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I checked a couple of of blood banks, including the American Red Cross and cancer exosomes are not listed, which is understandable since it is relatively new and technology is still advancing. There is a very good chance that someone can give blood in the early stages of cancer, way before it has been diognosed, where exosomes may be within the blood. A couple of questions. Are exosomes released in the very early stages of cancer, at the origin of tumor progression? and if so, I wonder what would happen? Could those cancer exosomes still junction in a different environment and be problematic to the receiver?
My coworker just brought up a very good question. He asked what would happen if you donate blood and there are cancer exosomes in the blood? Would those exosomes cause possible cancer in the person recieving the blood? This could be a major use for the hemopurifier to clean the blood of exosomes before a transfusion. Any thoughts? And I would guess that they do not check donated blood for cancer exosomes.
Correct...bummer. They should remove that so guys like me don't get excited....and now back to waiting...:)
"We have submitted an Investigational Device Exemption ("IDE") to the FDA"
I found this under "Company" in the 10Q. So, I'm guessing the IDE was already submitted, unless I read it wrong. I apologize if this is already known info. I just didn't see it before.
Smile, we are in the same hole as we have always been in. There is no bad news, just no news, which is our usual. So, as frustrating as it is the hole stays the same. Lets keep are heads up for the news we were promised and maybe we will look back at this and laugh. Either way I believe there is not much more we can do. Most of us are now in this SO DEEP we are locked in for the ride, so I say enjoy with anticipation of great news :)What else can we do? Selling is not an option for me at this point. How about buy more and go down with a bang...I'm staying positive and buying more on Friday if the price stays low, which it probably will.
I'm going with my guess that the FDA already has the IDE submittal and we should see approval in the coming months. I'm also guessing that the Darpa grant is "Forthcoming" HAHA and India will be up and running by the end of the year. WE MUST KEEP GOING IN THESE DEPRESSING TIMES....:)
Nanoparticle Tracking Analysis technology facilitates cancer metastasis research
http://phys.org/news/2012-11-nanoparticle-tracking-analysis-technology-cancer.html
This is interesting reading. Aethlon is mentioned by a patient on page 27 directed to the FDA.
http://www.fda.gov/downloads/Drugs/NewsEvents/UCM320310.pdf
I'm wondering if Aethlon submitted the IDE to the FDA without a news announcement. If Aethlon is expecting possible approval at the beginning of next year then I would assume its been submitted. Does Aethlon have to announce the submittal? Maybe Aethlon is expecting a quick reply since they have already been in contact with the FDA. I just can't figure out the delay, if there is a delay. Also, why a delay with the patient costs in India. JJ said over a month ago that it would come in the "Coming weeks" It's just tuff when you're expecting news that doesn't come within a certain time frame. I'm done rambling..
"Microscopic packets of stem cell factors could be key to preventing lung disease in babies."
Read the second to last paragraph. Just in our ballpark :)
http://www.eurekalert.org/pub_releases/2012-10/bch-mpo103112.php
Read Aethlon's exosome patent. WOW, I'm sure it took someone awhile to write this. Good stuff
http://www.patentstorm.us/patents/8288172/fulltext.html
As we already know, I would like to summarize my thoughts and projections based on recent cancer exosome news. Below was copied from the article "Aethlon Could Be Astronaut in MD Anderson Cancer Center Moon Shot Program"
http://biotechstocktrader.com/aethlon-could-be-astronaut-in-md-anderson-cancer-center-moon-shot-program-514/
" In the publication, lead author Dr. Hector Peinado said, “If, in the future, we were able to find a way to control the education of bone marrow cells, as well as the release and content of tumor exosomes in cancer patients, we would be able to curtail and reduce the spread of cancer, and improve the patient’s quality of life and survival.”
Recently JJ mentioned in his presentation that Aethlon could receive FDA approval as soon as the beginning of next year, 3 to 4 months away. The "Moon Shot" program is scheduled to begin in Feb. 2013.
Today we receive the following news, "The patent entitled "Extracorporeal Removal of Microvesicular Particles," provides Aethlon Medical the exclusive right to remove immune suppressive microvesicular particles, which include but are not limited to exosomes from the circulation of treated patients. A therapy able to inhibit or reduce the presence of cancer-secreted exosomes would address a significant unmet medical need in the effort to combat cancer."
Aethlon will hopefully soon provide news of the Hep C and exosome FDA submittal and hopefully the Darpa Grant and larger partners.
