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Contact Don Seiffert at the Boston Business Journal. He (they) did a few stories in support of ctix/ipix a few years ago.
I wonder if he's related to Hari Kumar, who was(is?) on the BOD of BioVie currently based out of Santa Monica, CA and spearheaded by ceo Jonathan Adams and formerly located in Beverly, MA - 100 Cummings Center, second floor,which employed Dr Elliot Erhlich as an officer. I had the chance to speak with a Hari Kumar(all these years I thought it was Harry) when he picked up the phone at ctix/ipix after I called and no one picked up the phone. I then began to enter extension numbers. A Hari Kumar picked up and gave me the number of the part time book keeper. I left a message- she returned my call.
Small world. Maybe one of the well connected here could ask the current ceo of ipix for clarification of (the) Kumar(s).
https://markets.businessinsider.com/news/stocks/distinguished-biopharma-executive-hari-kumar-joins-biovie-board-of-directors-and-purchases-company-stock-1001999237
"I looked at the list and I counted 4 companies that we can be pretty certain know about Brilacidin. C
Sorry to not have quoted you entirely. Here we go.
1."I looked at the list and I counted 4 companies that we can be pretty certain know about Brilacidin."
Who are the 4 companies YOU believe to be interested, and why?
2a. "I don't know if that means much ..."
Why not? You made your thoughts sound certain in your opening sentence. Why the introduction to opening sentence #2?
2b. "....but Ipix itself is doing everything right to have a really good chance to be noticed in a meaningful way. And that is a fact."
Your argument does not round out, imo.
"The company said they are trying to get a trial going for B. Does anyone know a Dr that could help? Anyone? Maybe a ER Dr? Anyone?"
Maybe Dr Robert Davey, who's right down the road(~15-20 minutes depending on traffic)? I know the the ceofo is busy(see how I saved some text?).
https://profiles.bu.edu/Robert.Davey
"...but Ipix itself is doing everything right to have a really good chance to be noticed in a meaningful way. And that is a fact."
Like moving to a shared , or virtual office? I'll call tomorrow and see if anyone picks up.
"...imho Abbvie and Pfizer look interesting as potential partners...
But everyone in the FDA/BP Conspiracy Theory is forgetting...HUMAN TRIALS is the big equalizer to BP...the results of a well run study by a Teaching (University) Hospital in U.S. or E.U. ... CANNOT BE DENIED...(look at what happened GILD's REM with partial unverified results of human trials)....BIG NEWS and the vultures will come out in droves to make a deal on a very efficacious Therapy...which BRILACIDIN has the potential to be!"
I reckon in these times BP has a better tuning fork to use against the rails as compared to the mason jar I use to decipher what might be coming down the rail.
Human trials are an equalizer which is why labs like those which people like Dr Robert Davey are starting with approved drugs first, but, I believe, will analyze anything with prospective evidence which I believe B showed initially and has moved to the next stage(likely as other non fda approved drugs).
Example of an approved fda drug now throwing its hat in the ring for covid-19: https://edge.media-server.com/mmc/p/wjbevioi
https://www.clinicaltrials.gov/ct2/show/NCT04349098?term=selinexor&recrs=b&draw=2&rank=2
TY for the post- just started reading it.
"The Company hopes to disclose the RBL’s research agenda for Brilacidin in the coming days."
I think this company (the ceo) has a trade mark on the emboldened phrase. Often used, never quantified.
Back up your post, please.
ANTICIPATION!
I asked you not to tell anyone!
Thanks alot,
Chris
"my friend Chris owns so many shares he’d front Leo a million $ if he’d ask. "
Are echoes returned from a chamber legally defined as negotiations?
"Leo, how are those negotiations going? Locust Walk assisting I'm sure... They've done wonders with OM..."
I read today that NY City is considering temporary mass graves.
https://www.nytimes.com/2020/04/06/nyregion/mass-graves-nyc-parks-coronavirus.html
FB,
I detect, and share, your concern and frustration. Wish I could guarantee that all will work out for the best, but can't.
