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https://academic.oup.com/noa/article/5/1/vdad106/7271271
In this phase II trial, we tested the combination of the antiangiogenic agent sunitinib with radiotherapy and temozolomide (TMZ) for newly diagnosed unmethylated MGMT GBM patients.
Our data suggest a potential benefit of combining sunitinib with chemoRT in MGMT unmethylated GBM.
Sunitinib potentially sensitizes MGMT unmethylated GBM to adjuvant TMZ.
NLR is a potential biomarker to identify responders to Sunitinib and chemoRT.
Hegi et al.,5 in a subset of 203 patients from the EORTC/NCIC phase III trial, showed that patients with unmethylated MGMT promoter did not derive a significant benefit from combined TMZ plus RT (median OS, 12.7 months) compared with those with methylated MGMT promoter (median OS, 21.7 months).5
Sunitinib has been FDA approved for metastatic renal cell carcinoma,13,14 gastrointestinal stromal tumors,15 and pancreatic neuroendocrine tumors.
Just talking out loud -------------------
potential - GBM Killer cocktail -
interferon alfa + temozolomide + poly-ICLC + DCVax-L + RT
not sure what the best order of things would be
ILT - thanks for posting that ..... and
Along the way (temozolomide), bumped into this, never heard of it but looking good ( I think ) - need the "oh great ones" to weigh
in - and - can't help it - that means senti will prob jump in
to - geez - oh well
product - interferon alfa
you mix it with - temozolomide
and throw them both at - newly diagnosed high-grade glioma (HGG)
Robot - thank you for posting this
Dendritic cell therapy for neurospoagioma: Immunomodulation mediated by tumor vaccine
January, 2024
Qian, D., Liu, Y., Zheng, J. et al.
ae - the date is
www.thelancet.com Vol 100 February, 2024
you can see it on the bottom of page 3
additonally, they wrote ......
Thanks Captain
Michael Bolton, 70, reveals brain cancer diagnosis:
https://www.dailymail.co.uk/tvshowbiz/article-12932251/Michael-Bolton-reveals-brain-cancer-diagnosis.html
https://www.nbcnews.com/pop-culture/celebrity/michael-bolton-was-diagnosed-brain-tumor-holidays-rcna132604
https://www.yahoo.com/entertainment/michael-bolton-reveals-diagnosed-brain-225030944.html
That was awesome - unequivically awesome.
Thank you.
to remind myself they were doing Sawston compassionate use
as early as 2/2022
and (not in post - but in article)
17 Feb, 2022
Announces Commencement Of Cancer Vaccine Production At Its Sawston, UK Facility
...today announced commencement of production of its first dendritic cell cancer vaccine for a compassionate use patient at its recently licensed production facility in Sawston, UK.
As previously reported, the MHRA license was received in December of 2021, following nearly two years of preparations. This included hiring and training of technical staff, preparation of approximately 1,000 regulatory documents (including Standard Operating Procedure documents and others), validation of facilities, equipment and protocols, and practice manufacturing cycles. This was followed by a review and detailed inspection by the MHRA.
https://www.prnewswire.com/news-releases/northwest-biotherapeutics-announces-commencement-of-cancer-vaccine-production-at-its-sawston-uk-facility-301484857.html
Imagine
You and I plan a robbery.
Our INTENT is to rob a bank.
During the robbery, one of us shoots and kills a guard.
It was NOT OUR INTENT to kill the guard.
Should the prosecutor/judge go after us for
- robbery
- murder
- both
============================================
This is exactly analagous to NWBO vs Citadel
Had they killed off NWBO - (15,000 * 13%) patients would
have died in 15 months from GBM and not had the chance to live at and beyond 60 months.
This is why - I think damages should be based on - the
difference between SOC vs DCVax outcomes (times)
annual GBM patient population (times) X years.
All the above - my opinion.
51P Phase IB (Ph1b), MESOVAX clinical trial of pembrolizumab (P) and dendritic cell vaccine (DCvax) in advanced pleural and peritoneal mesothelioma (M): Preliminary results
https://oa.mg/work/10.1016/j.iotech.2023.100524
Adam Feuerstein
12/17/2013
new - please see my correction
tt - please see my correction
ae - Please see my correction
Payment Calculation Proto-type -
https://cdn.jamanetwork.com/ama/content_public/journal/oncology/939074/coi220066t2_1674054621.36877.png?Expires=1704616066&Signature=0g4~SAb22~EPy2aoLeGi8qMnGhsKa3sLPUJ45EN3V9ZHP7ZXuPuPlEUt87U55vKPswIQcfhJTulOzIT-hsPisqEdit7MSbjIRoFEDxbKRuANaQYXGiHOzBCoKPeOdkUgVKaR22Pfvmo3QQkdktMv1jciyqtQCU5IFNBOr4LY~AT6t34aiT8H0vTglglIg9jOg17-CWjWylwqxQjMHR~NwJoIuGzysAvskaKQquX9uqQgbsAQeevwfRMO18e-hLYQCQhWfKlbmFrsN6vXKmmrn0PCnttPk5bVnuhlHMrOXwq0gcOjXuhce5vZX67ZPzGSbRAPuj1THOuWC1qx~mOTvw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA
https://www.cohenmilstein.com/case-study/northwest-biotherapeutics-inc-securities-litigation/
DD
Thank you very much for posting this ......
thank you very much for posting this ......
Understand
Captain
Please see bio's answer to my question and my response.
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=173523402
Don't want to go beyond that ....
regards
accelerated program is ILAP
Great Post - Itemizes all the key landmarks going forward.
Hoffmann6383 - Thank you for posting this ....
Smokey
Sorry to read about your discovery - but please hang tough thru your ordeal.
We both know your tough because any son of a bitch that dabbles in this
stock AND reads this board - has to be tough.
Finally, please trust that all longs here will be thinking of you going forward -
and I mean - close to everyday.
regards
Try to reach him via Northwest Bio
https://nwbio.com/nw-bio-presents-updated-data-from-dcvax-direct-phase-i-trial-at-5th-annual-smi-cancer-vaccines-conference-in-london/