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Inquirig,
You must be close to a record on this board for the most number of posts in a single day but who’s counting?; ). Hasta la vista!; ). Best wishes.
brooktrail1933,
That is correct. Best wishes.
Horseb4CarT,
But you do have to admit that “she” is helping us pass the time with much needed useless banter entertainment; ). Best wishes.
Inquirig,
I know what you meant. I also know you are wrong by what you meant and that you and the bosses will be the ones trying to find a seat on the rocket with no extra room. If you have never been in a simulated launch it’s a rough ride too but for as long as I have been here holding steady I’ve seen it all while accumulating along the way patiently waiting for the science to play out.
You see I can actually see the cards in Linda’s hands. Because of the science I stand behind her and have a great view so I think I’ll ask Linda to see your raise and call your bluff. I hope your husband doesn’t know you are about to be running around naked looking for a barrel while leaving the card table especially with all the guys here. Good thing for you there are mostly gentlemen at the table with Linda who will turn their heads while you exit in shame. I certainly won’t blame Linda for having a good laugh though ; ). Best wishes.
Inquirig,
In 2015 good news was turned to bad. Turns out JAMA Oncology validated that good news. I have been here 12 years watching and participating in the anticipation of next moves along the way. When I joined this board in 2016 a certain so called journalist had already severely tripped up over calling DCVax Direct no better than grapefruit juice and yet to the best of my knowledge there are yet survivors from the 2013 Phase 1 portion of its trial which of course make his comments look really ludicrous.
Along the way, I suggested to the board that spacing of the Direct treatments would change in any future trial and they did announce that specific change to what was anticipated. You see, science matters and gives insight into potential outcomes and measures so when you say buckle up it’s really more like strap in for the moonshot. You on the other hand seem content to be left behind or maybe right behind if you and the bosses sneak on board before launch ; ). Best wishes.
Pattyloco,
This is just part of the process that has been in place for way too many years when it’s obvious L is and has been proven safe for many years, had a signal of positive effect years ago and is now validated by JAMA Oncology. Those who want in from outside of retail are basically prevented from doing so by their own regulations and many friends if retail have been burned by manipulators so no help there either right now. At some point prior to expected approval volume will begin to increase on no news. Before then there will be pressure on the price until news because that’s what these guys do for a living but like biosectinvestor says this is to be expected. Their actions are predictable and they want to test your confidence and stamina. MHRA is on your side and Dr. Ashkan has said he expects approval in months. That’s a voice worth listening to because of his influence and passion for his patients. Best wishes.
Inquirig,
No, once again you demonstrate your lack of understanding. The stock price is hovering along the long term uptrend from March/April 2020 and getting waterboarded a little along the way. If you had been paying attention you would know that this was predicted here as expected. As several of us long term longs know and understand the cycles and the part that you and your partners play in the cycles, those who are prepared for the bottom of the cycle before the news comes are ready and waiting which frustrates ya’ll. Oh well, guess that’s the price you pay for this kind of work. At least you can work from home; ). Best wishes.
Inquirig,
“LP is a disgrace to all women” -Inquirig
Says the one who wants to bring NWBO price down to where she is at and destroy a company bringing a pathway to a cure for cancer patients to its knees. Not going to happen much to your chagrin. Hope you are representing the spoofers and the jury gets a good look at you if you continue down this path. Brutal stares I would imagine and guilt by association is difficult get away from. Like the old saying goes, turn or burn!; ). Best wishes.
exwannabe,
While that “process” is part of “the process” patients will not be held back from access very long when they realize that “the process” makes it illegal for them to live. In other words, label extensions will happen quickly or there will be a MAJOR uproar. The advances already made beyond the Phase 3 trial will be made known and the ability to produce the vaccines on a grand scale will not be a limiting factor based on capacity being created right now. At some point people will realize that “the process” has not been set up for their benefit. Myself and others will be happy to help make that very clear to legislators, regulators and others in the very near future if need be. When the NWBO court case gets to discovery and when Laura Posner’s amicus brief begins to get more mention everyone involved will be put on notice very publicly.
