Rec finished accum & now holding CTIX. I come here daily, listen more than I talk, and am grateful beyond measure for everyone's contributions.
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My gut instinct tells me Brilacidin is and has been a known quantity for some time by the political class, whom one could very easily presume would limit its accessibility exclusively to itself and its cronies, public and shareholders be damned. China has the molecular map, and we just saw Wuhaners dancing cheek to cheek in the streets with nary a care. It wouldn’t surprise me in the least if they’ve been producing our compound all year, just as they’ve stolen IP in every other industry. The world is a sausage factory. That said, let’s pray I win Fool of the Year award for my skepticism. I’ll hold my award up high.
Because there is zero imperative to save lives.
I’m nervous about whether these vaccines are setting up recipients for a paradoxical immune response when they are later exposed to wild virus. SARS Coronavirus vaccines have a nasty history of doing precisely that in both animal and human subjects in previous vax development efforts between 2002 and 2012. The world is palpably weird right now. I’m increasingly wondering if the overriding objective is to save lives from CoV, and thus fast track efficacious, cost effective treatments, or to thin the herd and thus thwart same.
Endpoints headline “Covid-19 roundup: It could be years before vaccines reach some countries”. With the obvious formulation and logistical difficulty the vaccine industry is facing, its nothing short of pure madness that OWS, the FDA, the pols and media alike have completely shirked their responsibility to expedite therapeutics, of which Brilacidin remains infinitely simpler and cheaper to compound, to store and to distribute. Madness.
WSJ ran a story this morning about the expected run on dry ice needed for upcoming vaccine shipments. Brilacidin was successfully lyophilized, to the best of my recollection, giving it a huge logistical advantage over the vax biz. Seems our competition and the government is hopelessly enamored with doing everything the hard way.
I’ve written Endpoints editors twice asking how they can justify calling their compilation “Covid 19 Roundup” when they conspicuously omit the entire therapeutic sector of biotech. *Crickets*
No. Unless our B data is total fabrication, there is zero justification to pivot away from C19. In fact, I would unequivocally allocate all our powder for C19. Here’s a reminder as to the FLIP SIDE of what our MAB competition brings to the table:
1) Low blood pressure
2) anaphylaxis
3) serious infections
4) Cancers
5) Serum sickness
6) Autoimmune thyroiditis
7) arterial and venous clots
8) congestive heart failure
9) bleeding
10) Interstitial lung disease
11) Hepatitis
12) Enterocolitis
13) Gastro intestinal perforation
14) Mucositis
15) stomatitis
16) Anemia
17) reduced white blood cell counts
18) Hypothyroidism
19) serious drug interactions
MABS aren’t all rainbows and puppy dogs. Brilacidin has what they don’t: An incomparable safety profile.
The buyouts leave me smh.
“Merck announced today it purchased OncoImmune & its experimental C19 drug for $425mm. CD24Fc appeared to reduce the risk of resp failure or death in severe C19 pts by 50%. These results [203 person Ph3 trial] floored Merck”. Does not a coin toss deliver comparable results?
“Battle of the BPs” - Detroit in the 70’s, Big 3 so fixated on besting each other’s rust buckets, they didn’t even see Datsun and Toyota coming.
Reminds me of the movie projector in elementary school... teacher always put the most popular kid in charge, instead of the kid who understood the principles of the thing, thus, for six years, every film sounded like it was being fired from a Gatling gun.
Aiming for mass vaccination with whomever’s brew has some plausible data, Pfizer or otherwise, which might actually be setting the subjects up for a future ARDS event when the variant comes down the pike. Of course, it would be PRed as idiopathic and commanding of yet another OWS with all the trimmings.. it stinks to high heaven.
I recall back around 2003 the early efforts to develop SARS vaccine enjoyed initial success with robust antibody response against the SARS du jour, but that when ferret models were exposed to live virus of a variant strain, they were decimated by hypercytokinemia
Politics. No other plausible explanation.
Good question. Veterinarians use drugs that are FDA approved for animal use and they can and do also use drugs approved for human use. The protocol is, first use the Standard of Care, aka, drugs approved for your specific species. If standard of care drugs have been exhausted, you may then exercise extra-label use of drugs FDA approved for human use. For some species, such as tortoise, there are no FDA approved drugs, and so the only option is extra-label. FDA and USDA strictly govern use of drugs in food animals, such as poultry, cattle, etc. In deciding how to dose a non-human species with Brilacidin, the DVM would essentially be experimenting based on whatever, animal data is published, if any. Though perfectly legal, there would be a certain veterinary liability when using a human drug off label for an animal.
My wife’s DVM practice is waiting with eager anticipation for Brilacidin to be made available.
What is NWBO, and what’s it’s relation to us?
