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New O/S 24 million up 16 million?
Marketwatch has this figure but OTCmarkets doesn't?
Very fishy?
I assume it's much higher?
Dilution is ugly?
IMO
.28? Where are the loser promoters today?
They still buying?
Were they ever?
One can only.ponder what they did with there .90s .60s .40s?
Guess they flipped for a loss?
Losers?
IMO
Hey copy and paste person if your are good with charting let the room know the current O/S?
Surely you have it?
No?
IMO
Nice flip the fake buys?
Sweet?
Tell us another Genprex fabrication?
IMO
$GNPX Oversold and Undervalued with a MC of only $3m
Things are so pitiful they are reposting almost 2 year old news?
Rock bottom?
Not even close?
Bankruptcy?
Just wait?
IMO
Trying to flood social media with hypothetical nonsense?
These 3rd party con job wanna be social media paid hacks invading everywhere with fake adding and dreamed up Genprex ideas?
All while GNPX sells shares?
The very meaning of a pure pump and dump?
Michael Redmond = Ryan Confer?
Are these guys who orchestrated crimes of selling shares based on the idea of Cancer research?
Who does that?
IMO
Genprex Provides Update on Diabetes Gene Therapy Program
February 18, 2025 Press ReleasesDiabetesgene therapy
Signs an Amended & Restated License Agreement for Multiple Technologies for Gene Therapy for Type 1 and Type 2 Diabetes
Forms a Wholly-Owned Subsidiary, Convergen Biotech, Inc., to Focus Diabetes Program Development
AUSTIN, Texas — (Feb. 18, 2025) —Genprex, Inc. (“Genprex” or the “Company”) (NASDAQ: $GNPX ), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, today announced the advancement of its diabetes gene therapy program, including its relationship and collaboration with the University of Pittsburgh of the Commonwealth System of Higher Education (Pitt).
The parties have updated and consolidated the Company’s existing license agreements for technologies from Pitt into a new exclusive license agreement for multiple technologies relating to the development of a gene therapy product for both T1D and T2D. Additionally, the Company has formed a wholly-owned subsidiary, Convergen Biotech, Inc., which will focus on the Company’s diabetes program development.
“We are excited about the advances we are making with our diabetes gene therapy program, including the updated, consolidated exclusive license agreement with the University of Pittsburgh for several technology combinations,” said Ryan Confer, President and Chief Executive Officer at Genprex. “We are also pleased to have formed our wholly-owned subsidiary. In addition, we’re having ongoing discussions with various patient advocacy groups. We believe GPX-002 is a highly innovative, emerging diabetes gene therapy, and we are working to advance this program toward human clinical trials.”
Exclusive License Agreement with the University of Pittsburgh
The new license agreement consolidates the Company’s licensed technologies from Pitt into a single updated agreement which replaces the existing license agreements with Pitt. The amended and restated agreement grants Genprex a worldwide, exclusive license to patent applications and related technologies and a worldwide, non-exclusive license to use certain related know-how, all related to a gene therapy for both T1D and T2D using the genes of the Pdx1 and MafA transcription factors controlled by insulin, glucagon and MafB promoters. This license creates a comprehensive panel of gene therapies exclusively licensed by Genprex for the Company’s diabetes gene therapy program.
“The latest exclusive license agreement synergizes our pre-existing relationship with the University of Pittsburgh, strengthens our intellectual property portfolio for the diabetes gene therapy program and provides Genprex with valuable rights over multiple diabetes gene therapy combinations that we believe have the potential to disrupt the diabetes market,” said Thomas Gallagher, Senior Vice President of Intellectual Property and Licensing. “These technologies are currently being evaluated in preclinical studies at the University of Pittsburgh. As we continue to optimize our construct, we are making strides toward clinical trials.”
The licensed technologies are based on the same general gene therapy approach under Genprex’s original licenses, whereby an adeno-associated virus vector containing the Pdx1 and MafA genes is administered directly into the pancreatic duct. In humans, this can be done with a routine endoscopy procedure. GPX-002 is being developed using the same construct for the treatment of both T1D and T2D. In T1D, GPX-002 is designed to work by transforming alpha cells in the pancreas into functional beta-like cells, which can produce insulin but may be distinct enough from beta cells to evade the body’s immune system. In a similar approach, GPX-002 for T2D, where autoimmunity is not a factor, is believed to rejuvenate and replenish exhausted beta cells.
Each of these technologies may have the potential to provide long-term efficacy, potentially changing the course of this disease for the millions of patients around the world with diabetes. All of the diabetes technologies licensed from Pitt by Genprex were developed in the laboratory of George Gittes, MD, Professor of Surgery and Pediatrics and Chief of the Division of Pediatric Surgery at the University of Pittsburgh School of Medicine.
