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Agreed..Also I have not seen any proof that the IP and assets of BGEN have been removed by Charles and Joseph. I hear a lot of discussion about this on the other board also..But I'm not convinced it has been separated. As you and I agree..These guys own a LOT of Shares of ENZC.
I must have missed something. Where do you see that the IP left BGEN?
April 26th PR...
Sagaliam Acquisition Corp. Announces Novation Agreement with Enzolytics, Inc.
Sagaliam Acquisition Corp.
Fri, Apr 26, 20246 min read
NEW YORK, NY / ACCESSWIRE / April 26, 2024 / Sagaliam Acquisition Corp. ("SAGAU", "SAGA", SAGAR") (the "Company") announced that Sagaliam entered into a Novation Agreement with Enzolytics, Inc. (OTC PINK:ENZC), Biogenysis, Inc. (BGEN), and Virogentics, Inc. (VIRO) (together the "Parties"). ?Under this restructured agreement SAGA retains 100% ownership of VIRO, ITV-1, the nutraceutical products and license along with VIRO's other assets. This agreement transferred ownership of Biogenysis, Inc. ("BGEN") and it's IP, patents and associated asset being developed back to ENZC in exchange for a reduction of the price from $450,000,000 to $290,000,000 with the dividend of the purchase shares to come directly to the ENZC shareholders from SAGA. The Parties believe this will significantly shorten the time needed to obtain regulatory approval to initiate the dividend of the 29 million SAGA shares issued for the purchase of VIRO. All other terms and conditions of the purchase agreement, including the make-whole provision relating to the 29 million SAGA shares, remain in place.
Barry Kostiner, the CEO of Sagaliam, commented, "After the Sagaliam - Enzolytics transaction was closed in September, we have worked together with the Enzolytics management team to tweak the details for mutual benefit. We are excited about moving forward with the Virogentics team. The ITV-1 therapy has potential to significantly improve effectiveness and reduce costs of the standard of care for HIV. Additionally, ITV-1 is believed to have therapeutic application to other chronic conditions including diabetes, cancer and other conditions known to be impacted by peptide therapies targeting inflammation. Our IPF nutraceutical has received strong consumer approval, and we will be ramping up our marketing efforts, in parallel with our other nutraceutical products. Through the Novation Agreement, return of Biogenysis to Enzolytics, and reduction of shares issued, we believe that we have a strong foundation for building a valuable pharmaceutical company with global impact, in partnership with our colleagues at Enzolytics. We are also working with Enzolytics on building the sales, marketing and distribution infrastructure for our nutraceutical products."
Steve Sharabura, the CEO of Enzolytics, commented, "The Novation Agreement is an exciting development for Enzolytics. It serves as a solid foundation for building both Enzolytics and Sagaliam as significant biotech companies that are independent entities, but that work closely together. Enzolytics is proud to be a major shareholder in Sagaliam. The two companies have several initiatives in the works, specifically in the areas of medical testing, medical devices and an expanded nutraceutical product line. Negotiations are ongoing between Sagaliam and Enzolytics on these matters."
Harry Zhabilov, the Chief Science Officer of Virogentics, commented, "With the completion of the Novation Agreement, we have visibility to funding and the success of both companies. We now have a platform that allows us to implement our vision of bringing our technology to commercial implementation. We are also in advanced discussions with multiple synergistic biotech companies that are interested in joining our platform. After much anticipation, we are excited about moving forward on bringing our therapies to improve the lives of many patients with multiple chronic conditions, as well as increasing the near-term revenue of our nutraceutical products."
About Sagaliam Acquisition Corp.
We are a blank check company incorporated under the laws of the State of Delaware on March 31, 2021 for the purpose of effecting a merger, capital stock exchange, asset acquisition, stock purchase, reorganization or similar business combination with one or more businesses or entities. Sagaliam intends to continue to pursue the consummation of a business combination with an appropriate target.
Virogentics, a subsidiary of Sagaliam, is advancing multiple therapeutics targeting numerous infectious diseases. One patented and clinically tested compound, ITV-1 (Immune Therapeutic Vaccine-1), is a suspension of Inactivated Pepsin Fraction (IPF), covered by U.S. Patent Nos. 8,066,982 and 7,479,538. Studies have shown it to be effective in treating HIV/AIDS. ITV-1 has also been shown to modulate the immune system.
continued.....
