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sentiment, could that 21 day standstill be possible merger of Cognate and NWBO? They are synergistic businesses
Nice post forumreader, good to see you. Great they acknowledged DC-Vax L.
biosectinvestor, thanks for posting! We forget LP has more shares than any of us, so she took the biggest hit along with NW funds. Let's hope it all good, once final results are positive.
thanks sentiment, nice find. we are all waiting for those final data analysis and results!
DC-Vax rules! Nwbo rocks!
barcode, I hope you are right but I bet they are just crazy busy and totally understaffed. Wouldn't surprise me if it got overlooked with all the financings they have to do recently. They run bare bones but you'd think they just ask their law firm to respond. The judges are super lenient about these cases anyways so I'm sure they will work it out.
astavakra, I think everyone would be just ecstatic with just topline. The rest will just be cherries on top! The data is going to be incredible and so informative. I believe Dr.Liau already has great insight as to what is happening. She is the steady rock and calmness in all this drama. She feels confident of efficacy and approval based on 25% of patients with long term survival of over 5 years. The fact that we still have not reached 233 OS when 248 PFS occurred sometime between 11/16 - 1/17 is further proof that the OS is slowing to a crawl... Hence we have our LONG TAIL... Now if we could just get some decent financing once we get topline!
barcode, that is interesting. Thanks.
thanks barcode for the update, much appreciated.
etienne, well said, thank you! feels like it's been forever but that's great for the 100 still alive patients. Hope they get this vaccine approved!
thanks smokey, nice you got to speak with him. Dr. Bosch told us the most important fact that there are 100 alive patients... everything else will fall into place once they unblind.
thanks flip, I do! Idk why all these short mb people are so upset about the financing. You'd think they would be happy. Longs have waited this long... then we have those 100 alive folks... sure are some lucky institutions getting those shares at 20 cents... imho hope the powers that be let the sp run!
Dok, If I were Senator McCain and I found out DC-Vax L had 100 alive survivors (out of 331) of Ngbm in a Phase III trial that has lasted over 10 years. I'd be demanding that treatment NOW! He seems like a smart guy and hopefully his DOC's are looking out for him. IMHO
Thanks Leprecon, great post from UCLA Dr.Liau,Dr.Prins, NWBO-Dr.Bosch. Nice reminder that this trial has been going for a very long time and we still have 100 alive going strong with only 2 events per month. That's why they are all living longer cause 90% yes over NINETY PERCENT of patients are all on DC-Vax L... with such mild side effects it should be approved. IMHO Thanks for all your work and contributions to this board, much appreciated, Best.
leprecon, Wow, thanks! pretty impressive. disclosures noted...here we are in 8/2017 with 100 still alive patients and .24 cents sp... things that make you go hmmm.... imho
maverick, nice post, LP an early Elon Musk? lets hope so... Best...
Elecsol, that would be a beautiful sight!, LP, LG etc.. all would certainly be justified after all the crazy allegations and outright slander that have been thrown at them. Thank god Dr.Liau has no financial interest or she would of been dragged through the dirt as well. Best to all...
Elecsol, Hope NW will start buying now that the lawsuit is settled. Just in time for data lock and topline!
Great luck, Best to all...
Hi meirluc, I wasn't talking about blended MPFS. I was just talking about the 83 PFS patients. check out barunuuk's posts for blended MPFS. Thanks... It sounds pretty reasonable to use both DC-Vax and Optune depending on your subtype..
barunuuk, I agree with you, does paint a brilliant picture. I tend to be more positive, 83 PFS out of more than 100 alive patients with most enrolled close to two years or 24 months as of August, 5th 2015. Pretty impressive IMHO... great luck to patients and investors... we must wait...
Barunuuk, have you thought to run the numbers on the second half of the trial. As per Dr.Bosch the midpoint of enrollment was reached May, 2014, that was 38 months ago. If you think that by now all of the first half of the patients should have passed by now, then the numbers are even more astonishing. 83 PFS out of 110 vaccinated patients in second half of trial. (75%) WOW! lets say we have 25% LONG LIVED SURVIVORS from first half (28 patients) that still leaves us 55 patients from the second half so (around 50%) are still PFS after minimum of 13-17 months as of Feb.2017 now we are close to 20-24 months.
Barunuuk, Rk wrote that the number was 306 enrolled prior to 8/15 so that leaves 25 patients enrolled from 8/15 to 11/15. Given 90% are all on DC-Vax, I think safe to say, most all 83 PFS were on vaccine, close to 38% as of 2/17.
H2R, touche' excellent observation!
Hi flip, nice to see you post! We need your updates!!! Thanks! Yes sorry for AZN results for stage IV lung cancer. Hope they run a trial with DC-Vax soon or offer BO to NWBO after phase III readout!
how many shares of NWBO does LP own and how many shares does Christine Yonemura own? Who stands to lose more? Strange or coincidence that a UCSF kidney transplant nurse would file a lawsuit against NWBO for the MFN clause that protects NWBO from hostile takeovers and control of SP to protect investors. Maverick has gone into detail as to how the game has been played and how it has been used to collapsed the SP at NWBO. Lets hope it all works out for the best.
senti, hope you have informed NWBO management and they have provided this info to the judge and council.. seems like pure malicious intent, jealousy and bad karma. Yikes! hope the Judge reprimands them for this farce, to disrupt innovation at UCLA... really has caused so much grief and waste of time/money for everyone involved. thanks for all your updates and research!
