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Fitch downgrades U.S. long-term rating to AA+ from AAA
UPDATED WED, AUG 2 20238:26 AM EDT
Immucura's treatment
ADVFN_doclee
a) Thanks
b) Your command of the subject matter is way beyond mine (thats good)
c) A simple question - whatever their treatment -
could they pick it up now and plop it down in the USA
and open for business?
If not, how are they getting away with it now in Europe. I am just NOSY
d) thanks again for your efforts
regards
Note - really enjoyed this
Click on the + sign for Sunday September 10, 2023
https://www.cns.org/annualmeeting/program/all-sessions?search=linda+liau&type=&date=&track=
ADVFN_doclee - nice find - wow
hope you will share whatever information they give you ......
fyi - and I don't have a link
a) a bunch of spanish doctors ran a P2 dendritic cell vaccine trial years back
b) it failed
c) (remember its *how* you MIX the ingredients that matter)
fast forward to now
a) spanish doctors write an article throwing SHADE on *our* DCVax trial
b) I bump into this Immucura company that *seems* to be selling
DC Vaccine (not DCVax-l or DCDirect) as a --treatment--
c) IOW - where is their --approval-- to offer the stuff as a treatment and
what are spanish laws
d) I bump into an english woman (breast cancer) who via
gofundme is going to Spain (don't know where) to get DC treatment
thanks for contacting Immucura
Japanese scientists successfully use artificial DNA to kill cancer cells
Ryan General
Tue, August 1, 2023 at 5:34 PM EDT
Immucura offers dendritic cancer care RIGHT NOW
https://immucura.com/
(clicking it may time out - but the web page will display)
Can only takes private payments - which means it crosses country lines in
the UK and Europe w/o a problem
I was wondering - is she using them for breast cancer -
shes in UK going to Spain for dendtritic treatment
https://www.glasgowlive.co.uk/news/glasgow-news/humble-lanarkshire-nurse-terminal-cancer-27433343
Health outcomes in economic evaluation: the QALY and utilities
Over my pay grade
https://www.google.com/search?rlz=1C1WDIF_enUS1061US1063&q=how+NICE+calculates+QALYs&tbm=isch&source=univ&fir=a-xMipudtiYL3M%252CFxkFMKmHQ7f5GM%252C_%253B6kOwAKPTuKxAPM%252CmgWwWbb-32NCwM%252C_%253BJRmk27zr-BnEMM%252CFxkFMKmHQ7f5GM%252C_%253BpNH4x3DDDvcjIM%252CRnnddgMm-4pioM%252C_%253BL1PG-F8rYmzV7M%252CFxkFMKmHQ7f5GM%252C_%253B1psV-wEj6XQqNM%252CbVBafW0lk93I1M%252C_%253B5wORolX23XT_IM%252CFxkFMKmHQ7f5GM%252C_%253BiUI7sl6yDoTjxM%252CDCnOm-nTS21hDM%252C_%253B2xb6aIavPsKYEM%252C_eVZ3S2fvCI0hM%252C_%253BAL_51TncbIutPM%252CDCnOm-nTS21hDM%252C_&usg=AI4_-kQ3lPou85o6djNj3XO1hB-mZ0WR7Q&sa=X&ved=2ahUKEwj50uDEn7yAAxUDMVkFHSB4Cj8QjJkEegQINxAC&biw=1237&bih=525&dpr=1.5
Click RIGHT MOST area
https://www.google.com/search?rlz=1C1WDIF_enUS1061US1063&q=how+NICE+calculates+QALYs&tbm=isch&source=univ&fir=a-xMipudtiYL3M%252CFxkFMKmHQ7f5GM%252C_%253B6kOwAKPTuKxAPM%252CmgWwWbb-32NCwM%252C_%253BJRmk27zr-BnEMM%252CFxkFMKmHQ7f5GM%252C_%253BpNH4x3DDDvcjIM%252CRnnddgMm-4pioM%252C_%253BL1PG-F8rYmzV7M%252CFxkFMKmHQ7f5GM%252C_%253B1psV-wEj6XQqNM%252CbVBafW0lk93I1M%252C_%253B5wORolX23XT_IM%252CFxkFMKmHQ7f5GM%252C_%253BiUI7sl6yDoTjxM%252CDCnOm-nTS21hDM%252C_%253B2xb6aIavPsKYEM%252C_eVZ3S2fvCI0hM%252C_%253BAL_51TncbIutPM%252CDCnOm-nTS21hDM%252C_&usg=AI4_-kQ3lPou85o6djNj3XO1hB-mZ0WR7Q&sa=X&ved=2ahUKEwj50uDEn7yAAxUDMVkFHSB4Cj8QjJkEegQINxAC&biw=1237&bih=525&dpr=1.5#imgrc=pNH4x3DDDvcjIM
https://academic.oup.com/bmb/article/96/1/5/300011
sharpie510 - great post - thank you
newman - thanks for posting this ,,,
Once they complete their -
Scientists Intrigued by Clever Trick That Makes Cancer Cells Self-Destruct
Victor Tangermann
Mon, July 31, 2023 at 10:23 AM EDT
Researchers have discovered a mechanism that forces cancer cells to self-destruct, hijacking their ability to replicate uncontrollably and turning it against themselves.
