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At the end of the video there was the question about raising money. CEO CM said they would 'clean up the share structure and warrants if needed first'.
So whatever that means it seems like it's not a pressing issue and they are confident there may be better opportunities available after the Feb final Data are released and End Points are identified for the Phase 3 Trial or EUP...
I was unrealistic and not smart enough to try a 'stop' for some shares and still hold this shaken tree with both hands. I hope the 'longest / smartest / dumbest' here either were the first 'stopped out' or can share with me in the risks - rewards ahead.
Been DD'ing and this still looks the best R-R to me and is by far my largest in this sector...GLTA...
Currently 18K patients intubated out of 120K hospitalized in USA today... Minus costs of logistics and infusions, minus 50% for NRX. Lets get realistic... Ass-u-mes 100% of patients on intubation get just this one drug and all others are stopped.?.
No debt but Cost of 1.5B new shares dilution to run Trials? 2.7B OS now.
And taking their 50% of RLF-100 with them, apparently? with Dr JJ. Brpa was in trouble financially? But with the merger now has NRX drugs but owes payments. At least they brought a Nasdaq listing to NRXP in the RM.
But where does that leave RLF? Still paying for R+D, PAID for R+D thru dilutions. RLf has world market 80/20 and US 50/50 revenue splits with NRX as leading production and distribution partner. Is that why the new guys?
I hope the data is as good as the EAP. maybe everyone will be happy in Jan...GLTA...
Everything probably will wait for the new year, including how NRXP will use these fine new managers @ RLF-NRX to make some plan for abused RLF shareholders (SHARES) to CONTINUE to pay the bills. That way RLF-100 can be hijacked without NRX sharing even this small payout with RLF to help pay the R+D / production / distribution - logistics planning / ADVERTIZING. . . Tax selling till then here in the US where most of the RLF shares are held, especially the 'spikes'. Then more bonus CoC payments all around ...
RLF and VIPs are great re-discoveries, EVERYTHING else is in question. Maybe Ben DoveR/S will be the answer.
Increases thru January at the least due to Xmax travel.etc
Current treatments in question for no positive effect.
The latest treatment is Rem plus baricitinib resulting in 1 day shorter hospital stay and they are now EUA. Couldnt find anything about how this 'cocktail' is effecting WHO ratings...GLTA...
https://news.wbfo.org/post/holiday-gatherings-expected-increase-covid-hospitalizations
https://www.healthline.com/health-news/study-finds-antiviral-meds-like-remdesivir-have-no-effect-on-covid-19
I hope the video today helped us all understand the WHO criteria and allowances for Endpoints for COVID. Their continued contacts with their DSMB and the FDA seems to support their possible future actions for Endpoints.
Full data may still show WHO level changes at 28 day data which is unknown. Then 'the rest of the story'.
Well, Nothing right now is working to help COVID patients. Not alone or as a 'cocktail'.
Glad AGN put out some news trying to clarify things.
Some think this tiny company has a foot in the door no one else has. Some are shooting technical arrows and some see boogie men.
Reality, there is NO COVID Cure in spite of the efforts so far. per WHO / NEJM.
https://www.healthline.com/health-news/study-finds-antiviral-meds-like-remdesivir-have-no-effect-on-covid-19
It's just a speculative OTC stock that has a chance to possibly be a Treatment piece* in the COVID battle.
*Oh yea, currently the WHO and NYJM say no drugs are working alone or as 'cocktail' pieces in the COVID fight. Healthline newsletter, 12-11-20...GLTA...
Maybe FOX will send a reporter for an interview or rebroadcast this one.
The news is out and wont be updated on Biopub, IMO.
Full Data ASAP. 2021.
12-10 + 28 days + 7 to 14 days, IMO. I'll wait the gamble out.
"the pump dont work 'cause the vandals took the handles"
Real world news. There is no cure for COVID, just maybe something that helps.
He said it's time to lay the cards on the table and see what they are. Wine? Nothing is a COVID cure. Cocktails? Maybe...
https://www.healthline.com/health-news/study-finds-antiviral-meds-like-remdesivir-have-no-effect-on-covid-19
BTH>NASH>AGN stuck for the ride? Dont need a weather vane to know which way the wind blows.
