Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Linda Powers try Elon Musk for Direct funding
(after MHRA approval)
He reads/writes like Ernest Hemingway - so - about DCVax
* one liner - Liau invented the "production" line - dendritic cells and brain tumor
* one liner - Powers invented the "production" line - clinical trial progress
* one liner - NWBO attacked by short sellers (Gates > tsla short selling > Elon upset)
* one liner - repeated manipulative spoofing of NWBO’s stock from December 5, 2017 – August 1, 2022,
* two lines - Direct attacks all solid tumors & see Phase 1 result
* two lines - see Lung and Pancreatic results
ILT
Agree with all you said - but now we know how fast the critter could go
if really pushed ......
MHRA approves COVID-19 vaccine trial in 7 working days
23 April 2020
https://www.gov.uk/government/news/mhra-approves-covid-19-vaccine-trial-in-7-working-days
hope
thanks
but as I know you know - we gotta hurry
a) get DCVax to patients
b) upgrade DCVax so it is even more effective going forward
being a nut job - my perspective
a) humans didn't start writing until 2600 BC (IRAQ)
b) first human male didn't appear until 330,000 years ago (mendez) +/- 75000 years
c) first human female didn't appear until 200,000 years ago
d) we are all CT-M168's
e) thereafter - Dr Liau kicks cancer in the ass - and we begin to "pile on"
I think it is the iPhone of solid tumor cancer treatment ....
and I hope they go after lung cancer in their next DCVax-Direct
trial
10/6/2023
UK production for GBM vaccine begins
between 7 to 9 people die in the UK each day from GBM .....
90 review days should be max -
the UK had 4-6(?) hospitals in the trial (can't remember) ..... - so they can
reach out quickly if they have a question
What is the Tumor Microenvironment?
The Essential List of Regulatory Authorities in Europe
See their Table
https://www.raps.org/News-and-Articles/News-Articles/2020/1/The-Essential-List-of-Regulatory-Authorities-in-Eu
senti
thank you .... great stuff
now I see flipper's point
future reference - CSF1R gene
https://www.ncbi.nlm.nih.gov/gene/1436
https://medlineplus.gov/genetics/gene/csf1r/
2019
Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
https://www.nature.com/articles/s41467-019-11053-8
================================
I expect:
a) DCVax to be approved in the UK in 2024
b) thereafter - *All* GBM patients and their doctors will seek DCVax in the UK
c) Patients will include patients in the UK - USA - Europe - Asia
d) Patients will have - on balance - 15 months to 1) have surgery 2) get the tumor
to NWBO to create vaccine 3) have a doctor inject them with the vaccine
e) Not sure which insurance companies / countries will cover surgery costs
f) Not sure which doctors are allowed to inject patients i.e. local doctors or UK doctors
g) The demand for DCVax for GBM will exceed 40,000 patients a year
Scroll Down
Information from Allen Turner
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173464640
I expect:
a) DCVax to be approved in the UK in 2024
b) thereafter - *All* GBM patients and their doctors will seek DCVax in the UK
c) Patients will include patients in the UK - USA - Europe - Asia
d) Patients will have - on balance - 15 months to 1) have surgery 2) get the tumor
to NWBO to create vaccine 3) have a doctor inject them with the vaccine
e) Not sure which insurance companies / countries will cover surgery costs
f) Not sure which doctors are allowed to inject patients i.e. local doctors or UK doctors
g) The demand for DCVax for GBM will exceed 40,000 patients a year
Real quick - Dr Liau and her troops have to discover way(S) to defeat the
tumour microenvironment (TME) problem.
Doing so will increase the ALIVE count after 5 years
senti -
thanks ......
the sad truth is the ONLY thing out there for GBM is DCVax - and hoping -
that hoffman's Poly-yadayadayada (can't remember the 4 letters) is a home run
to the positive - think about it - after all this time DCVax will finally be in
patients from the UK - USA - and Europe sometime in (June/Aug) of 2024
hope you and your family are doing well
regards
Learn to read
Our findings support the notion that activation of G?12 signaling contributes to a phenotypic shift towards a more invasive and mesenchymal tumor growth pattern. Thus, downregulation of this signaling pathway could be efficacious in treating GBM by decreasing therapeutic resistance and the tumor infiltration that contributes to recurrence.