Here in America, you can get updates daily((by county-not town(in MA)) which makes me wonder why. Why not show the hot pockets?
Friday 3-13-20 it was noted that has been this and made tremendous(not defined) progress(only 2247 cases in the U.S). The U.S was presented as the cats meow when compared to other areas of the world, pretty astounding claim. Twas stated that had to do with the early designation and the closing of the borders.
Someone said,"And, as you know, Europe was just designated as the hotspot right now, and we closed that border a while ago. So that was lucky or through talent or through luck. Call it whatever you want. But through a very collective action and shared sacrifice and national determination, we will overcome the threat of the virus."
Wish I cold tell all what they want to hear, but can't, nor few(if anyone)
"This is the beginning of week 10 of the current Covid19 season.
There are:
5506 recovered patients. I assume some, not all, of these were in hospital during treatment.
3165 reported deaths. I assume most/not all were in hospital during treatment.
3512 currently in hospital as serious/critical patients.
https://www.worldometers.info/coronavirus/
Between 6K and 12K hospitalized with Covid19 related problems so far.
At the end of the 10th week of (out of 21 weeks) the 2018/2019 flu season there had been a total of 835 laboratory confirmed flu related hospital admissions.
A difference by factors between 7 and 14.4.
Given the exponential increases of Covid19 those factors probably won't apply, but assuming they do, without successful interventions against Covid19, by the end of the third week of June we'll have had 4.529 million to 9.317 million hospital admissions (using the 2018/2019 hospitalized number).
Dividing the current US death number by the above current hospitalization range 25% to 50% of those admitted to hospital will not survive.
It's an expansion of flu vs. Covid19 perspective to consider."
Who knows how to equate this thing? I use the closed case numbers, meaning recovered vs. death, which represents those who've gone full circle. It currently stands at 81% recovered, 19% dead.
KarinCA,
Agree. It took how long to put together? Days. How long for a vote? What was once balanced is long gone. Libra has left the people.
How are you feeling?
"It seems there may be unknown genetic or other factors that make some more susceptible especially the healthy young people who succumb quickly and the resistant older individuals with multiple risk factors who barely get sick.
It would make a good research project."
I'm sure there are many attempting to piece the puzzle together.
I read, a week or two ago, that virus's thrive on elevated blood suger(hyperglycemia). I could not confirm it. What did make sense is that diabetes has been listed as not a good thing to possess if one becomes infected with covid 19. Neither is heart disease and a couple other ailments which are ensnared by diabetes.
Being a type 1 diabetic for over 40 years(pretty could control for t1d, a1c low 6's(which is HIGH for the general public)), I did a little research and discovered that blood sugars rise as people get older.
"RESULTS—In the FOS and NHANES cohorts, A1C levels were positively associated with age in nondiabetic subjects. Linear regression revealed 0.014- and 0.010-unit increases in A1C per year in the nondiabetic FOS and NHANES populations, respectively. The 97.5th percentiles for A1C were 6.0% and 5.6% for nondiabetic individuals aged <40 years in FOS and NHANES, respectively, compared with 6.6% and 6.2% for individuals aged ≥70 years (Ptrend < 0.001). The association of A1C with age was similar when restricted to the subset of FOS subjects with NGT and after adjustments for sex, BMI, fasting glucose, and 2-h postload glucose values.
CONCLUSIONS—A1C levels are positively associated with age in nondiabetic populations even after exclusion of subjects with IFG and/or IGT. Further studies are needed to determine whether age-specific diagnostic and treatment criteria would be appropriate."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551641/
The advancements in blood sugar control have moved astronomically in the past few decades. Diabetes, mainly via out of whack blood sugars, can stress the body/organs. I wonder, if elevated blood sugars do feed covid 19. Perhaps "a trial could be experimented with in hospitals on covid patients to maintain blood sugars at the safe, but lower ends(70-90 mg/dl), to starve the virus?