Some original rap for youall ganstarz.
ANYthing that actually helps patients will mater even if it is a Secondary outcome measure now. IMO.
Phase 3 with Primary outcome priorities changed, Maybe. EUA was mentioned?
"The trial found that none of the drugs studied provided any benefit for the patients in any of the areas that were assessed"
https://www.healthline.com/health-news/study-finds-antiviral-meds-like-remdesivir-have-no-effect-on-covid-19
A MUCH better PR, thanks CM.
Of course this is relevant and the new PR better explains it. There is a huge current need for successful Treatments. COVID isnt going away soon, XMas travel, vaccinations starting in spring with distribution and logistics issues. 40% wont take it and 20% still wont wear masks...
Blue Crystal balls say AGN will have data early, by January and apply for FDA EUA using time off ventilators and less time in hospital for patients...
The firm noted that this suggests that patients may be recovering more quickly with Ifenprodil, which might help in reducing the number of days required for hospitalization. The company pointed out that even though the average number of days in the hospital is not one of the exact predetermined metrics included in the interim analysis, this data will be included in the final data set as some other firms have been successful at gaining emergency use authorization from the U.S. Food and Drug Administration based solely upon the ability to reduce the number of in-hospital days.
The company's CEO Christopher J. Moreau remarked, "While we are very pleased that the interim data has provided us with some positive trending information, we still need to evaluate the full definitive results and statistics to be presented with the final data set...We will be especially interested to see the numbers on the overall time spent on ventilation and rate to ventilation to be reported in the final data set."
Thanks to K*
https://www.streetwisereports.com/article/2020/12/16/pharma-developer-reports-interim-data-is-trending-positively-in-phase-2b-3-covid-19-trial.html
This PR should/could of been 'positively trending', maybe even explosive if it correctly contained what CEO CM related in the "try to explain FU PR" video he seems to need to do after most PRs and certainly a Halt. They had time to make it powerful but F*ed Up, again.
NEWS ratings with O2 levels and other SIGNALS were seen!
The PR could of/should of explained why the limited info and made SOME attempt at being written in an unmistakable POSITIVE light!!!
So, RLF now get 50% of US distribution/profits and NRXP takes 50% of the biggest market along with RLF-100 to NRXP. RLF gets the rest of the world and the bills. LOL.
NRX gets huge fulfillment bonuses and RLF is not mentioned in that part of the deals. EUA? FDA hopeful approval by 2022. Bonuses for all. Change of Control bonuses for JJ and NRX/BR execs-BoD.
Then. More bonuses at RLF 'extraordinary' meeting / quorum / Vote to set this all up.?.
Why would they buy RLF after this deal? When?
Gem double wins and RLF shareholders pay GEM thru more dilution for RLF-100 R+D and Trials.
150k patient RLF stockpile for possible sale by Q1 2021. 50% of any profit goes to JJ and friends/BR.
Even worse than I had thought. Sorry, JMHFO...
sorry 2 the RLF Vote - meeting/quorum is already controlled by GEM. Large group of US shareholders meets Ben DoveR/S ...
Now you are saying RLF may be back in the NRX/BR IPO, to join in a R/M by paying/acquiring NRX and now friends to manage World wide / US sales and logistics for RLF-100, Inhaler Trials, consolidate GEM holdings.?...hmmm...
Many many, we all lo$t on paper on a GOOD news day.
The proof may be in the Full Phase 2b Data. I'm waiting, Duh.
Still a GOOD speculative investment in COVID science. IMO. No guaranteed bets or forced gambles.
General Public vaccination starting by late spring.?.
I noticed I was drinking a Canadian whiskey so I changed to Hornitos anos and a lime. It's 4:20 somewhere.
'A' is recovering slowly, off intubation...GLTA...
Why T F Didn't the PR say, Ifenprodil has 'positive trending' signals from NEWS ratings for O2 levels, time off ventilation,(blah blah woof woof), that our CEO CM is NOW saying in this Video.?.
Who proof-read that PR.?. And we PAY for these PR services.
A couple of casual (stupid) words and PRIME info missing sent AGN down 30%. The stock was Halted with Plenty of time to craft a better, even explosive, PR.
