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Obviously the Trial data is directly related to the Fast Track. The Fast Track is on moderate COVID with strict Limitations and Exclusions for Patient needing breathing support. I Got it...Plenty of room for other possibly more effective Drugs and certainly (as stated by this CEO) room for combinations and Drugs for the most seriously ill...
Why doesn't Relief seek the sickest patients in their clinical trials.?.
Compare Exclusion criteria with another company's Inclusion criteria. Obviously a drug that is for sicker patients will work for those not so sick. I wont post the name. The hype is here but it may still be a rush to successful data readouts. JMO. What the Trials state/are trying to prove matters. JMO. Some act like this is a done deal for all COVID issues. I dont think so. These criteria leave alot of open ground...
Disclaimer, I missed the <$.15 boat and watched it sail. But I never say never, this is the play today, Congratulations.
aviptadil NCT04360096 Not yet recruiting (inhaled)
Inclusion Criteria:
Moderate or Severe COVID-19 by FDA definition with no evidence of Respiratory Failure
Capable of using mesh nebulizer to administer medication with assistance if needed
Exclusion Criteria:**
Evidence of Respiratory Failure
Use or impending use of ventilation or high flow nasal oxygen 20L or greater
-------------------------
NCT04311697 recruiting (intravenous)
SOC is defined not to include extracorporeal mechanical oxygenation.
Verses.....
"Inclusion Criteria:
Male and female subjects aged ≥18 years of age
Confirmed coronavirus infection
Positive real-time fluorescence polymerase chain reaction of the patient's respiratory or blood specimens for COVID-19 nucleic acid
Viral gene sequences in respiratory or blood specimens that are highly homologous to COVID-19
Any other diagnostic test accepted by local regulatory authorities
Must be hospitalized and requiring supplemental oxygen, or on non-invasive ventilation or high flow oxygen devices (Score of 4 or 5 on WHO Ordinal Clinical Scale)"!!!
===========================
Thankyou, I was checking things too and use Yahoo, others. That's the Summary page and I cant figure it out. Thought it might the be float, but not. Those numbers seem common.
Confusion about the Clinicaltrials.guv info and MC/OS. Overall a winner so far and possibly much longer. Never say never, just missed the < $.20 boat. ..As it lloks maybe another boat will come along, JMHFO...
To others; I've seen insiders and institutions sell into frensies with their financial incentives.
Just bored, sorry for the disruptions, I guess. ..
Wow, WHALA. 2.1B shares X $.62 = $1.3B MC.
Drug production is for the Trials so far.
Bye and GLTA...
ClinicalTrials for ifenprodil are seeking the sickest patients using breathing support. Done#2...GLTA...
Seems logical/obvious about IV vs inhaled, but why the SOC definition and treatment exclusion data I quoted.
I already stated I missed than passed on past entry points and wont chase this for reasons also already stated. I'm nobody and gone now.
Youall can continue your agendas without my alleged interference and discussion subjects...GLTA...
Aviptadil by intravenous infusion + standard of care
Aviptadil by intravenous infusion + standard of care (SOC). SOC is defined not to include extracorporeal mechanical oxygenation. Those requiring ECMO will be withdrawn from the study as treatment failures.
Same quote with nebulized drug'
Those sickest patients will be moved to the 'compassionate care" trial. Is this right or not?
I am not posting opinions, read the links and ClinicalTrials.Gov postings. Note the 2B+ shares and debt/financing...
Opinion follows.
A quad from $.15+ or better yet a 10+ spot from $.05 a couple weeks ago is great but the next quad will be tough. Other drugs work differently and there is plenty of room for several solutions or a combination of treatments...GLTA...
Guess I'll post this again. Just facts from the Exclusion Data on these trials. Nothing I made up. Just like the 2B+ shares that scared me away and influenced my decisions. Congrats to all here, I missed the quad$+. ...GLTA...
As stated on a much less used MB, "one poster on a obscure MB will not change the stock's trading". Youall stop calling me out and I'll stop posting my DD again and again. Argue about my apples not some oranges. I certainly didnt write the trial parameters...GLTA...
Congratulations on all the success investors have had here. I'll pass with this action and PPS/MC, missed the real money, my bad...
aviptadil NCT04360096 Not yet recruiting "(Nebulized)"*
Inclusion Criteria:
Moderate or Severe COVID-19 by FDA definition with no evidence of Respiratory Failure
Capable of using mesh nebulizer to administer medication with assistance if needed
Exclusion Criteria:
Evidence of Respiratory Failure
Use or impending use of ventilation or high flow nasal oxygen 20L or greater
NCT04311697 recruiting "(IV)"*
SOC is defined not to include extracorporeal mechanical oxygenation.