“East Asian countries seem to fare much better than the West when it comes to mask wearing!” True. Hyper-compliance is in their DNA. Have you ever driven behind one on the road? It’s as if there’s some larger-than-life hall monitor spectoring over them at all times. We Americans, however, are an incorrigible lot.
Nice piece! “Innovation Pharmaceuticals: Has The Stock Reached an Intermediate Bottom Yet?”
Someone play devil’s advocate here.. Surely someone in Trump’s circle is aware of Brilacidin and the Rem/Brilacidin combo results. What is conceivably being argued against advancing Brilacidin? “Oh it’s only in early stage clinicals, Rem was much further ahead”, “Safety and tolerability are suspiciously too good, ergo: it can’t be efficacious”, “the compounder needs 6-8 weeks to deliver”.. what is it? I know we’re in some Tower of Babel bizarro world, but some things are so intuitive, you’d think they’d break out on their merit.
Ah jeez.. Now they’re giving him Remdesivir.. this is downright embarrassing for Gilead.
"Hospitalized patients"... Can we even find 120 hospitalized patients?
Per a roster posted by Andrew Bostom, out of 48,299 positive cases from 37 major US University hospitals, there are but 2 hospitalizations in Wisconsin and San Diego.
"9/22/20 update on C19 among students on campus since August, from 37 U.S. universities: Despite ~48,300 “+ C19 tests” near absence of reported C19 hospitalizations, and zero reported deaths"
insert-text-here
As has been the case since January, even with a finely honed BS-o-meter, its hard to know what to believe anymore.
“Not your every day lackadaisical FDA” Is it coincidence that Trump & wifey test positive within hours of this response? I’d like to think a team of commandos rappelled through the skylights and took Hahn’s wife and kids at knifepoint to coax that slacktard into action, but then again I’ve been watching too much Netflix
Somethings twitching
If they would just strap their dead filly to the back of our Secretariat, they might cross the finish line.
My dad emailed things just like this when he was three sheets to the wind. Let’s hope it’s celebratory drinking.
Not sure how much corroboration is needed here, I stated that my wife, a DVM, sent a blurb or two to the White House email touting the latest combo therapy findings contained in the recent PR. Anyone can email the White House.. in fact, I’d encourage you and everyone to do the same. Certainly nothing to lose in trying.
Dr Wifey has also sent a blurb or two to the White House email touting this statistical 100% clearance of virus combo therapy in RBL trials.
“We may not need Remdesivir, but we need Gilead.”
Truest post of the year.
“Would Gilead have had to give permission to use Remdesivir in the study[?]”
Remdesivir is a crack whore. It’s they who ask permission from us.
Brilacidin alone reduces viral load by 95-97%... mix in hapless, exhaustively-propped-up Remdesivir to push those numbers up 2 points (less than the margin of error) and Voila’! You successfully lower the safety profile, sextuple the price and NOW it seems viable! It makes so little sense, I simply must buy more shares.
RBL, Peer Review, FDA, NIH, and the whole "Operation Warp Speed" ensemble is a total Keystone Cops skit. There ARE, however, minds who can grasp the concept of a real-time response, as evidenced in our ICBM missile defense systems (incidentally, a feat once considered mathematically impossible; likened to a "bullet hitting a bullet") Wish our national epidemic response was staffed by a similar caliber.
Onset of numbness and tingling is what tells me my Zolmitriptan is minutes away from annihilating a splitting migraine. A fleeting inconvenience for some very welcomed relief. If I don’t feel that numbness and tingling, I know CVS sold me generic/counterfeit Zomeg
With SI comparators like those, I’m surprised they didn’t include Nitrogen Mustard
Queue up Monty Python's "I'm not dead yet"
Leo should’ve approached the Sinaloa Cartel with Brilacidin. Expedited scale-up of Central American manufacturing, established layered distribution networks, in-house security, strong product loyalty, routine elimination of competitors...
The persistent mention of Remdesivir among all your Brilacidin points reminds me of the Monty Python Spam skit, where every possible dish must include an obligatory side (or two or three or all) of the world’s most reviled substance. All in good humor, though. Thank you for your consistently excellent posts.
And unfortunately for the devote’s to endless clinical procedure, Brilacidin preempts the need for combo trials with anti-inflammatory and anti-microbials due to its integrated 3-in-1 formulation. We really play some dirty pool.
Thank you mods for keeping farrell’s post 316207 in the stickies- A valuable and still-relevant contribution, especially to newcomers.
Politicians know Rem isn’t worth a flip (cost/benefit-wise) which is why they’re all personally using HCl. But they have to (1) look like they’re doing something/anything and (2) Remdes’ price point provides more kickback and graft than a $640 toilet seat.
Demolition Man got so many things right.. "Gilead was the only company to survive the biotech wars. Now all drugs are Remdesivir"