This is an election year and stuff is going to be said to the people that gets them really riled up like has not been seen for a while as divisiveness and anger has been rising to a boiling point. Whoever supports the right kind of change will gain the support of the people but this isn’t going to be pretty as even the immigration and asylum policy work is being asked to be held up as an election year talking point. I am not looking forward to any attempt at foot dragging L and Direct through “the process” because that will be just one more item on the list for folks to be angry about this year with any attempt to do so. The time for patients first is now and the time to strike the first big blow is when the iron is hot!; ). Best wishes.
Inquirig,
Law school and you say the halt was bad when after the screening halt all the treatment arm patients continued to enroll and receive benefit based on JAMA Oncology peer review of methods and conclusions utilized in the statistical analysis plan?; ). Try again. What law school did you go to? Linda Powers went to Harvard. Best wishes.
biosectinvestor,
The more she posts the more I think she is a new hire from one of the spoofers trying to engage us here. I would think if working for Citadel they would hire someone who digs a little deeper instead of exposing themselves so quickly to an obvious lack of understanding about the topics they post on. Best wishes.
dstock07734,
I think Linda Powers and Merck know the magnitude of what is coming and with Dr. Linda Liau connected with those at Amgen, they would seem to be another vetted big pharma. I believe that Mr. Cofer Black is way out front of this and has been vetting future potential partners for quite some time along with helping gather info for the court case. I believe several big names will not have any chance at a spot at the table with NWBO and I believe Linda has a potential independent route set up with CRL and independent supportive financing in all of this too just in case things don’t go as planned. Linda works very hard to stay ahead of all possible contingencies she can think of. Having a minimum of two to three (BMY?) big pharmas vetted and a potential interim independent route keeps everyone honest.
You have done a really good job of digging and pulling time lines together that mostly all point back to the time when NWBO had their first look at the unblinded data after data lock. While some might ask why would companies spend all this money on buildout for something not even approved yet or final agreements in place, I would ask what is the cost of missing out by not being ready when it is. Companies have placed much bigger bets on losers than what might be considered by some to be unwarranted and ill advised preparation for the DCVax PLATFORM TECHNOLOGY if that is what it is. Thanks again for all your deep dives. Best wishes.
flipper44,
“The process” of validation of treatments like DCvax-L and Direct, which have been known to be safe for many years and demonstrating a measure of positive effect, are in place to protect the status quo. This protection comes from the same type of thinking that Ken and other market makers share about the need to spoof as part of creating an orderly market. Their claim is that the chaos of disruption needs to managed to create fewer casualties, especially as related to them it seems.
There is a point to be made in this type of thinking because truly disruptive change has the ability to disrupt economic stability on a global scale and that can lead to unrest and wars if there is no guiding path in place to prevent this from happening. The issue is who should be guiding this. The elite believe it should be them which keeps them in control and with greater and greater power while the multitudes suffering intuitively know this is not true.
As this dichotomy of thinking becomes more exposed through the internet we need to take steps to reverse the framework of law that supports the status quo. To do this one must understand the law and demonstrate the need for change. Laura Posner has been doing this with the amicus brief presented to the Supreme Court. In it she indicates the failure of the court to address the issue of tracking securities being sold to the public in relatively blinded fashion. This has given rise to abuse such that a portion of current law intending to correct this abuse is being ignored by the court. She reminds the court of this and that proper tracking utilities are in place but not being recognized by the court as being able to do this. The brief suggests that court inaction to rule on this ability to track securities accurately is actually causing existing law not to be enforced hence the need for the court to rule that tracking is not only possible but already very doable and valid. In fact, the court itself could be found to be negligent and serving the interests of lawbreakers (potentially as co-conspirators being the unspoken) if not ruling properly in this regard. With this warning (amicus brief) in place Laura has paved the way to hold even those sitting on the highest court accountable to the people and the law designed to protect them. Currently that law is serving as nothing more than a facade and pretense. As such criminal activity can continue to go on nearly unchecked except with fines designed to appease the public again through pretense and a cost of doing business wrist slap fine for wrongdoers.
