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Can you confirm that Merck has actually closed this deal as it looks like they are not the only potential suitors of Acceleron. BMY has the most ties with Acceleron. I cannot find confirmation.
Thanks BSB, nothing like boots on the ground DD.
It seems to me that more and more articles are looking at DCVAX-L as a promising therapy.
Here is another new study that mentions DCVAX-L as promising. Something in the air maybe.
Published Sept 15th.
From Article..
We coupled our preclinical observations on cDC1 with studies in patients. There has been significant work on the use of DC in GBM immunotherapy. Specifically, DCVax-L is a DC therapy vaccine platform in which autologous monocyte-derived DC are loaded with a patient’s tumor lysate and transferred back into the patient (79). Studies have also demonstrated the capacity to enhance the migratory activity of these DC by pre-conditioning to potentially improve patient outcomes (80). While these approaches are promising, we focused not on DC as a therapeutic approach in this study, but rather on the location and phagocytic function of endogenously arising cDC subsets in patients undergoing brain tumor surgery. We identified CD141+ cDC1, CD1c+ cDC2, CD14+ monocytes, and CD16+ monocytes, as well as CD4+ and CD8+ T cells in GBM.
These findings extend our observations in mice, in which we observed that the tumor is infiltrated with DC far beyond the normal background for steady state brain.
Article at:
https://www.biorxiv.org/content/10.1101/2021.09.13.460088v1.full.pdf
Great post ATL. Here is a titbit from an article published today that mentions upcoming DCVAX.
From Article:
6.2.2. Vaccine-Based Therapy
Training the immune system with vaccination is a very hot topic nowadays, and it can be a useful tool against tumors as well. Tumor-associated and tumor-specific antigenes (TAA and TSA) generate the immune response: a protein vaccine against EGFRvIII (rindopepimut) has promising early results [41]. Another potential target is survivin from the apoptosis inhibitor protein family (SurVaxM) [42]. Besides protein-based vaccines, preliminary results with activated autologous dendritic cells (e.g., DCVax) are also hopeful.
HSPPC-96 (heat shock protein peptide comlex-96) is the pioneer representative of personalized cancer vaccines. It is made by training the patient’s immune system to recognize the gp96 heat shock protein and its related proteins that are extracted from his or her own tumor tissue [43].
Page 9 of the article.
[url][/url][tag]https://www.mdpi.com/1422-0067/22/18/10005[/tag]
Yup, a lot of wandering around the desert looking under rocks has been going on the past couple of months. Maybe a beautiful oasis will reveal itself soon to turn things positive.
You obviously have never really understood how big an impact the approval of this technology will have on oncology. You are looking at a completely disruptive technology impacting billions of billions of dollars currently being accrued by BP who not only control how patients are treated but how the many side effects are also treated. This paradigm shift will also impact companies like Novacure drastically as well as many thousands of emerging tech companies trying to find the answer to cancer. When the survival data is revealed for the hardest to treat cancer how many patients with other types of cancer will demand off label usage of L and D in the not so distant future. LP is being cautious for a reason and IMO her waiting for TLD at the same time as publication is critical in revealing irrefutable proof that a new SOC is about to be approved. NWBO has been relentlessly attacked for many years and the reasons are obvious. A major disruption is about to occur and how this is presented to the world is critical. All IMO. GLTY.
What you obviously do not realize is that necrosis of the tumor will show up very quickly once D is injected. You also have understand that once L is approved the platform can be established. Defeating cancer in the hardest to treat area will be the catalyst for far quicker approvals for L as well. The D platform will be established far quicker than what you obviously realize. Doc Logic has been pointing to this for some time.
The only hammer blow that will land a true strike are on those blinded by greed for the dollar rather than those blinded by the true beauty of the science. The final nail will bring out a lot of rancid noise that will gradually be drowned by the joy of celebration as the knowledge of this gift sinks in worldwide.
Spot on to the two of you. My wife and I have built a sizable sum of shares and have continued to do so for the past 5 years. Both small and large retail buyers have made it possible for one of the most important breakthroughs in science to make it to a position that it can at last make inroads into mankind’s harshest of diseases. My hope is that our collective belief and perseverance will remind everyone that sometimes the little and not so little guys can help scientists such as LL achieve their incredible discoveries even when the might of the big guns is against such innovation.
The ill informed are always quick to judge and have the loudest mouths. When all the facts are revealed you will be eating all sorts of humble pie. You obviously have absolutely no idea what it takes to introduce a paradigm shift in technology.
