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You are to be congratulated for making a nice profit.
They may have deployed the money they would need to exercise at this time.
I sell weekly covered calls and I'm often low on available cash.
I imagine some of the people on the other side of the trade are low on cash too.
As a country we pay more than nearly everyone else and get a terrible result for our health care dollars and you think that is just happenstance?
[Insurance: $2,973,247,470
Including health, property, and car insurance companies, along with agents and brokers, the insurance industry has historically been the second most generous/aggressive industry in lobbying for their interests. In 2019, spending was $155.3 million. Following the passage of the ACA and subsequent developments under the Trump administration, health insurance companies have been very involved in the legislative process, looking to influence new regulations. In 2019, the leading insurance industry lobbyist corporation was Blue Cross/Blue Shield.]
I laugh when someone says the insurance companies(huge lobby) would love A2-73.
It would be a lose/lose situation for them.
Lost revenue and lost power/control.
If you're feeling up to it, Nature magazine could use a little schooling.
https://www.nature.com/articles/d41586-018-05719-4
https://www.nature.com/articles/d41586-021-00260-3
I'm assuming they did as they've done very well in managing share count thus far.
I meant more of a copycat,herdlike move by others who envisioned the riches to be had from the giant moves in Gamestop ect.
I'm feeling a little naive here but after Gamestop, AMC and others and then SAVA and AVXL, I assumed they were more of the same, just a pivot toward biotech.
100 + million shares in one day seems a giant "tell" to me.
Might there be any "reversal of aging" effect or with an older person would typical aging just slow?
They could yet expire worthless.
This moonshot isn't based on fundamentals.
I bet the people working at Anavex who have lots of options have streaming quotes running in the corners of their screens.
30 million plus shares trading.
It's just a ticker to many of the participants but we're still sure to get a lot of eyeballs.
A day or two ago I thought I might be switching to $7.50 calls.
Guess not.
I guess I'm done selling $5 covered calls.
They studied it for MS so you're a bit off track.
I like how she refers casually to the future tense, as in "when it's approved" and "when it's made available".
Despite the word "partner" being mentioned hundreds of times on this board Dr. Missling has always been clear that we would only partner in the later stages for the bigger indications. We won't be in the later stages in 2021.
What makes you think we will be partnering?
Positive(albeit partial) PDD results and great Rett results drove us to the nosebleed level of $7.69.
What's coming in the next 6 months pales by comparison.
Not happy, just saying.
I don't see any catalysts as big as the recent Rett stuff for quite some time, so sadly I think down is in our future.
"Net loss of $26.3 million, or $0.45 per share for the year, compared to net loss of $26.3 million, or $0.54 per share in fiscal 2019."
Does this mean we have 20% more shares than we had at this time last year?
Does this mean we'll not see results in the first part of 2021?
"Plan to advance the AVATAR adult Rett syndrome study into a pivotal Phase 2/3 clinical trial."
There's a guy named Tom Bishop from BI research that usually asks a few good questions.
I would take it too and that's something I thought I'd never say about a drug.
New(to me) drug side effect for those of you out there keeping score.
Excerpt from article...
[One prominent medical study begins: “The incidence of pathological gambling in Parkinson’s patients is significantly greater than in the general population.”
Dozens of studies have confirmed this. Even among people with no history of poor financial decisions, a typical Parkinson’s drug regimen increases the likelihood of compulsive gambling.
It’s a big deal. Doctors have been sued. Casinos have been sued. Pharmaceutical companies have been sued – all linked to compulsive gambling after taking Parkinson’s medications. A Louisiana lawmaker once raided his campaign account to go on a gambling spree. He claimed his addiction started soon after he began treatment for Parkinson’s. “The drugs involved, I’m sure they had something to do with it,” he said.
Other Parkinson’s patients suffer cheaper but similar side effects: superstitious beliefs and delusions.