The Company has finalized components of the diabetes construct and is continuing with its planned preclinical studies. Genprex plans to request FDA’s guidance for the preclinical studies needed to file an Investigational New Drug (IND) application and initiate first-in-human studies and is poised for FDA Guidance on IND-enabling diabetes studies by the second half of 2025.
Formation of a Wholly-Owned Subsidiary
In addition, as announced in September 2024, Genprex believes separating its diabetes program from its oncology program into a new, wholly-owned subsidiary could expedite clinical development and enable potential direct investment and strategic collaboration into its diabetes program. In connection with the intended separation of its diabetes clinical development program, Genprex has formed a wholly-owned subsidiary, Convergen Biotech, Inc. Genprex believes implementing this initial step and facilitating the separation of its diabetes program into Convergen Biotech will allow both Genprex and Convergen Biotech to enhance each program’s focus on meeting the needs of their respective markets and patients. The decision to implement this initial step of the reorganization demonstrates Genprex’s strong ongoing commitment to the Company’s streamlined, focused strategies and prioritization of its ongoing research and development prioritization initiative.
About Diabetes
According to the U.S. Center for Disease Control as of 2024, 38.4 million Americans, or approximately 11.6% of the U.S. population, have diabetes. Approximately 10% of this total has T1D and approximately 90-95% of this total has T2D. It is also believed that more than 97 million Americans aged 18 years or older have prediabetes. In 2021, approximately 537 million adults (20-79 years) worldwide were living with diabetes, and the total number of people living with diabetes is projected to rise to 643 million by 2030 and 783 million in 2045. Approximately 7.7 million adults over the age of 20 live with T1D worldwide, and approximately 1.6 million children and adolescents under the age of 20 live with T1D worldwide. Also in 2021, diabetes caused more than 6.7 million deaths globally and diabetes resulted in approximately $966 billion dollars in health expenditures, a 316% increase over the preceding fifteen years.
About Genprex, Inc.
Genprex, Inc. is a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes. Genprex’s technologies are designed to administer disease-fighting genes to provide new therapies for large patient populations with cancer and diabetes who currently have limited treatment options. Genprex works with world-class institutions and collaborators to develop drug candidates to further its pipeline of gene therapies in order to provide novel treatment approaches. Genprex’s oncology program utilizes its systemic, non-viral Oncoprex® Delivery System which encapsulates the gene-expressing plasmids using lipid-based nanoparticles in a lipoplex form. The resultant product is administered intravenously, where it is taken up by tumor cells that then express tumor suppressor proteins that were deficient in the tumor. The Company’s lead product candidate, Reqorsa® Gene Therapy (quaratusugene ozeplasmid), is being evaluated in two clinical trials as a treatment for NSCLC and SCLC. Each of Genprex’s lung cancer clinical programs has received a Fast Track Designation from the FDA for the treatment of that patient population, and Genprex’s SCLC program has received an FDA Orphan Drug Designation. Genprex’s diabetes gene therapy approach is comprised of a novel infusion process that uses an AAV vector to deliver Pdx1 and MafA genes directly to the pancreas. In models of Type 1 diabetes, GPX-002 transforms alpha cells in the pancreas into functional beta-like cells, which can produce insulin but may be distinct enough from beta cells to evade the body’s immune system. In a similar approach, GPX-002 for Type 2 diabetes, where autoimmunity is not at play, is believed to rejuvenate and replenish exhausted beta cells.
Company’s CEO and CFO Highlights its Cutting-Edge Gene Therapy Programs
AUSTIN, Texas — (Sept. 23, 2024) — Genprex, Inc. (“Genprex” or the “Company”) (NASDAQ: $GNPX ), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, today announced the Company’s President, Chief Executive Officer and Chief Financial Officer, Ryan Confer, was featured in CEO/CFO Magazine discussing the Company’s novel gene therapies for cancer and diabetes.
In this article, Confer describes the Company’s gene therapy approaches in oncology and diabetes, recent updates to the Company’s Acclaim clinical trials in lung cancer, and the Company’s new use of biomarker testing for its oncology program. In diabetes, Confer comments on the popularity of GLP-1 agonists such as Novo Nordisk’s Ozempic® and other new diabetic treatments, the future of potential partnerships and collaborations in gene therapy and for Genprex, and the medical and investment community’s understanding of the potential value of gene therapy for diabetes.
Confer states in the CEO Magazine article:
“One thing we are excited about – as we just recently announced – is our plan to launch a spin out of our diabetes program into a wholly-owned subsidiary of Genprex. We believe this will allow us to explore potential partnerships with those entities solely focused on the diabetes program and find the right funding, partners, and collaborators that could drive these programs forward, which is important to us in terms of getting these innovative drugs to patients faster and to creating value for our stakeholders.”