12/16/2023
Ga12 signaling regulates transcriptional and phenotypic responses that promote glioblastoma tumor invasion
https://www.nature.com/articles/s41598-023-49164-4
England as a testbed for DCVax Direct
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(23)00530-2/fulltext
https://www.thelancet.com/cms/10.1016/S1470-2045(23)00530-2/attachment/62ab8df7-71bf-4085-a8e6-c91b83d62077/mmc1.pdf
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(23)00530-2/fulltext#figures
Table 2:Landmark Survival Rates in Patients With nGBM and rGBM
https://cdn.jamanetwork.com/ama/content_public/journal/oncology/939074/coi220066t2_1674054621.36877.png?Expires=1704616066&Signature=0g4~SAb22~EPy2aoLeGi8qMnGhsKa3sLPUJ45EN3V9ZHP7ZXuPuPlEUt87U55vKPswIQcfhJTulOzIT-hsPisqEdit7MSbjIRoFEDxbKRuANaQYXGiHOzBCoKPeOdkUgVKaR22Pfvmo3QQkdktMv1jciyqtQCU5IFNBOr4LY~AT6t34aiT8H0vTglglIg9jOg17-CWjWylwqxQjMHR~NwJoIuGzysAvskaKQquX9uqQgbsAQeevwfRMO18e-hLYQCQhWfKlbmFrsN6vXKmmrn0PCnttPk5bVnuhlHMrOXwq0gcOjXuhce5vZX67ZPzGSbRAPuj1THOuWC1qx~mOTvw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
Bristol Myers to pay $800 million to Chinese drugmaker to develop cancer drug
The Future of Ovarian Cancer Treatment with Antibody-Drug Conjugates (ADCs)
//////////////////////////////
Unlocking the Secret: How One Protein Can Halt Lung Cancer Spread
By TULANE UNIVERSITY DECEMBER 14, 2023
About lithium
-Brand names: Priadel, Camcolit, Liskonum, Li-Liquid
Lithium is a type of medicine known as a mood stabiliser. It's used to treat mood disorders such as:
mania (feeling highly excited, overactive or distracted)
hypo-mania (similar to mania, but less severe)
regular periods of depression, where treatment with other medicines has not worked
bipolar disorder, where your mood changes between feeling very high (mania) and very low (depression)
Lithium can also help reduce aggressive or self-harming behaviour.
Lithium is available on prescription.
https://www.nhs.uk/medicines/lithium/about-lithium/
ILT
thanks for pointing this out ......
Therapeutic cancer vaccines: advancements, challenges, and prospects
Published: 13 December 2023
https://www.nature.com/articles/s41392-023-01674-3#Fig2
Moderna CEO Says Melanoma Vaccine Could Be Available By 2025
https://www.barrons.com/news/moderna-ceo-says-melanoma-vaccine-could-be-available-by-2025-32ee9605
Moderna, Merck vaccine with Keytruda cuts risk of deadly skin cancer returning in half, data says
https://www.cnbc.com/2023/12/14/moderna-merck-cancer-vaccine-reduces-risk-of-skin-cancer-return.html
Moderna-Merck vaccine cuts odds of skin cancer recurrence in half, study finds
https://www.cbsnews.com/news/merck-moderna-vaccine-skin-cancer-melanoma/
Major Vaccine Breakthrough Could Spell Hope For Treating Aggressive Breast Cancer
A recent Phase 1 clinical trial has returned positive results.
https://www.iflscience.com/major-vaccine-breakthrough-could-spell-hope-for-treating-aggressive-breast-cancer-72025
Citadel to Return $7 Billion of Profit to Hedge Fund Clients
https://finance.yahoo.com/news/citadel-return-7-billion-profits-152213299.html
About Hiltonol® = Oncovir=Poly-ICLC
Dendritic Cell Vaccination in Conjunction with a TLR Agonist Polarizes Interferon Immune Responses in Malignant Glioma Patients
2023 Sep 12
Richard G Everson 1 2 3, Willy Hugo 2 4 5 3, Lu Sun 1, Joseph Antonios 1, Alexander Lee 1 6, Lizhong Ding 4, Melissa Bu 4, Sarah Khattab 1, Carolina Chavez 6, Emma Billingslea-Yoon 1, Andres Salazar 7, Benjamin M Ellingson 2 8, Timothy F Cloughesy 6 9, Linda M Liau 1 2, Robert M Prins