actively trading these days
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
And way back we lost Lordane, which left us with absolutely no drugs at all. We have come a long way since then.
I know nothing compared with your usual analyses, but I happened to sit next to a young guy in the airport yesterday who is a med rep who sells drugs to pharmacies, out of Indianapolis. He stated in no uncertain terms that selling generics is where the money is. He is going to check out ELTP as an investment.
RespireRx Pharmaceuticals Inc. Announces Patent Filings Claiming Novel Lipid Based Formulations for Insoluble Compounds, Including Cannabinoids Such as Dronabinol
BY GlobeNewswire
— 8:00 AM ET 03/23/2022
Glen Rock, N.J., March 23, 2022 (GLOBE NEWSWIRE) -- RespireRx Pharmaceuticals Inc. ( RSPI) (“RespireRx” or the “Company”), a leader in the discovery and development of innovative and revolutionary treatments to combat diseases caused by disruption of neuronal signaling, in association with Jeffrey King Managing Attorney at Patent Networks Law Group, is pleased to announce that it has filed a provisional patent application describing novel lipid based formulation technology (LFT) that may be used to improve the solubility and bioavailability of poorly soluble drugs, particularly cannabinoids. Low aqueous solubility is a major problem encountered during the formulation development of drug molecules, with an estimated 70% of current drug research pipelines containing such molecules. Because of its recent use in the formulation of mRNA vaccines for COVID-19, LFT has become a focus for formulation research efforts.
ResolutionRx, our business unit focused on pharmaceutical cannabinoids, has been developing dronabinol (a synthetic form of ?9-tetrahydrocannabinol (“THC”)) that acts upon the nervous system’s endogenous cannabinoid receptors. Dronabinol was approved in 1985 by the FDA as Marinol® for the treatment of AIDS-related anorexia and later for the treatment of chemotherapy-induced nausea and vomiting. Using the commercial form of dronabinol, we have successfully completed two Phase 2 clinical trials demonstrating significant reductions in the major symptoms of obstructive sleep apnea (OSA). However, based on these results and those from pharmacokinetic studies, we have concluded that expansion of dronabinol’s use into OSA and other therapeutic indications will require new, improved formulations. As it is commercially sold, dronabinol is formulated as a sesame oil emulsion in a soft gelatin capsule that suffers from poor and highly variable absorption, low blood levels resulting from rapid and extensive (approximately 80%) first pass liver metabolism, as well as a relatively brief half-life (approximately 2 – 3 hours) requiring high doses in order to achieve sustained, therapeutic blood levels for 4 hours or longer.
In order to circumvent these problems, we have designated certain important properties around which we have created a number of lipid nanoparticle (LNP) formulations of dronabinol, three (3) of which (i) display appropriate water solubility and dissolution to improve absorption, (ii) nano-particle size and resistance to stomach acid conditions in order to reduce first pass liver metabolism and achieve higher and longer blood levels, as well as (iii) stability and ease of manufacturing to support commercial scale. Pending additional financing (availability of which cannot be assured), we plan to test these formulations in animal and human pharmacokinetic (PK) and pharmacodynamic (PD) studies. We believe that the development of a novel, proprietary formulation of dronabinol would not require significantly longer time to market entry compared to what would be required if we were to use the currently available soft gel capsule technology.
“We are very enthusiastic about our new LFT and its potential use in the development of formulations for a broad range of drugs, particularly our new dronabinol formulations. We believe that they may broaden the dronabinol market to include not only OSA but other indications, as well. For example, we believe that while dronabinol is approved for AIDS-related anorexia, its potential use in a broader form of the condition such as anorexia nervosa or avoidant restrictive food intake disorder (ARFID) would benefit from our improved formulations. Since dronabinol already has been approved for AIDS-related anorexia, we believe that a treatment specific formulation of dronabinol could be brought to market rapidly,” said Dr Arnold Lippa, Chief Scientific Officer, Interim President and Interim Chief Executive Officer and Executive Chairman of the Board. “The pharmaceutical use of cannabinoids is beginning to realize commercial expansion and we believe that our new technology can have significant impact.”