To read the article in its entirety, please visit the Media Coverage section on Genprex’s website.
About Genprex, Inc.
Genprex, Inc. is a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes. Genprex’s technologies are designed to administer disease-fighting genes to provide new therapies for large patient populations with cancer and diabetes who currently have limited treatment options. Genprex works with world-class institutions and collaborators to develop drug candidates to further its pipeline of gene therapies in order to provide novel treatment approaches. Genprex’s oncology program utilizes its systemic, non-viral Oncoprex® Delivery System which encapsulates the gene-expressing plasmids using lipid-based nanoparticles in a lipoplex form. The resultant product is administered intravenously, where it is taken up by tumor cells that then express tumor suppressor proteins that were deficient in the tumor. The Company’s lead product candidate, Reqorsa® Gene Therapy (quaratusugene ozeplasmid), is being evaluated in two clinical trials as a treatment for NSCLC and SCLC. Each of Genprex’s lung cancer clinical programs has received a Fast Track Designation from the FDA for the treatment of that patient population, and Genprex’s SCLC program has received an FDA Orphan Drug Designation. Genprex’s diabetes gene therapy approach is comprised of a novel infusion process that uses an AAV vector to deliver Pdx1 and MafA genes directly to the pancreas. In models of Type 1 diabetes, GPX-002 transforms alpha cells in the pancreas into functional beta-like cells, which can produce insulin but may be distinct enough from beta cells to evade the body’s immune system. In a similar approach, GPX-002 for Type 2 diabetes, where autoimmunity is not at play, is believed to rejuvenate and replenish exhausted beta cells.
GNPX...out for a wash...🥳
How come non of the 3rd party promoters will answer the current O/S of Genprex?
Can they?
Maybe they have a conscience where they can't lie only misleadi?
IMO
Coming off days lows nice here .40's in sight...
$GNPX Swinging for .50+...On News Watch Here! Conference finished yesterday and now think we see news real soon...Loading!!!
No more fake adding today? 3rd party promoters?
Taking the day off while the company offs another few million shares?
What's the O/S currently GNPX?
Surely people aren't adding based upon a company not reporting since last year?
Could be?
Ryan M Confer could be orchestrating one of the biggest con jobs in medical history?
Is Ryan M Confer CEO of Genprex stealing Investors money?
Is Ryan M Confer selling shares based off the sentiment of Cancer?
That would be the lowest form of life if anything Individual would do that?
IMO
The fake adding by 3rd party con artist promoters is laughable platered all over social media?
Typical cons over on X screaming about how they keeping adding over and over and over again?
I wonder if they sold the 1.40s they bought a few weeks back?
As GNPX keep selling they keep buying?
Lower and lower?
Shameful fake adding?
Gross?
IMO
$GNPX Adding here...Chart is reversing...
GNPX....3825...NHOD...🥳
georgie18
Member Level
Re: georgie18 post# 677254
Wednesday, March 19, 2025 10:26:41 AM
Post#
677268
of 677322
GNPX....37...HOD...🥳
georgie18
Member Level
Re: georgie18 post# 4054
Wednesday, March 19, 2025 10:04:27 AM
Post#
4056
of 4056
GNPX...3564...🥳...Trying to Reverse here...
georgie18
Member Level
Re: georgie18 post# 677148
Tuesday, March 18, 2025 7:41:03 PM
Post#
677236
of 677253
GNPX...Added some .33s...🥳
georgie18
Member Level
Re: None
Tuesday, March 18, 2025 10:55:31 AM
Post#
4052
of 4053
GNPX...42...Filled some here...🥳
GNPX....37...HOD...🥳
georgie18
Member Level
Re: georgie18 post# 4054
Wednesday, March 19, 2025 10:04:27 AM
Post#
4056
of 4056
GNPX...3564...🥳...Trying to Reverse here...
georgie18
Member Level
Re: georgie18 post# 677148
Tuesday, March 18, 2025 7:41:03 PM
Post#
677236
of 677253
GNPX...Added some .33s...🥳
georgie18
Member Level
Re: None
Tuesday, March 18, 2025 10:55:31 AM
Post#
4052
of 4053
GNPX...42...Filled some here...🥳
GNPX...3564...🥳...Trying to Reverse here...
georgie18
Member Level
Re: georgie18 post# 677148
Tuesday, March 18, 2025 7:41:03 PM
Post#
677236
of 677253
GNPX...Added some .33s...🥳
georgie18
Member Level
Re: None
Tuesday, March 18, 2025 10:55:31 AM
Post#
4052
of 4053
GNPX...42...Filled some here...🥳
Complete horseshit no you didn't?
