Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
We are all here for our own reasons. Some simple, some complex. I don't get bent over other people's motivations. I do try to perceive what they are though, so I can gauge the veracity of their opinions.
So far, it looks like typical 'Buy on the rumor, sell on the news' activity
What Happens After Your First Drug Approval
Interesting article by Derek Lowe:
pipelineDOTcoranteDOTcom/archives/2014/11/06/what_happens_after_your_first_drug_approvalDOTphp
Excellent
Tomorrow, tomorrow! I love ya' tomorrow. You're only a day away!
You can thank/curse me for that ear-worm.
Good story.
If AF is wrong inquiries as to his opinion as to what went wrong will likely be met with silence. Because that's what people do. There will be no feeling of shame. They ignore their failures and go on to the next thing to attack, because the best defense is a good offense. In this way, it's very much like politics.
Pyrr will be the authority on this, I just remembered something in an article I read some time ago. It had to do with the process of calling a trial early that involved only certain people being allowed to view the progress at certain points. In my scenario, it involved a data monitoring committee.
Here is an example from earlier this year:
Janssen Investigational Treatment for Schizophrenia Shows Positive Efficacy, Delays Relapse
Independent Data Monitoring Committee Recommends Halting Trial and Unblinding Data Based on Treatment Efficacy
TITUSVILLE, N.J., March 20, 2014 /PRNewswire/ -- Janssen Research & Development, LLC announced today that following an Independent Data Monitoring Committee (IDMC) recommendation based on positive efficacy, it has halted early a Phase 3 clinical study of paliperidone palmitate 3-month formulation, an investigational treatment for symptoms of schizophrenia in adults.
"We are really excited about this news because a medication's ability to delay time to relapse in schizophrenia has significant clinical and societal implications," said Husseini K. Manji, MD, Global Head, Neuroscience, Janssen Research & Development. "Being able to delay relapse can prove to be beneficial clinically to patients, to their caregivers and to the community."
The international, randomized, multicenter, double-blind clinical trial evaluated the efficacy of paliperidone palmitate 3-month formulation compared with placebo in delaying time to first occurrence of relapse of symptoms of schizophrenia. Study patients who were randomized to treatment were first stabilized with INVEGA® SUSTENNA® (paliperidone palmitate one-month formulation), an approved treatment for schizophrenia, prior to receiving the investigational 3-month formulation................
I know this was not directed to me, but from what I understand if there is an Independent Data Monitoring Committee, they are privy to the status of the trials and can recommend an early halt.
Hopefully, unlike Godot, our PR will arrive.
Very low volume. Positions are established. Waiting for Godot.
I can't watch that.
I wonder if she has heard of DCVax. It definitely would be a pass/fail situation for her and NWBO.
"You can't have everything. Where would you put it?" - Steven Wright
I was thinking of this, but I think the the philosophical angle fits way better. Hopefully, our victory in the war with the nattering naybobs of negativism will be complete..
A Pyrrhic victory is a victory with such a devastating cost that it is tantamount to defeat. Someone who wins a Pyrrhic victory has been victorious in some way; however, the heavy toll negates any sense of achievement or profit (another term for this would be "hollow victory").[1]
Etymology
The phrase Pyrrhic victory is named after Greek King Pyrrhus of Epirus, whose army suffered irreplaceable casualties in defeating the Romans at Heraclea in 280 BC and Asculum in 279 BC during the Pyrrhic War. After the latter battle, Plutarch relates in a report by Dionysius:
The armies separated; and, it is said, Pyrrhus replied to one that gave him joy of his victory that one more such victory would utterly undo him. For he had lost a great part of the forces he brought with him, and almost all his particular friends and principal commanders; there were no others there to make recruits, and he found the confederates in Italy backward. On the other hand, as from a fountain continually flowing out of the city, the Roman camp was quickly and plentifully filled up with fresh men, not at all abating in courage for the loss they sustained, but even from their very anger gaining new force and resolution to go on with the war.
—Plutarch, [2]
In both of Pyrrhus's victories, the Romans suffered greater casualties than Pyrrhus did. However, the Romans had a much larger supply of men from which to draw soldiers and their casualties did less damage to their war effort than Pyrrhus's casualties did to his.
The report is often quoted as "Another such victory and I come back to Epirus alone",[3] or "If we are victorious in one more battle with the Romans, we shall be utterly ruined."[4]
The term is used as an analogy in fields such as business, politics, and sports to describe struggles that end up ruining the victor. Theologian Reinhold Niebuhr, for example, commented on the necessity of coercion in preserving the course of justice by warning, "Moral reason must learn how to make coercion its ally without running the risk of a Pyrrhic victory in which the ally exploits and negates the triumph."[5] Also, in Beauharnais v. Illinois, a 1952 U.S. Supreme Court decision involving a charge proscribing group libel, Justice Hugo Black alluded to the Pyrrhic War in his dissent: "If minority groups hail this holding as their victory, they might consider the possible relevancy of this ancient remark: 'Another such victory and I am undone.'"[6]
Excellent
I'll be watching tonight here in Akron!
Excellent. Well researched and written.
Excellent
Shorting is a 'product' that generates comissions
Good piece of real estate
If you don't want to watch the video, just try to exit then click 'stay on page', and the entire text of the video will be displayed. You can skim it for the good parts.
That tells me another beat-down is in the offing
Yes, it is a red flag
Sarbanes-Oxley violations leading to material weakness doesn't necessarily mean that there is evil afoot.
Yeah.... definition #2 was what I had in mind! :)
We need someone to do drive by's and report back!
No problemo, BioInfo
Ask if he'd feel the same way if his mother was on the ship.
What a twit.
That is a good state of mind
Also, here is hoping more good survival stories are coming.
I don't see it either
Excellent. Looks like a source of income has started.
Stock is doing well, must be time for a new hit piece. ;)