their patent must include the government as a holder of the patent. Our money will be our money!
I found Bucillamine at 98%, 100 mg pills for $150. Doesn't say how many tablets/weight.
https://aksci.com/item_list.php?search=Bucillamine
Or 10g for $586 USD (treatment is 8400mg over 14 days)
https://www.aurumpharmatech.com/Product/ProductDetails/U15998
Why do we need government funding?
We have a supplier for raw ingredients:
"Kyungdong Pharmaceutical is on the rise due to the news of a raw material export license for'Busiramine', which is being developed overseas as a treatment for Corona 19."
Those ingredients will be sent to Atwill for manufacturing.
"AMS operates an FDA compliant facility with ISO 13485 2016 certification and operates under cGMP and specializes in the lyophilization and related processing of pharmaceutical intermediates, medical devices, nutraceuticals and nutritional ingredients and supplements."
If AWS can manufacture 1 billion pills for Vaxart, they could do 1 billion for RVV.
Supplies, distribution already in place. Why give the government royalties for IP?
MF says they have enough cash for the trial.
What is the advantage of government funding? I'd be for it if someone can explain why we need it.
DD people, read the MD&A... There is no gout research anymore.
"As of June 30, 2019, the Company wrote off the intangible asset under REV-002 as the Company has no further plan to commercially exploit the patent."
2.6 million shares shorted. Says 1 day to cover. Probably will be half a day as we hit 4 mill yesterday. Slight squeeze. Not epic. Besides they are shorted but they have warrants to help.
From what I have seen that is his address. The Revive address passes "good" emails on to MF. His answers are usually short. How many people does he reply to that ask the same questions? Is there a trial? How many people? Blah blah. If you want a real response, come up with a worth while email for him to respond to. He's not going to formulate a long response, answering questions from shareholders with 20k shares. Must be slightly annoying to him.
Tomorrow's news: 2 clinical sites cancel due to harrassing phone calls... Stop it!
The two trials are the Clinical trial NCT04504734 and the Expanded Access Program. The Clinical trial has 3 arms, 100mg, 200mg, and placebo. Expanded access is 200mg.