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It's so agreeable to see you folks agreeing.
If memory serves, canine osteo-scacoma ( and HER2 by inference) is perhaps our oldest construct...So it's certainly about time.
Questions;
Will we be manufacturing the vaccine for them with our big, idle, mfg plant?
Is there any IP protection we can wield in it's defense?
Is the logical, follow on, human HER2/osteo sarcoma clinical trial series planned or in progress yet?
Gotta suspect that the expectation of an imminent , thrilling Lombardo announcement is wishful thinking, if not greed on our parts.
Concur that the 17% jump is because we finally have some official FDA validation that our constructs are approvable after a painfully long stretch of no significant news and sinking PPS.
It's mighty sweet to look way up and see the distant surface of the proverbial water come a bit closer.
"People will figure out soon enough that what the company has here is a cure for cancer. When that happens, it’ll rain for all of us!:"
Cattdog, We've both been here for years on end earnestly thinking that. But it hasn't happened convincingly enough.
It's been clear, all along, that the only way to make that happen is to push through a large, well conducted, definitive and convincing, Ph 3 clinical trial.
We've done everything else, we had the $ to do it at one time; but....
We can only hope that the curse of weak management has finally lifted, that the canine sarcoma med gets approved and that we get EU approval..all so we can finance the proper Ph3 trial we've desperately needed all along.
Then, folks will take us seriously and we can retire....maybe.
If you observe the Long term chart,
you will see we are riding a stuttering Yo-Yo.
Just be very patient (as promised events tend to slowly recede into the future).
The PPS will rise again!
~Riiiight!
Sell cheap now so we can limp away with a few battered pennies,
instead of waiting on the fairly good chance of reaping the benefits of a partial cure for cancers.~
Ever wonder why the longs curse the traders?
Hi Midas: Our bets are in and our fingers crossed, if a bit white around the knuckles.~
Agreed...Nothing for me to do is hunker down over the smoking remains and hope like crazy that the new admin is a heck of a lot more competent than the last. However ambivalent i may be about it.
I'm too far underwater here, and too stubborn to comfortably walk away.
The potential is there, but.....
Hi Dew:
The studies i'd read said that the problem lay in Roundup's breakdown products.
But that should have been in evidence in the studies you cited.
Well, good, cause we are all exposed to the stuff.
Woah, too much to respond to Terry!
I imagine we could have some real juicy conversations over a bottle of good scotch.
Good luck.
It's sure cheap now!
I think the serious money to be made here, is buy now and hold long term.
OT:
My concern is more with the breakdown products we end up eating.
We both know that in the face of increasing herbicide resistance, the applications specs are very often ignored.
But this is all pretty academic in a world where known chemical hormone mimics, (for example), are freely dispensed, and the rate of human sperm counts continues to fall alarmingly, while the rate of associated cancers continues to rise briskly.
Makes some precocious salmonids look pretty benign.
Hi Dew:
The ubiquity of Roundup ready crops is undeniable...Hence my "Rats-ass" statement.
My futile objection is that those crops are meant to be exposed to the herbicide in increasingly large amounts.
The papers i read addressed the carcinogenic nature of the breakdown products in lab animals..Which i take seriously as we cant test humans directly. Yes, not proof, but grounds for reasonable suspicion. A futile objection.
I brought it up as an example of the necessity of discriminating amongst the specific genetic modifications , because mass condemnation of GMOs hasn't been useful.
Science is value neutral ( in theory), neither all good nor all bad.
The value judgements are up to us and a whole bunch of other ignorant but opinionated fools. grin.
Terry:
The general public's distrust of the fruits of science is not altogether unjustified.
Yes, the failure of our education system is in large part to blame.
Critical thinking isn't taught, nor the basics of science.
But the "scientific" chemical industries has wreaked great havoc on our health, even as they've given us great benefits.
More to the point, GMOs are already important for feeding the worlds growing population and will be even more critically important in the future.
But the questions folks should be asking,
is specifically WHICH genetic modification are we to be subject to?
The "Golden rice", the protein enriched wheat, the drought resistant or salt tolerating crops all seem extremely desirable.
But, I have real qualms about "Roundup ready" GMOs, for example, because it means we get to eat the breakdown products of Round Up which are proving carcinomas.
The BT crops spook me as those bio-molecular mechanisms tend to be evolutionarily conserved . ETC
But our GMO salmon would be welcome on my table without reservation.
Part of AQB's sales burden will be educating folks about the difference.
Hi Midas:
Looks like a lot of large hands in that little pie.
Looks like we've stopped falling, maybe.
I'm getting in on this dip...
Even with the recent drop i'm nicely ahead on CELG.
Another quarters report and we're up another 14% or so the last couple of days on earnings again.
This puppy is performing better than anything else i hold.
Ouch!
Good attitude, and i agree.
I keep seeing references to long read sequencing of late,
when it was really rare not so long ago.
One advantage to the merger is that we shed the present management plague, if at great cost.
We might end up with a small interest in a company with an approved, needed, product on the market and management clever enough to pull off a merger from a disadvantageous position.
Perhaps they can then get our stuff approved too.
Isn't that a good attitude? sigh
Well Terry, if the declining SPs of my miscellaneous bio stocks are the objective indicator...
Yup, we're obsolete and the nation is abandoning the science that brought us such prosperity.
The pendulum generally reverses direction eventually. Hope that won't be too late for us and AQB.
OTOH, commercially farmed , medicated, penned salmon are terribly vulnerable to population collapse.
If that happens when we finally have our production volume up,
we will be sitting pretty.
Most folks don't give a rat's posterior about GMO labels. Just look at the fast food they gobble happily.
Way too soon to get impatient Masters, as we've discussed previously.
This isn't a silicon valley startup.
The whole flaming thing is unforgivable.
People are suffering horribly while they maneuver to line their pockets with the stockholder's hopes and $.
Criminal behavior is an understatement!
".
India's Premier Stock Exchange BSE and World's largest Insurance Exchange Ebix, Inc. Sign MOU to Launch Joint Venture Company, for Setting up Pioneering Insurance Distribution Network in India"
RR continues expanding by acquisition and partnership.
Despite fierce short attacks, the company has grown enormously over the years. Look at the 3 year chart!
I think EBIX is quite undervalued . India is growing at a rapid pace with a deep education system and RR is able to tap that for top programming talent.
Applause!
As a shareholder, it's hard not to take it personally.
I wonder if the SEC has any teeth left?
Pretty disgusted!
Lame business majors with no interest in the science nor saving lives!
Fiscal duty to the shareholders has been abandoned completely.
It shouldn't take more than about 15 minutes before the legal actions begin to flood in and swamp what remains.
I only wish the legal attack could be restricted to admin personally.
It seems to me that the selloff is considerably overblown.
CELG still has an impressive pipeline, cash and a talent for picking up new drugs very profitably.
As this drop illustrates, there is a substantial failure rate in clinical trials, but the market gasps and clutches it's proverbial breast in surprise each time.
Seems to me to be a very clear BUY signal, and i will as soon as it stops sinking!
We keep making short term decisions that yield energy now at an ill considered cost in the future.
So i view the energy future as a mixed bag that includes disasters no many hands.
They have both, and the waste continues to pile up in both nations.
Nuke plants tend to be sited in the worst places for long term cleanup , radio-actives control, waste removal necessity, and decommissioning.
Is cheap and inaccurate good enough for "precision medicine" and ground shaking research? Sometimes.
Wait till we start seeing influential, widely cited, genomic papers withdrawn because long sequencing revealed the flawed conclusions.
Just read the first pages of the telephone book merger proposal and proxy; and came away gritting my teeth.
Management looks extremely self serving at our expense.
I'm voting no, even if it folds the company..
The proxy proposal looks profoundly ugly.
Bah: Qualcon extended the tender offer again on the same lousy terms as the PPS continues to slowly inch up behind their backs.
So our new drug that gives a small population of doomed children a chance at life, only sold about as many doses as last quarter.
Everyone knew it was a small patient population and another important test of the success of our anti-sense platform.
As a reward, the SP plummets 10%!..A genuinely chicken-ship reaction from the market
RE China and nukes.
Yeah, probably and they can have it.
Nukes are just as shortsighted as burning coal.
Masters;
We won't see many new orders till we get wider recognition in the research community...This is the path.
Thanks Wshaw!
HDW
Because our important IP has aged out and expired so our patents are no longer defensible?
Thus far CAR-T is restricted to blood cancers and has ferocious side effects..as bad as the strongest chemo.
Solid tumor cancers probably won't be defeated by any single therapy. Even the best of them only cure a % of patients and many of those fall out of remission.
Our constructs have some very impressive trial results and if we can stop fooling around and get management to move them forward to FDA approval, we should do VERYwell.
We are mincing around fearing dilution while people die!
No wonder the market has lost faith in ADXS!
"C'mon Tony, Get it done .....$30 plus"
C'mon Keith, that's just plain unrealistic. Why pay $30 when they can get it for $3 in the open market?
Many of us longs have a whole lot of $ and a whole lot of years invested in betting on this aging science. I sure don't want to see that sold out from under us when it should be worth a huge amount properly developed and managed.
ADXS has done the heavy lifting save the multiple Ph 3 trials ( which should have been done when we had the $ and they were much cheaper)
The endzone is in sight and you want to sell the ball cheap!
Fergettit!
It is; but HDW,
we are going to be kicking ourselves all over the place if it rebounds. like it usually does.
If it reaches the $2s...I won't be able to resist.
Makes no sense Easy:
They both lost major $ like we have.
Nah..That's only short mouth talk!
Only a fool sells near the bottom.
"Be greedy when other's are fearful" Said the oracle.
Those of us who have been around a while know that
the SP always sinks between major positive news events.
While management doesn't appear to be moving our science forward at a reasonable pace, and that's discouraging, we do have some clinical trials still in the mill that should come home sooner or later.
And we have a rather vague and distant promise that we'll finally apply for EU approval "before the end of the year" now.