IMO
GNPX...Added some .33s...🥳
georgie18
Member Level
Re: None
Tuesday, March 18, 2025 10:55:31 AM
Post#
4052
of 4053
GNPX...42...Filled some here...🥳
Ryan M Confer should be in jail if he is taking part in a pump and dump medical scheme diluting mass shares and not reporting the numbers?
How come Genorex does not report current O/S?
What are they hiding?
Is the O/S still 8 million?
Ryan M Confer CEO of Genprex are you there?
IMO
What's the O/S currently? If you're going to promote absolute trash scams please come with updated info?
IMO
gnpx.................................https://stockcharts.com/h-sc/ui?s=gnpx&p=W&b=5&g=0&id=p86431144783
Love heavily diluted garbage Pharma plays picked up some .43s this round stop loss .41. Could it go back to .20s maybe will catch and reassess but been steady .40s for another possible dilution flip.
Stop selling lies? GNPX took a shelved product, tweaked it and is now selling millions of shares based upon it?
It's the same gang over and over diluting shells?
You're literally down 20% since yesterday horrific .55 call?
Just like the calls at 3 dollars 2 dollars 1 dollar?
Imagine people actually listened?
All the the inner workings of this pyramid scheme need jail time?
Payne is dead?
Redmond moved on?
Confer is a nervous wreck?
IMO
IMO
Oh the con artist 3rd party promo gang storming the interwebs claiming they keep buying?
Which is the same claims they have been making from 3 dollars to 40 cents?
Same adding at every level?
Same losing at every level?
All while they can't even tell you what the O/S has ballooned to because GNPX refuses to update it?
Dilution?
Scam?
Going to sub penny?
But no worries they will offer another reverse split soon?
Pump and dump pyramid scheme?
IMO
Yup in there and been adding to average down...🥳Thanks didnt notice today's news...
GNPX.53 +11% 8m floater results lung cancer good... A significant antitumor effect was also found in non-humanized NSG mice, although the antitumor effect was greater in humanized mice, suggesting that the effects of NPRL2 gene therapy are achieved through the immune system. This is consistent with a more detailed analysis showing that NPRL2 gene therapy induces antitumor activity against KRAS/STK11 mutant anti-PD1 resistant tumors through dendritic cell mediated antigen presentation and cytotoxic immune cell activation. KRAS/STK11 mutant tumors are particularly resistant to treatment, and demonstrating efficacy in this setting suggests that a wide variety of lung cancers could potentially be targeted. This potentially would include the approximately 30% of NSCLCs that have KRAS mutations.
What a horrible trade? You've done nothing but post buys lower and lower?
Feeding right into the dilution?
While claiming some false DD led you to Invest?
How could anyone be this wrong every time?
IMO
Seems they haven't reported the O/S since November?
Any guesses why?
I have an idea?
Theft?
IMO
These con artist promoters are now updating there calls lower lower and lower?
Always adding?
PPS always dropping?
They mist be shorting?
GNPX could be a pyramid scheme using the sympathetic nature of Cancer as a way to dilute and steal funds from innocent investors?
IMO
You are down already? You've called this from 2.00 to .71 adding all the way?
You might want to DD because at this rate it appears your are just losing money and giving out bad advice?
IMO
GNPX...76...Added on News...🥳...https://www.prnewswire.com/news-releases/genprex-announces-first-patient-dosed-in-phase-2-expansion-portion-of-acclaim-3-clinical-study-of-reqorsa-gene-therapy-in-combination-with-tecentriq-to-treat-small-cell-lung-cancer-302358445.html
georgie18
Member Level
Re: georgie18 post# 4032
Monday, December 16, 2024 9:31:30 AM
Post#
4034
of 4037
GNPX...$1.26...🥳...AUSTIN, Texas , Dec. 16, 2024 /PRNewswire/ -- Genprex, Inc. ("Genprex" or the "Company") (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, today announced that it has completed the Phase 1 dose escalation portion of the Acclaim-3 clinical trial of Reqorsa® Gene Therapy (quaratusugene ozeplasmid) in combination with Tecentriq® (atezolizumab) as maintenance therapy to treat patients with extensive stage small cell lung cancer (ES-SCLC). In addition, the Safety Review Committee (SRC) has approved the opening of the Phase 2 expansion portion of the trial.
The combination of REQORSA and atezolizumab previously received U.S. Food and Drug Administration's (FDA) Fast Track Designation for the treatment of the Acclaim-3 patient population, and the FDA has also granted Orphan Drug Designation to REQORSA for the treatment of SCLC.