Just thinking.
"So at this point with thousands of drugs being tested, what are the chances that B will play any kind of role in this? I know how most here feel about B, but realistically do we stand a chance to get anything out of this!"
At least thousands to one, hopefully better, based on what we investors have been told.
"I think it’s safe to say the death rate will go down substantially once the counting is better, and this virus reaction has been way over the top. There’s no easy way to explain Italy or Spain. Anomalies! Older population? Caught off guard? Too many Chinese in country? Who knows. The disease needs a therapeutic cure or remedy and a vaccine but it’s likely going to end up being little different than the common flu, or H1N1. Not a single T-ball game or bingo game was canceled for the Swine flu.
IMHO, BWDIK? I’m wrong a lot!"
Hopefully you're right. I wonder/hope obesity does not subject some, which America has a fairly elevated rate.
Quick test results have hit. Now, hopefully, they can scale up production beyond hospitals(hopefully doctors offices, health clinics, and finally by the general population).
When I was diagnosed with type 1 diabetes over 40 years ago as a teenager, the cutting edge take home test was comprised of a test tube, an eye dropper, a tablet provided by some fda approved company. I'd piss in a paper cup, extract the urine with the eye dropper,drop so many drops from the test tube, then drop the tablet into the test tube. Got results of blood sugar based upon three colors- too high, within range, too low- not nearly exact science.
Today I go to the doctor, they prick my finger draw blood and can tell my blood sugar AND A1C(3 month average blood sugar) in ~ 5 minutes vs weeks and months.
The world today is light years ahead in analytical capabilities.
I believe we shall rise above the bombastic, as we and the world have always done.
https://www.statnews.com/2020/03/21/coronavirus-test-returns-results-in-45-minutes/
Someone(KarinCA I think) posted yesterday that China ID'd covid19 by chest x-ray which shows the lungs(not sure the percentage of cases). The post noted that results were much faster than covid19 tests as well as cheaper.
Not an attempt to instill fear, it is what pandemics are. They multiply at an incredible rate. Today's total infections will likely double in 3 to 4 days, as will total death counts.
Hopefully the U.S. government didn't miss the train.
https://www.worldometers.info/coronavirus/country/us/
The handling by our leaders of covid-19 reminds me of ipix management and b.o.d.
Figures don't lie, but liars can figure.
Thanks for that link. Very detailed and informative.
"CV Taskforce has today indicated there are things in place to fast track through FDA hoops and red tape, and FDA is onboard 100%. I will be honest when I heard Pence was heading up this task I thought it would be not a good idea I would have preferred to see people with a PhD MD etc as the head.
Now having seen portions of their briefing I am glad he is there. Not to mention he has the ability to drop the hammer on the red tape and can quickly authorize emergency measures as required at Local and state measures.
$IPIX and Brilacadin Piercing the COVID-19 Envelope we hope."
Hope so, but it's likely all a hoax drummed up by democrats. Fake news as our Commander in Chief declares. The numbers I've been following since Saturday, 3-7-20 were total U.S. cases 409 vs current 1010, deaths 10 vs 31 current, total cases per 1M population 1.2 vs 3.1 current.
Don't worry be happy- while you can.
Not for nothing, but I believe Prurisol was defined as "late stage", or perhaps the company defined themselves(I forget which) as a late stage pharmaceutical company prior to P's fall from grace.
"Meanwhile the U.S. with its robust and mobile population appears to be "managing" the threat supremely better than other countries."
think it's too early to make the above noted claim. The U.S. to date has tested less than 2000 people, a fraction of some countries. China's death rate based upon total deaths/total cases is 3097/80,696 =3.84%. Italy 233/5883= 3.96%. USA 19/438= 4.34%.
Hopefully B can help.
https://www.worldometers.info/coronavirus/
"Review Article Supports Brilacidin’s Therapeutic Potential as a Defensin-Mimetic Drug Candidate"
Authored by a known slacker.
