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From the Yahoo Board:
One limitation of our meta-analysis is the heterogeneity of the studies. The observations of individual studies differed substantially, which we attribute to various reasons. First, there are a fair number of studies with only few study participants yet large effect sizes. Eight studies included less than 15 patients per group. These studies achieved great effects with Cyto Sorb intervention. By contrast, there are larger randomized controlled trials and observational studies with propensity score matching with notably smaller effect sizes. Secondly, the use of Cyto Sorb differed in many ways. The number of adsorbers, duration of therapy, time from diagnosis to first use of the adsorber, and blood flow rate were very inconsistent. Thirdly, medical conditions were compared that differ completely in their pathophysiology.....
By no means were all the studies suitable for inclusion in the meta-study.
Most of them were completely inadequate in terms of their scientific quality, had cohorts that were too small, used data from the same patients several times and compared completely different disease courses," explains Professor Schmidt.
Nevertheless, the meta-study does not exclude that CytoSorb might not have a positive effect under certain circumstances, emphasizes Professor Schmidt.
"In certain patients in the very early phase of sepsis, the adsorber could possibly help," he says. "But these are case-by-case decisions." In order to clearly prove the effectiveness, randomized, controlled studies on suitable patients in comparable disease states are missing.
Now that is a very good sign. Hopefully more will do the same!
Sar Pas,
No reply to my last post! The stock is now at 73 cents. Get out while you can. It is not on fire! I can't beleive that you have not responded.
He is a scammer and it will soon be delisted or he will have to do another offering. I lost thousands years ago. It is what Spiro does. He keeps on sucking in new money so that he can live the life of luxury while we all lose our shirts. That is what he does. Everyone needs to run as fast as possible and take their loses. This guy and his board should be shut down. I can't stand to see what you are all going through! Get out Now!
So what do you have to say now? Spiro has been sucking in people for years. Prepare yourself for another reverse split so that he can keep the money rolling in. I lost thousands years ago. He is a scammer! Run!
Biotech48,
Of course you must be joking. I have been a member of this board since 2018 and have placed 12 posts. Why not take a look. It is right there for you and anyone else to see.
I am not one to post as often as you and some of the others do however yes, I did see the article regarding sepsis. I read anything and everything regarding this company as I know you do as well. My statement was that we hardly see anything regarding sepsis any longer and that was the reason that I purchased the stock back in 2010.
Now we hope that they do succeed in another year or two and get any kind of an approval for whatever indication. I as many others will continue to hope for the best however, you should be able to agree that It has been a very long haul and now we have to hope that they do not do another reverse split next year. The cash burn is concerning. One 25 reverse split was enough for me! That said, it is very frustrating and I can understand Fantomphans frustration. Do you?
I am sorry to say that I have to agree with you. We have suffered threw this and his bumbling long enough. Doctor Chan has to go. No wonder Kathy is packing it in. As CFO, she knew what was coming! He should be following her out the door.
I bought into this company more than 10 years ago as a way to fight sepsis. Today, hardly a word regarding sepsis! I already went through a reverse split. And now we may be facing another! This is disgusting! Chan needs to be fired immediately!
Not a word from anyone in an effort to turn this nightmare around! I voted no! They should all be fired!
And not a word from anyone in an effort to turn this nightmare around! I voted no! They should be fired!
Canes,
I realize that! However, at these bargain basement prices I am simply questioning as to why they are not loading up? I am not referring to their options here. I am questioning why they are not buying more than they currently have with their hard earned dollars. I will continue to remain on hold until I see that they do in tandem and in full force.
Thank you for your response!
Where is our leader and his staff? Why are they not buying?
Anyone! What is going on here?
When will they say something, anything. Drifting in the wind. We go up and we go down, with the market. This is sickening!
Sent to Dr. Hahn,
Dear Doctor Hahn,
I apologize for taking up your time, however I wanted to make sure that you are aware of the above mentioned company. Please take a moment to review below.