Barunuuk, right on, looks more and more like DC-Vax is the only one standing. Dr.Liau is brilliant! Hope LP is giving those shares to some deserving individuals. At least she has Dr.Bosch and Dr.Boynton covered. Wish she could compensate Dr.Liau in some way but as Dr.Liau said should would do it for free cause she loves her job that much! Would be an honor to meet her one day! May be worth a trip to UCLA.
iwasadiver, another great post, Dr. Liau is as credible and authentic as they come. She is the epitome of class, smarts, integrity, compassion, absolute inspiration and hope for human kind. As she said there is always hope. Dr.Liau, stated around 25% of ngbm patients can obtain 5 years or longer survival with DC-Vax L. New SOC with further expansion into all tumors.
iwasdiver, great post, definite game changer.
Amen...
nice post Rk, I think you are right about OS in the placebo non-crossovers given the high 132 SAE's. Nice insight about MGMT methylation status and possible interruption or termination of TMZ treatment.
Screening halt due to excess Leukapheresis draws/risk makes sense given the high number of SAE's. I was just getting caught up on mb and liked this post from you.
Hi basin, nice post! hope we get to those valuations soon!
Hi anti, I was agreeing with your assessment, positive perspective, attitude for waiting till NWBO SP rise to it's rightful price. It is tremendously undervalued and naked shorted imho. I will be patient like you and wait for proper valuation. Best to patients and investors. my post was deleted, idk all I said was right on to your post.
err you really don't get it, if dc-vax was not working as some are saying then it should be same as SOC. Most all SOC have progressed or passed by 5 years.. from median of trial is 38 months or so...(76 months for complete trial) at 33 months (or 66 months) we had 83 PFS patients so.. 83 PFS out of 110 alive at that time? 2 patients per month rate per Dr.bosch.
83 PFS over 110 alive is over 75 % of our patients remaining are Progression Free with minimum of 17 months from initial screening or 14 months from randomization. errr.. most if not all SOC would of progressed by that time even if MOS is 20 months? which could be likely due to crossover at progression option, per Dr.Bosch 90% of patients are on DC-Vax.... hmm over 75% of remaining survivors were PFS as of 2/2017... in a trial that is now 76 months and counting... that's some math... what are the chances of over 70% Ngbm patients being PFS at 17 months now 20 months.. is that ground breaking??? imho yeah maybe they say there should be 90 patients still alive but should there be over 70 of them that are progression free??? hence our long tail has begun... at 2 deaths per month we could be waiting a very long time for the rest to progress and pass...
Thank you flip, for all your solid, reasonable, measured answers. You are a treasure for this board. Your contributions are much appreciated. imho median enrollment of 38 months 5/2014, most if not all the SOC for the first half of the trial have passed... leaving us 55 (SoC) or so in the second half and if DC-Vax had no effect it should be tracking the same as SOC that leaves us 110 for vaccine/treatment arm. We are 38 months max and 20 months min for that second half with 100 patients still alive 6/2017 and 83 PFS 2/2017, thats ground breaking! imho Hopefully we will data lock and unblind soon, I'm with you, no way would you have 83 PFS in a trial running this long in ngbm with those numbers! There is efficacy per Dr. Liau,
flip,let the herd rip the wolf pack to..shreds... I agree PFS is in, hopefully they have scrubbed data by now and data lock with topline should be available as soon as OS 233 is in. You don't have to be a genius if you have 98 alive and most if not all are from the treatment arm, especially the PFS ones. We already know all if not most of SOC have progressed or passed by now. imho
yes she didn't say it but the chart said it. Only blue and green were color coded at bottom of chart. Upon progression they can decide on second surgery, then have the surgery or decide for alternative treatment and or crossover to DC-Vax. It takes time for them to have second surgery and decide their options upon progression. imho
senti, Dr.Liau presentation was 12-15-16 when she said 86% was on DC-Vax with no SOC left that had not evented. The SOC arm have up to 3 months to crossover to DC-Vax upon progression so that 90% in June presentation by Dr.Bosch could just be the remaining SOC deciding to crossover to DC-Vax after second surgery etc... Having 100 still alive in June out of 331 patients with no SOC that have not progressed is shocking and the FDA should act. IMHO I agree with flip. given DC-Vax safety profile this should be a go directly to AA.
sparky, you should, make sure you call first and they are in the office.
biobrooklyn, welcome, congrats, and thank you! Great Luck to all patients, all investors. Glad your fund is accumulating, excellent timing. We do have excellent moderators and contributors. Lets hope data is spectacular and out soon. Hard to ignore 100 still alive patients with GBM.