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I warned everybody Seymour approves posts to IHUB. It's great that we have a crook reading discussion about his biowreck crime spree.
If only NNVC drug batches were as "consistent" as the bullshit spewed by Seymour and his henchmen. NNVC really would have a cure then from everything from AIDS to zits, athlete's foot to bad breath.
Actually Seymour did address it in the letter:
"We have been working on developing a number of analysis and characterization assays necessary for enabling batch-to-batch consistent production of our materials since moving to the new campus."
Translation in plain English -- still no batch-to-batch consistent production. What Seymour "forgets" to mention is that without consistent production NNVC is dead in the water. No clinicals. Not even TOX.
The prototype results bullshit -- if one is inclined to believe them -- are completely worthless. Great prototype results are apparently easy with nanomedicine -- being able to make consistent batches to move onto the TOX stage is another story.
No wonder they didn't even bother hiring a virologist until recently. Why bother?
"We don't care if you're a whale or a salamander..." another LIE
"However, one set of toxicities that cannot readily carry over from preclinical testing to humans is immunotoxicity. The immune response can be elicited by different sources. Biologics such as proteins, peptides, antibody fragments, and nucleic acids in nanoparticles can serve as antigens. Interaction of drug and carrier can result in conformation changes that increase immunogenicity."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326161/#Sec14
Wealth of information in that link.
"Although small-scale processes may achieve reproducibility with well characterized components, once beyond the early prototype, the reproducibility and consistency of the constructs remain a constant challenge for the scale-up and manufacturing process..."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326161/
Sound familiar????? And why should anybody believe NNVC is special -- because of the "early prototype" the National Institute of Health warns about relying on?
Another Seymour lie is about how clinical trials will magically go faster for his drugs because of the nature of the disease being short.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326161/
Wrong.
"Overall, nanomedicines may present additional development and regulatory considerations compared with conventional medicines....there is no doubt that the field of nanomedicine is still at its early stage, with success stories few and far apart. Most nanomedicine research, while exciting and technically advanced, is in early stages of development and is only slowly being translated into clinical trials and medical practice."
So of course it's a scam -- Seymour has known for a long long time that lack of consistency is a game ender yet has continued to hype to the public how easy it all is despite knowing it is next to impossible if not impossible.
It was never about the "size" of each batch but the consistentcy between batches. Scaling from 200g to 500g to 100000000000g batches doesn't mean shit and never meant shit. That was all to keep the Joe Sixpacks happy while having no clue what the real problem was.
The move to Herpescide was met with clueless applause because that would "only require 200g batch sizes which they already achieved."
Size doesn't matter. Consistentcy matters.
Herpecide is just as match dead in the water as Flucide. Nobody should care about old testing with INCONSISTENT batches. The jumping around to new flavors of the month then even new candidates (despite the old ones being "perfect") was always, at best, to buy more time to try to solve the consistency problem that's plagued NNVC forever. At worst, they aren't even trying to solve that problem and/or they know it's impossible to solve.
No matter what, Seymour has not been forthcoming with shareholders -- not by a long shot -- and has gotten rich off of the backs of naive hard-working investors who were foolish enough to trust him.
Big pharma isn't interested in this cute-all joke for one simple reason: It's a scam.
Who cares how great a melted snowflake that no longer exists is?
If NNVC can't make CONSISTENT batches of drug just like all the other failed or failing nanomedicine companies then it is a dead duck.
Two batches are needed for TOX. Two inconsistent batches is just as worthless as zero batches.
Stick a fork in NEVERCIDES.
American association of pharmaceutical scientists
"only a relatively small number of nanoparticle-based medicines have been approved for clinical use, with numerous challenges and hurdles at different stages of development"
"The complexity of nanoparticles as multi-component three dimensional constructs requires careful design and engineering, detailed orthogonal analysis methods, and reproducible scale-up and manufacturing process to achieve a consistent product with the intended physicochemical characteristics, biological behaviors, and pharmacological profiles"
"Although small-scale processes may achieve reproducibility with well characterized components, once beyond the early prototype, the reproducibility and consistency of the constructs remain a constant challenge for the scale-up and manufacturing process."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326161/
Seymour's spin was "of course we verified the batch" but what he "forgot" to say is that he didn't verify multiple batches to make sure they are CONSISTENT each other and not just unique snowflakes.
