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Kentucky:
Xena:
falconer:
whippinsaw...that's what I was looking for...thanks....IMO, when this is applied to AD and other indication results the entire control-hide and watch process used by hedgies and other insider media methods will go up in smoke. As caregivers, patient family members and clinicians are recognized then all bets are off. BOOM.
falconer:
mapman
Looking for ref doc/links to Dr.G.'s recent comments on social media, possible uses. Recall seeing recent comments here but cannot locate. TIA
Doc328:
Nice...in fact, friggen excellent
Jimbo:
falconer...thanks again for your continued contributions here.
We do need to somehow develop a device to be used for the conversion scientific knowledge into money. The conventional method for doing this is tricky, requiring a lot of patience and tolerance. I plan on starting on my proto stage for this device right after I finish up my "Way Back-Forward" device. This device will allow the user to project themselves into a preselected future time, make observations and then return to act on what was learned. So far I have launched 2 dogs and a series of cats but they are stuck out there in the future.
Will keep you informed. For now I am stuck here.
Agreed...not good situation. I am not happy either.
IMO, this whole thing is beginning to stink real bad. I value and trust many of the posters here and the collective capabilities to spot a winning company. (you both and others at the top).
Instincts are telling me there is a lot we do not get yet but whatever it is, if the laws of science mean anything, we are on the correct horse. But, we saw during AAIC 2018 what the current system is capable of and now we see seemingly even more concerning evidence.
Lets stay alert b/c these guys are capable of just about anything. Feels like there are massive technical/medical/regulatory and financial issues playing only a couple of atomic layers below the surface.
Like you, If I did not think AVXL was the right organization and products I would just not be here.
This is not a drill.
stress....SP fluctuations may lead to:
stres/
noun
noun: stress
1.
pressure or tension exerted on a material object.
"the distribution of stress is uniform across the bar"
synonyms:
pressure, tension, strain
"the stress is uniform across the bar"
the degree of pressure exerted on a material object measured in units of force per unit area.
2.
a state of mental or emotional strain or tension resulting from adverse or very demanding circumstances.
"he's obviously under a lot of stress"
synonyms:
strain, pressure, (nervous) tension, worry, anxiety, trouble, difficulty; informalhassle
"he's under a lot of stress"
something that causes mental strain.
plural noun: stresses
"the stresses and strains of public life"
3.
particular emphasis or importance.
"he has started to lay greater stress on the government's role in industry"
synonyms:
emphasis, importance, weight
"laying greater stress on education"
emphasis given to a particular syllable or word in speech, typically through a combination of relatively greater loudness, higher pitch, and longer duration.
"normally, the stress falls on the first syllable"
synonyms:
emphasis, accent, accentuation; More
beat;
ictus
"the stress falls on the first syllable"
verb
verb: stress; 3rd person present: stresses; past tense: stressed; past participle: stressed; gerund or present participle: stressing
1.
give particular emphasis or importance to (a point, statement, or idea) made in speech or writing.
"they stressed the need for reform"
synonyms:
emphasize, draw attention to, underline, underscore, point up, place emphasis on, lay stress on, highlight, accentuate, press home
"they stressed the need for reform"
antonyms:
play down
give emphasis to (a syllable or word) when pronouncing it.
synonyms:
place the emphasis on, emphasize, place the accent on
"the last syllable is stressed"
2.
subject to pressure or tension.
"this type of workout does stress the shoulder and knee joints"
Who do I thank for forcing me to look this up??
Thanks anyways...
These two sentences are an example of a non sequitur. The Latin words non sequitur literally mean 'it does not follow.' There is a divide between the premise and the conclusion, which results in something called a fallacy. Simply put, the conclusion does not follow the premise.
tradeher-agree totally-
Somehow AVXL has to find a way to reset the trials clock. As long as the results clock has no means of accelerating results then micro bio's are screwed. We are at the mercy of the big money who can/will pick us apart and steal the IP. We need an effective virtual trial system which accelerates all trials. AI simulation of trials outcomes based on established knowledge is a must have and is not a fantasy. Then, old school real time based trials can be used to verify simulated-v predicted/expected outcomes. It happens in all tech business/military/space flight systems where regression curves are developed and used to accelerate time/temp/physics/microbiology. Just do it. Use the knowledge gained to develop better precision testing methods. Being precise on the predicted controls of inputs is only half the battle. We can do a lot better. Trial clocks have not ever been reset and they need to be, now that some controls over input precision is at hand. The entire cycle needs to be reengineered. This is just another example of how the FDA and industry could work things that matter.
Talon, your observation on sp is as excellent one. We know from recent AAIC conference papers that BIIB are capable of misleading practices. this week a Boston publication describes BIIB recent firing of one employee for whistle blowing. They claimed she was dropped b/c of org changes.