*my additions
I wore a steel helmet and a hat only while fishing (melanoma), so unsupported opinions from anyone doesnt get thru it, just facts. I do and have always posted references. You Know this already.
As stated elsewhere I was fishing so had missed the @.15s and wont chase this. Too much baggage, IMO. This repurposed drug doesnt treat the most serious patients in the main Trials. Compassionate use is great but the main Trials are not targeting the sickest most in need.
Another repurposed drug we both own stock in and post at, DOES and requires that condition in their Trials and has 1/15 the shares and no debt... Hope youall make the 10 bagger here for the 4B+ market cap that represents. Take a profit A*, and have 3/4 shares free, be happy...
aviptadil NCT04360096 Not yet recruiting
Inclusion Criteria:
Moderate or Severe COVID-19 by FDA definition with no evidence of Respiratory Failure
Capable of using mesh nebulizer to administer medication with assistance if needed
Exclusion Criteria:
Evidence of Respiratory Failure
Use or impending use of ventilation or high flow nasal oxygen 20L or greater
NCT04311697 recruiting
SOC is defined not to include extracorporeal mechanical oxygenation.
Youall better READ the data and quotes posted here by those with hats. Argue FACTS with supporting Links Please. Not inferred personal opinions. Kind of like I do...GLTA...
An + Am can go and be derogatory on that other stock, as clearly seen one is the most on that board depending on their position...JMHFO...
It is an extreme distinction between needing ventilation and those not needing it. * trials are looking only for patients needing breathing support, the sickest patients and Relief is treating those patients before that stage. I READ the ENTIRE study parameters. Links were posted. The subject of outstanding shares and possible valuation is ALSO a common discussion. Just simple math in Black and White. Current Drug production is for Trials...GLTA...
"Manufacture and release of investigational product was completed within 60 days of FDA’s approval to proceed with the clinical trial."
I dont see this saying anything about worldwide production or distribution.
For a buyout after good data $2 seems good, IMO. 5% of Gilead is a pretty big price. Although I've read from $5 to $100+ here. 2 B+ shares, + ...
The Trial IDs are posted with the Exclusion data quotes.
The limitations on ventilation or Oxygen are copied from the Clinical Trial 'Exclusion data'.
There is another company with Trials that requires the sickest patients and use of supplemental breathing support.
Plenty of room for several treatments and combinations of drugs...GLTA...
Good to see AGN's Ifenprodil COVID Clinical Trials are setting a higher bar then some currently prominent COVID trials.
We seek the sicker patients!!!
"Inclusion Criteria:
Male and female subjects aged ≥18 years of age
Confirmed coronavirus infection
Positive real-time fluorescence polymerase chain reaction of the patient's respiratory or blood specimens for COVID-19 nucleic acid
Viral gene sequences in respiratory or blood specimens that are highly homologous to COVID-19
Any other diagnostic test accepted by local regulatory authorities
Must be hospitalized and requiring supplemental oxygen, or on non-invasive ventilation or high flow oxygen devices (Score of 4 or 5 on WHO Ordinal Clinical Scale)"!!!
What use is a "severe" COVID treatment that cant be used on patients that are on ventilators? Both intravenous and inhaled versions have this criteria?
aviptadil NCT04360096 Not yet recruiting
Inclusion Criteria:
Moderate or Severe COVID-19 by FDA definition with no evidence of Respiratory Failure
Capable of using mesh nebulizer to administer medication with assistance if needed
Exclusion Criteria:
Evidence of Respiratory Failure
Use or impending use of ventilation or high flow nasal oxygen 20L or greater
NCT04311697 recruiting
SOC is defined not to include extracorporeal mechanical oxygenation.
Trial Info
aviptadil NCT04360096 Not yet recruiting
Inclusion Criteria:
Moderate or Severe COVID-19 by FDA definition with no evidence of Respiratory Failure
Capable of using mesh nebulizer to administer medication with assistance if needed
Exclusion Criteria:
Evidence of Respiratory Failure
Use or impending use of ventilation or high flow nasal oxygen 20L or greater
NCT04311697 recruiting
SOC is defined not to include extracorporeal mechanical oxygenation.
