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No board for PCLIX ?
PIMCO Commodities Plus Inst
https://www.pimco.com/en-us/investments/mutual-funds/commoditiesplus-strategy-fund/inst
caution, it inflames at higher doses. and inflammation can be dangerous. can they prevent it? and fda would be crazy to approve without a retrial. they stopped the retrial prematurely and now they’ll have to redo it all over again
fda would be crazy to approve it without a retrial. there is a risk for inflammation with the higher doses. what are the long term effects of that? and can it be prevented?
just detecting a contamination, or attenuation of the vials would be enough to invalidate the results...
if you dissolve the company, and the money in the bank is more than the total cost of shares.
I think, at least, it cannot go lower than ~$0.50 I think at that point it becomes profitable again to acquire the shares and loot the money in bank.
the trade price went down to $4.30 the last business day before the announcement too..
“From British Columbia to now New York, via Switzerland and Greece, so far no less than 7 different headquarter locations in less than 8 years for Anavex Life Sciences…”
https://link.medium.com/EtbauvIm7Z
the first option, whats preferred shares? why are they so pricey? are these not listed on the stock market?
third option, is that 100% discount then? or why would someone use the second option, 50% discount if you can get them for free?
If I sell tomorrow and someone buys 15% of the shares afterwards, would I still get the extra shares even though I have sold mine?
is the broker keeping track of this?
avxl profile as a company. headquarters moving all the time, short term employees, advertising company that gets options to buy at lowest rate, and profit by arbitrage, I wouldn’t hope for a break-through there. It’s for playing.
I think neurotrope, people actually believed in it, and now it’s worthless anyway, why sell it for peanuts? might as well follow it to the grave... there is still a chance they find something positive in the secondary results and raise the stock somewhat...
ebencestat was showing cognitive benefit in phase II trial too, but was discontinued by biogen, just a few days ago
does it mean the stock would get so diluted and low in value that it would get delisted if that happened? is that what poison pill means?
yes both extremes are bad, just the biomarkers or just the clinical diagnosis. Last year, a study came out for nilvapidine. it had prmising potential but it too failed miserably, and without any biomarkers.. Noone has a clue, Did all the patients really have alzheimers? was the dosage adequate or too low? or what went wrong.,
https://www.alzforum.org/news/research-news/nilvadipine-fails-slow-cognitive-decline-ad-patients
clearing amyloid has not worked, Bace inhibitors have not worked either, but what studies are you referring to regarding tau?
the only company I know that has got ANY results with tau at the moment is axon, and their results have been positive so far (not game changing though but a big step from what’s available for clinical use right now)
The additional shares protection offer is good to the 19th. Will the shares plunge even more on Friday?
BIIB stops both Elenbecestat and BAN2401 prematurely, stating too much risk... I believe (but I may be wrong) these were the last of BACE inhibitor trials...
What made them lose heart, despite II trials saying it was showing cognitive benefit?
Sorry I assumed the researchers themselves were not blinded. Or at least someone wasn’t.
you’re right. I was looking at SIB-L.
SIB:
The SIB contains 51 questions which take a total of about 20 min to administer, and the possible scores range from 0 to 100. The SIB is divided into 9 subscales, viz. social interaction skills (score 0-6), memory (score 0-14), orientation (score 0-6), language (score 0-46), attention (score 0-6), praxis (score 0-8), visuospatial ability (score 0-8), con- struction (score 0-4) and orienting to name (score 0-2), each of which yields individual scores. There is no cut-off score for normal subjects as the test is only intended to be used with patients known to be severely impaired. However, it is possi- ble to grade the severity of impairment by rating those who score less than 63 on the SIB (corresponding approximately to less than 4 on the MMSE).
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.808.1112&rep=rep1&type=pdf
They must have seen it’s going sideways from the start. Why did they not stop it??? The result is definitely far from the compassionate-use patient results... or does it mean there IS a lucky subgroup ? This is just too odd..
you’re giving the SIB numbers too much weight. The error margin is 3.7. When MMSE is not measurable they use SIB which gives them another 0-40 scale. Below the error margin just means zero.
Sugar pills 0 : 0 Bryostatin
Hi, sorry for the newbie question, what does CU stand for?
Where is the scientific report?
Did just a press release plunge the stock or is there an actual scientific report?
A month ago Akron said :
Currently, our improvement data is the best anyone has.
https://m.benzinga.com/article/14046592
How does that translate into worse than placebo?