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Lets have a steady climb today
Indeed. See ya'll back here to kick arse tomorrow
Get out the paint brush
It's like tug O war
3-4 PM should be interesting indeed
weeeeeeeeeeeeeeeeeeeee
Should be a fun afternoon. IMO
Here we go
Good news here today
107K ON THE BID 1.18
Every stock is pumping Coronavirus right now. Don't buy the high
Who's the jackass who paid 35 ? fess up
Can't be green everyday
Absolutely... Beer gonna taste good tonight! Cheers
314K ON ASK LOL
BOOM!!!!!!!
Afternoon run cometh
bahahahahahhaa
The sky is falling crowd has shown up. Sell and move on if you don't like it.
Yep, little tree shake up we go
On a positive note.... Good morning everyone :)
Good day. Finished strong
Nice bids
Hey! Welcome aboard PB. Good to see ya here
Afternoon charge is beginning
Still ticking 64 / 65
HERE WE GO
Are we gonna have a little pep in our step into close today? She's holding nicely through the lunch dip.
215K 1.71 VOLUME POURING IN
weeeeeeeeeeeeeeeee
Nobody selling, move that monster bid up or smack that ask
Nice bids this morning, someone knows something.....
1.60 was up. Got painted. Good day here
1.60 close will be nice
haaaaaa nice try
Here we go
I'll admit I own at 1.88 had no more powder to avg down. Held through the storm
She's rippin PM
LOL
-- Study results show TUSC2 overexpression decreased thyroid cancer tumor
metastasis and increased sensitivity to apoptosis by increasing
SMAC/DIABLO and Cytochrome C protein levels
-- Study highlights the possibility that TUSC2 may also be effective in
thyroid cancer therapy and adds to the growing body of research on TUSC2
beyond the non-small cell lung cancer indication the Company is initially
pursuing
-- TUSC2 is the active agent in the Company's Oncoprex(TM) immunogene
therapy
AUSTIN, Texas & CAMBRIDGE, Mass.--(BUSINESS WIRE)--January 29, 2020--
Genprex, Inc. ("Genprex" or the "Company") (NASDAQ: GNPX), a clinical-stage gene therapy company utilizing a unique, non-viral proprietary platform designed to deliver tumor suppressor genes to cancer cells, announced that independent researchers reported in a recent study that TUSC2, a tumor suppressor gene and the active agent in Genprex's Oncoprex(TM) immunogene therapy, is a potential target and biomarker for thyroid carcinoma. Genprex has no affiliation with these researchers.
Published in the International Journal of Molecular Sciences, the study reports that TUSC2 overexpression decreased thyroid cancer proliferation, migration and invasion. Cell proliferation, migration and invasion ability are essential steps in tumor metastasis. TUSC2 forced expression reduced thyroid cancer cell proliferation and could represent an important tool to arrest cancer cell proliferation, while TUSC2 restoration decreased the migration and invasion of thyroid cancer cell lines.
The study also found that TUSC2 increased sensitivity to apoptosis by increasing the SMAC/DIABLO and Cytochrome C proteins, which play major roles in apoptosis. TUSC2 forced expression increased these protein levels, and, inversely, the silencing of TUSC2 induced resistance to apoptosis.
Based on the results of the study, researchers concluded that TUSC2 is negatively associated with thyroid cancer aggressiveness and, thus could be a novel target and biomarker for thyroid cancer therapy.
"We continue to be encouraged by data resulting from studies conducted at multiple research institutions suggesting that TUSC2 may be an effective treatment for many types of cancer, now including thyroid cancer," said Rodney Varner, Genprex's Chairman and Chief Executive Officer.
The authors further state that thyroid carcinoma is the most common endocrine cancer and includes many different forms. Anaplastic thyroid carcinoma (ATC) is the rarest but most lethal subtype. ATC patients usually present a rapidly enlarging neck mass, a high rate of distant metastases and approximately 95 percent mortality at six months. Conversely, papillary thyroid carcinoma (PTC), the most common type of thyroid cancer, is generally characterized by good outcomes, as it is highly curable by surgery and radioiodine therapy. However, some PTC patients have an aggressive disease and can develop distant metastasis.
The same researchers have previously reported that TUSC2 is downregulated in almost all ATC samples and in the vast majority of PTC samples, suggesting TUSC2's important role in thyroid cancer progression. In 2019, an estimated 50,000 patients in the U.S. were diagnosed with thyroid cancer.
Genprex is conducting clinical and pre-clinical research to evaluate the effectiveness of TUSC2 when combined with targeted therapies and immunotherapies for non-small cell lung cancer. Existing pre-clinical data also suggest that TUSC2 may be effective against breast cancer, glioblastoma, head and neck cancer, kidney cancer, and soft tissue sarcomas. This new independent study raises the possibility that TUSC2 may also be used to treat thyroid cancer.