Rel* our (current - main) competition PLANNED Trials want patients that are not using ventilators, either inhaled or intravenous. How is that a treatment for severe COVID.?.
aviptadil NCT04360096 Not yet recruiting
Inclusion Criteria:
Moderate or Severe COVID-19 by FDA definition with no evidence of Respiratory Failure
Capable of using mesh nebulizer to administer medication with assistance if needed
Exclusion Criteria:
Evidence of Respiratory Failure
Use or impending use of ventilation or high flow nasal oxygen 20L or greater
NCT04311697 recruiting
SOC is defined not to include extracorporeal mechanical oxygenation.
This is a Scam, read the Trial info. Both inhaled and intravenous for MILD COVID, what use are drugs that wont be used with people on ventilators?
aviptadil NCT04360096 Not yet recruiting
Inclusion Criteria:
Moderate or Severe COVID-19 by FDA definition with no evidence of Respiratory Failure
Capable of using mesh nebulizer to administer medication with assistance if needed
Exclusion Criteria:
Evidence of Respiratory Failure
Use or impending use of ventilation or high flow nasal oxygen 20L or greater
NCT04311697 recruiting
SOC is defined not to include extracorporeal mechanical oxygenation.
Shoulda coulda woulda, was busy fishing, didn't @ $.17. Not chasing for a flip but hope youall kept some free shares. Maybe will fly tomorrow=forever. Heard some investors say they would never touch OTC again and then a PK catches fire... Dont like the snorting thing with lung issues, counterintuitive, IMO. But no one cares with 150M traded. Still alot of folks may want profits with 2+B outstanding and $.05 a week ago...GLTA...
Maybe DD Algernon/ AGN. Ifenprodil Phase 2b/3 Trials
The advice is related to shell's discussion and our's from the past.
Science is on our side too. There is room for many supportive answers to COVID. Come on GVI/Novotech...DAYS please, surprise us...
Nice to be able to reply...TCM*...GLTA...
Congratulations, now sell some at a profit and be happy.
Rif just shows how hungry the market is for even 'Possible' results and what can happen.
Time for Mr Monroe to kick our CROs in theass. Their scientists should recognize the possibilities of Ifenprodil and strongly represent us, IN PERSON to possible enrollment sites. They are taking our money just as in South Korea. Months is a BS answer.
Again Mr Monroe if you read this, what about 'orphan' or IND status and where is Canada?
I had hope of AGN leading the pack for treatment Trials. We are still at the fore front but the Swiss hype and IND status will make AGN prove success as compared to theories.
Somewhat disappointed with our CROs, expected more from both. But we really dont know progress and first dosed patient news came out at the same time as other news dominated the field.
Canada could have been more supportive and the AGN/USFDA team should be pushing our story VERY harder here. What happened with 'orphan drug' or IND status?
The Swiss will still need to actually have pertinent new data re; snorting ED drugs for COVID (2B OS 2018 and PK debt).?. I am betting the AGN story will raise to the top through the Science and undeniable data. First to data may still happen. The need for verified COVID solutions are expanding as is the IPF/CC/ARDS recovery caseloads. Treatments will be long term, IMO...GLTA...
My point was complete sarcasm. An ED drug repurposed (2B OS, flying) and a shroom company. Scams, Claims IMO with much weaker stories than AGN. Kal quote was before halt (noted) and it was pathetic volume considering the news. Thats why the halt, to gather interest. IMO.
AGN science is strong enough to have FDA IND or other support, IMO. We need news of further/completed enrollments then strong data. ASAP! That's our bet here, IMO...GLTA...
I think we will get news of the 2b/3 COVID Trial enrollment next week. I hope the theory of enrollment means dose start in the IPF Trial will be true...GLTA...
Our competition others have posted about are interesting;
Relief (rlf) is repurposing the drug Aviptadil..artcle follows??
https://www.timesofisrael.com/erectile-dysfunction-drug-shows-promise-treating-covid-israeli-innovator-says/
Revive(rvv) has this in the latest PR...
Currently, the Company is exploring the use of Bucillamine for the potential treatment of infectious diseases, with an initial focus on severe influenza and COVID-19. With its recent acquisition of Psilocin Pharma Corp., Revive is advancing the development of Psilocybin-based therapeutics in various diseases and disorders. Revive’s cannabinoid pharmaceutical portfolio focuses on rare inflammatory diseases and the company was granted FDA orphan drug status designation for the use of Cannabidiol (CBD) to treat autoimmune hepatitis (liver disease) and to treat ischemia and reperfusion injury from organ transplantation. For more information, visit www.ReviveThera.com.
