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2nd detailed video exposing COVID19 as presenting most risk for those with oxidation stress, inflammation, resulting in Endothelial cell dysfunction and thrombosis.
Do you know a drug that reduces oxidative stress, increased NO? I think you do
Couldbebetter, did you watch it?
Vascepa has a role in treating COVID-19
When you watch this explanation you’ll learn how COVID-19 damages endothelial lining via oxidation
This is where Amarin needs to do some studies
Good discussion of what we know and don’t know re COVID-19
KevGee - your idea of a settlement idea has merit
It now might be in best interest of both parties to settle now
Bravo!
kiwi, PUBMED is your friend
thanks Raf, appreciate the Pacer updates
Raf, despite my progressive views, I’m a capitalist and want our economy back as much as you.
But I’m also pro-life like most conservatives.
with your plan, how many more people have to die? Hundreds of thousands? a million? That doesn’t seem to be a pro life position to me.
BTW With social distancing here are current COVID19 deaths by week to date
8 weeks ago: 0 deaths
7 weeks ago: 12 deaths
6 weeks ago: 41 deaths
5 weeks ago: 195 deaths
4 weeks ago: 1,195 deaths
3 weeks ago: 5,983 deaths
2 weeks ago: 16,684 deaths
1 week ago: 33,268 deaths
Right now: 49,861 deaths
Hawk, Weeks old? Is it no longer accurate CT Scan? Please elaborate
ilovetech,
This is generally a place of science based investors. Anecdotal evidence isn’t proof of it’s efficacy. If it works the placebo controlled doubled blind trial will show that
Why can’t we leave politics out of science? Your truth should be my truth. Truth doesn’t conveniently change because of ideology.
Thanks for sharing. And I’m happy your family member came off ventilator
9/10 that require ventilators don’t so you got very good news - congrats
Montana, you’re natively social distanced - which sounds good to me.
Yes, urban areas, urban families are live, transport and work in very close proximity.
Last summer I was in NYC and my colleague wanted to use subway at rush hour. As I approached the sea of people swarming tightly together I felt anxiety build. I turned around and headed for street level. It was pouring rain and it took me an additional hour to get back to Grand Central Station. I need my space but millions all over the globe choose cities to live in. Perfect environment for pandemics to explode. Rural areas are susceptible and in some ways more vulnerable because the rural hospital is usually under staffed and not well equipped.
It will be interesting to see how Las Vegas and Georgia fare as they attempt to reopen
From what I’m reading, we’d have to institute the Taiwan process of screening, tracing and mitigation to stamp out this virus. You have to attack it and move quickly to identify test infected, trace contacts and quarantine. If you do that well, you can manage to reopen.
Here’s Doc walking you through CT Scan of lungs showing effect of COVID19 on healthy middle age male. You decide if it’s overblown or not.
So what constitutes your young and healthy pop.? Which age?
And who is deemed unhealthy?
How do you ensure the young \ healthy asymptomatic carriers don’t spread to those old and vulnerable?
What about those deemed old or unhealthy who need to work? Are they allowed to work? How do they work without risk of infection?
Who is liable if they contract the virus and die at work?
What obligations do your young and healthy pop have in protecting older and vulnerable coworkers?
How is it SK had 250 deaths vs our 48K when both countries got infected at the same time? Sure, NK is a smaller country but what can we learn from their success? Anything?
Montana, we lost 48,000 Americans in past 8 weeks and roughly 4 weeks of using “stay at home”
if we use your hypothesis as correct and didn’t stay at home, didn’t use social distancing, didn’t close businesses, what does your model project would be dead by now, and how many more by September?
Mr Trump tonight suggested 'injection' of disinfectant to beat coronavirus and 'clean' the lungs
Ok with that Raf?
You can’t have it both ways Raf
Either the risks are overblown and no need to stay at home, and businesses stay open and no need for social distancing
or
the virus is virulent, extremely contagious and poses a mortal risk to millions of Americans
Which is it?
Thanks, this is a perfect example of what is required to safety reopen and why we won’t on a national basis.
Trump cannot force States to accept the Taiwanese type of controls, loss of privacy and nation-wide screening, tracking processes across our nation, and the reason why there’s a consortium of states coordinating their own measures to reopen while other states throw caution to the wind.
Is it death rate that matters most or contagiousness?