RespireRx Pharmaceuticals Inc. Announces Discovery of a New GABAkine Neuromodulator that Protects Against Seizures and Lethality
BY GlobeNewswire
— 8:00 AM ET 03/16/2022
Glen Rock, N.J., March 16, 2022 (GLOBE NEWSWIRE) -- RespireRx Pharmaceuticals Inc. ( RSPI) (“RespireRx” or the “Company”), a leader in the discovery and development of innovative and revolutionary treatments to combat diseases caused by disruption of neuronal signaling, is pleased to announce that scientists associated with the Company have published a manuscript detailing the pharmacology of its newest asset, D5-KRM-II-81. The paper titled Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the a2/3-selective GABAkine KRM-II-81 in Biopharmaceutics and Drug Disposition. 2022 Feb 22. doi: 10.1002/bdd.2313. Epub ahead of print. PMID: 35194800.
The multidisciplinary team of authors was led by Dr. Jeffrey M. Witkin, a senior research fellow at RespireRx with contributions from academic collaborators at the University of Wisconsin-Milwaukee, Ascension St. Vincent and Indiana University/Purdue University, and the University of Belgrade in Serbia. Authors also include Arnold Lippa, RespireRx Executive Chairman, Interim President and Interim Chief Executive Officer and Chief Scientific Officer. Dr. Lippa is a pioneer in this field since its inception being the first to identify compounds with anxiolytic effects without sedation and to bring them into clinical development (e.g., ocinaplon) while another co-author, Dr. James M. Cook has been inventing key compounds for modulation of GABA-A receptors for several decades.
Since the FDA approval of brexanolone (Zulresso®) for post-partum depression in 2019, several new potentiators of GABA (GABAkines) have entered into the pharmaceutical pipeline. KRM-II-81, originally synthesized by Dr. Cook, is being developed by EndeavourRx, the Company’s neuromodulator business unit, because of its ability to selectively amplify inhibitory neurotransmission at a highly, specific subset of GABAA receptors, thus producing a unique efficacy profile with reduced side effects. The Company currently is focusing on developing KRM-II-81 for the treatment of epilepsy and acute and chronic pain which includes inflammatory and neuropathic pain, which we refer to simply as pain. The findings of broad antiepileptic activity in models of pharmacoresistant epilepsy and in models of pain have encouraged the development of this compound.
D5-KRM-II-81 a structurally related analog is being evaluated by EndeavourRx as a potent, and orally-bioavailable backup that will be used as needed as KRM-II-81 enters its clinical development. Doses of D5-KRM-II-81 as low as 2 mg/kg provided enduring exposure of plasma and brain of rats after oral administration. Importantly, like KRM-II-81, D5-KRM-II-81 completely prevented clonic seizures, tonic seizures, and lethality induced by the GABA receptor antagonist chemoconvulsant pentylenetetrazol. Experimental work in human epileptic brain tissue from patients that are resistant to standard of care antiepileptic medicines is ongoing.
Senior author Dr. Witkin commented, “The antiepileptic potential discovered for D5-KRM-II-81 allows this new orally-bioavailable analog to assist with our drug development efforts in pharmacoresistant epilepsy and pain. Given the large unmet medical need in both of these areas, we are excited to have this new structural analog in our hands.”
Letter to Stockholders and Other Stakeholders: A Brief Summary of Our Progress During Past Twelve Months and a Peek Looking Forward
BY GlobeNewswire
— 8:00 AM ET 03/07/2022
Glen Rock, N.J., March 07, 2022 (GLOBE NEWSWIRE) -- RespireRx Pharmaceuticals Inc. ( RSPI) (“RespireRx” or the “Company”), a leader in the discovery and development of innovative and revolutionary treatments to combat diseases caused by disruption of neuronal signaling, is pleased to provide a brief summary of our accomplishments during the prior twelve months as well as a peek looking forward. As we begin this new year, it is appropriate to briefly summarize our progress this past year and describe how we plan to move forward.
To our Stockholders and other Stakeholders:
Thank you for your continued support and shared confidence in the Company’s efforts.
Possibly most visibly, the Company has implemented an internal restructuring plan with the hope of unlocking what we believe is unrealized value, based upon our two research platforms: pharmaceutical cannabinoids and neuromodulators.
ResolutionRx
Cannabinoids/Dronabinol
In ResolutionRx, our pharmaceutical cannabinoid platform, we are developing proprietary compounds based around dronabinol, an already FDA approved drug that targets the CB1 and CB2 receptors of the brain’s endocannabinoid system. While we have successfully completed two clinical trials demonstrating the ability of dronabinol to improve obstructive sleep apnea (OSA), the commercially available form of dronabinol suffers from poor absorption, rapid and extensive liver metabolism and brief duration of action, requiring the use of high doses.