thanks for posting -
looks like Univ of Alabama and Duke are all fired up about DCVax trial results
University of Rochester
Nov. 21, 2022
Personalized Immune Therapy Extended Survival in Patients with Aggressive Brain Cancer
Researchers announce breakthrough in brain cancer vaccine trial
by: Melanie DaSilva
Posted: Jan 6, 2023 / 07:50 AM EST
Updated: Jan 7, 2023 / 11:14 AM EST
https://www.wpri.com/health/lifespan-to-announce-results-of-vaccine-trial-for-aggressive-brain-cancer/
Glioblastoma and Fighting Brain Tumors with a New Vaccine
Heinrich Elinzano, MD
May 18, 2023
Lifespan - 10,644 Views
Clinical Trial Results for World’s First Glioblastoma Vaccine
by Amelia Garrison
November 17, 2022
New Vaccine Targets Inflamed Brain Cells Associated With Alzheimer’s
July 31, 2023
Brain Where Conscious Experience Lives
31 July 2023
Protein GRP78 - unexpected bad guy
Scientists Discover a New, Unexpected Way That Cancer Cells Spread
31 July 2023
Scientists Discover Hidden Weakness of Deadly Brain Cancer
UNIVERSITY OF CALIFORNIA - SAN FRANCISCO JULY 29, 2023
“Gabapentin actually kept the tumor from expanding,” said Krishna. “This makes us hopeful that combining gabapentin with other glioblastoma therapies could stave off some of the cognitive decline we see in patients and perhaps extend their lives.”
HOMEHEALTH NEWS
Scientists Discover Hidden Weakness of Deadly Brain Cancer
TOPICS:BrainBrain TumorCancerGlioblastomaUCSF
By UNIVERSITY OF CALIFORNIA - SAN FRANCISCO JULY 29, 2023
DD
Very, very sorry.
A phase III randomized controlled trial conducted on nGBM and rGBM reveales DCVax-L prolongs the OS with acceptable toxicity
*** More than 14,490 Americans are expected to receive a GBM diagnosis in 2023.
*** It is estimated that more than 10,000 individuals in the United States will succumb to glioblastoma every year.
*** GBM accounts for 50.1 percent of all primary malignant brain tumors.
*** The five-year survival rate for glioblastoma patients is only 6.9 percent, and the average length of survival for glioblastoma patients is estimated to be only 8 months.
*** Mean age at diagnosis is 65.
*** Survival rates and mortality statistics for GBM have been virtually unchanged for decades.
*** Despite first being identified in the scientific literature in the 1920’s, there have only been four drugs
and one device ever approved by the FDA specifically for the treatment of glioblastoma.
*** None of these treatments have succeeded in significantly extending patient lives beyond a few extra months.
*** In addition to being life-threatening, GBM – and its harsh treatments – inflict devastation upon the brain,
which controls cognition, mood, behavior, and every function of every organ and body part.