My hope is to get this product known as Cytosorb, fast tracked in the USA. I truly believe that an awesome game changing player is sitting on the bench.
I have been following this company for more than 10 years. Cytosorb to date has been approved in 58 countries around the world including ITALY, CHINA, GERMANY, FRANCE , INDIA, AND IRAN TO SAVE LIVES IN THE ICU. Five Thousand filters have been recently shipped to these countries. Cytosorbents manufacturing plants right here in New Jersey are working overtime to supply the aforementioned countries with these life saving filters to those in need. It is not a drug but a devise that cleanses the blood. The company is working with many government agencies including the U.S. military and DARPA. .
I am attaching a four minute clip which was recently taken on March 9, 2020 from Liz Claman's show on Fox News. Please give it a minute to load. You will find Cytosorbents CEO Philip Chan explaining what the blood filter is doing to save lives and how the Chinese have requested additional filters since they have found it to work!
Thank you for reading my e-mail and taking a moment out of your schedule to review the clip.
Sincerely,
Fair enough in that he did mention it briefly on the Clayman broadcast. Wasn't that the time to say that we are saving lives in Italy which is one of the many places that we are approved along with some statistics? That is what is bothering me. Not any mention as to what we are doing there. In all honesty, I find that very concerning. So the question remains what are we doing in Italy along with everywhere else that we are approved and worth mentioning. I feel that he dropped the ball.
This at the least deserves a company P.R that they could then personally send to the FDA, Gottlieb and all of the doctors in the house along with all of us doing the same. It's their job to do so.
Glad you brought up Italy. I have been asking myself for almost two weeks where are the reports from Italy and why are so many dying. We are approved in Italy so what gives? Why not a word?
Why is it that when we sent the translated information to Chan regarding China that he only mentioned China on the t.v. broadcast? Why didn't he mention Italy and what we are doing there if anything at all. There should be no excuses. This is his job and now we are emailing and texting everyone we can with a thank you from Chan. Something seems to be very wrong here. This is outrageous in my opinion.
Been here since 2012 and now that the time is right to shine we are the ones to run with this to the people in charge! This is not right.
Fantomphan...No credit here
I have been here since 2012. Bought in at .12 cents. So sorry to here about Bertha. Too bad he is missing all of this. He is in my thoughts and prayers!
Not one for posting and grateful to all that do. I simply translated from Techxen's post "Is this Cytosorb" and the post by SSMMSS Translation: In the Roman Children Hospital. They deserve the credit. I simply assisted.
Just one of the silent majority.
Thanks!
From The Roman Children's Hospital Translation
Pope Children's Hospital:
Success with new leukaemia treatment In the Roman children's hospital Bambino Gesù, a 14-year-old has been treated with a new method against blood cancer. The team around the doctor Gabriella Bottari successfully used the blood purification method CytoSorb for the first time.
Never euthanasia and aiding suicide Stefanie Stahlhofen and Eliana Astorri -
Vatican City According to the Papal Children's Hospital Bambino Gesù, it was the first successful treatment of a young person worldwide with the help of the so-called CytoSorb method. This technique for blood purification was used in combination with an immunotherapy. Thus, side effects of the immunotherapy CAR-T could be reduced and finally blood cancer was defeated. The case has already been published in the journal Critical Care Explorations, the physician in charge, Gabriella Bottari, told us:
"The case we published involved a 14-year-old patient with leukaemia who, after treatment with CAR-T cell therapy, had severe breathing problems due to inflammation. The boy was then admitted to the intensive care unit, where we initiated the usual relief measures. In addition, we carried out extracorporeal blood cleansing "For the follow-up Combination of two treatment methods Gabriella Bottari is certain that the combination of the two treatment methods was successful. The blood purification helped to contain the inflammation without any negative interaction with the immunotherapy. The boy quickly responded positively to the treatment, so that the CAR-T immune therapy could be continued.
