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From the Abstract----"Results
The trial was successful, since the differences in the least-squares mean (LSM) change from baseline to 48
weeks between the blarcamesine and placebo groups were -1.783 [95% CI, -3.314 to -0.251]; (P = 0.0226)
for ADAS-Cog13, and -0.456 [95% CI, -0.831 to -0.080]; (P = 0.0175) for CDR-SB in patients with early AD.
In addition, validated biomarkers of amyloid beta pathology, plasma Aß42/40 ratio increased significantly (P
= 0.048), demonstrating strong anti-amyloid effects of blarcamesine in Alzheimer’s disease patients, while
MRI revealed significant reduction in brain volume loss, including whole brain (P = 0.0005), comparing
treatment to placebo.
Power---Mar.9 conference---here you go !!- https://cslide.ctimeetingtech.com/adpd24/attendee/confcal/show/session/105
skit--nice post and agree-----" Hopefully they're preparing for a well orchestrated PR campaign."---sure is time for that "surprise"---time to "tell the world--WGT" !!!!
" clarity before the summer!"--I would prefer before spring !!!!
Jon--" without letting the voucher cloud his judgement and move on full speed."---does Missling have a "full speed"---no where to be seen---keeps kicking the can down the road--he's an expert at that !!!!
nidan--"GIANT BP $$$$ acquisition, just waiting to happen."--pray tell--in what decade ????? TGD slower than slow !!!!!!
power---"Biogen Plunges as Alzheimer Drug’s Slow Uptake "--our drug is better---just have to get it approved--it's about time !!!!!! Let's go Chris--people are waiting !!!
Reported today by Vanguard--increases holdings in Anavex--good to see---
File Date Form Investor Prev
Shares Latest
Shares ? Shares
(Percent) Ownership
(Percent) ? Ownership
(Percent)
2024-02-13 13G/A VANGUARD GROUP INC 4,144,500 4,360,648 5.22 5.31 Over 200,000 share increase
mpr--strongly agree on this--" doesn't want to waste their effort to file an NDA in OZ because it is too"--been there the longest with our trials--Aussie gov kicking in some funds---how can this place be "too small"?--take any approval that you can get---would gather much attention (which we need badly)--EMA and FDA would follow--totally stupid TGD would NOT pursue this opportunty !!!!!
" while shareholders get effed. This has to STOP."--agree strongly with this---"shareholder value"---Missling doesn't give a shit--get something approved already---enough fukin around--earn your salary Chris--that's the way we do things around here---garbage leadership--no where to be seen !!!!
Jon---" being laid will hopefully encourage the EMA to move."--nice "wishful thinking " post--but far too many "maybe---maybe if "---still no real WGT information---where is that 4 leaf clover ?? mine kind of disappeared !!!! just have to "keep on dreamin"
" then bleeding down to reach the pivot low at 5.30.
Posing the question, will 5.30 become the finished bottom in this cycle? My view thinks not, but I-- MARK this post as 1 BIG KROC of Brown SMelly stuff
mrp-" came from IR not me"---oops----gottcha !
mrpl--" We aren't going after TGA approval cause it's too small."--too small ????? get one approval and things would mushroom--strongly disagree if tht is the reason not "lobbying" in Australia----we have proven we have the goods there !!!!!! Numerous trials WTF !!!!!
Australia--been very quiet as of late--didn't Anavex hold a ## of trials there ?? Didn't the Aussie government help fund some of those trials ? very surprised we have heard nothing from down under--one would think..........!!!!!!
"Where is the sense of urgency from DM, BOD"--another great question--no "sense of urgency" observed--if this takes 2 months or 20 years no one at the co. seems to care!! Get your asses moving people!! 42 folks in the office now? doing what ??
Dr. Stephen MacFarlane talks about Anavex 2-73---8 years ago---why is this taking this long ???https://www.heraldsun.com.au/news/national/steve-macfarlane-explains-the-alzheimers-worldfirst-drug-trial-at-caulfield-hospital/video/03fe27ae89bdce4912cabf865a99ed80
"The peer review will give everyone a clearer picture"--the thing we are all waiting for--please come soon !!!!
