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When you see a print like this:
16:00:06 .. $6.50 .. 1,413,200
It's most likely M O C orders.
This guy sounds like a winner - quite a background.
wuflu stats - USA deaths from/with the virus:
Jan 2021 - 3161 per day
Feb 2021 - 2555 per day
March 2021 - 1273 per day
Was this really about 2 morons eating raw bat meat, or did that lab do this with malice/aforethought?? I doubt we ever find out, for sure.
Patients should be doing face to face visits with their cardidocs, before long, again..
Sales did pretty well, especially considering the large cut back in expenses.
This seems like a very broad label, is it not?
Product name:
ACTIVE
Vazkepa
EU number: EU/1/20/1524
Active substance: icosapent ethyl
Indication: Vazkepa is indicated to reduce the risk of cardiovascular events in adult statin-treated patients at high cardiovascular risk with elevated triglycerides (≥150 mg/dL) and
• established cardiovascular disease, or
• diabetes, and at least one other cardiovascular risk factor.
birdbrain, going on mute, and I hate to do that. Enough problems in the world without that kind of bs.
Yes, Tuesday, I'm hoping they show a 50% sales increase or more, QoverQ.
Thanks Fly, good post - they have really trashed all the bios I own - AMRN not the worst one.
Almost certainly, it was the lawyers ideas on what to do about all of these situations. Thero pays them big bucks and depends on them to run the show. He's not a lawyer, and depends on them, to make the right decisions.
If all those short-busters from gme get involved, we could see a really nice move.
I'd like to see all those goldman skumbags take a big hit.
Wow HK, very well written, thank you.
Thanks to all that helped with the rule60 thing. I looked at a couple of the docs, but it's all over my head.
Here's hoping dudu can put the law ahead of being a lib tard.
Sweet, it may work on many other forms of cancer.
S A artucle:
HLS Therapeutics highlights promising VASCEPA data analysis
Mar. 17, 2021 11:55 AM ETAmarin Corporation plc (AMRN)By: Aakash Babu, SA News Editor5 Comments
HLS Therapeutics (OTCPK:HLTRF) announces that Amarin's (AMRN +3.0%) VASCEPA showed a 28% and 32% significant reductions in first and total strokes compared to placebo, and resulted in reductions in first and total ischemic strokes by 36%, without increasing hemorrhagic stroke, in statin-treated patients with elevated cardiovascular risk.
HLS is the exclusive licensee for VASCEPA, and owns commercialization rights under a September 2017 agreement.
The company said that consistent reductions in overall stroke and in ischemic stroke were observed across multiple subgroups in the REDUCE-IT STROKE trial. The new analysis of data from the trial was presented at the International Stroke Conference 2021.
The REDUCE-IT STROKE analyses examined stroke rates across the enrolled patient population (n=8179). Enrolled patients were required to be treated with statins and other conventional therapies, and all patients had either established cardiovascular disease or diabetes and had other cardiovascular risk factors such as elevated triglyceride levels.
Health Canada had approved Amarin's Vascepa (icosapent ethyl) to reduce the risk of cardiovascular events in certain high risk patients, in December 2019.
Great job, Ralphey.
Mayo clinic hasn't gotten the word:
https://www.medscape.com/viewarticle/944012?src=WNL_clfoc_210315_MSCPEDIT_TEMP2&uac=362266DV&impID=3244390&faf=1#vp_1
Thanks again, Marjac, good luck to all the S H.
chinaflu data:
USA deaths:
Jan 2021 = 3161 per day
Feb 2021 = 2555 per day
Mar 2021 = 1648 per day for the first 12 days
Data comes from:
https://www.worldometers.info/coronavirus/country/us/
Expecting con gress to fix anything is usually not a good idea, we just hope for the best.
The only thing that will stop the shorts/high-speed trading is reinstating the "uptick" rule. Unfortunately, that's not going to happen, there's too much money at stake, for the big players on the street.