BUT again, a Video has to TRY TO Re-Explain that this is a POSITIVE GOOD GREAT event...JMHFO...GLTA...
Damage to the Lungs may take longer than was hoped to show the healing effects and be seen in a long term recovery.?. Expecting a strong patient uptrend at the 15 day Data point 'in humans' may have been too high an expectation.
Mortality? What can they say about that or most results except "positive trending"?
The 'positive trending' is certainly better than colonquin/others which were a negative.
The Secondary endpoints seem more realistic with effects of treatment time allowing it to fully work. Seems by this data that at the 15 day period it will just begin affecting recovery and 'I hope' to see Ifenprodil show stronger results given the extra time periods in the 28 day Secondary data.?.
Time to being on ventilation or coming off along with overall mortality and final time spent in a Hospital were all set for 28 day analysis.
I see medchem's reply to Top 3 question, thumbs up...
As stated in the PR, an EUA was granted for minor improvements from Rem. It was mentioned for a reason, I hope.?.
Ifenprodil doesn't seem to be the instant COVID-19 killer of our dreams but is showing some effectiveness and is safe with COVID patient's conditions. More time and that 28 day Data may still show Ifenprodil will be a stronger treatment than what is available now.?.
...GLTA...
science guys???
I was concerned that the Primary endpoints were directed at 15 day results. Expecting a strong patient uptrend at this early time in humans may have been too aggressive. Damage to the Lungs may take longer than hoped to show healing effects.
The 'positive trending' is certainly better than colonquin/others which were a negative.
The Secondary endpoints seem more realistic with effects of treatment time allowing it to fully work. Seems by this data that at the 15 day period it will just begin affecting recovery and 'I hope' to see Ifenprodil show stronger results given the extra time periods in the 28 day Secondary data.
Time to being on ventilation or coming off along with overall mortality and final time spent in a Hospital were all set for 28 day analysis.
As stated in the PR, an EUA was granted for minor improvements from Rem. It was mentioned for a reason, I hope.
Ifenprodil doesn't seem to be the instant COVID-19 killer of our dreams but is showing some effectiveness and is safe with COVID patient's conditions. More time and that Data may still show Ifenprodil will be a stronger treatment than what is available now...JMHO...GLTA...
science guys???
Most likely to compensate for any drop outs during the Trial and to get full power of the Trial. They did un-blind the early 102 data and it was said they paid a % penalty for that too.
? Will there be a presentation of some sort at this 'extraordinary' meeting or is this just a 'quorum' to pass BoD business? Dates for more data releases is set for mid Jan 2021.
That was a great football game tonight...GLTA...
Unanimous approval from DSMB for continuation of Trial to completion. WHO and Universities say Rem and other top used drugs are having limited success at best. A low bar and Great Need.
My sad opinion is that the continued exponential growth of this disease will need all possible support. Just like the Pfizer and other vaccines will All be needed and used as fast as they can be made. For some time to come, IMO.
Sad to Opine, but first to market may be like the Pfizer and other vaccines, ALL will be needed in as great a quantity as possible, ASAP, as the COVID-19 disease is seeing exponential growth...
The WHO and Universities say Rem and other top drugs in use so far are showing limited benefits to none...
From the last article it seems that the SoleTrout assisted IPO will be just NRX and RLF will stand alone with RLF-100.?.
https://sonix.ai/r/xtrz7PUXeMjvyvbr48n12Ucj/share
13000 vaccinations for Maine? 7B people to vaccinate? Priorities surely. Many say not months but years until that is done.
The world will certainly will need Treatment medications. One that is scalable for a huge population of infected or those that will be infected. WHO and University Researchers say Rem and top other drugs showing minor/NO success...
https://bangordailynews.com/2020/12/10/news/maine-days-away-from-1st-coronavirus-vaccinations-but-the-process-will-take-months/
Well, we all hope so.
"“We’ve tried to be efficient*, we’ve tried to be effective**, get information to investors*** and hopefully, we find that the drug is effective. Because we want to start to see if we can get that drug into physicians’ hands so that they can start to use it****. That’s the goal here.”