The suspect drugs – dopamine agonists – help reduce Parkinson’s tremors. But as a nasty side effect they can fool patients into believing the world is giving them concrete signals: that there are patterns to exploit at casinos, that conspiracy theories are real, that a person obviously loves or hates you, or that a full moon portends disaster.
That’s what dopamine does: it reduces skepticism and pushes the signal-to-noise ratio heavily towards signal, offering a rewarding brain buzz for finding patterns in the world whether they’re real or not. It’s gullibility and overconfidence’s best friend.]
Thank you all for your kind words.
My mother passed away peacefully in her sleep last Sunday at the ripe old age of 91.
She spent the last 3 years in the memory care wing of a faith- based nursing home type of facility.
While neither of us are/were Jesuit I can't speak highly enough nor can I recommend strongly enough a faith- based facility.
The care and cleanliness were exemplary.
While the cost was 5k per month(paid for by her estate, not trying to paint myself as a financial hero) it was less than comparables.
While never formally diagnosed, her condition is what killed her.
She no longer recognized food as food(just something to be expelled from her mouth) and starved herself to death.
In reflection I'm happy she passed.
She no longer knew who she was(which puzzled and distressed her) nor did she recognize anyone.
She cried a lot.
My greatest fear was she would become combative with staff and at 5' 2" and lately weighing less than 100 lbs. the thought of her being manhandled distressed me greatly.
I don't believe this occurred.
Her physical heath was excellent and I believe she would have surpassed 100 easily.
Here's hoping future generations do.
Thanks for this.
I always prefer the written word.
Am I right in assuming the OLE is low dose?
Was that Captain Christopher Pike singing baritone?
Hear, Hear!
I sold half my shares a year ago, too risky for that much money.
But as the good news has trickled in I've been buying.
Shocked that I'm able to buy in the 5's & 6's considering the trial results and that it was 4ish a year ago.
"The Anavex team also coordinated with international advocacy organisations including Reverse Rett, Rett UK, Rett Syndrome Association of Australia, Telethon Kids Institute, and Pro Rett to gain a better understanding of the needs of the global Rett syndrome community.'
Wow!
I knew the Rett community was organized but I didn't realize there were so many individual ones.
"the Shake It Up Foundation for Parkinson’s Research and its international partners has committed to invest into Anavex up to 50% of the costs of a disease modifying clinical study to develop ANAVEX®2-73 (blarcamesine) for the disease modifying treatment of Parkinson’s disease."
It's the 50% that's key to me.
Anything less than 50% and in my mind I put the indication on the back burner with MS.
But I think we do well with Rett and I believe we get approved for Alzheimer's. Whether it becomes the SOC for either remains to be seen.
The bars seems quite low and I believe we've already cleared both.
"I hope that we will have PDD full data or at least more data by then."
That one bugs me.
The optimists would say it's being withheld for a super secret reason and we're sure to be pleased.
I find it hard to be in that camp.
1,397,411
Intriguing.
Years ago Dr. Missling said something akin to "Later on people will see why we proceeded the way we did".
As I look at the way things stand currently I wonder if the plan is becoming clearer.
A small Alzheimer's trial to introduce the world to blarcamesine.
Then a ph2 PDD trial(double blinded placebo controlled in case results were even better than expected) to provide guidance for an anticipated ph3 PD/PDD trial.
Simultaneously, as Bio recently put forth, a series of Rett trials logically arranged to build upon each other.
I wonder if at the beginning the powers that be at Anavex believed they were going to change medicine in a profound way and the intelligent path forward was to start with a whisper and build to a crescendo.
As an aside, I think I speak for many on this board that we're pleased you've made additional share purchases along the way since your steadfast conviction has helped make the wait more tolerable.
I missed the rare diseases video.
Might I trouble you for a link?
I think Rett approval will mean a number of new trials.
The Rett revenue should be enough when one considers the skill Dr. Missling has displayed in running trials on the cheap.
And this was the low dose!