The road to accountability has been made long and difficult because of the framework that must be dismantled and opposition to what must be done. The attempt to do this is being made by those who see and are able to make a difference like Laura Posner and Linda Powers. There are many more who see the need and are called upon to support those out front by getting the truth out to all so that past silence by many is turned into a great deafening shout by the voice of the people. Those are the people who are no longer willing to pay the price for the benefit of the elite and are willing to shout out to their elected leaders “Can you hear us now?”. Best wishes.
CaptainObvious,
At this point in time it should be a point well taken and addressed by management and the board of directors with regard to fiduciary duty and arms length negotiations prior to commercial manufacturing. Up to this point keeping the entire process moving forward and confidential has been of great importance and worth. The next steps will obviously need to include more forthrightness and the next ASM is a proper time to begin to address this as it likely will occur close to approval. The lawyer’s amongst us would likely know how to properly bring this up with any needed leverage to assure it gets addressed timely. Best wishes.
thermo,
You and Mr. Bigger have been pretty quiet since strongly suggesting the benefit of partnership or other to NWBO management a while back. With all the tea leaves being read here now about potential Merck interest I would not be the least bit surprised if there is predominant silence from you both based on your due diligence. Thanks again for all your contributions here over the years and praying your brother is still going strong. Blessings and best wishes.
manibiotech,
Large numbers of similar sized block trades are generally algo derived and sometimes seem to have a coded message embedded. The common codes attached to lot size were shared on the board here a few times but I do not remember them all and of course they are not considered absolute but sometimes trends are found with them. Since most of the shares traded on the OTC might be directed to dark pools the codes might also trigger other codes not seen. Best wishes.
meirluc,
This whole thread is why I expect an update on Edens in the not too distant future whether milestone payments infer it anyway or not. If it is included in the MAA then there might not be a formal validation, just hints based on payments found in a Q, until the MAA is approved as I doubt this rises to the level of needed separate disclosure. This is one more piece that flipper44 (hat tip) and others of us might fit into the Merck/NWBO possibilities that they want quiet until the right time too; ). Best wishes.
Sojourner55,
Thanks, I rely a lot on recall from memory as a way to keep sharp and because this “gift” has been very useful in putting together the big picture not only here but with scripture, world history and science combined. I am convinced that there is a matrix like logic to everything that happens based on preordained design by an intelligent creator and ordered interaction within its borders by creation that appears to fall within the realm of randomness but is in fact preordained as allowance. Sometimes allowance of choice has become so painful that even the creator has lamented and even wished out loud that our choices within those set limits were never allowed (repents that humankind and other beings were brought into the picture because of choices leading to great wickedness even though choice can also lead to sacrificial love). I’m pretty sure Noah and Moses can confirm this and unfortunately there is more of what happened in their times coming. In the mean time, looking for the interim victory and answer to many prayers with NWBO ; ). Best wishes.
manibiotech,
Yes but I do not recall the specifics. What we do know is that HE and the PIP included them and that is a good indicator that they are already considering this. I have seen decisions to expand in actual approval decisions as well, I just don’t recall offhand where I saw this. Best wishes.
FeMike,
There was no testing in the Phase 3 for lower grade gliomas but the regulators can add them in based on supplemental evidence provided if they are convinced there is efficacy to be found there as well. I believe it comes down to regulator decision based on ancillary evidence because NWBO did not originally test this in patients in this trial. Best wishes.
georgebailey,
Wish I had it in front of me but I do remember reading something about it at one time and when exwannabe brought it up he reminded me of that. I think it is in one of the last quarterlies. Best wishes.
