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The only ones who it is becoming more risky for are doubters, nay-sayers, and shorts. As the company has started playing their cards very close to the vest, it takes away all of their firepower and gives them nothing to twist and distort. Every day we get that much closer to their inevitable demise. Every single indication we have been given has been extremely positive and completely unassailable.
Awesome!!
GLTAL.
Thinking that there could be 4 months before the price makes a decisive move upward is hard to conceive of. With the timeline that the company has laid out we should see two of the new trials start before then. In 4 months we should be well beyond $15.
That is unless you believe that the company has misrepresented their intentions, which there is absolutely no evidence of.
IMO.
Technical analysis fills the days I guess... not much else though. These tiny, non-important moves of the stock price are nothing. They are just the result of manipulation and day-trading. Quite tiring.
Once the mainstream market gets caught up with the new science AVXL is working on, maybe they can offer the deserved respect and support that it deserves.
Till then, it's like it says..."hope deferred maketh the heart sick". Hang in there fellow longs. Great news is closer every day!
I'm glad Missling is at the helm. He isn't rattled by all the talk about the "necessity" to partner up and sell the farm. All we would gain by doing that is a few months earlier results at best. Let's keep it in house till we can call the shots and make demands. (Which won't be that long of a wait)
If they find a correlation between DNA and the "Super-Responders" it will be a major scientific breakthrough in itself.
Imagine identifying a gene that enables you to respond to a certain medication better than another person! We may be on the verge of gaining a much deeper and thorough understanding of what AD is.
Can you say "Nobel Prize"??!?!
"Shake-N-Bake!"
I think a lot of money is sitting on the sidelines waiting to see things actually start happening. There has been A TON of talk from Anavex, but little real developments in the past 5 months.
I absolutely have no doubt myself that many very important things have been happening behind the scenes this year, but we need to see things happening on stage!
Agreed.
My Gosh! This again?!?
It didn't get presented. Doesn't matter why. And it's not important. PK/PD isn't going to be "big news". It's not going to change the pps. It is nice to see, but from an investors viewpoint it's not going to matter. Why waste time and energy anticipating it?
New trials starting. That is the game-changer. That is something to anticipate that will actually drive the pps up considerably.
IMO.
Anyone else see an abstract like he describes?!?!
I agree that the study extension is of little importance in and of itself. Any further updates will be met with little or no excitement from investors.
However, when you couple the extension with the upcoming phase 2/3 I think it becomes extremely relevant. As we get into the 2/3 we hope to see efficacy right from the start. Nay-Sayers are going to start saying that the results don't mean anything until you get deep into the study. Perhaps 6 months to 1 year.
What happens if we see a correlation between the 2a study (which most fly-by investors are not valuing based on n=32 and lack of placebo) and the 2/3 early results? Savvy investors will see how the 2/3 placebo-controlled, n=300 study shows similar results.
The conclusion that will be reached is that the awesome results we got from the 2a (including the 104-week extension) will quite possibly be repeated with the 2/3.
This is the reason we should be excited to see continued great results from the 2a. We aren't going to see price spikes based on it. But it is going to show where 2/3 is heading if the data correlates.
Also...continued safety results will smooth out the road to approval. Possibly approval in the next year and a half.
PK/PD will move the price a small amount. Nothing major IMO.
I think the Rett trial starting is going to be a much bigger deal. I agree totally that the Rett trial should start in July some time.
I feel that the Parkinson's trial is going to be a monster catalyst. If the trial goes well just think of the publicity we could get with the MJFF involved.
Closer...every...day...
Better get long before it's too late!!
Post of the month.
Tic tock...tic tock...
Tic tock...tic tock...tic tock...
He stated very clearly multiple times that it would be a 12 week trial. No more, no less.
Closer to Rett trial every day... getting closer to the big short squeeze every day too...
The tension builds...the anticipation is killing me...
I don't know anyone who wears "blinkers".
26.38% and rising...
True...what a dangerous situation you describe for anyone shorting AVXL. Just one PR away from total disaster.