Thanks Raf, considering that most patients are still not seeing their docs, I think we're doing all right.
The problem is, what's it going to take to get the lolifes to start covering??
Study Tracks Delayed Local Reactions in 12 Recipients of Moderna's COVID-19 Vaccine
By Reuters Staff
March 04, 2021
(Reuters Health) - Local reaction to Moderna's COVID-19 vaccine can appear up to 11 days after vaccination and symptoms can persist for as long as 11 days, a team of Boston doctors warns in an online letter to The New England Journal of Medicine.
Their analysis of 12 patients with delayed reactions after the first dose of the vaccine found that when delayed reactions occurred, the median time to onset was 8 days and symptoms resolved after a median of 6 days.
Reactions didn't always occur at the injection site. A 40-year-old woman developed papules on her palm and fingers that were believed to be the result of a shot. A 43-year-old man developed urticarial plaques on his elbows.
Such side effects may catch many doctors and patients by surprise, because "these reactions have not been consistently recognized, guidance regarding the second dose of vaccine has varied and many patients have unnecessarily received antibiotic agents" to treat them, said the team led by Dr. Kimberly Blumenthal of Massachusetts General Hospital.
They said the reactions are not a reason to eschew the vaccine.
About 84% of people who get their first dose of the Moderna vaccine have some type of reaction, such a muscle soreness or tenderness, and 0.8% of patients in the initial vaccine trial reported a delayed injection-site reaction on or after 8 days.
A delayed reaction such as erythema, induration and tenderness was less common -- seen in 0.2% of patients -- after the second dose. Most symptoms resolved after 5 days.
In their examination of the phenomenon, the Blumenthal team details 12 cases where the recipients saw any immediate side effects disappear, only to have a reaction sometime between 4 to 11 days after the first dose.
Their symptoms persisted for 2 to 11 days.
Five of the reactions in the 12 patients produced grade 3 plaques, meaning their diameter was at least 10 cm in diameter. Some had systemic symptoms associated with the vaccination.
The 47-year-old man whose symptoms reappeared 11 days after vaccination had initially suffered pain, fatigue, myalgias and a 7 cm lesion. His symptoms resolved after 6 days and his second dose produced fatigue, fever, chills and a similar-size rash.
The 49-year-old female whose symptoms persisted for 11 days developed two separate lesions 3 to 4 cm in diameter 8 days after her shot, along with pruritus, burning, pain, warmth, erythema, induration, and hyperpigmentation near the injection site. Her second dose produced chills and myalgias, slight erythema around day 2 and idiopathic urticaria recurred on day 12.
All 12 patients were given a second dose despite their delayed reactions.
Seven had a complete resolution of their symptoms before that second shot. Three had hyperpigmentation, with one having a burning sensation, another reporting tingling and dullness at the site. One had pain and itching. The 12th had mild elbow symptoms.
After the second dose, half "did not have a recurrence of large local reactions, three patients had recurrent reactions that were similar to those after the initial dose, and three patients had recurrent reactions that were of a lower grade than those after the initial dose," the Blumenthal team reported.
In those cases, it took a median of 2 days for the reactions to appear.
SOURCE: https://bit.ly/30aJtPe The New England Journal of Medicine, online March 3, 2021.
It moved pretty quickly from 4.50 to 11, and even faster, back to 5 - so, anything is possible.
It's always felt to me, like it's all about trading, with not many long-term investors.
Looks like they're not done trashing the biotechs yet. I look for 2 more days of it.
Wow, $35.41 - it would be great if we could get even half of that. The mkt doesn't seem to have much faith in the company, and I expect that's from the slow increase in revenues.
There's just nothing to engender excitement/interest.
The slimeballs have cut it half, it's horrible what the shorts do to corporations, and investors.
It's up quite a bit from year end, but still small. They are shorting it every day tho.
This stock sure makes some violent moves, 11 to 6 in a couple of weeks. let's hope it goes back up, as fast.
J&J’s 1-dose shot cleared, giving US 3rd COVID-19 vaccine
LAURAN NEERGAARD and MATTHEW PERRONE
Sat, February 27, 2021, 3:22 PM·5 min read1 / 3
Virus Outbreak J J Vaccine
FILE - This July 2020 photo provided by Johnson & Johnson shows a vial of the COVID-19 vaccine in Belgium. The U.S. is getting a third vaccine to prevent COVID-19, as the Food and Drug Administration on Saturday, Feb. 27, 2021 cleared a Johnson & Johnson shot that works with just one dose instead of two.(Johnson & Johnson via AP, File)
WASHINGTON (AP) — The U.S. is getting a third vaccine to prevent COVID-19, as the Food and Drug Administration on Saturday cleared a Johnson & Johnson shot that works with just one dose instead of two.
Health experts are anxiously awaiting a one-and-done option to help speed vaccinations, as they race against a virus that already has killed more than 510,000 people in the U.S. and is mutating in increasingly worrisome ways.
The FDA said J&J’s vaccine offers strong protection against what matters most: serious illness, hospitalizations and death. One dose was 85% protective against the most severe COVID-19 illness, in a massive study that spanned three continents — protection that remained strong even in countries such as South Africa, where the variants of most concern are spreading.
“This is really good news,” Dr. Francis Collins, director of the National Institutes of Health, told The Associated Press Saturday. “The most important thing we can do right now is to get as many shots in as many arms as we can.”
Shipments of a few million doses to be divided among states could begin as early as Monday. By the end of March, J&J has said it expects to deliver 20 million doses to the U.S., and 100 million by summer.
J&J also is seeking authorization for emergency use of its vaccine in Europe and from the World Health Organization. Worldwide, the company aims to produce about 1 billion doses globally by the end of the year. On Thursday, the island nation of Bahrain became the first to clear its use.
On Sunday, a U.S. advisory committee will meet to recommend how to prioritize use of the single-dose vaccine. And one big challenge is what the public wants to know: Which kind of vaccine is better?
“In this environment, whatever you can get — get,” said Dr. Arnold Monto of the University of Michigan, who chaired an FDA advisory panel that unanimously voted Friday that the vaccine’s benefits outweigh its risks.
Data is mixed on how well all the vaccines being used around the world work, prompting reports in some countries of people refusing one kind to wait for another.
In the U.S., the two-dose Pfizer and Moderna shots were 95% protective against symptomatic COVID-19. J&J’s one-dose effectiveness of 85% against severe COVID-19 dropped to 66% when moderate cases were rolled in. But there’s no apples-to-apples comparison because of differences in when and where each company conducted its studies, with the Pfizer and Moderna research finished before concerning variants began spreading.
NIH’s Collins said the evidence of effectiveness shows no reason to favor one vaccine over another.
“What people I think are mostly interested in is, is it going to keep me from getting really sick?” said NIH’s Collins. “Will it keep me from dying from this terrible disease? The good news is all of these say yes to that.”
Also, J&J is testing two doses of its vaccine in a separate large study. Collins said if a second dose eventually is deemed better, people who got one earlier would be offered another.
The FDA cautioned that it's too early to tell if someone who gets a mild or asymptomatic infection despite vaccination still could spread the virus.
There are clear advantages aside from the convenience of one shot. Local health officials are looking to use the J&J option in mobile vaccination clinics, homeless shelters, even with sailors who are spending months on fishing vessels — communities where it’s hard to be sure someone will come back in three to four weeks for a second vaccination.
The J&J vaccine also is easier to handle, lasting three months in the refrigerator compared to the Pfizer and Moderna options, which must be frozen.
“We’re chomping at the bit to get more supply. That’s the limiting factor for us right now,” said Dr. Matt Anderson of UW Health in Madison, Wisconsin, where staffers were readying electronic health records, staffing and vaccine storage in anticipation of offering J&J shots soon.