* With investor's money;
** COVID Clinical Trial completing with interim Data asap and full data end of 1 / 2021. IPf next focus;
*** Regular updates;
**** There it I$...GLTA...
Well, it's official. Trial status change...
https://clinicaltrials.gov/ct2/results?cond=&term=Ifenprodil&cntry=&state=&city=&dist=
Sad info. Cases of pregnant women or giving birth that have been infected by COVID. In their teens and twenties. They are part of the rest of All other patients now less prioritized due to the huge COVID efforts and then possibly being exposed to the Viruses at Hospitals and Doctor's offices. Pregnancy and other patients require in person Hospital visits.
Currently the advice for Positive COVID-19 Patients is to 'isolate' with common cold treatments for 10 days and call back if symptoms get worse. WTF? SAD, IMHFO. There should be something for between diagnosis and Hospitalization. Ifenprodil?
Infusions and all the peripheral needs they require like Doctors, Pharmacy (drug prep and storage), Nurses, monitoring, specialists, (lawyers?) ect are at least as expensive as the drug being given. Very expensive. Being precise and giving Any drug is complicated.
Just a Drug course for cancer Optivo $80k, Keytruda $150K, Yervoy about $400k, so a survivor from Cancer may have a $1M bill. Sometimes courses are repeated.
SAME Costs for COVID but exaggerated (X10?) with Emergency priorities and safety as possible. The best help right now is the SOC and the Nursing staff's' hard work. According to the WHO and John's Hopkins the 'Big four treatments' are not statistically helping.
More Bat Soup. 'Hope' for an Available COVID-19 vaccine possibly early summer,I signed up at my provider... 58% If...
With these reactions to the pandemic there will be lots of Sorrow for a Long time.
God please watch over us. But maybe this is His way to save the Earth from us?. Rolling 1 again...GLTA...
Sad info. Many cases of pregnant women or those giving birth have been affected by COVID.
Sadder...
My wife's nephew's 'at term' wife (22 years old) was tested positive about 12 days ago and told to isolate with normal cold medicine.***!!!
5 days ago she had breathing problems and was admitted and had a emergency C-section.!. 'J' is fine and their 2 year old 'L' is fine too and have tested negative as we all have.
'A' remains hospitalized with intubation now at Providence MC. SOC only, they will not discuss RLF or other 'treatments''..
We are all helping the family and extremely cautious ie. masks-gloves-glasses/ionizers/lysol and isolation etc.
'A' feels she got exposed to it during the many visits to her DR as her 'term' came close.
***FKN Bat Soup, why the wait for any treatment for her? Fury, insanity!!!
Lack of Leadership, 8 + months into this pandemic, in America, WTF?
He got 3 kinds +, immediately!
More Bat Soup
I have survived 4 cancers and asked my Dr when I could 'hope' for a vaccine and reply was after healthcare workers, possibly early summer...
With these reactions to the pandemic there will be lots of Sorrow for a Long time.
God please watch over us. But maybe this is His way to save the Earth from us?...Bye for a while and...GLTA...
CM actually stated the cost of Rem @1500 per treatment course, so I think he was implying Ifenprodil could be less. Half? I feel it needs to have a competitive price. 20M + not recovered and about 10% in Hospitals. so $1.5B initial market now with no end in sight and continued increases in patients. Big 4 treatments are a failure so far according to the presentation and JH.
Stockpiles will be a Major market. Prescriptions for Ifenprodil may include pre-hospitalized patients too.Soooo.
I am hoping the discussions with a partner/licensees or BigP taking over the IP for a couple $B are the best plans. Strike while the market is hot ASAP, IMO.
I had also hoped that LS5 had set the proper tone here with the support and buying by his group. Lowball biddings for teeny lots and weak hand sells are not the smartest moves at this point, IMHFO.
/
...GLTA...
World wide, 68M total cases with 831K reported today, 1.555M deaths and 15K reported today, 43M recovered leaving an unrecovered possible 23M possibly needing some effective treatments.
Nothing has shown late stage recoveries except this. Hopefully there will be fast work toward Inhaler version with preventive and / or early treatment...GLTA...
Search 'Coronavirus Map'
CEO CM had a reply to the 'pricing' of 'a course of treatment' question... Interesting reply...GLTA...