We have been developing novel, proprietary formulations for dronabinol that utilize lipid nanoparticle (LNP) technology and have identified several unique formulations with which we plan to conduct animal and human pharmacokinetic studies. We believe these new LNP formulations have the potential to overcome many of the shortcomings seen with the commercially available form of dronabinol. Overcoming these issues could greatly expand the use of dronabinol for the treatment of disorders that require longer durations of action and less variable blood levels, such as the treatment of obstructive sleep apnea and other conditions.
In support of this program, we have patents pending claiming blood levels, doses, duration of action and intend to submit additional patent applications claiming composition of matter, method of manufacture and method of treatment for dronabinol and other cannabinoids.
EndeavourRx
EndeavourRx, our neuromodulator platform, is made up of two programs: (a) our AMPAkines program, which is developing proprietary compounds that are positive allosteric modulators (“PAMs”) of AMPA-type glutamate receptors and (b) our GABAkines program, which is developing proprietary compounds that are PAMs of GABAA receptors.
AMPAkines
In ongoing studies with Dr. David Fuller, our collaborator at the University of Florida, CX717 and CX1739, our lead clinical stage AMPAkines, continue to show enhancement of motor function in rodents after experiencing spinal injury. Dr. Fuller published the results of last year’s work in two peer-reviewed journals. In particular, the latest paper, published in the Journal of Neurotrauma (http://doi.org/10.1089/neu.2021.0301) describes research conducted for the first time in awake freely moving rats as late as two weeks after having previously undergone unilateral spinal hemi-transection at the C2 spinal level. For the first time, low dose administration of either CX1739 or CX717 was shown to improve not only motor nerve and muscle activity recorded electrophysiologically from the lesioned side, but to significantly improve actual motor functioning and breathing, even under respiratory challenging conditions. The importance of these findings is described in the article by pointing out that the majority of the approximately 500,000 annual spinal cord injury (“SCI”) cases reported globally involve injuries to the cervical spinal cord and, in severe cases, require the use of mechanical ventilation or direct diaphragm pacing to sustain ventilation.
These recent results have provided great impetus to conduct a Phase 2 clinical trial in patients recovering from spinal injury. Clinical sites have been identified and, pending financing, plans have been drafted to update the current CX1739 IND to incorporate a new clinical protocol and conduct the study.
With regard to intellectual property, new patent applications have been filed claiming the use of AMPAkines for the treatment of spinal cord injury and attention deficit hyperactivity disorder.
GABAkines
In our GABAkine program, KRM II-81, our lead GABAkine, is being developed as a potential breakthrough treatment for treatment resistant epilepsy and chronic pain. After our first full year of working with our new research scientists, Drs. Jeffrey Witkin and James Cook, Senior Research Fellows, and Dr. Rok Cerne, Senior Scientist, considerable headway has been made.
Drs. Witkin and Cerne have conducted pharmacology, metabolism, pharmacokinetic and safety studies to be included in future FDA filings. Several articles describing the results of these studies have been published in highly regarded peer reviewed journals, including two review articles and a book chapter detailing the anti-epileptic and analgesic properties of KRM II-81 and its importance in the overall field of GABAkines. Two additional manuscripts have been accepted for publication and an additional manuscript has been written.
Dr. Cook has begun scaling up chemical synthesis of KRM II-81 in order to provide sufficient active pharmaceutical ingredient (API) to begin IND enabling preclinical studies, which we plan to conduct this year pending financing. In addition, substituted analogues of KRM II-81 have been made, particularly a soluble analogue that displays a similar pharmacological profile as KRM II-81.
Corporate Presentations
During 2021, our executives presented at multiple conferences, including BioTech Showcase, OTC Ventures Market Podcast, Life Sciences Investor Conference and the June 2021 Access China Biotech Virtual Investor Conference. Due to the COVID epidemic, these conferences were held virtually. In January 2022, Company executives presented at the 2022 Biotech Showcase and participated in multiple one-on-one meetings with prospective strategic partners, prospective investors and prospective relevant service providers. Company executives intend to participate in additional conferences, and to present in other forums.
Financing
Despite the successes of our research and development team, our major challenge has been to raise substantial equity or equity-linked financing to support our research and development plans, while minimizing the dilutive effect to pre-existing stockholders. At present, we believe that we are hindered primarily by our public corporate structure, our common stock not being listed on a national exchange, and low market capitalization as a result of our low stock price. Our shares are quoted on the OTCQB, the OTC Market’s venture market with the ticker symbol RSPI.