Organizations establish their own cultures regardless of the field they are in. I would dearly like to see our SP perform better ASAP but not at the expense of solid credible science.
Good idea...what are the odds. Let's do Lottery style.
Locate and interview/video all the AD trial survivors world wide. The people can be located from trial records used by Anavex,Lilly,PZ,BIIB,J&J, etc from every country WW. Compile all the records of those who have been (insert defined rules here) successfully treated. Verify that all pts were properly determined to be legitimate AD (some stage) diagnosed prior to their trial starts.
Now when you conduct the post trial interviews conduct patient interviews and series of standard cognitive tests under strictly controlled conditions.
Summarize the results and report using video evidence along with other best methods to demonstrate the efficacy of the treatment and trail results.
Results show what??? Oh, there are no known post AD trial survivors WW with the ability to participate in and interview?? You say they have either passed or cannot respond due to their AD condition (can't show any cognitive skills needed for testing). The only test patients ever to survive any such AD diagnosis are Anavex A2-73 patients and they are all doing well, some even returned to normal live-(see testimonial videos ).
Well, there it is then, the entire AVXL trial population are liars, including hospital staffs and clinical staff. You cannot prove they are really AD survivors and since no one has ever survived AD diagnosis we must conclude the whole thing is a farce,it never happened. The statistics say the claim of effective treatment is not a valid conclusion. These things never happened or can be statistically rationalized away as not significant findings. Done.
Talon-Falcon-totally agree
Any theories on why the SP keeps falling, even when we didn't screw anything up or missed a date? going up is OK ya know.
plexrec...great effort.
Someone w/skills and knowledge to set up a site where we can all send and retrieve relevant notes/facts/stories/pr's etc. Maybe we can inspire AVXL to take us seriously about wanting them to be much more vocal w/stories and news. Maybe we can avoid the legal bitching and all the AH's who always show up with expert opinions on why things cannot be done...Like someone said..."First, kill all the lawyers".
drv17...
cninc...I have seen these but there is no posted link that I am aware of. Having continuous access for ref would be helpful.
Cool...will be off line until about 9:00 AM EST
sokol [quoteThe AVXL 2-73 stories about responders needs to be spread as the Anavex clinical trials progress. ][/quote]
Exactly correct. Patients stories Must be credible, technically accurate and truthfully done. That is all we need.
Biostockclub...Tripletts????WHOA NICE-God Bless them all
I can not do the victim thing well at all. The system is clearly broken. If we have to wait for BP/FDA/layered politicians on the payroll we are screwed.
I like the leapfrog idea. Getting real people who have recovered from AD is a showstopper. Having the results demonstrated is key and would overwhelm the foot draggers instantly. I feel no obligation to defer at this point to the incompetence now driving the bus. They have just again demonstrated their capability and we need to remove them. patients/caregivers/RWD-RWE/infrastructure/medical staff and RTT initiative is available.
Redefine the process for conducting trails based on RWE-and quality of life. Ban all BP interests from any involvement until we are done. Australia, Spain and NA are ready. IMO, we should assume that no one in the existing establishment would help.
MycoftHolmes...many thanks for your excellent follow up. BR
Biostockclub, as you point out, the AAIC 2018 process was a kind of humbling learning experience. Those of us who were certain the AAIC staff would intervene and take a bullet on the BIIB show were wrong. I hope we now see that no one is going to call the establishment system out. It is broken, unable to fulfill even the most basic legitimate science forum goals. Many wait and expect to experience the best, state of the art credible science on a disease that takes no prisoners. AAIC's judgement was questioned and they folded like a wet noodle.
I have learned I think that the Dr.Fleming antibiotic cycle will repeat itself unless there is a science process AD+ intervention. AVXL has much stronger AD science than any other PII/III biotec. What we heard was a muffled attaway-so what. We need some way of getting our story out and some way of becoming credible quickly at the highest level. That will take money, connections, political strength and a machine to make it move when we need it to. Non of this is consistent with the current AVXL culture.
Multiple simultaneous trials will help a lot but that involves basically following the same ole established path. We do not own that process path and we are not configured to pull it off quickly. I am as big an AVXL fan/supporter as any and will not change but I also see a flaw. We owe it to ourselves to call it like it is. We cannot rely on the rest of the world to value the AVXL science until they see it work which is going to take a long time. We do not have a long time. We need an intervention like a partnership, FDA open technical recognition, political boost, maybe even recognition by another country as an expedited trial. If only Fleming were here we could ask him about a do-over process.
Genee, you misunderstood. I was not happy with the content of AAIC response. I was happy they sent a nicely written professional answer. Sad to say it was content free" That was my concern and still is.
My response: