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No, and that doesn't matter -- the US is dead. Judge Du and the appeals court, carrying water for cheap drug interests, killed it.
It's all about ROW, but to get enough juice out of ROW, you have to have something stunning. Like Alzheimers.
The US deserves to have a massive CVD crisis. We deserve everything we get for stifling innovation and kowtowing to Big Pharma. We deserve terrible medical care, expensive treatments that do nothing while effective cheaper ones are snuffed out, and we deserve to be pumped full of experimental vaccines that are inadequately tested and have all kinds of terrible side effects.
The US sucks ass. We deserve to suffer from the system we insist on.
This is a wasting trust providing attractive comp packages to mediocre executives until the cash flow runs out UNLESS we get another stupendous indication.
CVD = money for compensation to execs and that’s it.
I will be plant food by the time anything comes of this particular exploration.
Why are they doing an article at all? There's no unmet need here for any kind of analysis. It's just a fluff hit piece.
I think that is kind of what I'm saying
The fact that NWBO is at $1.15 is MIRACULOUS, and that anyone benefitting from that miracle should take profits NOW.
Just like I should have taken AMRN profits in October of 2018 and gone away, never to suffer with this POS again.
There's also almost certainly illegal use of paid pumpers to support the stock kiting effort. Other CEOs have gotten investigated and ousted for this stuff.
A lot of this falls on the fuzzy line between civil and criminal wrongdoing.
The technical details don't matter. She's a predator. She learned everything she needed to know about fleecing shareholders at Enron.
Stock kiting
Endless insider dealing
Failing to properly disclose a whole host of insider dealings
Failing to disclose material news/information to shareholders
It's all stuff that if the SEC bothered to investigate, would make this thing come down like a house of cards
She’s a master of securities law navigation. She learned that at Enron.
100% nonsense. DCVax does nothing. PFS HR > 1. OS a joke. So you switch to comparing to stale historical controls.
FDA likelihood of approval = 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001%
This trial failed 7 years ago. And everyone on the inside knows it. You are being milked for every last nickel to put into the pockets of Linda and Friends.
It shocks me every time I look at this and think, “Ostensibly smart people are being duped by this.” How is this possible?
It’s hardly like I have the trading high ground after riding AMRN back down to $1 and change…
But anyone who doesn’t see NWBO for what it is — a total scam — well, if you insist on getting screwed — up to you.
Look at the details. NOTHING IS GETTING APPROVED WITH A COMPARISON TO HISTORICAL CONTROLS.
Jesus. Are you serious?
Sell now. Get the money out.
Linda is counting on you holding the bag. Don’t.
Changing the primary endpoint to OS against historical controls? Jesus. You are falling for that?
Nope. Wrong. NWBO is a scam.
What you do is up to you.
It seems there are a lot of people here who own both AMRN and NWBO
So let's be clear about a few things:
- All that matters is winning. Buying low and selling higher. That's it.
- AMRN is legitimate and EPA is real. But the company sucks. Its management has sucked.
- NWBO is a scam. Its CEO is a criminal. DCVax was abandoned by the mainstream biotech community decades ago.
You may have made, and still could make, good money on NWBO. Take your winnings. The company is a complete fraud.
Great advice. I hope red wine is equally protective.
Yeah, that's easy for YOU to say...
You don't have an artificial digestive tract composed entirely of styrofoam like I do!
Babr success in court is always possible, conceivably, but our track record is utter garbage and the system is against us. No one cares about protecting small biotech proprietary rights. All they care about is cheap drugs and Big Pharma, who flood the political zone with lobbying dollars.
Hot Tub Santa is the Harvey Weinstein of the North Pole
Oh the stories I could tell you. We all knew, but we were afraid to lose our cushy Elf jobs.
Hi MRM. That's quite a pile you have there.
We will never get to $6.65 on the pure CVD indication. The rest of the world sucks, and we're a eunuch in the US.
If we get a COVID or Alzheimers indication, sheer volume will give us profitability in the US -- albeit on a fuck-generics basis -- but ROW if these things were in play would be enough to get us to a buyout.
I hate everybody, and I wish someone would drive a spike through my skull.
Thanks.
We still have our Alzheimer's trial, but is that really a big opportunity?
What was that? Get off my lawn.
I was always for fracking. I don't... I don't... I am always for fracking.
Is there any more Cinnamon Toast Crunch?
Is 2012 a long time ago? Maybe for the current gang...
What does this company do again?
I can't really tell from press releases and presentations. It looks like they just go to conferences and grant themselves stock.
I think the RRR is geographically dependent. Efficacy is a function of how unhealthy people naturally are. The Japanese in the aggregate are simply not as unhealthy as their Western counterparts.
Vascepa does shit
Now let’s find out what all!
Looks like it was a modest positive MRM. We'll need your compound return calc at the end of today of course.
We survived a binary threat. On to the next one -- MITIGATE -- which is finally skewed in our favor. If it doesn't help COVID, we don't go bankrupt, we just miss an opportunity at share price salvation.
The scientific reaction to this generally should be, “flawed trial, but corroborates REDUCE-IT. Pretty clear the MO stuff was bullshit.”
The trial produced exactly the results one would have expected from JELIS.
It’s not EPA’s fault the trial was severely underpowered (only 48% to detect the trial benefit).
Trial needed 500 events to be properly powered, and probably had only around 250.
For all the flaws, it produced almost exactly the result to be expected from JELIS with a 70/30 male population (I had estimated just over 22% RRR).
EPA works just fine! It was just a weak trial!
80% powered to show 30% RRR was just poor trial design.
1/
— Sanjay Kaul (@kaulcsmc) November 6, 2022
RESPECT-EPA ⁰Open-label active control RCT evaluating purified EPA (1.8g/d)+statin vs statin alone in Japanese pts with stable CAD. No mineral oil pbo.⁰PEP: CV death, MI, stroke, hosp. for UA or CR.
Enrolled 3900, randomized 2600 (EPA/AA <0.4)
80% power for 30% RRR, pbo 12%
This won’t hurt us but it won’t support a big reversal.
We did dodge a bullet, however, and now can move on to other trial catalysts.
The results were pretty much the same as REDUCE-IT
It makes it clear that MO theory is nonsense and that the shit works.
But the trial was apparently not well run and so it leaves the door open for ratfucks like Nissen to naysay.
Will be interesting to hear what more objective pundits think.
We need to be realistic here
The Nissen scumbags will ignore the RRRs and talk only about p = .0547
21.5% RRR primary, p = .0547
26.4% RRR Hard MACE, p = .0306
Trial corroborates REDUCE-IT clearly but was very underpowered relative to REDUCE-IT
The trolls will spin the primary p-value but this does nothing but support REDUCE -IT
First slide looks hopeful…
In Japan people already have higher serum EPA — they start from a higher base
The men had higher RRR in JELIS, just FYI