Everyone sick at same time means its likely you’re in a hallway waiting for a nurse, bed etc. as hospitals become overwhelmed
Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner
https://www.biorxiv.org/content/10.1101/848093v4.full
Patent granted to Nippon making 96-99% pure EPA
https://patents.google.com/patent/US10576053B2/en
Agree, if they don’t win appeal / reversal, leave US Mkt entirely.
Why prime mkt just to hand over billions? If Trump wants medical innovation and reduction in healthcare costs, he has to provide incentives. I say the heck with US. Let the generics bear brunt of education, further scientific elucidation of Vascepa MOA.
Nobody in their right mind would fault Amarin.
I’d also make a branded version at 50% increase of current Rx and let current and future Rx be fulfilled at much higher cost to
Consumers and Insurance carriers
Let the ADA and AHA fight with FDA and Congress, judicial system.How many lives will be lost because of Judge Du?
I say screw US mkts.
PUBMED is your friend
Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?
https://www.sciencedirect.com/science/article/abs/pii/S0188440920302927
I'm sure 8gm over 24 hrs is safe
What toxicity could emerge?
Euro already declared 5gm to be safe
Doctors can do it now. I wouldn't be surprised to see a physician report success stopping Cytokine storm using very high does V
Zip, I'm thinking very high doses - 8gm daily and above
Dr Bhatt agrees
@DLBHATTMD Doctor, much is published on EPA diminishing cytokine storms. Why not try escalating dose of Vascepa with #COVID19 patients? Hard to imagine a serious SE from such therapy ( e.g. 8gm+ more daily)
— JohnCappello (@JohnCappello) April 14, 2020
here is just one article https://t.co/ZUm71Wxqct
EPA shown effective in the suppression of inflammatory cytokines
Articles
https://scholar.google.com/scholar?q=%22eicosapentaenoic+acid%22+Cytokines&hl=en&as_sdt=0&as_vis=1&oi=scholart
The Doctor is in, patients not so much. This barren office as tweeted by a Card was confirmed by AMRN Rep. Doctors (Cards) are available!
And reps are taking advantage of it
Waiting room, outpatient cardiology @MassGeneralNews
— Sek Kathiresan MD (@skathire) April 10, 2020
Suspect similar scene for outpatient practices throughout country pic.twitter.com/mdMPU9xsGI
My expectations
Reps active with webinars, remote meetings. Reduced patient office traffic ( emergency only) has increased physician availability to participate in education. Rx can be issued, changed without office visits.
With CVD a most serious risk factor in COVID19, opportunity exists to reduce risk, especially in seniors. I would expect Amarin to be making good use of current pandemic for good of public health.
Since every Rx will be to someone on a Statin Rx, why not combat a Generic entry by differentiation. An example is to provide an Rx composed of both a statin prescription "included free of charge" with each Vascepa prescription. One Rx comes with two drugs.
That would eat into generics statin business, establish Amarin as one-stop-shop for all CVD Rx, which primes pump for the eventual combo version.
Statins are dirt cheap, and wouldn't dent profits - it would put pressure on generics since they'd have to match same packaging, further making the business less profitable for generics
it's more of a marketing angle, but I can see ways to create differentiation Call it "Vascepa + "
Kiwi,
There is no law that forces a company to sell its drugs in the US. why is it against the law for Amarin but not Mochida? Maybe you can share some of that California ganja your smoking
Amarin can layoff sales reps, stop funding science, raise prices - or if they found the market untenable because of unfair competition, they can choose to leave it and sell its drugs elsewhere.
don't smoke it so early in the am...
Amarin should cease all US operations immediately. Cease all advertising, all conferences, scientific sponsorships, education, sales, and marketing. It should state supplies of Vascepa are being scaled back can not be guaranteed for the US. It should state the burden of bringing breakthrough therapies comes with high risk and high reward. Be removing financial rewards for the risk fo capital, it forces small companies like Amarin to seek alternative markets that protect their therapeutic investments.
It needs to shock The FDA, Medical Associations, and the millions of patients to bring the egregious decision to the forefront. Everyone needs a harsh reminder that the you cannot expect the development of breakthrough therapies without protecting these small companies who risk investors capital with a fair balance of financial reward
its time to take off the gloves.
?These results confirm that EPA is a tumor suppressor in human ovarian clear cell carcinoma cells and functions through a novel fatty acid receptor, GPR30, indicating a mechanistic linkage between omega-3 fatty acids and cancers.
?https://www.ncbi.nlm.nih.gov/pubmed/32138466?
Good video summary of CoronaVirus
$4B / opp on Flu alone
Adds credibility for Corona Virus Vaccine
Congrats longs $90 share coming