Absolutely correct, I have been buying as soon as it dipped below 1.50 and will continue to do so. This type of opportunity that allows those in the know to continue building a winning position on a soon to be released paradigm shift in technology is once in a lifetime. To pass on such an opportunity would be like kicking a gift horse in the mouth. The current market price is the gift so accept it with open arms and continue to build your legacy.
It has been an interesting year none more so than BP's insistence on pursuing mRNA vaccines. Maybe this is their way of competing against the truly innovative biologics that are about to be released to the world. We are still very early on in understanding the true impact and side effects of mRNA's some of which are concerning. In NWBO and their method of introducing bad proteins to dendritic cells we have a method that introduces next to no side effects. I see a future where our children are born into a world where their dendritic cells are introduced to all the bad proteins from the get go to help build their immunity. Their very own dendritic cells can be harvested, matured and introduced to any type of threat and given to them anytime they need a booster if required or to combat new threats. Dendritic cell vaccines are the future as their is no better way of combating disease than your very own immune system. We are at the cusp of a paradigm shift in not just oncology but perhaps all diseases. No wonder Cognate now CRL are expanding their facilities on such a scale.
Bio, I got a feeling Doc is talking about data coming from the compassionate arms and from the many patients that were originally tied into the trial but were considered to be early progressors (not a real word but hey). I have a feeling that they are able to make many decisions based on unblinded data not related to this trial. JMHO.
That my friend is why so many of us are so invested in this little company because L is just the tip of the iceberg and a behemoth is waiting in the wings.
Hi Sojo, just wanted to thank you for your continued insights to the trends that you have so kindly donated to this board. Your insights have proved to be a valuable tool to many, and long may they continue, looking forward to the Everest like spike in the not to distant future.
Thanks for that astounding piece of news. Everything is starting to come together and the long drawn out waiting game has obvious purpose that will drown any noise coming from the soon to be extremely cheap seats while those of us in the front rows will be cheering to high heaven as the curtain to a beautiful future of oncology care is revealed to the world.
Your written English is far superior to anything I could offer in German and what you said rings true for any person with a positive outlook in life. I have many German, French, Danish, Dutch friends and always appreciated there ability to speak multiple languages. Us English speakers are lazy but probably due to English being the international language of choice, still I would love to expand on my rather limited linguistic abilities.
We on this board look forward to Your big reveal. I am sure if it looks as good as NWBO you will get many following and the expertise shown by many on this board will be a bonus for your next pick. Good luck to you.
For now we longs sit tight and wait for the inevitable, confident that a paradigm shift in oncology is upon us.
Many of us had a chuckle over your rejected challenge. Speaks volumes. I wonder if the rest of the short brigade would be willing to enter such a bet. I have put them on ignore for a while now but see that many here continually challenge them.
Hyperopia, thanks again for this great DD and in fact for all the great DD you have provided to this board over so many years.
Thanks Dr B for a great presentation of the slides. I did like the question to patients asked on slide 1 relating to slide 13 “Would you like 100% chance of survival for 3 to 4 months more, or 25% chance of survival for 3 to 4 years” followed by most patients choose the later.
This in my mind is very revealing and her last question was aimed at the 4 agencies that this entire presentation has been aimed at.
I am expecting some exciting news very shortly.
Interesting, my childhood was spent in Zimbabwe, Malawi, Kenya, Sudan, Somalia’ UK, Louisiana, Jamaica while at the same time attending boarding school in Kenya then Scotland (never did get a Scottish accent but can turn it on anytime) and then LSU.
Adulthood was just as turbulent with spells in Africa, Europe, UK and now the US.
I have my Green Card so just waiting to convert to Citizenship.
Funnily enough the Zimbabweans under the leadership of Managwa are willing to reinstate my citizenship. Maybe I will end up with both and travel in Africa as a Zimbabwean as you get many benefits.
Anyway looking forward to more travels down the road and of course the day that DCVax becomes a household name that will extend so many lives and give them added chances to explore this exhilarating world.
Being a landlocked Zimbabwean who respects hyenas and loves the beach it kind of fits. Now reside in sunny St Pete after a spell in Santa Barbara and San Diego. Miss Africa a bunch I must say as well as quirky UK and sunny Spain but hey the color of life is a beautiful thing. Looking forward to changing my status from Stateless to US citizen so the World opens up again and waking up one day to the news that oncology is moving into a new era.