The FDA said studies detected no serious side effects. Like other COVID-19 vaccines, the main side effects of the J&J shot are pain at the injection site and flu-like fever, fatigue and headache.
The FDA said there is “a remote chance” that people may experience a severe allergic reaction to the shot, a rare risk seen with the Pfizer and Moderna vaccines.
The vaccine has been authorized for emergency use in adults 18 and older for now. But like other vaccine makers, J&J is about to begin a study of its vaccine in teens before moving to younger children later in the year, and also plans a study in pregnant women.
All COVID-19 vaccines train the body to recognize the new coronavirus, usually by spotting the spikey protein that coats it. But they’re made in very different ways.
J&J’s shot uses a cold virus like a Trojan horse to carry the spike gene into the body, where cells make harmless copies of the protein to prime the immune system in case the real virus comes along. It’s the same technology the company used in making an Ebola vaccine, and similar to COVID-19 vaccines made by AstraZeneca and China’s CanSino Biologics.
The Pfizer and Moderna vaccines are made with a different technology, a piece of genetic code called messenger RNA that spurs cells to make those harmless spike copies.
The AstraZeneca vaccine, already used in Britain and numerous other countries, is finishing a large U.S. study needed for FDA clearance. Also in the pipeline, Novavax uses a still different technology, made with lab-grown copies of the spike protein, and has reported preliminary findings from a British study suggesting strong protection.
Still other countries are using “inactivated vaccines,” made with killed coronavirus by Chinese companies Sinovac and Sinopharm.
___
Associated Press journalists Ricardo Alonso-Zaldivar and Marion Renault contributed to this report.
___
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.
Just got my 2nd PFE vaccine shot - no reaction at all. The only person I've talked to that had a problem with PFE shot, was one guy in his 70's - the other PFE recips were all trouble free.
Several I've talked to that got Moderna have had problems - I would take the PFE shot, if you have a choice.
Doc Mirkin mentions V in this email, first I've seen of him knowing about it:
People who had higher blood levels of omega-3 fatty acids at the time of a heart attack were far less likely to die or to have repeat heart attacks within three years, compared to those who had lower levels (J Am Coll Cardiol, Nov, 2020;76(18):2089-2097). The sources of omega-3s in the 944 heart attack patients in this study included both fish and plants.
Omega-3 fatty acids can help to lower high triglycerides, which may help to prevent heart muscle damage before and during a heart attack (Circulation, Aug 2, 2016;134(5):378–391). Omega-3s also significantly lower inflammation, an overactive immunity that increases heart attack risk (Cardiovasc Res, 2009;82:240-249). People whose diet includes deep-water fish are at a reduced risk for suffering and dying from a heart attack (Circulation, 2018;138:e35-e47).
Possible Benefits from Prescription Fish Oil Pills
If you have high blood levels of triglycerides (>150mg/dL), a major risk factor for heart attacks and diabetes, you may benefit from taking high-dose prescription fish oil omega-3 pills. Vascepa was the first FDA-approved drug to reduce cardiovascular risk among patients with elevated triglyceride levels, as an add-on to statin therapy (FDA press release, December 13, 2019). In a study of 8,179 patients over age 45 with a history of heart disease or diabetes, those who received Vascepa were significantly less likely to have a cardiovascular event such as a stroke or heart attack. Vascepa's active ingredient is eicosapentaenoic acid or EPA, an omega-3 fatty acid derived from fish oil. Other prescription fish oil products approved by the FDA include Lovaza, Epanova and Omtryg.
The prescription sources of omega-3s appear to be preferable to over-the-counter fish oil pills because they are more concentrated and contain only EPA, while over-the-counter products contain both EPA and DHA (docosahexaenoic acid), which may raise LDL cholesterol. The prescription pills may also be less likely to be rancid or contaminated (Cardiovasc J Afr, 2013;24:297-302). However, they are expensive and will only be covered by insurance if you have the high triglycerides that they are approved to treat. Check with your doctor.