StonkMaster,
We are waiting on approval and Edens validation. You saw ATLnsiders point being made about lower grade gliomas likely being added in to GBM and rGBM approval. I say add all future trials waiting on Edens validation as well. Now there may be validation of Edens already in place but exwannabe has a solid point to be made about Edens development and that is at least two milestone payments have yet to be reported. This does not mean it’s not done yet and payments made, we don’t know even though the Captain showed us there were some significant days of share increases in the last 60 days, but reporting on it is likely a quarterly or ASM type of update event instead of PR until approval because bigger revenues can’t begin until approval anyway. So until we get any other interim update about Edens we are very likely waiting on approval. That’s when much more news and projections can be shared. Best wishes.
flipper44,
The right kind of announcement on the combo trial start can and will make a difference especially when data from the L +Poly ICLC trial and any update on the keytruda trial gets put along side of it if Merck makes any mention of it. Best wishes.
flipper44,
My observation was from an intraday price I saw flash in the last ten trading days. When I think we are getting close to a change in direction I start peeking at price, trade size and volume on at least two different sites and sometimes those sites don’t reconcile meaning they are looking at and reporting different sites themselves. This is why I expected the one site to be the one pushing for another shot at what I saw as an interim, not longer term, double bottom intraday test. Best wishes.
Sojourner55,
Thanks; ). I am no good at showing the stop offs with graphics and charting so appreciate the help with flipper’s question. Just trying to keep fellow longs informed while we wait so if they have the patience and the powder they can take advantage of what others are trying to do in the short term to try and get some to give up while we wait. By the way, $.60 represents baseline on the long term trend from March/April 2020 and that trend has held up pretty well even though waterboarded a few times by market makers to try and shake longs off the trail ; ). I also thought I saw a $.55 intraday price on one of the screens I was looking at in the last two weeks but those numbers often differ from each other depending on which site I look at when I do check. I don’t check that often except when I think a temp low or high might be setting in. Best wishes.
Funny that I already posted that this is what the market makers and traders would attempt to do and here we are. Is this really so difficult to see after all these years?; ). Best wishes.
ison929,
They want to test at $.55 to see if they can get it lower or call the interim double bottom and are waterboarding the baseline uptrend to do so. If $.55 holds they likely let it move higher again. Traders want to make money while they wait too. By the way, there are strong longs that have stated they have trading accounts apart from their regular accounts. I just admit this is true and accept that everyone has their own investment structure that they believe works for them. I learned long ago to accept this as a given. Best wishes.
learnincurve2020,
Maybe protege Dr. Tim is ready to become department head and someone with an MBA focused on treatment reimbursement and strong desire to continue with research oversight might be elevated from within the ranks and prepared for what a partner that recognizes her talent and abilities might have in mind? Do you ever try to look at the big picture?; ). Best wishes.
iclight,
It was a safety study that ended up proving its worth to several patients that have lived well beyond their projected disease state lifespan. The MO was not tumor shrinkage like chemo is known to do but rather tumor size increase as immune cells flood the tumor to kill it as happened with Allan Butler. That dead tumor mass was then surgically removed and as far as I know he is still alive today after essentially running out of options for treatment. Last I checked with thermo his brother was an ongoing survivor from Direct Phase 1 as well so your claim is based on a measure that YOU want to claim because that was a measure that was still being used in immunotherapy trials. By using OS as compared to ECAs the benefit is clearly seen as were the live beneficiaries of treatment.
Just a reminder for those unlike iclight who already knows but chooses to ignore, Direct Phase one was limited by 3 different dose levels one of which was determined to be best, two different methods of activation used one of which ended up being like a placebo comparator, only one tumor injected thus allowing genetically altered metastasis to survive, termination of treatment when treatment induced pseudoprogression occurred and improper spacing of treatments due to concern by regulators of auto immune response. Best wishes.
manibiotech,
Manufacturing for L GBM, rGBM and lower grade gliomas might be covered by Advent and CRL but everything else must be prepared for now if label extensions or tissue agnostic designation is granted soon based on proteomics and all currently available data. This starts with safety which is not in question and then is built upon by proteomics which has provided extremely strong evidence. A partner would see an opportunity to hit the ground running and never look back because of how far advanced NWBO has taken this platform to remove obstacles. Eyes have not seen nor ears heard what has been built and prepared for so to speak. When eyes and ears open then what has been transpiring will have been made known. Best wishes.