For this reason, the Company has implemented an internal restructuring plan through which our two drug platforms have been reorganized into separate business units and may in the future be organized into private subsidiaries of RespireRx. We believe that by creating one or more subsidiaries to further the aims of ResolutionRx and EndeavourRx, it may be possible, through separate finance channels, to optimize their asset values and make them more attractive for capital raising as well as for strategic transactions.
The Company is also involved in business development efforts (licensing/sub-licensing, joint venture and other commercial structures) with a view to securing strategic partnerships that represent strategic and operational infrastructure additions, as well as cash and in-kind funding opportunities. These efforts have focused on, but have not been limited to, engaging with brand and generic pharmaceutical and biopharmaceutical companies as well as companies with potentially useful formulation or manufacturing capabilities, significant subject matter expertise and financial resources.
No assurance can be given that any financing or business development transaction will come to fruition or that if it does, that the terms will be favorable to the Company.
Regulation A Financing
The Company filed a Form 1-A which included an offering circular that was qualified by The Securities and Exchange Commission on December 13, 2021 and subsequently amended. The offering is of the Company’s common stock and is up to $7.5 million at $0.02 per share and allows for multiple closings until October 31, 2023 unless earlier terminated by the Company. With the current stock price below the offering price, to date, no closings have taken place.
Departure of Mr. Timothy Jones
Mr. Timothy Jones submitted a letter of resignation as the Company’s President and Chief Executive Officer and as a member of the Company’s Board of Directors effective January 31, 2022 subject to the execution of a termination and separation agreement with certain conditions precedent to its final effectiveness, which agreement was executed and all of which conditions have been met. Dr. Lippa has agreed to serve as the Company’s Interim President and Interim Chief Executive Officer until a replacement President and CEO is hired, while retaining his titles as Chief Scientific Officer and Executive Chairman of the Board.
Summary
As you have now read, in the past twelve months, we experienced successes in the furtherance of our research and development despite our financing challenges. With the hoped for success of our ongoing financing efforts, we have plans in place for the following major projects in 2022, which we intend to implement if we achieve the hoped for success of our ongoing financing efforts:
1. conduct animal and human pharmacokinetic studies with three new proprietary dronabinol formulations in order to choose the best one for conducting a Phase 3 clinical efficacy study for OSA in 2023.
2. conduct a Phase 2 clinical trial investigating the effects of CX1739 in patients with SCI.
3. conduct sufficient preclinical IND enabling studies to support an IND for KRM II-81, our lead GABAkine, allowing the start of Phase 1 clinical trials in 2023.
And to our shareholders and stakeholders we are grateful for your support and look forward to a successful 2022.
Sincerely,
Arnold S. Lippa, PhD
Interim President, Interim Chief Executive Officer, Executive Chairman and Chief Scientific Officer
Wow. Great job Bill. Keep it coming.
Because if they were to try to buy a huge number of shares on the open market, the pps would probably rise above 0.015. This guarantees a low price. IMO.
Fantastic news. We are getting there.
Has anyone seen a "run" in ANY OTC stock in the past year? I have never seen the OTC market so flat in almost 20 years of trading these things. Really boring.
Exactly what I want to know. On the one hand, we are reducing the use of plastic bags nearly everywhere, but now this.
No, that is all baloney.
Nope. From Scientific American:
"According to the U.S. Geological Survey (USGS), the world’s volcanoes, both on land and undersea, generate about 200 million tons of carbon dioxide (CO2) annually, while our automotive and industrial activities cause some 24 billion tons of CO2 emissions every year worldwide. Despite the arguments to the contrary, the facts speak for themselves: Greenhouse gas emissions from volcanoes comprise less than one percent of those generated by today’s human endeavors."
Always do, but what I hear is remembered for about 30 minutes.
How do you know this?
L2 is finally shaping up a bit.
Go First Wave.
This is the most informative, succinct, and optimistic post I have seen in a long time. Sounds about right.
I think that investor conference convinced some investors to jump in. I congratulated Margolis this morning on his presentation, which I thought was excellent. He responded to me within 30 minutes.
The recent investor conference presentation by Jeff Margolis is well worth watching. Well done Jeff.
I don't get the BB anyway. What shares would he buy back? If he buys some of all those restricted shares, that won't help the SP anyway. We need to see the 188M shares outstanding reduced to affect the SP.
Did that guy actually exist?
All my sticks have been in the toilet for months. So, any little tick up is appreciated.