Enzolytics, Inc. Overview
Enzolytics, Inc. is a drug development company committed to commercializing its proprietary monoclonal antibodies and proteins to treat debilitating infectious diseases.
Biogenysis, a subsidiary of Enzolytics, uses proprietary techniques to produce fully human monoclonal antibodies (mAbs) against infectious diseases. The technology is currently being employed to produce monoclonal antibody therapeutics for treating the CoronaVirus (SARS-CoV-2), HIV-1 and the Feline Leukemia Virus. The Company has also identified conserved epitopes on and has plans to produce mAbs targeting many other viruses, including H1N1 Influenza, HTLV1 & HTLV2, Leukemia Virus, Herpes Simplex I Virus, Respiratory Syncytial Virus (RSV), Smallpox Virus, Rabies, Influenza A, Influenza B, Ebola Virus, Epstein Barr Virus, and Monkey Pox Virus. The Company has also analyzed epitopes of animal viruses and plans to produce mAbs for treating these animal viruses.
Virogentics, a subsidiary of Enzolytics, is advancing multiple therapeutics targeting numerous infectious diseases. One patented and clinically tested compound, ITV-1 (Immune Therapeutic Vaccine-1), is a suspension of Inactivated Pepsin Fraction (IPF), covered by U.S. Patent Nos. 8,066,982 and 7,479,538. Studies have shown it to be effective in treating HIV/AIDS. ITV-1 has also been shown to modulate the immune system.
This Aug 24th 2023 PR gives us a breakdown of VIRO and BEGN and what they contain.
ACCESSWIRE
Biogenysis’ International Patent Application, Covering Its Anti-SARS-CoV-2 Monoclonal Antibodies, Advances to Prosecution in Europe and as a U.S. National Stage Application.
ACCESSWIRE· Enzolytics, Inc.
Enzolytics, Inc.
Thu, Aug 24, 202310 min read
COLLEGE STATION, TX / ACCESSWIRE / August 24, 2023 / Biogenysis, Inc. (OTC PINK:ENZC) (or the "Company"). Biogenysis, a subsidiary of Enzolytics, Inc., announces the progress of its Patent Cooperation Treaty (PCT) application covering its inventions relating to Anti-SARS-CoV-2 Monoclonal Antibodies. The PCT application has now advanced to filing as a U.S. National Stage Application in the U.S. Patent Office and as a formal European Patent Organization (EPO) application. The EPO application makes possible coverage in the 39 contracting countries within the EPO. These countries include all of the countries in the European Union, the United Kingdom and the extensive list totally 39 member countries throughout Europe and adjacent regions. https://www.epo.org/about-us/foundation/member-states.html.
The pending applications contain 23 separate patent claims covering (1) the 19 discovered highly conserved antigens and epitopes (sites) on the SARS CoV-2 virus, (2) antibodies that bind to the disclosed antigens and epitopes, (3) vaccines based on the antigens, (4) methods of treating, preventing, or reducing the risks of SARS CoV-2 infection with the antigens or binding proteins, and (5) methods and kits for detecting or diagnosing infection by SARS CoV-2 using the antigens or binding proteins.
Through computer analysis (Artificial Intelligence (AI)), the Company discovered 19 immutable conserved virus sites on the COVID-19 virus by analyzing 2.8 million SARS CoV-2 isolates. This analysis identified these critical, conserved, immutable epitopes of the virus. These sites are now claimed as patentable based on their novel specificity and the finding that they are conserved on SARS-CoV-2. This is significant because antibodies produced to bind to these conserved, immutable sites can neutralize the virus without the possibility of "virus escape" due to virus mutation. Specifically, virus mutants will still contain these target sites allowing these specialized monoclonal antibodies to neutralize the virus even as it mutates.
The Company's patent applications claim the use of any one identified epitope or any combination of any of the multiple identified epitopes in any of the following ways:
For producing a therapeutic monoclonal antibody to treat the CoronaVirus.
For making a vaccine against the CoronaVirus.
For creating related prophylactic/therapeutic methods relating to the epitopes/antigens.
For use in any diagnostic test to identify whether a person has the CoronaVirus.
The Company has produced and is producing fully human monoclonal antibodies against these claimed sites. The International Patent Office has confirmed these discoveries as being novel and inventive, capable of being patented and claimed exclusively for a 20-year term in each member country under the Patent Cooperation Treat in which the Company pursues these claims.
The Company also has similar PCT applications pending covering discovered immutable conserved epitopes (binding sites) on the HIV virus and the animal Feline (cat) Leukemia Virus (FeLV). The Company has also analyzed the amino acid sequences on numerous other human and animal viruses and plans to also produce anti-mAbs targeting these sites and will file for U.S. and international patents on these discoveries. These discoveries include the Company's findings from analyzing the human viruses H1N1 Influenza, HTLV1 & HTLV2, Leukemia Virus, Herpes Simplex I Virus, Respiratory Syncytial Virus (RSV), Smallpox Virus, Rabies, Influenza A, Influenza B, Ebola Virus, Epstein Barr Virus, and Monkey Pox Virus.
The Company has also analyzed and identified conserved and immutable epitopes in animal viruses including Equine Infectious Anemia Virus, Feline Immunodeficiency Virus, Koala Retrovirus Virus, and Elephant Endotheliotropic Herpes Virus. Using the Company's technology currently being used to produce monoclonal antibodies against human viruses, therapeutic mAbs may be produced to treat these animal viruses.
The Company fully expects the issuance of multiple international patents covering these discoveries accomplished through the Company's unique process using computer analysis (AI) to identify conserved, immutable epitopes on the target virus. Biogenysis' proprietary AI platform, invented by Dr. Gaurav Chandra, Biogenysis' CEO, has been used to analyze the sequences (structure) of 2.8 Million SARS-CoV-2 virus isolates to identify conserved sites. As a part of this process, 3-dimensional models of these conserved targets were generated, and the targets were analyzed for linearity, accessibility by antibodies, and neutralizability by antibodies. From this, Biogenysis scientists are producing multiple broadly neutralizing antibodies targeting these multiple conserved, immutable epitopes on the targeted virus. The monoclonal antibodies directed against these targets will expectedly be universal, durable, broadly neutralizing, and unaffected by virus mutation.
The Company considers the expected patent protection to be highly significant, recognizing that for a monoclonal antibody to be effective (that is, to be fully capable of neutralizing a virus), it must target an immutable site on the virus. Otherwise, virus mutation will render the therapeutic ineffective. Biogenysis' methodology for producing monoclonal antibodies is unique and innovative, unlike those other biotech companies employ. The Company's antibodies are made from human "immune-B cells" obtained from convalescent individuals (or animals in the case of veterinarian monoclonal antibodies) who have recovered from the target virus. The Company's monoclonal antibodies are not "humanized" but are fully human monoclonal antibodies where the original antibody affinity and specificity are maintained, and the chances of immunogenicity are minimized.
The Company believes its discoveries will be significant to the success of the Company. Although the COVID-19 pandemic was reported to be over, it is now recognized that COVID-19 will be with us from year to year. The global market size for effective treatments in 2022 was $16.43 billion. The global Monoclonal Antibodies market size was $185.50 Billion in 2021, with an expected compound annual growth rate (CAGR) of 11.30% from 2022 to 2030.
The Company's near-term objective is to collaborate with pharma entities and license its technology or partner with major pharma entities now producing therapies for COVID-19.
Regarding the Company's therapeutic against HIV, the Company has produced a fully human anti-HIV monoclonal Antibody, Clone 3. The Company is now producing additional anti-HIV mAbs to be used in combination. Experts agree that a cure for HIV may be found in the production and administration of multiple anti-HIV monoclonal antibodies. This is the Company's goal. The Company has successfully produced and tested, in vitro, one HIV monoclonal antibody (Clone 3) and has identified 7 additional immutable conserved sites on the HIV virus against which it is in the process of producing anti-monoclonal antibodies. These antibodies will be produced as fully human, with the starting point being human "immune-B cells" from long-term non-progressor HIV patients. This production is being conducted with pharmaceutical entities to accelerate the process of production and testing of the monoclonal antibodies.
In 2021, the global HIV drugs market was $30.46 billion, with this market projected to grow to $45.58 billion by 2028. The global Monoclonal Antibody market size was $185.50 Billion in 2021, with an expected compound annual growth rate (CAGR) of 11.30% from 2022 to 2030.
The global market for Human Monoclonal Antibodies in 2022 was $55 Billion.
The Company's near-term objective is collaboration with pharma companies producing treatments for HIV. The current HIV treatments available do not cure and must be taken for a lifetime. The Company is focused on licensing or partnering with major pharma entities now producing treatments for HIV. To accelerate and fully execute the successful production of the multiple monoclonal antibodies, the subject of the Company's intellectual property, the Company continuously engages with multiple pharma entities to accomplish the successful goal of production, testing, and delivery of successful therapeutics.
Gaurav Chandra, Biogenysis' CEO, stated, "Amid alarming concerns regarding COVID mutations, it is crucial to prioritize efforts towards achieving broader immunity against variants, longer-lasting protection, and preventing infection and transmission. Utilizing intranasal IgA monoclonal antibodies effectively attains high secretory IgA levels, reflecting mucosal immunity. The Biogenysis anti-COVID monoclonal antibodies, both IgG and IgA, being universal, broadly neutralizing, durable, and unaffected by mutations, are a critical solution to this pressing issue."
Charles Cotropia, Enzolytics' CEO, said, "We have a well-defined strategy for developing an Intellectual Property portfolio to secure significant patent protection covering our therapeutic discoveries in numerous countries around the world. With these rights secured, we will focus on potential partnering or licensing the technology to international pharmaceutical companies working in the areas in which we are focused. Obtaining international patent coverage will be significant in achieving this objective.
"The necessary technology is now in hand for producing these therapeutics for use in the treatment of many infectious diseases. The earlier announced plans for the sale of Biogenysis and Virogentics, subsidiaries of Enzolytics, to Sagaliam Acquisition Corp. (NASDAQ: SAGA), a special purpose acquisition company ("SPAC"), comes at an opportune time. Once completed, this transaction will provide Biogenysis and Virogentics with the capital that will make possible final development of the therapeutics now being produced."
I LIKE THE WHOLE DEAL AL LOT BETTER!!
Hey...What can I say..Now I have 3,000,100 shares..
That 100 was mine..lol for the fun of it....
I cant imagine our new CEO making these statements unless they are going to happen. Why create more confusion and liability at this point. My hope remains that some type of dividend will happen.
https://finance.yahoo.com/news/formulation-business-strategy-132700137.html
Congrats CJ2. Best feeling in the world. I got 3 grandkids and 1 on the way. Happy Daze.! GO IGPK.
Volume is picking up. Someone may be previewing the filings.
Thank You docsetc for taking all that time and effort to check it out.
I guess all the research is finished. Patents are the key now . So no need to kill any more rats.
I stickied your post FrankMD.
Thats sad.....I think there was a big mess and its slowly getting straightened out.
I just gave you your first follow. I like how our other is moving also. The news was good on it today.
I thought it was a mistake...I really liked your thought process. I hope all of JFHE is rolled into IGPK..GLTY.
Not sure what you are talking about..I have never been mean to anyone. Just commenting on your post . I thought your post was a very good post.
MrMyers. I appreciate your analysis.! My thoughts are. => If the IGPK shares are not adjusted (via RS) then current JFHE shareholders would possibly get 2.625 shares (thats 1.68 B / 640MM ) for each of their JFHE shares. This would only consider the 1.68 B shares held at the DTC. If full AS of 4.65 B is used then JFHE holders would get 7.27 shares (4.65 B / 640 MM) for each of their JFHE shares. But that would entail using the entire AS which I don't think any company would want to do. Normally non issued shares are usually held for future needs.
All of this though is based on the assumption that all of the assets of JFHE are loaded into IGPK. (which I believe will happen).
Excellent NEWS.!
I keep checking the filings.
Is anyone else excited about seeing how the numbers look $$$..?
Grabbing all I can today. Need to be loaded up prior to close today.
This is the POST OF THE DAY..! LOL
Nice NEWS this morning.
If you OWN ENZC stock..You will get the dividend. PERIOD.! EODiscussion.
Float is 41 million shres.
I see a major insider purchase on 2/20 of 400,000 shares.
News on March 6th seems substantial.