exwannabe,
.. manufacturing capacity is almost ready to go for worldwide distribution from the get go. I mean why wait with manufacturing when it’s a sure thing ie 17 missing SOC/placebo patients explained by Fraunhofer as having the trial enrolled to the point statistically necessary, validated by JAMA Oncology, with SOC no longer being fit for purpose and actually a known lesser treatment especially for low absolute lymphocyte count patients that were only allowed into the trial in Germany where all or almost all of the non randomized patients came from. Yep, 5 years later finally all the boxes checked off or almost checked off. Best wishes.
Horseb4CarT,
Royalties are to go to the Regents of UCLA for any L commercial production which apparently includes Specials. This is why Dr. Linda Liau had to acknowledge a connection to NWBO when the Regents received any royalty payments before being brought in as part of the scientific advisory board. Best wishes.
learningcurve2020,
You prove once again that you and the crew have NO CLUE about the science. Many of the business oriented longs here have been learning while others have not and it shows up at times in discussions. This platform is THE FUTURE for all solid tumor cancers and is ahead of the pack by a very wide margin even though some folks need to try and convince otherwise for funding and survival. Yes, this is really that BIG of a deal and the IP is Fort Knox like protected which several BPs and hedge funds are going to find out the hard way. Best wishes.
learningcurve2020,
Yep, a billion dollars might not even get you a spot at the table to determine how to advance Direct let alone creating any chance at buying rights to it outright. I can’t help you if you or others can’t understand the implications from the patents or how badly it was hampered in Phase 1 due to it being classified as first in man.
This is why long time longs laugh at some of the low ball estimates some have given for the buyout value of this platform. Validation won’t take anywhere near the time many anticipate. Autologous DCs are autologous DCs no matter what stage of maturation they are in. Best wishes.
ilovetech,
I know what you are saying but the real first step is admitting that the Lord is right about our situations and our need. After that all the rest can be taken care of. I also know that what happened with the people during Noah’s time will happen again. This is because the love of the truth was not found in them then and that is happening today as well. Warnings will be ignored just like many have not liked or commented on your post. That video is spot on and points to a spiritual battle even if not explaining it and is in line with what will happen according to scripture with regard to worldwide economics. Rejection of this warning message by many does not mean we stop trying to get the message across because those who do prepare will be able to help some who are unable to. I believe NWBO will be the conduit for me and others to do this. Best wishes.
meirluc,
This Merck move coincided with the Cognate expansion and CRL buyout of Cognate and further planned expansion in January/February 2021. Are we seeing any connections yet?; ). Anyone see a bigger boat being built?; ). Best wishes.
ATLnsider,
As predicted, NWBO needed a bigger boat, likely before submission!; ). Best wishes.
Smitty5150,
I appreciate and respect your take as one trying to keep it real based on your experience and understanding which I would not want to under estimate because of your contributions to this board. Even if we differ on a few things we agree that there is significant value to be realized here and that is worth some applause for team unity in and of itself. Best wishes.
learningcurve2020,
NWBO has commercialization rights to L and more importantly pretty much everything about Direct, which has ALWAYS had key IP protected beyond ANYONE’S reach. You may not know this but your bosses do; ). Best wishes.
ilovetech,
I agree but as you can see the hope presented for change has been hedged against by a move to the Stockholm area, a purchase of farmland and other real estate. The author is no longer in the securities market by his own admission. In other words, his hope for change before it’s too late has no real wager on that hope.
Seems to me that the takeaway for investors in NWBO is to have cash on hand, no debt or as little as possible and have securities completely or nearly completely out of street name so that potential collapses of financial infrastructure do not end up causing change of ownership to the protected class from current owners even if a temporary great devaluation of said securities should occur. NWBO management has also suggested to investors that maximum security of their shares comes when they are no longer in street name. This video explains indirectly why quite well. This video also explains why the likes of Citadel and others so boldly proclaim their importance to the market and their professed necessary way of doing things without regard for the law. Best wishes.