Based on full safety data, which showed no dose limiting toxicities (DLTs), the SRC determined that the Recommended Phase 2 Dose (RP2D) of REQORSA will be 0.12 mg/kg. This was the highest dose level delivered in the Phase 1 portion of the trial. The SRC also recommended the trial advance to the Phase 2 expansion portion of the study, which the Company has now opened for enrollment.
Good Job fraud promoters coming in and plastering crap about this pyramid scheme at 1.5 now almost down 50% in just about a month?
Well done?
How many got diluted?
Tough to say since GNPX doesn't report?
Loophole?
Nothing like a scam off the backs of Cancer?
Ryan Confer might be knowing frauding the public off the idea of Cancer?
What kind of low life does such a thing?
Rodney Varner the man with many names and many years of stick manipulation does suddenly and Ryan Confer takes over?
How deep does the pyramid scheme of GNPX go?
IMO
Unlimited theft in the name of Cancer research?
It's one thing to create an imaginary product and sell shares of its ideas?
But to sell shares based on the idea of combating cancer takes some sick people?
IMO
GNPX...$1.26...🥳...AUSTIN, Texas , Dec. 16, 2024 /PRNewswire/ -- Genprex, Inc. ("Genprex" or the "Company") (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, today announced that it has completed the Phase 1 dose escalation portion of the Acclaim-3 clinical trial of Reqorsa® Gene Therapy (quaratusugene ozeplasmid) in combination with Tecentriq® (atezolizumab) as maintenance therapy to treat patients with extensive stage small cell lung cancer (ES-SCLC). In addition, the Safety Review Committee (SRC) has approved the opening of the Phase 2 expansion portion of the trial.
The combination of REQORSA and atezolizumab previously received U.S. Food and Drug Administration's (FDA) Fast Track Designation for the treatment of the Acclaim-3 patient population, and the FDA has also granted Orphan Drug Designation to REQORSA for the treatment of SCLC.
Based on full safety data, which showed no dose limiting toxicities (DLTs), the SRC determined that the Recommended Phase 2 Dose (RP2D) of REQORSA will be 0.12 mg/kg. This was the highest dose level delivered in the Phase 1 portion of the trial. The SRC also recommended the trial advance to the Phase 2 expansion portion of the study, which the Company has now opened for enrollment.
GNPX...$1.12...🥳...Psar flipped Bullish...Bollies are starting to Squeeze here...Been averaging down and Accumulating...
New O/S 8,508,068 six million shares diluted since last report month back?
6 million shares while the con artist 3rd party promoters came in and played pump n dump with the shell?
Don't anyone worry the O/S is going much higher and the PPS is going much lower?
Does Ryan M Confer understand about pyramid schemes?
I believe Rodney Varner is going to have some explaining to do where he is headed?
If Ryan M Confer turned out to take the torch from Varner by getting cancer products tweaking them and diluting shares while creating a false hope then this won't be his last time getting involved in possible pyramid schemes?
IMO
You think you know the current O/S or will you guess at that as well?
GNPX is a pyramid scheme?
IMO
I think it will run but "when" is the question, depends on if we get a favorable settlement or judgement from the court case. I think the appellant is running the clock to come up with a decent enough settlement agreement because in my opinion, a court decision would ruin them.
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Our technologies are designed to administer disease-fighting genes to provide new therapies for large patient populations with cancer and diabetes who currently have limited treatment options.
We are developing gene therapies for patients with cancer and diabetes to bring new therapies to large patient populations. Our lead product candidate, Reqorsa® Immunogene Therapy, is designed to be administered in combination with other therapies, including targeted therapies and immunotherapies, for non-small cell lung cancer and small cell lung cancer.
We have assembled a multidisciplinary team of executives and advisors with broad business experience in the biotech and pharmaceutical industries, and research and clinical experience at preeminent medical and academic institutions around the world. Our management team pairs an unmatched expertise with a knack for innovation in research.
At Genprex, we are committed to developing life-changing gene therapies for patients afflicted with cancer and diabetes. We are dedicated in our efforts to helping patients with limited or no treatment options to have access to new and advanced therapies to more effectively treat their disease.
Ryan Confer Appointed Genprex President and CEO and to its Board of Directors
AUSTIN, Texas — (May. 1, 2024) — Genprex, Inc. (“Genprex” or the “Company”) (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes, today announced the Company’s participation in the following upcoming investor and industry conferences to be held in May 2024.