Yes, folks, NNVC can make useless 500g batches of drug that can't even start TOX testing.
Because she never got 3 CONSISTENT batches. Maybe, just maybe, one batch worked but it doesn't matter. That batch was unique and melted away. Every batch is for FDA purposes a random soup and useless.
It's ALL in the 10K. Everybody is waiting for TOX which is impossible to happen. Seymour was so proud about scaling up to 500g, oops 200g, oops not even that.
Reality, as spelled out in 10k, they can scale up to 500g and hell up to 1kg but only "certain parts" of the batches. They cannot make CONSISTENT batches. Without CONSISTENT batches, as earned in the 10K, they can't even think about doing TOX.
TOX requires 3 CONSISTENT batches. Not quite identical but close enough. NNVC can make 200g and 500g batches all day long. But each batch is a unique snowflake and totally useless.
Nobody likes to feel scammed but it's far more profitable to embrace reality.
None of them received CONSISTENT batches of drug. Instead they got unique snowflakes.
At best this is a cute science project with no value.
Read the filings -- for 12 years NNVC has tried and failed to make consistent drug batches of ANY size. FAIL
Try reading the 10K -- that's exactly where I got my facts from. The 10K warns they need to make consistent batches and have yet to do so hence only 1 batch sent to BASI which is completely useless. NNVC warns the consistency problem is shared by other companies also failing. They all make batches that are unique from each other like snowflakes.
Aspirin wound be illegal if every time a company made a batch of pills the batch had different levels of drug/binding ratio. NNVC doesn't make drugs -- it makes random unique snowflakes.
Now we know why the push for ebolacide. It was their only hope if the disease got out of control. Unique snowflakes that can't even enter TOX testing are worth a shot if they hadn't failed miserably on the spot.
What good is "proving" a drug that can never be duplicated again?
No wonder NEVERCIDES keeps changing candidates. They don't have any duplicatable drugs. They only have useless unique snowflakes.
WTF? ROFL!!! I laughed so hard I spit coffee all over the place and I didn't even have any coffee today.
And people wonder why I can't step away from this entertaining true crime story.
PS -- Seymour does look stuffed and mounted in that pic. Hmmmm.
Its NNVC's claim not mine. NNVC, like other failed nanobiomeds, can't produce anything but useless unique sbowflake batches. You're welcome. I solved the riddle. Now be wise and look for an exit from this trash.
I'll be more than happy to meet Seymour at an FBI office in person. I'll be armed to the teeth with 12 years of his fraud.
Did I finally and successfully put the pieces together on something solve the puzzle?
And all from my smartphone and my chemistry education consisting of high school "C" chemistry class?
"A major problem in the field of nanomedicines has been that most nanomedicines have been found to be notoriously difficult to manufacture in a consistent manner from batch to batch. This is because of the complexity inherent in making large molecules, and the very nature of polymer and particle making processes."
--NNVC 10K
According to the same 10K, NNVC is having the exact same consitent batch problem and only sent one batch to BASI because they've been unable to make even two batches of any size consistently. There is no evidence nor reason to believe NNVC is better off after 12 years than any other nanomedicine failure.
It's a 12 year running same "bottleneck" that is the exact same problem every other failed nanomedicine company has run into.
True crime stories have been EXTREMELY popular for decades if not centuries.
And now with the addition of social media, true crime stories such as the NNVC one can be watched live and spectators get to even play an interactive role. Yes, it's quite cult-like addicting!
Can you imagine if social media existed back in Mr. Ponzi's day when you was peddling what would become later known at the Ponzi Scheme? Many of us would give our left arms to go back in time and interact with Mr. Ponzi and his promoters.
This snake oil scam NEVERCIDES claiming to cure all viruses yet can't even make a single verifiable batch of drug that is consistent with the next batch is truly amazing. In a year or two, this type of snake oil sham may become known as the Seymour Scheme.
"A major problem in the field of nanomedicines has been that most nanomedicines have been found to be notoriously difficult to manufacture in a consistent manner from batch to batch. This is because of the complexity inherent in making large molecules, and the very nature of polymer and particle making processes."
The filings say they need to make 3 consistent batches. Nothing in the filings even remotely suggests they have ever done so at ANY batch size. The filings also say only a single batch was sent to BASI. Obviously that's completely useless because there is zero consistentcy determination from a sample of 1.
