Saturday, December 03, 2016 1:12:26 AM
"only a relatively small number of nanoparticle-based medicines have been approved for clinical use, with numerous challenges and hurdles at different stages of development"
"The complexity of nanoparticles as multi-component three dimensional constructs requires careful design and engineering, detailed orthogonal analysis methods, and reproducible scale-up and manufacturing process to achieve a consistent product with the intended physicochemical characteristics, biological behaviors, and pharmacological profiles"
"Although small-scale processes may achieve reproducibility with well characterized components, once beyond the early prototype, the reproducibility and consistency of the constructs remain a constant challenge for the scale-up and manufacturing process."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326161/
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