Compelling Data Validates the Potential of Reqorsa® Immunogene Therapy and the Oncoprex® Delivery System as Innovative Cancer Treatments
Multiple clinical trial sites to be opened under collaboration with large network of community-based oncology practices
Genprex, Inc. is a clinical-stage gene therapy company focused on developing life-changing therapies for patients with cancer and diabetes. Genprex’s technologies are designed to administer disease-fighting genes to provide new therapies for large patient populations with cancer and diabetes who currently have limited treatment options. Genprex works with world-class institutions and collaborators to develop drug candidates to further its pipeline of gene therapies in order to provide novel treatment approaches. Genprex’s oncology program utilizes its proprietary, non-viral ONCOPREX® Nanoparticle Delivery System, which the Company believes is the first systemic gene therapy delivery platform used for cancer in humans. ONCOPREX encapsulates the gene-expressing plasmids using lipid nanoparticles. The resultant product is administered intravenously, where it is then taken up by tumor cells that express tumor suppressor proteins that are deficient in the body. The Company’s lead product candidate, REQORSA™ (quaratusugene ozeplasmid), is being evaluated as a treatment for non-small cell lung cancer (NSCLC) (with each of these clinical programs receiving a Fast Track Designation from the Food and Drug Administration) and for small cell lung cancer. Genprex’s diabetes gene therapy approach is comprised of a novel infusion process that uses an endoscope and an adeno-associated virus (AAV) vector to deliver Pdx1 and MafA genes to the pancreas. In models of Type 1 diabetes, the genes express proteins that transform alpha cells in the pancreas into functional beta-like cells, which can produce insulin but are distinct enough from beta cells to evade the body’s immune system. In Type 2 diabetes, where autoimmunity is not at play, it is believed that exhausted beta cells are also rejuvenated and replenished.
We are committed to fighting cancer and diabetes by continuing to develop unique and innovative gene therapies.
Our pioneering technologies are at the forefront of gene therapy and we stand behind our high-quality technology platform.
We have integrity and high ethical standards, and we believe in responsibly transforming the lives of those affected with cancer and diabetes.
Our commitment, excellence in technology, and integrity behind what we do enables us to be trailblazers in the effort to change the lives of patients afflicted by cancer and diabetes.
We have assembled a multidisciplinary team of executives and advisors with broad business experience in the biotech and pharmaceutical industries, and research and clinical experience at preeminent medical and academic institutions around the world. Our management team pairs an unmatched expertise with a knack for innovation in research.
Our lead drug candidate, REQORSA® Immunogene Therapy (quaratusugene ozeplasmid) for non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), is designed to interrupt cell signaling pathways that cause replication and proliferation of cancer cells, target and kill cancer cells, and stimulate the natural immune responses against cancer. REQORSA is an immunogene therapy in that it combines features of gene therapy and immunotherapy. It up-regulates TUSC2 expression in the cell, and also increases the anti-tumor immune cell population and down-regulates PD-L1, thereby potentially boosting the immune response to cancer.
In 2020, the FDA granted Fast Track Designation for REQORSA in combination with AstraZeneca’s Tagrisso® (osimertinib) in late-stage NSCLC patients with EFGR mutations whose tumors progressed after treatment with Tagrisso. In 2021, the FDA granted Fast Track Designation for REQORSA in combination with Merck & Co’s Keytruda® (pembrolizumab) in late-stage NSCLC patients whose disease progressed after treatment with Keytruda. In 2023, the FDA granted Fast Track Designation for REQORSA in combination with Genentech, Inc.’s Tecentriq® in patients with extensive-stage small cell lung cancer (ES-SCLC) who did not develop tumor progression after receiving Tecentriq and chemotherapy as initial standard treatment. The FDA also granted Orphan Drug Designation for REQORSA for the treatment of SCLC.
REQORSA consists of the TUSC2 gene expressing plasmid encapsulated in non-viral nanoparticles made from lipid molecules (our ONCOPREX® Nanoparticle Delivery System) with a positive electrical charge. REQORSA is injected intravenously and specifically targets cancer cells, which generally have a negative electrical charge. REQORSA is designed to deliver the functioning TUSC2 gene to cancer cells while minimizing their uptake by normal tissue.
Tumor biopsy studies conducted at MD Anderson show that, in three patients, the uptake of TUSC2 in tumor cells after REQORSA treatment was 10 to 33 times the uptake in normal cells. We believe that REQORSA is the first systemic gene therapy to be used for cancer in humans.
Unlike many other gene therapies, REQORSA is administered intravenously and it does not need to integrate into the patient’s DNA. Many other gene therapies require complex procedures that result in permanent changes in a patient’s DNA, including the removal of cells from a patient and the modification of those cells which are then reinfused into the patient.
Multimodal Mechanism of Action
Many approved cancer therapeutics target only single molecules or a single specific genetic abnormality related to driving the proliferation and survival of cancer cells. In contrast, REQORSA has been shown to have a multimodal mechanism of action whereby it interrupts cell signaling pathways that cause replication and proliferation of cancer cells, re-establishes pathways for programmed cell death (apoptosis) in cancer cells, and modulates the immune response against cancer cells. REQORSA also has been shown to be complementary with targeted drugs and immunotherapies.