If each batch varies widely and isn't consitent it's impossible to perform any TOX studies. Human patients can't be given drugs whose properties are random and non-TOX-tested.
There is no evidence NNVC is any different than all the other failing nano companies who are running into the same game-ending problem. The 200g/500g crap sounds like bullshit from the start. If they could make say 50g consistent batches then they'd just make a ton of them and combine them. Or at least claim "hey we made three consistent batches now we just have to scale up from there. 12 years? C'mon.
No wonder they want to change virus targets and then change "lead candidates" as often as Seymour changes his depends. Every wonder drug and every candidate keeps running into the exact same problem: you don't even have a viable drug if the drug changes every single time you go to make it.
NNVC makes snowflakes -- looks pretty, sounds pretty, but each one (batch) is unique and thus utterly useless.
Has NEVERCIDES ever made two consistent batches of ANY quantity size in the last 12 years?
If the answer is no, could there be something inherent with the process that makes that impossible?
And if consistency is a make or break FDA requirement, could this all mean NNVC is a dead duck and Diwan and Seymour have been well aware of that from day 1?
Just kind of thinking out loud but I invite any responses. Maybe I'm totally off base.
It's important to remember -- anybody sharing positive info, however relentlessly incorrect and financially painful, is doing so out of the goodness of his heart to help his fellow man.
Anybody countering that God-awful and usually wrong positive info, like me, must be getting paid. It's the only explanation as to why anybody in the year 2016 enjoys social media.
For 800,000 clams and his main job being flapping his gums, I think shareholders deserve accurate assessments on the state of things and where and when they are headed.
Unless, of course, he's getting paid to put lipstick on this pig.
Have you heard of dengue?
True, if Seymour is mounted and stuffed, it's probably a bad idea to fight him.
Back on June 4, 2016 somebody asked me:
200g batches still a FAILURE:
"We believe that approximately 200g production batch size should be sufficient for the Safety/Tox Study batch as well as for the Phase I and Phase II human clinical trials drug batches. We will need to successfully produce at least two batches that meet our quality assurance criteria before we can produce a clinical product batch."
GOOD NEWS!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Only one more month after today of tax-loss selling!
WEEEEEEEEEEEEEEEEEEEEEEEE!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
I for one apologize for recommending people sell this scam at $5 to $7 per share.
Such depravity of me!
It's more fascinating the the SEC apparently "named" a "shareholder" in a "complaint."
(1) The SEC rarely to never names an ordinary shareholder in anything unless that shareholder is a promoter who did something illegal.
(2) If it's a "complaint" then the investigation has escalated to a lethally serious level.
(3) The SEC smelled smoked 5 years ago? Where there is smoke there is fire and 5 years later the "smoke" smells like a blazing inferno.
Investigations take many months to years. Then the Wells Notice hits with an average of 5 months to 1 year before formal charges are announced.
It's a long process and the more a company continues to shoot itself in the foot the longer the SEC takes. NNVC is building a beautiful case for the SEC. Why should the SEC have rushed 5 years ago when there has been 5 years of ever-ridiculous fraud since?
I have personally helped the SEC in the past, which is well documented with my posts on IHUB, in nailed a medical-related scam before.
Two SEC enforcement attorneys contacted me in that case asking for help. I gave them a lot. I posted details of what happened. Not long later the SEC nailed the scam just as I saw it would based on the details I shared with the enforcement attorneys.
I see deja vu with NNVC.
I know a lot more about the SEC investigation into NNVC than many would think. In fact, it would absolutely blow most people's minds.
This is almost rhetorical from my end -- What questions did the SEC have for NNVC in its investigation? Was it an informal or formal investigation? How do we know the investigation has ended?
Wrong. It's an argument for avoiding this SEC-investigated scam entirely.
Speaking of rotten clams.....
NNVC's last clam is looking dangerously close to the expiration date.
I used to do only do fine dining until I was foolishly sure NNVC wouldn't fall below 2 clams.
Now I usually dine on Alpo.
One of NNVC's chief promoters and penpals informed the public about an SEC investigation and even said he was named in the complaint. If that is all true, once an investigation evolves into a complaint it generally either has to be settled or brought to trial.
The SEC won't list the NNVC investigation on its website or any investigation on its website. They will only list the charges against NNVC when they come out.