"Well" maybe that IS a good longer term strategy. Beginning 'piping and bagging' to extract the Methane from cattle farms and garbage dumps. Certainly help the environment. The science to refine extracted and easily store NGs is here already. Maybe the Biden Infrastructure plan will include NG / RNG. Weening from much dirtier gas/oil will need a cleaner combustible ...
But today...
Many of the used capped frack wells have lots of Natural Gas. This easily accessible source could and should be captured and used, along with the NG that is allowed to escape or is burned while extracting the oil and sludge. At Shale areas where they continually move and re-drill/frack for extracting, there are lots of capped well heads. Empty wells in other areas have been used for NG storage...GLTA...
66M cases worldwide with 700k new cases a day, 42M recovered and 1.5M sadly deceased with 12K+ a day, leaving a tragic 22M not recovered and this is apparently the possible current market for a successful and safe Treatment. IMO.
Vaccines to be starting next year so continued increases in cases is expected for some time...
Many are concerned about taking vaccines.
Many still dont social distance or wear defensive/preventive masks, especially in the USA it seems, causing continued future infections.
World wide licensing for production through a Big Pharma seems the best way to distribute enough to all the places where it is needed.
Say 10% to 30% or more will want a pill with effective results compared to tough and/or expensive infusion courses or a semi effective (at best) drug like REM. JMHO.
The safety record implies that Ifenprodil can possibly be given as an outpatient medicine for the earlier cases not yet hospitalized. There is also a possible use for recovering patients with lung damage for the ARDS/IPF issues many suffer after basic recovery.
Lastly, CEO CM discussed the questions about a COVID 20-21 etc that current vaccines probably wont be effective against. There will be continued need for Treatments.
I feel Good about this investment for several strong reasons...GLTA...
Thanks to all the posts taking time from other work and investments to compassionately watch out for BRTX shareholder's and their investment money.
Pretty dumb to kill a run-up for a quick few grand when there are such strong possibilities. No proof it was inside pukes, as at this point there is probably inside knowledge. So?
Flipping for pennies is the new normal. I wish for the days when a trade took some more effort than a click. These new normals wont matter if the data is strong.
A low bar exists from Rem and others that brag on limited success. There is now also concerns of effectiveness of the vaccines with minority populations. Availability of Treatments etc and enough hospital space in rural communities is again an issue.
I believe the science will prevail and make us all happier. A continued cautious population is not trusting vaccines and there are those that still blatantly refuse to participate in social distancing and preventive/defensive masks.
The hope is to eventually tamp down the spread. But currently the abundance of infections and progressions to hospitals continues, especially in the USA, Sad.
Our entrant to help the COVID fight may be life saving for some/many.
Ifenprodil is an easier remedy to produce, administer to patients and with a reasonable treatment cost. No difficult infusion courses or reactions noted in the Trial DSMC reviews. Unanimous consent.
A world wide pandemic market that needs a simple and EFFECTIVE treatment. Maybe an approval for Ifenprodil thru the FDA EUA program can really help.
Not a bad investment to place a bet on, IMO. This is now my biggest stock bet so I sure hope I'm right in my rants/post, LOL...GLTA...
I think we will hear about a Lead investigator and Trial site. It's implied that is done when a Trial is being designed for approval and then enrollment.?.
The company is probably doing more than waiting for CPAs and reading message boards, they just might be working on this.
Chart trading on an emerged BK? But you say to buy @ $.oo5.?.
Many are making a lot of noise for such mere differences in their possible bet here. Probably sell for a $.005 flip, GLWT as a strategy. 100% profit, LOL.
Throw a couple grand (X10?) at a possible win or not, bfd.
Auctus wont kill this possible Golden Goose. IMO. Their profit is in the Trial, ASAP, IMO.
A Billion shares @<.015 or driving this to BK again probably isn't their plan. Volume will dry and they'll be skrood too, holding infinite shares. Patience, JMHO...GLTA...
Redo, This stock has been a Dog so far but I dont think Auctus will let this fail. It's in their best interest to support the Phase 2 trial. No point to sell @ the current PPS, more chips please, no whine.
My total Respect for the devil's dogs...GLTA...