Pathetic volume. Can't blame Kal for the sellers. I hope some here are buying some shares to help support the PPS.
A couple of the stocks mentioned here as competitors, with some similarities of treatments to AGN, have the 'longs' pumping hard on medias and there is strong volume. Here we p*ss on posts due to semantics.
AGN has 2 separate indication Trials and has officially started dosing in the first. Recruitment news for the COVID Trial is due next and could be strong. IPF/CC only needs 20. Funding is in place. No debt and <200M OS if fully diluted. Maybe I'm tha D*A*?
Dr Fousi says we are still in first wave. Gov Coumo asks 'with the last few months after NY, how is it that other States and the Gov is not better prepared with NO National plan for testing and wider support for treatments? Just hype of Remdesivir, the in house Gilead/Wuhan accomplices and other lies from the Top. Looks like there will be a market for Any solutions and room for many. All JMHFO, of course..GLTA...
PS, Halted while I babble.
Yes good news. I had bigger hopes that enrollments for both Trials were moving much faster. No COVID enrollment update or word of strong enrollments for the IPF Trials. Oh well, milktoast, but at least something.
“As the study progresses, the Company will make an assessment of the enrollment rate and will provide an update to the market on a projected completion date as well as when the data will be expected.”
Over expectations of a biopharma, we got '0' from SK and now finally something (1) on the original Trial. Come on Novotech / GVI, give us full enrollment by September...GLTA...
- 28% @$.15 with 100M+ traded today and 2.1B outstanding. RLFTF /?
...GLTA...
About time, we're still burning Arab war oil and dealing with the pollution...
https://finance.yahoo.com/news/california-sued-over-climate-change-123025779.html
With Canada's day off I would guess that the company may need to get any info and assess it tomorrow, leaving Wed + for any update, if any this week. I think we are all tired of the dribble of little 'PRs'.
They may hold off if things are doing very well to announce better than expected recruitments. Possibly occurring in both the IPF and COVID Trials.
Or Not and they are progressing slower. They certainly dont want another South Korea. JMO..GLTA...
Looks like they scrubbed any reference to United Cannabis corp / CNAB. Back to UCANN?
Updated, yea sure...GLTA...
Key word, 'Trials'. That was $3M for each right? Raising money @ $2.?+-? after a successful early Phase 2 data, say of 10M shares and moving forward with a Phase 3, sure do it, IMO.
Longs lived thru a PP @$.05 after RS and then the recent @$.24.?... The big dilution is done, IMO... As Smoki said, these are cheapies...Good data we fly and bad , well this is an OTC bet...JMO...GLTA...
Wow. "Spending a $500,000 on marketing
When you don’t have a product to sell
Is poor leadership...imo..I could take some time to go over the financials "
Maybe some company DD or read other poster's efforts...
Maybe also listen to the videos, less effort needed, where the CEO attempts to mollify over expectant-under informed investors, explaining the 'repurposing" drug concepts, explaining the challenges and successes.
Our time may come and then we all can feel smart and richer, or not. I believe and have done my DD. Been here thru the genuflecting and changes, bth/nash/agn. Own alot for me and waiting for cash to clear and buy more, doubling again. I understand OTC bets, most dont succeed but I continue to find Ideas I will invest in. Of course I'm just a pissant old corporal.
IMO, all the late arrivers here are at a financial advantage compared to long time Longs.
I usually include relevant links or DD not just my humble F*n opinions, but. I was going to post about CKD/IBS, link @ bottom.
We can only buy, hold or sell these company's stocks, hopefully on fore sight. We dont run them. Investing on hind sight is less desirable...
CKD etc...
https://www.kidney.org/news/covid-19-patients-are-becoming-kidney-patients-most-americans-unaware
mmmb
He tries and documents. You dont. Your drivel is a waste of space. Moderators, please delete this and that.
End of month is today, so any results should wait till next week as follow up to last Video. IMO. Excessive shareholder expectations in the OTC and pharmas in specific are not real, IMO.
Yes Ill stay with Ifenprodil, rvv will also need to pay for and design their shroom/cbd/seaweed trials. Will institutions be open for that?..GLTA...