Jon--nice post--"The peer review coupled with positive FDA feedback will propel us"---very true--big question of course is WHEN?????????.anyone know ????
pw---"So, I'm thinking management and BOD are planning for cash to be coming forth from other sources, likely in calendar 2024"--thanks--sure hope that cash will be showing up---let's get that approval !!!!!!
Power-and tradeher--care to comment on yesterday's earnings CC ?? All systems go ? any surprises ?? Holding onto WGT ??? I'm a bit disappointed in "The lack of progress-new news !!!!"
Xena--many thanks for posting this transcript---much appreciated !!!!
PW--" if Tom Skarpelos continues to support Dr. Missling,"--thanks for your reply----also here "waiting" we do have "the science"
"Missling makes it damn hard to have faith in the company."---true words--and Missling is still CEO--if he were on a baseball team he would have been "benched" long ago---nothing but "strikeouts" !!!!
vispach--"Still invested, but disillusioned ." exactly how I feel--I'll add very disillusioned !!!!
powerwalker--could you address this ?--you are a poster I have a high regard for--I see you've been here longer than I have--I have always thought our "Science' was tops--yet am puzzled by our "lack of progress" in getting the ball over the goal line !! " The sad part about this stock is overall the market is on a serious run up and all the indexes are at all-time highs and yet we just sit here not doing a whole lot of anything" TIA
poque--"Stock & Missling "---Missling could not care less--he is a POS CEO---shareholder value ??? WTF is that--"as excited as we are"--a bunch of Bullshit--Bernie Madoff copier !!!! Lots of promises--zero deliveries !!!
"The Excellence Trial was again a smashing success in reinforcing this fact.
And, in fact, everyone got better during the Trial.----When true--and I say this is----why not "Approval Now" ?????
Could someone please explain--in laymen's language--not a med-person here----" the early conclusion is that the placebo rate could have been higher in the study due to a slight imbalance in disease severity at baseline, across the treatment arms [groups], and the 2 to 1 drug to placebo randomization ratio."------TIA
tradeher--great article--thanks for posting--!!!
mrp--"Kinda feel WTF is going on?'--kind of agree with you--no one here knows Jack Sht what is going on ! Because of lack of transparency and very very poor communication from our CEO who could care less about his shareholders ! Whole situation really sucks bigtime--Yea Chris we are all as excited as you are--how long have we heard this Bullsht ?????
Talon-" that partner appear when we apply for a new drug status with the EMA."--and in your opinion this will happen when ????
crescent---"-hiding fundamental information that should be shared with the owners (shareholders) of AVXL. By keeping everything a closely held secret, he does nothing but feed"--my thought also--none of us really have a clue as to what is going on--"behind the curtain'--"under the radar"--all BS---tell the shareholders--wait for "peer reviewed'--how much longer--1 month--3 months--co. knows full AD trial results--this waiting Krap getting very old !!!! Lots of promises---where are the results ?????
power--"That said, I agree with you that a well-worded PR giving the world as a detailed status report "--mission impossible !! we should get so lucky !!
In the last 2 company pr's--mention of Karuna Therapeutics--" KarXT from Karuna Therapeutics (KRTX), a muscarinic M1 receptor"- kind of getting a hint TGD may be looking to partner???????? Hint-Hint--look what we have !!!!!!!
Meaningful news coming when ??? Peer review?? Europe??? Australia ?? Parkinsons ?? Been a very long wait !! How much longer ??Either the drug works or it doesn't--would be nice to get some confirmation !!
Mc-"Great news"--why so ?????????
doc--" Blarcamesine a 5% chance to get approved f"--WTF is doc ?? he doesn't know everything !!!!!
I've always been told--"call'm as you see'm---exactly what I do !!
power--"Investor, you, too, should make a change with your tag line as your remarks"--Congrats for "calling out" investor---champion "basher" on this board--finally someone calls it as it is--has bashed this co.as long as I can remember--I'm here 8yrs+!!!!! bash-bash-bash investor--always something negative to say!!!!!! Feb'ish !!