Looking decent here today.
We are getting there.
DA?
If it was just one stock, I would be worried about THAT stock. But this is a general pattern, which I do not understand. But I am not that worried. There will be a general recovery.
I have emailed Jeff 4-5 times over the past year. He has always been helpful and answered my emails within a day.
Each of the 14 stocks I either own or follow have plummeted over the past few months.
First Wave BioPharma Announces Independent Data Monitoring Committee Provides Positive Interim Safety Assessment for Part 2 COVID-19 RESERVOIR Clinical Trial of Niclosamide for the Treatment of Gastrointestinal Infections
BY GlobeNewswire
— 7:00 AM ET 11/30/2021
BOCA RATON, Fla., Nov. 30, 2021 (GLOBE NEWSWIRE) -- First Wave BioPharma, Inc. ( FWBI), , (“First Wave BioPharma” or the “Company”), a clinical-stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for gastrointestinal (GI) diseases, today announced that an independent data monitoring committee (DMC) has recommended that enrollment continue in Part 2 of the ongoing RESERVOIR Phase 2 trial evaluating FW-COV as a treatment for COVID-19-related gastrointestinal (GI) infections. FW-COV is a proprietary, oral, tablet formulation of micronized niclosamide developed to remove SARS-CoV-2 (SARS2), the virus that causes COVID-19, from the GI tract.
The DMC recommendation was based on its review of the safety data collected from the first 25 patients enrolled in Part 2 of the RESERVOIR trial. The review of the data uncovered no safety issues. Part 2 of the study will enroll up to 150 patients.
James Sapirstein, President and CEO of First Wave BioPharma ( FWBI), stated, “The DMC’s review of interim safety data was very positive with no substantive safety issues documented in the initial 25 patients dosed in Part 2 of the RESERVOIR trial. This news comes at a critical time in the COVID-19 pandemic with the rise of the fast-spreading Omicron variant, declared last week by the World Health Organization as a variant of concern. Because niclosamide targets the entire virus, and not just the spike protein, we believe that FW-COV may prove effective against multiple strains of COVID-19 and may provide an effective therapeutic to help millions of COVID-19 patients overcome the debilitating and often overlooked effect the virus can have on the GI system. Based on current timelines and pacing of enrollment, which is strong, we expect to report topline results from the RESERVOIR trial next year, including an assessment of FW-COV’s ability to clear the COVID-19 virus from the GI tract.”
RESERVOIR is designed as a two-part, two-arm, randomized, placebo-controlled Phase 2 study with a primary purpose to confirm the safety of FW-COV and assess the drug’s ability to remove the SARS-CoV-2 (SARS2) virus from the digestive tract. Patients enrolled in Part 2 of the study are randomized to receive either niclosamide or a placebo treatment for 14 days. After 14 days, patients will cease treatment but remain under observation for up to six weeks, with additional follow-up observations at 4 month and 6-months to assess persistence or recurrence of symptoms. The efficacy of FW-COV is measured by the rate of SARS2 clearance from stool samples assessed by PCR test, comparing the niclosamide arm and the placebo arm. Long-term observation could indicate whether niclosamide treatment has the potential to prevent “long haul” COVID-19 symptoms.
James Pennington, M.D., Chief Medical Officer of First Wave BioPharma ( FWBI), commented, “Despite vaccination campaigns and booster shots, COVID-19 and its growing family of dangerous variants continue to spread, and the virus’ lingering effects have developed into a major medical issue for millions of people. Research suggests SARS2 may form reservoirs in the GI tract and cause illness long after the abatement of the initial infection. Early data demonstrated that our micronized oral niclosamide therapy is well tolerated, and we believe that FW-COV may have the ability to remove these viral reservoirs from the GI tract, adding a much needed drug to the COVID treatment regimen.”
Additional information about the RESERVOIR trial can be found at www.covidgi.com and on ClinicalTrials.gov.
RespireRx Pharmaceuticals Inc. Announces Publication of Preclinical Results Supporting the Use of AMPAkines in the Treatment of Human Spinal Cord Injury
BY GlobeNewswire
— 8:45 AM ET 11/29/2021
Glen Rock, N.J.,, Nov. 29, 2021 (GLOBE NEWSWIRE) -- RespireRx Pharmaceuticals Inc. ( RSPI ) (“RespireRx” or the “Company”), a leader in the discovery and development of innovative and revolutionary treatments to combat diseases caused by disruption of neuronal signaling, is pleased to announce the publication by Dr. David Fuller (University of Florida) and his colleagues of two new, scientific articles in major, peer-reviewed journals. In these new studies funded by grants from the National Institutes of Health, Dr. Fuller, a long-time RespireRx collaborator, describes the ability of CX1739 and CX717, the Company’s lead AMPAkines, to improve motor nerve activity and muscle function in animal models of spinal cord injury (SCI).