Agree, at this point in time silence is golden and I believe that the one’s truly confounded by this are in reality the detractors. Some longs may be fidgety but there have been enough bread crumbs thrown out along this long and windy road that at some point all those bread crumbs will reveal a truly golden path forward for this little company that can. All I know is that day is not too far off now and my patience and support is unwavering. A paradigm shift is the cause for this period of silence because when it breaks, the crescendo of noise that follows will be monumental.
As always Doc you are right on point and for all longs this little piece of insight is pure gold.
Thanks for such a great post. My families belief in this technology only grows stronger by the day.
That is one huge leak, 1.3 m volume, you having a laugh right.
Senti, you continually shine a torch that illuminates bread crumbs into large loaves for many on this board. Much appreciate your brilliant dd.
A very interesting development and a clear sign of developing manufacturing abilities to meet demand on a global scale. Looks like the manufacturing muscle and capabilities have suddenly been vastly improved for future NWBO demand.
You and I have for the longest time believed there to be a whale in the background pulling the strings. What else can possibly explain the past couple of years as well as the timeline since datalock. NWBO has a gift that will be a paradigm change in how cancer will be treated and this big a message and change has to be treated with the highest degree of care because of the impending destruction it will cause to many companies reliant on chemical and devices. There will be very strong voices opposing this new paradigm and those voices will only grow louder as the picture becomes clearer to the world. Having a Merck at the helm will serve to lessen the impact of this expected opposition.
By my reckoning that number of shares will be worth plus 1 million in the coming months but I know you have plenty of other shares so if diversifying raises your comfort level good for you. Best of luck with CYDY. Another way of making money while we wait for the big reveal is to now swing the highs and lows of NWBO while anticipation rises which if you use 50,000 shares will make a nice bit of money. Sojo will help in that regard .
My deepest condolences to you and your family.
A very Happy Birthday to you, I am invested for many of the same reasons, hope your Birthday wish comes true, if not it will soon.
Now that list would make for a very quite board. Trawling through so many posts looking for something interesting is very tedious and it so happens that you end up ignoring so many posts made by certain individuals that using the ignore button is the way to go.
Looking forward to a positive upswing soon.
Bio, some people just need to go to sleep with a security blanket and it seems that in this case the 4 day argument is their extra thick security blanket. For most of us longs the security blanket is made up of real DD and known facts about the science as well as the new endpoints which are a massive bonus to all of us.
NWBO are sitting on a paradigm shift in technology and how that is presented to the world is going to be super important as well as earth shattering for many industries.
We are a tiny group of investors who one day will be sitting back in the knowledge that we managed to be a part of something truly special right from the start. When the world awakens to the possibilities of this technology that investor base will become massive.
Happy New Year to all and all the best in 2021.
When JJ comes to realize that scientists are as corruptible as the next human and just because they sit behind a white coat does not mean that they are any more intelligent than their fellows. It constantly amazes me that so many people put blind trust in all who don a white coat just because these people dedicated a few years to study. The type of human always defines their interests and those that serve their own ego’s as in all walks of life are a danger to humanity. Believe me the scientific world is full of overblown ego’s that have been a constant source of danger to the world we live in. The world is a long way from having a science community that serves to better humanity rather than the puppet masters who demand profit at all costs.
Merry Xmas to all, looking forward to a beautiful New Year for all NWBO longs.
Thanks for all the great info regarding warrants and all the best over the Christmas period. Hoping the New Year is good for all.
Fred, thanks for this and in future you need to be careful about the detail you post on any social media site as it took me no time to determine that you are indeed a legit person with regard what you posted.
The simple answer to all your insecurities relating to company silence is that LP has already chosen her partner many years ago. It has been tasked on NWBO to make sure the results are so groundbreaking that value will be instantly recognizable. We are talking about a titanic shift in the treatment of all cancers.
Do you think it wise to beat your drum in the faces of so many competitive companies and BP’s who rely on cancer treatment for their survival.
You are very naive to think that when a tiny company is holding such a groundbreaking technology that many nefarious forces will not try to take them down. We have all witnessed their actions for so many years.
Believe me, when TLD hits it will be pretty much game over for many companies who will have to rethink there entire strategies to compete in the new paradigm of immunotherapy.
Silence has worked and allowed this company to survive to the very cusp of TLD. I think much of the credit must be given to LP’s tactics despite the frustration many shareholders have vented.
16000 shareholders mostly retail are banking on success and that in itself is pretty amazing. I think that LP and her team understand this and will soon be presenting a paradigm shift in oncology care and the only thing you will be able to do is stand up and applaud.