In any case, Rett should be starting within about 4 weeks from now... give or take. IMO.
No doubt!! My point exactly!!
Can't wait for it to start!!
You can't argue with success. 2-73 is succeeding at every turn despite the supposed negative points being made by some.
You want to know why the Rett trial scares the snot out of them?? Because you can see a seizure. You can't build up a "house of cards" argument about how the trial participants aren't really improving. AD is much easier to attack. Rett will be so much harder for negative posters to criticize.
When the Rett trial shows a severe drop off in the number of seizures it will be an unassailable victory for 2-73. There will be no other side. 2-73 will have worked. Period.
Go AVXL!!
Volume is big because of all the sophisticated investors buying shares hand over fist.
Not much...same old manipulation. Nothing to give any consideration to.
FUD-makers running rampant. Get ready...news must be imminent! What's it going to be??
Data?? Trial starting?? Patent?? BIIB results??
All of the above???
Hehehehe!!!
Probably not hugely in my opinion. The Rett trial starting is paramount.
At least three meaningful and important catalysts should happen before the end of July in my opinion:
1) 104-week extension update
2) PK/PD data for 2a AD trial
3) Start of Rett 2a trial
We could see more (patent info, BIIB results) but if we see just these three in that short of a timeframe... I think we are sitting $15+ by end of July.
$30+ by end of 2017.
IMO.
So...what I see is that your chart analysis tells us that we should be watching for:
$4.50
$4.60
$4.70
$4.75
$4.88
$5.00
$5.25
$5.30
$5.50
$5.85
$5.90
...and...
$6.00
Is there any number between $4.50 and $6.00 that you aren't "calling"? Basically whatever it does, you're covered.
I don't need a chart to find my sell point. I go by the number of digits in the pps.
4 digits or more and I sell everything.
M happy to wait as long as it takes. No reason to doubt AVXL or 2-73 at this point. As long as they keep making good progress (like they have for the last two years) I'm staying long and strong.
The market isn't "punishing" anything. At worst it is stagnant. It's waiting patiently for the next catalyst.
1) Data
2) Rett starts
3) Parkinson's starts
4) AD starts
All happening this year. Going to come soon and often.
Rett trial has got to start within next 4 weeks IMO.
That'll shut up the Negative Nellies for a while. I think we go to $10+ very quickly on that news.
Timeline as I see it:
Now-July: - Start of Rett phase 2.
- More 2a AD data
Aug-Sept: - Start of Parkinson's ph2.
Sept-Nov: - Start of AD phase 2/3
- Conclusion of Rett 2a
Dec-Jan: - Release of Rett 2a data
-Conclusion of Parkinsons 2a
Feb-Mar:-Release Parkinson's 2a data
-Possible approval for Rett
-Initial data from AD 2/3
-More AD 2a data
If this is close to what happens, it looks like the great results/news will start piling up into a tsunami around the end of Q1 2018.
Nope. That's the only thing that matters as I said. Glad to hear Missling stating again that they are starting all three this year and we may even get data this year. That was great to hear again.
To get data out by years end on a trial that runs 3 months would mean it needs to start very, very soon. I'd guess it would need to be fully enrolled by August sometime.
Getting exciting!!!
Need to start the trials for Rett, Parkinson's, and Alzheimer's. Nothing else matters.
Should see data for Rett around the end of the year. As soon as we do, it should be approved very quickly. And with Parkinson's and Alzheimer's trials underway by then it will be a whole new ballgame.
It will not be an experimental drug, but by then it will be a currently approved and available drug. If promising data is forthcoming from the AD at that time...it will be liftoff!
Is your proposed schedule based on your knowledge of the time involved in genetic testing and analysis as it relates to drug response?? Or are you just pulling dates out of the air?
They said that they're doing genetic testing on the super responders. Sounds like they're going to use genetic testing as part of the screening process for recruiting for the A.D. trial. That sounds awesome. That also explains to an extent the delay.
Looks like nothing doing again today. No PR this morning. No pre-market sales. No news coming today. Just same old rehash of same old info.
Oh well. It will happen someday. Just keep patient.