The good news from the Bambino Gesù has already spread in specialist circles, the Italian doctor reports: "The boy was able to leave the intensive care unit after 15 days - that is a relatively short time. The boy soon no longer needed artificial respiration and was able to leave the intensive care unit after 15 days - that is a relatively short time. Later he was discharged from hospital completely and is now still in the aftercare programme with colleagues in haematology and oncology.
According to the German Cancer Society, approximately 13,700 people contract leukaemia every year; four percent of these are children under 15 years of age. According to recent reports, the chances of cure are increasing. Does the success of treatment at the Papal Children's Hospital Bambino Gesù confirm this trend? Doctor Gabriella Bottari does not want to jump to conclusions: "We want the positive effects of this therapy to be higher than the side effects" "I don't have any figures at hand, because we are looking after the cases where complications occur, and so far that is more than 50 percent. We hope that the new method will make it possible to reduce the number of discontinued CAR-T immunotherapy treatments. We want the positive effects of this therapy to be greater than the side effects. "
In 1924, the children's hospital was given to the Pope as a gift. The Italian doctor Gabriella Bottari and her team will continue the fight against cancer. In addition to her, around 2,000 doctors and nursing staff take care of the well-being and recovery of the sick children and adolescents in Bambino Gesù. The "Jesus Child Hospital" has been in existence for more than 150 years. The hospital became the Pope's clinic in 1924: At that time the founding family, the Roman noble family Salviati, donated the clinic to the Pope (vatican news - sst)
The Full Post Translated to English
The Concord Medical Team . . . Do addition on the basis of pre-treatment
2020-03-06 00:54
Here, wuhan Tongji Hospital, The Sino-French New Town Hospital District Concord ICU, the most critical of the treatment of patients with new coronary pneumonia. On the morning of March 5, two patients were still undergoing ECMO treatment, 16 were receiving invasive mechanical ventilation, 3 were undergoing noninvasive ventilation and high-flow oxygen therapy, 3 received continuous renal replacement therapy (CRRT), and 2 received bedside electronic tracheoscopy and sputum under the mirror. Seven other patients had erratic hemodynamics and varying degrees of shock.
For critically ill patients, who face multiple organ damage caused by infection, any single drug and monotherapy can be pale in the face of rampant viruses and must be treated with a comprehensive treatment regimen. Under the instruction of President Zhao Yupei, in accordance with the principle of "what is missing to make up for what" selection of cardiac professional, kidney professional and critical medical professional sinologists 20 people to reinforce Wuhan. Two weeks on, what did this "special legion" do in Wuhan? Let's take a look
Extending patient life with more treatment strategies
On the evening of February 19th, he arrived in Wuhan, and the third batch of medical team members was officially put on duty early the next morning. With the strength of the expert team, Concord medical team three-level check room system is more perfect, composed of Li Taisheng, Du Bin, Yan Xiaowei as a member of the expert group, Liu Zhengyin, Wang Jingxuan, Zhou Xiang, Qin Yan as the third-line examination professor, ICU and internal medicine experienced associate professor, senior doctor as the second line (medical team leader), other doctors for the first line of the "Concord Corps."
From left to right: Li Taisheng, Ma Jie, Gao Peng, Yan Xiaowei, Wu Wei, Tian Ran
In the joint efforts of all medical team members, in the front and rear remote inspection room, led by President Zhao Yupei personally, concord ICU ward treatment strategy is more and more clear, more and more methods. In view of the severe immune response of new coronary pneumonia, personalized glucocorticoid therapy was adopted, the target drug toads were applied to the clinic earlier, and the adsorption treatment of inflammatory factors was carried out earlier, which prolonged the survival time of patients to a certain extent.
The medical team is also trying to improve patientimmunity. More emphasis on nutrition and albumin stability, to maintain the balance of hydropower electrolytes, according to the national guidelines for the diagnosis and treatment of new coronary pneumonia increased thymus peptides and traditional Chinese medicine treatment, to a certain extent to improve patient resistance.