Get Your Omega-3s from Foods
The possible benefits of over-the-counter fish oil pills are controversial (Clinical Nutrition, May 19, 2017) and I believe that you should be able to get enough omega-3s from eating oily fish (such as salmon or sardines) and a wide variety of plants. Some foods are marketed as particularly rich sources of omega-3s -- flaxseeds, chia seeds, hemp seeds, soybeans, seaweed, algae, perilla oil and so forth -- but you can get plenty of omega-3s in your regular diet if you eat lots of ordinary vegetables, nuts, beans and other seeds. Omega-3 fatty acids are classified into short chain fatty acids found in plants and long chain fatty acids found in fish. The health-promoting benefits of omega-3s come primarily from the long chain omega-3s, but some of the short chain omega-3s in plants can be converted to long chain omega-3s, so you can get the heart attack preventing benefits with a healthful plant-based diet (J Am Coll Cardiol, 2020;76(18):2098-2101).
Issues with Over-the Counter Fish Oil Pills
• A review of ten large randomized studies that followed 77,917 people, average age 64, for an average of 4.4 years, showed that taking fish oil pills did not prevent heart attacks, heart diseases, or major clotting events such as strokes (JAMA Cardiology, Jan 31, 2018). These studies were done with healthy people and on those with prior histories of heart attacks, diabetes, high blood cholesterol, or taking statin drugs.
• More than 21 studies have shown that fish oil pills do not prevent or treat any form of heart disease (Curr Cardiol Rep, Jun, 2017;19(6):47).
• From 2005 to 2012, 22 studies showed no benefit in preventing heart attacks or strokes in high-risk populations including people who were obese, did not exercise, ate meat daily, smoked, had a history of heart disease, had high cholesterol, had high blood pressure or had Type 2 diabetes (JAMA Intern Med, 2014;174(3):460-462).
• A review of 28 studies showed that fish oil pills did not help to prevent heart attacks (Clinical Nutrition, May 19, 2017).
• A clinical trial of 12,000 people found that fish oil pills did not reduce the rate of death from heart attacks and strokes (N Engl J Med, May 9, 2013; 368:1800-1808).
The debate over possible benefits from fish oil pills probably occurs because there is no way to monitor the quality of the pills taken by the people in these studies. Stale omega-3 oils in pills can be harmful and increase heart attack risk, which would cancel out any benefits that might be shown. If you decide to take fish oil pills, cut open the first capsule in the bottle and smell it. If it has a strong fish-oil odor, get rid of them. See Check Those Fish Oil Pills
My Recommendations
• The evidence that eating fish twice a week helps to prevent heart attacks is so strong that I believe everyone should do that.
• If you don't like fish and want to take omega-3 pills instead, realize that they may not be beneficial, and remember to test for rancidity by breaking open a capsule from each bottle you purchase. If they smell fishy, throw the whole bottle out, since rancid fish oils increase risk for heart attacks and certain cancers.
• If you are a vegan who eats no seafood, be sure to eat a wide variety of plants and include lots of seeds (beans, nuts, whole grains, seed oils and so forth). Also take vitamin B12 pills to prevent nerve damage caused by lack of that vitamin.
Thank you, Marjac - can't wait to read it. I'm really excited about it, as I'm sure you guys are.
Lizzy, we certainly have a large difference in our opinion of management. If dudu had not wrecked the stock price, I think the posts would read a lot differently. Her decision was not Thero's fault and I doubt he's even the one that made the decision on 9th circuit.. It's West coast and so is the lawyer's office - San Diego.
When you folks keep trashing management in public, all you're doing is running off potential buyers...... It takes a steady stream of new buyers, just to keep the stock from falling - let alone, going up.
I can understand the shorts doing that, but if you really own the stock, you night want to re-think your actions.
Good job, Captain.
You can be assured that Amarin has tested the generic product, and likely keeps testing it, at short intervals. That's their easy way out, with the thieves from hikma.
Marjac, thanks for all your work, is there some way we can get to read it?