What do his old friends at the Boston Business Journal have
to say?
Why their silence? Part and parcel?
"This time it's different...cause the US government plan on picking up the tab from start to finish (it's bout time)."
It's not "different" til any of their proposed products are proven effective. It's been a slow, and questionable, grind.
K's the cats meow, P has run down our legs, B for OM...UM...but it will take down coronavirus!
Go IPIX!
Thanks for the second(48) article, informative.
"... Imagine out of nowhere virology labs and Bio labs are ringing the phone asking..."
Why doesn't anyone answer?
"This is just beginning. Nice but nothing to what's coming our way. Let LW do its job. They have the IPIX WONDER drug to promote. It should be a easy sell with their expertise. I am sure the bidding has begun."
Let us hope so, but be cognizant of the number of companies involved and curious about covid-19, endeavored in the same pursuit as ipix.
There are 58 clinical trials listed ((most, if not all, quiet recently (feb, 2020)).
https://clinicaltrials.gov/ct2/results?term=covid-19&draw=5&rank=12#rowId11
Appears to be another unnamed leader in "the field", as we have been told on many other occasions. I'll just wait, and hope, that the latest proclamation(made by an unnamed company source this time) rings true.
ha
Good post, thanks for doing the homework and clarifying.
Prurisol showed potential too.
"..... And B has already shows that it can cure serious infection in one dosage and cure inflamming at the end of the colon and may do many other things. ..."
It has not shown nor accepted, and won't be until it has completed the necessary clinical trials for the targeted indication(s). There are indications from early trials that it could be successful and it appears they/he are tweaking things to determine the most optimal outcome(s).
""Novel coronavirus vaccines
Brilacidin by Innovation Pharmaceuticals
Innovation Pharmaceuticals announced that it is evaluating Brilacidin, a defensin mimetic drug candidate, as a potential treatment for coronavirus. Brilacidin has shown antibacterial, anti-inflammatory and immunomodulatory properties in several clinical trials."
I'm waiting for the company to announce next that they are investigating what that yellow thing in the sky might be.
"I was surprised the SP didn't rise higher when IPIX announced that Locust Walk was "further engaged," to lead negotiations for B-OM, given LW's good track record. Its all about "show me the money" and the OM and UC/CD indications are billion dollar markets waiting to be tapped by Brilacidin.
Dr. Bert didn't get a deal done, and as a skin doctor (dermatology), his value to the company decreased when the P drug was scrubbed. As CMO he got no B-OM deal inked, and I suspect Leo asked for his resignation knowing Locust Walk could fill his negotiator shoes.
IPIX has valuable assets ready to be unlocked, and AlfaSigma has rights of first refusal for one of them.
With a projected 40+ Billion dollar market for UC and Crohn's, and a pill that targets the colon with Brilacidin as payload, we could see some fireworks sooner than later."
Clearly the ipix commander in chief is top notch, isn't he? He's the last man standing and has a keen eye for trimming the fat. Evans gone, Jorgensen gone, Menons gone, Junior gone, Bertolino gone, ....
He knows how to build a team!
Wasn't JT responding to the following post by djs 7 regarding B-OM?
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=153923293
"January 29, 2020 (GLOBE NEWSWIRE) Innovation Pharmaceuticals Inc. (OTCQB:IPIX) (“the Company”), a clinical stage biopharmaceutical company, has further engaged Locust Walk, a leading global life sciences transaction firm serving as its strategic advisor, to lead the Company’s out-licensing negotiations for rights to oral rinse Brilacidin for the treatment of Oral Mucositis (OM)."
I thought B-OM was being taken orally (swish and spit) with the hope of eventually putting it in sachet form.
"Wait until you see it loitering at .18/.19 prior to breaking through .20. Talkabout feeling better!!! It might take a few weeks but it’s coming!
Go Locust Walk!"
Ir certainly has, and is, going nowhere fast based upon past, and current, company history.