The first paper entitled “Spinally delivered ampakine CX717 increases phrenic motor output in adult rats” was published online ahead of print in the journal Respiratory Physiology and Neurobiology (https://doi.org/10.1016/j.resp.2021.103814) and describes the ability of direct spinal administration of CX717 to increase the amplitude of motor nerve activity on the side ipsilateral (same side) to that in which a unilateral cervical transection had been made to anesthetized and ventilated rats.
Commenting on these results, Arnold Lippa, Ph.D., Chief Scientific Officer and Executive Chairman of the Board of Directors said, “In combination with prior studies, these new results demonstrate that AMPAkines may potentially have broad effects on both the brain and spinal cord to enhance spinal plasticity and improve motor function in patients with different forms of SCI.”
Unlike the above and all prior published articles, the second paper entitled “Ampakines stimulate diaphragm activity after spinal cord injury” was published online ahead of print in the Journal of Neurotrauma (http://doi.org/10.1089/neu.2021.0301) and describes research conducted for the first time in awake freely moving rats as late as two weeks after having previously undergone unilateral spinal hemi-transection at the C2 spinal level. For the first time, low dose administration of either CX1739 or CX717 was shown to improve not only motor nerve and muscle activity recorded electrophysiologically from the lesioned side, but to significantly improve actual motor functioning and breathing, even under challenging conditions. The importance of these findings is described in the article by pointing out that the majority of the approximately 500,000 annual SCI cases reported globally involve injuries to the cervical spinal cord and, in severe cases, require the use of mechanical ventilation or direct diaphragm pacing to sustain ventilation. Also, in confirmation of previously reported results in anesthetized animals, the AMPAkines improved, in awake freely moving animals, the motor facilitation produced by an episode of acute intermittent hypoxia (AIH), a treatment currently used in the rehabilitation of SCI patients.
As Dr. Fuller concluded in this paper, “Our study provides evidence that even lower ampakine doses can effectively stimulate breathing and diaphragm muscle activity in a pre-clinical model of cervical-SCI, with no evidence of adverse effects. Furthermore, ampakine treated animals are capable of increasing respiratory motor drive to a larger degree when challenged, a response often dampened in SCI patients. Lastly, the current data suggest that pairing low-dose and low impact ampakines with even a single brief hypoxia exposure may have value in the context of neurorehabilitation paradigms.”
Dr. Lippa said, “As part of our ongoing AMPAkine collaboration with Dr. Fuller, these exciting new research results add considerable support to the concept that AMPAkines might be a new therapeutic alternative for significantly improving clinical recovery from SCI, when given alone or in combination with other types of rehabilitation. As such, they strengthen our intention to translationally extend this work to human clinical trials.”
Website for what?
I realize that what we say here, our predictions, are based on nothing but hope. But, eventually, out of the blue, there should be a PR about a reverse merger. The CEO is not staying current with filings for fun, it's for money.
I agree. I have never seen such a beating.
Really good interview. Margolis represented RSPI quite well.
RespireRx Pharmaceuticals Inc. Announces Video Interview of CFO
BY GlobeNewswire
— 8:45 AM ET 11/04/2021
Glen Rock, N.J., Nov. 04, 2021 (GLOBE NEWSWIRE) -- RespireRx Pharmaceuticals Inc. ( RSPI) , (“RespireRx” or the “Company”) a leader in the discovery and development of innovative and revolutionary treatments to combat diseases caused by disruption of neuronal signaling, is pleased to announce the public availability of a video interview of its Senior Vice President, Chief Financial Officer, Treasurer and Secretary, Jeff Margolis, by ProActive Investors.
On Thursday, November 4, 2021, a recorded video interview of Jeff Margolis will be available for viewing by the general public by following this link:
Google him. He is there.
That looks very good.
Geesh, this CEO is a busy guy.
Pretty typical Friday. Relatively low volume, nothing dramatic happening. Surprised there was news today.
Good response N.A.T. Thanks.
Can someone tell me how many of the 28B O/S are restricted or tied up in some way? That is, what is the float?