Overcoming Drug Resistance
Resistance to targeted drugs and checkpoint inhibitors develop through activation of alternate bypass pathways. For example, when PD-1 is blocked, the TIM-3 checkpoint is up-regulated. We believe that REQORSA’s multimodal activity will block emerging bypass pathways, thereby potentially reducing the probability that drug resistance develops.
Combination Therapies
Our preclinical and clinical data indicate that REQORSA is well tolerated and may be effective alone or in combination with targeted small molecule therapies. Preclinical data indicate that REQORSA may also be effective with immunotherapies, and in a three-drug combination with immunotherapy and chemotherapy. These data suggest that REQORSA, when combined with other therapies, may be effective in a large population of lung cancer patients.
To learn more about scientific evidence and studies supporting REQORSA and the TUSC2 gene, please refer to our Clinical Trials and TUSC2 Bibliography pages.
In diabetes, we have exclusively licensed from the University of Pittsburgh multiple technologies relating to the development of a gene therapy product for each of Type 1 and Type 2 diabetes.
The same general novel approach is used in each of Type 1 and Type 2 whereby an adeno-associated virus (AAV) vector containing the Pdx1 and MafA genes is administered directly into the pancreatic duct. In humans, this can be done with a routine endoscopy procedure. Our diabetes product candidates are currently being evaluated and optimized in preclinical studies at the University of Pittsburgh.
GPX-002 is designed to work in Type 1 diabetes by transforming alpha cells in the pancreas into functional beta-like cells, which can produce insulin but may be distinct enough from beta cells to evade the body’s immune system.
GPX-002 has been tested in vivo in mice and nonhuman primates. Earlier studies in diabetic mouse models showed that an earlier version of GPX-002 restored normal blood glucose levels for an extended period of time, which lasted approximately four months, and markedly increased the mass of insulin producing beta cells. According to the researchers, the duration of restored blood glucose levels in mice could potentially translate to decades in humans.
In Type 2 diabetes, GPX-003 is believed to work by replenishing and rejuvenating the beta cells that make insulin.
In August 2022, we entered into a one-year sponsored research agreement with the University of Pittsburgh for the use of GPX-003 in a non-human primate (NHP) model in Type 2 diabetes.
In February 2023, the Company’s research collaborators at the University of Pittsburgh presented preclinical data in a NHP model of Type 1 diabetes highlighting the therapeutic potential of GPX-002 at the 16th International Conference on Advanced Technologies & Treatments for Diabetes (ATTD 2023) in Berlin, Germany. The statistically significant study results showed that after infusion of the AAV engineered construct all eight of the NHPs had:
We believe the data in NHPs demonstrate the potential for this gene therapy treatment to eliminate the need for insulin replacement therapy for Type 1 and Type 2 diabetic patients.
To learn more about scientific evidence and studies supporting GPX-002, GPX-003 and the Pdx1/MafA genes, please refer to our Clinical Trials and Pdx1/MafA Bibliography pages.
Our oncology platform utilizes our non-viral Oncoprex® Nanoparticle Delivery System. Using this system, anti-cancer genes expressing DNA plasmids contained in lipid nanoparticles are delivered intravenously to the patient. This platform, originally developed through collaborative research between the University of Texas MD Anderson Cancer Center and the National Institutes of Health, has been optimized to work with our initial drug candidate, Reqorsa® Immunogene Therapy (quaratusugene ozeplasmid).
REQORSA® utilizes the ONCOPREX® Nanoparticle Delivery System to encapsulate the TUSC2 gene in positively charged nanoparticles that bind to negatively charged cancer cells, and then enter the cancer cell through selective endocytosis, a process by which cells take in substances from outside the cell by engulfing them in a vesicle. The nanoparticles in our system differ significantly from liposomes historically used for drug delivery in that they are true particles encapsulating the therapeutic payload within a bilamellar lipid coat.
Our systemic, nanoparticle, non-viral delivery system, which is being used in our clinical trials for the treatment of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), is designed to be small enough to cross tight barriers in the lung, but large enough to avoid accumulation in the liver, spleen and kidney. The cationic (positive) charge of the nanoparticles target cancer cells. A Phase 1 clinical trial showed that intravenous REQORSA therapy selectively and preferentially targeted tumor cells, resulting in anticancer activity. The nanoparticles are non-immunogenic, allowing repetitive therapeutic dosing and providing extended half-life in the circulation.
In mice studies, the nanoparticles have been shown to be taken up by tumor cells after REQORSA administration at 10 to 33 times the rate they are taken up by normal cells.
We have administered REQORSA to more than 50 patients in Phase 1 and 2 clinical trials using our systemic, proprietary, ONCOPREX non-viral delivery system.