*** Glioblastoma (GBM) is one of the most complex, deadly, and treatment-resistant cancers.
https://braintumor.org/events/glioblastoma-awareness-day/about-glioblastoma/
thanks -
Hoping its Unmethylated MGMT focus turns out to be a success ,,,
and down the road can be teamed up with DCVax (all versions) which
I expect to be approved late 2023 or early 2024
Temferon
* FDA provided an orphan drug status - glioblastoma multiforme (GBM)
* temferon for ... approximately 200,000 patients
* About 60% of the GBM population has unmethylated MGMT promoter status which Temferon targets
* Temferon release antitumor agent IFN-a by altering Tie-2-expressing monocytes, which restores the immune system and offsets tumor growth
* NCT03866109
https://www.targetedonc.com/view/fda-gives-orphan-drug-designation-to-temferon-for-glioblastoma-multiforme
L - thanks for posting that -
here is Hannah's timeline
Christmas Day 2021 - sick
Christmas Night - she ended up in Royal Derby Hospital
Royal Derby Hospital - They thought Hannah had appendicitis
Royal Derby Hospital - operation to remove it.
Royal Derby Hospital - appendicitis FINE
Royal Derby Hospital - sent her home and for six weeks she barely left her
bedroom because she was still so sick,
despite the anti-sickness medication
Royal Derby Hospital - back to hospital because nosebleeds and headaches
Royal Derby Hospital - They gave her contraceptive pills - would settle things down
Royal Derby Hospital - tried Hannah on a different contraceptive
Royal Derby Hospital - brushed over it as her hormones being all over the place
Royal Derby Hospital - Then on 16th July 2022 Hannah was taken by ambulance to Royal Derby Hospital
Royal Derby Hospital - Hannah demanded a CT scan.
Royal Derby Hospital - they came back and told Hannah she had a brain tumour (16th July 2022)
Royal Derby Hospital - held Hannah 3 weeks
Royal Derby Hospital - doctors believed it was an oligodendroglioma
Royal Derby Hospital - said Queen's Medical Centre (QMC) in Nottingham would see her as an outpatient
Royal Derby Hospital - after hassle - sent Hanna to - QMC Nottingham
QMC Nottingham - August 2022 ?? - 1st week
QMC Nottingham - August 2022 ?? - 2nd week - hoping to hear it was an oligodendroglioma, but he said they weren’t sure what it was
QMC Nottingham - August 2022 ?? -
August 2022 ?? - 3rd week - back to Royal Derby Hospital
Royal Derby Hospital - gave Hannah - huge dose of steroids
August 2022 ?? - 4th week - drove here back to QMC Nottingham
QMC Nottingham - surgeon told us it was epithelioid glioblastoma (GBM)
QMC Nottingham - take her home, make memories, remember how she smells, and take lots of videos, because we were going to lose her
QMC Nottingham - radiotherapy for six weeks, 30 rounds, and has just completed her fifth round of temozolomide
October 15th 2022 (???????)
DCVax-L was associated with a 20% relative reduction in risk of death
the benefit of which increased over time.
Dendritic Cell Vaccination Meaningfully Improves Survival Outcomes in Newly Diagnosed and Recurrent Glioblastoma
Nov 21, 2022
Nicholas Wrigley
https://www.cancernetwork.com/view/dendritic-cell-vaccination-meaningfully-improves-survival-outcomes-in-newly-diagnosed-and-recurrent-glioblastoma
If Citadell contacted STAT - did they contact Nicholas Wrigley to get a 2nd opinion. Did Citadell contact **anyone** else
except Adam Feuerstein?
I just walked past the Citadel building and I swear, I heard the Darth Vader theme.
— Adam Feuerstein ✡️ (@adamfeuerstein) June 3, 2022
Legend - this maybe above your pay grade - but might be worth a look
Jessica Bengels
https://www.politico.com/news/2023/07/25/hunter-biden-judge-plea-deal-phone-call-00108184
Curve - their always looking for good people
Jessica Bengels
https://www.politico.com/news/2023/07/25/hunter-biden-judge-plea-deal-phone-call-00108184