I'm looking forward to the next few months. I really don't think it will be too long before I see you guys in Vegas. :):)
The Hemopurifier(R)is discussed in the last paragraph as a noval treatment . I think I read this article in the past, but I'm not sure.
http://www.news-medical.net/health/Hepatitis-C-History.aspx
"A partnership shall prove successful for you" I hope my fortune cookie is right :)
Trojan Horse Drug Therapy Provides New Approach to Treating Breast Cancer
http://www.sciencedaily.com/releases/2012/10/121002092835.htm
Aethlon Could Be Astronaut in MD Anderson Cancer Center Moon Shot Program
This is interesting.
http://secfilings.com/News.aspx?title=aethlon_could_be_astronaut_in_md_anderson_cancer_center_moon_shot_program&naid=264
For some reason I never was able to read this, so I thought there may be others on this board who missed it as well. I read the abbreviated version, but can't recall seeing this. It's Aethlon's "Exosome removal as a therapeutic adjuvant in cancer" I also did'nt see it on Aethlon's website, but I may have not looked very good.
http://users.ugent.be/~kraemdon/Exosomes-microvesicles/Marleau%20et%20al.,%20J%20Transl%20Med.,%202012_removing%20exosomes%20from%20circulation%20anti-cancer%20therapy.pdf
I got this from a poster on yahoo's board. Dr. Fadem has a connection with MD Anderson as some of you already now. The next few months should be very interesting :)
http://nephron.org/nephsites/nic/fadem
Hypoxic enhancement of exosome release by breast cancer cells
http://scienceindex.com/stories/2534633/Hypoxic_enhancement_of_exosome_release_by_breast_cancer_cells.html
Exosomes are nanovesicles secreted by tumour cells which have roles in paracrine signalling during tumour progression, including tumour-stromal interactions, activation of proliferative pathways and bestowing immunosuppression. Hypoxia is an important feature of solid tumours which promotes tumour progression, angiogenesis and metastasis, potentially through exosome-mediated signalling. Breast cancer cell lines were cultured under either moderate (1 % O2) or severe (0.1 % O2) hypoxia. Exosomes were isolated from conditioned media and quantitated by nanoparticle tracking analysis (NTA) and immunoblotting for the exosomal protein CD63 in order to assess the impact of hypoxia on exosome release. Hypoxic exosome fractions were assayed for miR-210 by real-time reverse transcription polymerase chain reaction and normalised to exogenous and endogenous control genes. Statistical significance was determined using the Student T test with a P value of < 0.05 considered significant. Exposure of three different breast cancer cell lines to moderate (1 % O2) and severe (0.1 % O2) hypoxia resulted in significant increases in the number of exosomes present in the conditioned media as determined by NTA and CD63 immunoblotting. Activation of hypoxic signalling by dimethyloxalylglycine, a hypoxia-inducible factor (HIF) hydroxylase inhibitor, resulted in significant increase in exosome release. Transfection of cells with HIF-1alpha siRNA prior to hypoxic exposure prevented the enhancement of exosome release by hypoxia. The hypoxically regulated miR-210 was identified to be present at elevated levels in hypoxic exosome fractions. These data provide evidence that hypoxia promotes the release of exosomes by breast cancer cells, and that this hypoxic response may be mediated by HIF-1alpha. Given an emerging role for tumour cell-derived exosomes in tumour progression, this has significant implications for understanding the hypoxic tumour phenotype, whereby hypoxic cancer cells may release more exosomes into their microenvironment to promote their own survival and invasion.
I understand your reasoning, but they truly believe they have, or will have a breakthrough in cancer within the decade. Why annouce something that's hard to believe. Something that gives hope to everyone. So, what is it? Is it just hope that great minds will come together? Maybe the hope of new drugs and ten years of development?, or is it one new find that could change everything. I feel it's a new find; a totally new direction in the fight of cancer. Cancer exosomes are relatively new in the cancer community and play a major roll in determining the cancer type and hiding from our immune system. So, if we can collect exosomes then we can manipulate the exosomes to work on our team. I think it"s the exosomes and turning those exosomes into bombs to attack its host. IMO Aethlon was asked to present, so MD Anderson must have had a good reason for listening. Plus their starting point is in line with Aethlons start for FDA studies. It may just be a coincidence, or maybe not. Either way it very exciting... :)
I find it interesting that this news comes out soon after the presentation by Aethlon. Plus they talk about "commercialization of new discoveries," Well, what new cancer discoveries do you know about? besides exosomes. They are starting Feb 2013, which gives Aethlon plenty of time to gain FDA approval for exosome studies in the US. I feel that a break through in cancer must be in the exosome area. Very very interesting. IMO :)
Yep, good to see everyone. We are back in business. Now let's hope Aethlon kicks in :) I was thinking we should have news next week regarding enrollment and pricing at Medanta. JJ mentioned it would be announced this month. Next month should be positive with IDE updated submittal to the FDA. Hep C plus exosomes....Owesome ...:)
Good move. I'm buying more if it stays around .08 by Friday. And Yes, I moved over from the Yahoo board.