A Phase 1 clinical trial showed that systemic, intravenous REQORSA therapy using the ONCOPREX Nanoparticle Delivery System selectively and preferentially targeted tumor cells, resulting in clinically significant anticancer activity. The nanoparticles are non-immunogenic, allowing repetitive therapeutic dosing and providing extended half-life in the circulation.
Our earlier clinical trials have also shown that REQORSA therapy using the ONCOPREX Nanoparticle Delivery System is well tolerated in humans and can be delivered at high therapeutic doses. We believe the ONC-001 clinical trial was the first systemic gene therapy clinical trial using a nanoparticle delivery system to deliver a tumor suppressor gene.
Genprex’s Chief Medical Officer discusses the Company’s collaboration with a large network of community-based oncology practices to open additional sites for the Acclaim-3 clinical trial in SCLC
The KOL event, “Bringing Gene Therapy to the Fight Against Lung Cancers,” features discussions by Alexander I. Spira, MD, PhD, FACP; Daniel Morgensztern, MD; and Mark S. Berger, MD, Chief Medical Officer at Genprex, highlighting REQORSA® as a potential treatment for both NSCLC and SCLC.
Innovators with Jane King profiles tech companies and thought leaders in the space. Genprex (NASDAQ: GNPX): is focused on developing life-changing therapies for cancer & diabetes patients.
In this exclusive Global One Media interview, Genprex, Inc. (NASDAQ: GNPX) Chief Financial Officer, Ryan M. Confer, delves into Genprex’s groundbreaking work so far in clinical-stage gene therapy.
Video Highlights Validation of the ONCOPREX® Nanoparticle Delivery System with a Second Tumor Suppressor Gene
Watch Genprex’s KOL event, titled, “Groundbreaking Data From Preclinical Study Reported at ATTD 2023: Novel Gene Therapy To Treat Type 1 Diabetes.” This discussion is moderated by Genprex’s Chief Medical Officer, Mark Berger, M.D., and the data is presented by George Gittes, M.D., Professor of Surgery and Pediatrics and Chief of the Division of Pediatric Surgery at the University of Pittsburgh School of Medicine.
Genprex, Inc. CEO Rodney Varner tells Proactive the FDA has granted Fast Track Designation to the company’s lead drug candidate, REQORSA Immunogene Therapy, in combination with Merck & Co Inc (NYSE:MRK)’s Keytruda in patients with stage III or IV non-small cell lung cancer (NSCLC), where disease progressed after treatment with Keytruda.
Note: When you click on media articles below, a new page will open indicating that you are leaving the Genprex, Inc. website and entering a third-party website not affiliated with Genprex Inc. or any of its affiliates. No information contained in a linked site has been endorsed or approved by Genprex, Inc. and Genprex, Inc. is not responsible for the content of such third-party websites.
Genprex’s Chief Financial Officer, Ryan Confer, shares his insight on partnering with academic institutions, the benefits, and best practices
Diabetes is the most expensive chronic illness in the U.S., with $1 of every $4 in healthcare costs going to care for diabetics. The National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP) estimates that $237 billion is spent directly on diabetes-related medical costs every year, while another $90 billion is lost each year due to reduced productivity associated with diabetes.
Bell2Bell’s latest podcast features Chairman, President and CEO Rodney Varner and CFO Ryan Confer of Genprex, Inc. (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients living with cancer and diabetes. In this interview, Varner and Confer discuss the journeys that led them to Genprex and the promise of the company’s drug development pipeline.
Bell2Bell’s latest podcast features Dr. Mark Berger, Chief Medical Officer of Genprex Inc. (NASDAQ: GNPX), a clinical-stage gene therapy company focused on developing life-changing therapies for patients living with cancer and diabetes.
On the heels of the release of recent positive safety and early efficacy data related to the phase 1 portion of its Acclaim-1 phase 1/2 clinical trial for non-small cell lung cancer evaluating REQORSA in combination with Tagrisso, Genprex has released a new patient video featuring an NSCLC patient from the phase 1 portion of its Acclaim-1.
Genprex Inc., a clinical-stage gene therapy company, is focused on developing for these patients with serious medical conditions and unmet need new and better treatment options that are life-changing.
Reprogramming the course of cancer and diabetes, Austin-based Genprex is on the cutting edge of technologies to address the biggest health concerns
Genprex, a clinical-stage gene therapy company, has recently released groundbreaking data from a non-human primate study evaluating a novel gene therapy to treat Type 1 diabetes.
With results of an animal study published in February 2023, Genprex aims to add credibility to another genome editing approach in the hunt for a functional cure to T1D.
How one company seeks to provide hope to cancer patients through more effective treatments.
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