Strengthen the strength of critical care, care more systematic regulation
Sun Hong, the captain of the third batch of medical teams, is a member of the Professional Committee of The Chinese Nursing Association for Intensive Care and has rich clinical experience in critical care. She led a third group of 13 critical care nurses quickly integrated into the team, bringing the total number of critical care nurses at ConcordIC to 44, or 33 percent of the nursing team.
The nursing team is discussing clinical work
The team of critically ill nurses has played a leading role in rescuing critically ill patients with experience and strong strain. They also give full play to their professional advantages, especially for CRRT, lying in place ventilation, artificial airway sputum, mechanical ventilation and other special nursing skills, so that nursing work more orderly, more standardized, more secure.
Through the joint efforts of Concord nursing team, the core system of medical care has taken root in the Concord ICU in Tongjizhong District of Wuhan. The New Coronary Pneumonia Heavy and Critical Patient Care Code, drafted by Concord Care Team, was approved by the National Health and Health Commission and issued to the local authorities by document on 29 February. In order to strengthen the close observation of patients' condition changes, pay attention to the coordination of medical care, and start the joint shift system of medical care from 22 February, with good results. In order to meet the needs of clinical patients treatment at the same time the implementation of impeachment row system, arrangements for nurses to take a break, pay attention to the physical and mental health of nurses.
Try new technologies and new projects to give patients hope
The nephrology team earlier carried out blood filtration adsorption and cytosorb adsorption to treat inflammatory storms. At the busiest time, 6 CRRT slots are performed 24 hours a day. Up to now, blood filtration adsorption was involved in the treatment of a total of 7 patients, all treated patients increased IL-6 and other cytokines were decreased. Under the combination of other treatment measures, one of the patients successfully removed the trachea intubation, and the average course of the other 6 patients exceeded 3 weeks, prolonging the patient's life.
They didn't stop exploring. According to the literature reported that cytokine adsorption on the inflammatory factor adsorption effect is better, nephrology director Li Xuemei immediately contact overseas procurement and donation, complete the ethical application, from the United States adsorption column and Germany's supporting pipeline breakthrough difficulties came to concord ICU ward. From March 3, the "new weapon" has been used in clinical treatment, with the expectation of generating more benefits for early stage patients in severe illness.
The nephrology team carried out early blood filtration adsorption and cytosorb adsorption therapy
The most important life support for critically ill patients includes breathing and circulation. The cardiology team carried out more extensive bedside ultrasound cardiac examination, paying attention to the patient's heart structure and function, mastering the circulating blood volume state, and targeted circular support. Early application of tozhu monoantigen in clinical practice, this treatment program has been approved and promoted by the National Health And Health Council. In view of the sudden death of patients with critical lying diseases due to arrhythmia, the strengthening of the cardiology team makes the rescue more efficient and orderly.
Do bedside ultrasound cardiac examination for patients
Under the guidance of Secretary Zhang Liyang and Vice President Han Ding, the third batch of medical team members held the "to do addition for the treatment" quickly integrated into the Concord army, to the treatment of severe new crown pneumonia launched a "total attack." With the deepening of people's understanding of the new coronavirus, the continuous exploration of treatment programs, an increasingly mature, for the criticaland and critically ill patients of comprehensive treatment is forming. When the smoke is scattered, the Concorde will give a loud answer in a firm voice: "I am!" "
Text/Chen Mingyu Luo Xin
Picture/First Team Supplied
Editing by Zhang Liyang Editor/Chen Minghui
Editor/Liu Xiaokun returns to Sohu for more
Disclaimer: This article only on behalf of the author himself, Sohu is the information release platform, Sohu only provides information storage space services.
Patient Critical Care Zhao Yupei Yan Xiaowei Chen Minghui