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Nahhh, Fred Flintstone has Covid and Wilma is researching QuadraMune.
Seriously, once news starts circulating that there is a scientifically based, clinical-trialed "Nutritional Supplement Designed to Protect Against COVD-19," kabooomage. If QuadraMune is positioned as a super-premium nutraceutical, watch. There's always a market for the best of the best.
Dr. Fauci: Vitamins boost immunity. I do it myself.
He's talking Vitamins C and D, but the conversation sure encourages a positive attitude towards nutraceuticals and TSOI's scientifically based nutraceuticals, IMO; i.e. QuadraMune.
"Your immune system is responsible for fighting off viruses, but it can only do so properly if it is strong and healthy. And with the coronavirus still spreading, it's more important than ever to make sure your immune system is in tip-top shape. That's why Anthony Fauci, MD, director of the National Institute of Allergy and Infectious Diseases (NIAID), recommends two vitamins you should take to boost your immunity: vitamin C and vitamin D."
"If you're deficient in vitamin D, that does have an impact on your susceptibility to infection. I would not mind recommending—and I do it myself—taking vitamin D supplements."
A must read. Thanks for the link.
Thomas E. Ichim, PhD, TSOI Director, great to see you here. Appreciate that you're open to questions even though most of us couldn't dissect a rubber frog. Long story.
Anyway, curious about the role of tau, the protein implicated in Alzheimer's, which is thought, under certain conditions, to disrupt the brain cells from communicating with each other.
As you know, the prevention of Alzheimer's is one of the holy grails of medicine.
Is TSOI looking at tau with ProJuvenol or other combinations of nutraceuticals? Too complicated, too much to hope for?
So Snotta, in your humble opinion ...
Which requirement wasn't met?
OTCQB Eligibility Requirements
Which requirement wasn't met?
https://www.otcmarkets.com/corporate-services/get-started/otcqb
> U.S. companies must have audited annual financials by a PCAOB auditor. (Tier 2 Regulation A Companies are exempt from requirement to use a PCAOB auditor for their initial audit)
> Meet minimum bid price test of $0.01
> Not be in bankruptcy
> Have at least 50 Beneficial Shareholders, each owning at least 100 shares
> Have a freely traded Public Float of at least 10% of the total issued and outstanding of that security.
> Companies with a freely traded Public Float of at least 5% (and $2 million in market value of public float), or a separate class of securities traded on a national exchange may apply for an exemption (see OTCQB Standards)
> Have a transfer agent that participates in the Transfer Agent Verified Share Program (US Companies only)
> International companies must be listed on a Qualified Foreign Exchange (or SEC Reporting) and submit a Letter of Introduction from an approved OTCQB Sponsor
Reporting Requirements
Meet one of the following Reporting Standards:
> SEC Reporting Standard
> Regulation A Reporting Standard (Tier 2)
> U.S. Bank Reporting Standard
> International Reporting Standard
> Alternative Reporting Standard
Timely disclosure of material news
Corporate Governance Requirements (Alternative Reporting only)
> Have a board of directors that includes at least two Independent Directors
> Have an Audit Committee, a majority of the members of which are Independent Directors
Verification Requirements
> Maintain a Verified Company Profile
> Post initial and annual verification and management certification SEC Reporting Standard
https://www.otcmarkets.com/files/otcqb_standards.pdf
More/Details
News that makes you go Hmmm.
Unilever PLC acquires Liquid IV, a U.S.-based health-science nutrition and wellness company. Terms not disclosed.
Liquid IV - nutraceuticals, functional drinks - but doesn't appear to be in the same league as TSOI per science-based, targeted nutraceuticals.
If Unilever or another consumer-focused company, not necessarily big-pharma, is waking up to the idea of science-focused, natural products, TSOI should be extremely valuable.
TSOI long.
Read the 13G and you'll see Puritan Partners LLC is at 369 Lexington Avenue, 25th Floor New York, NY 10017. Sig: Richard Smithline who runs Centrecourt Asset Management, small-cap investments, at the same address.
Sheesh. The mink outbreaks are “spillover” from the human pandemic—a zoonosis in reverse that has offered scientists in the Netherlands a unique chance to study how the virus jumps between species and burns through large animal populations.
That mink are susceptible wasn’t a surprise, because they are closely related to ferrets, says Wim van der Poel of Wageningen University & Research, which has an animal health laboratory here. (Both mink and ferrets can also contract human influenza viruses.) Like humans, infected mink can show no symptoms, or develop severe problems, including pneumonia. Mortality was negligible at one farm and almost 10% at another. “That’s strange—we don’t really understand it,” says virologist Marion Koopmans of Erasmus Medical Center in Rotterdam. Feral cats roaming the farms—and stealing the mink’s food—were found to be infected as well.
Why Does the Coronavirus Hit Men Harder?
Over all, the scientists found, the women’s bodies produced more so-called T cells, which can kill virus-infected cells and stop the infection from spreading.
Men showed much weaker activation of T cells, and that lag was linked to how sick the men became. The older the men, the weaker their T cell responses.
TSOI: One of QuadraMune's components is an "activator of T cells."
https://www.nytimes.com/2020/08/26/health/coronavirus-men-immune.html
> Women produce a more powerful immune response than do men, a new study finds.
>>>>>>> Women mount faster and stronger immune responses, perhaps because their bodies are rigged to fight pathogens that threaten unborn or newborn children.
> You could imagine scenarios where a single shot of a vaccine might be sufficient in young individuals or maybe young women, while older men might need to have three shots of vaccine.
----------------
What the heck are T-Cells?
Each T-cell can fight only one type of virus. T-cells are like a special forces unit that fights only one kind of virus that might be attacking your body.
Two types of T-cells in your body: Helper T-cells and Killer T-cells. Killer T-cells do the work of destroying the infected cells. The Helper T-cells coordinate the attack.
[Lots more to research.]
Immunity might last only a few months?
TSOI: QuadraMune!
https://www.nytimes.com/2020/08/24/world/covid-19-coronavirus.html?action=click&module=Top%20Stories&pgtype=Homepage
First Confirmed Case of Virus Reinfection Found in Hong Kong
> Researchers said a “young and healthy” patient had a second case more than four months after the first, suggesting immunity might last only a few months.
TSOI: Current clinical trial aims to assess in a 500 volunteer trial the efficacy of QuadraMune in reducing infection in individuals at high risk of COVID-19. [ClinicalTrials.gov Identifier: NCT04421391]; that is, to assess statistically significant increases in immune response activity within 5 days.
IF QuadraMune can increase immune response to the degree that it neutralizes the COVID-19 virus naturally, the mind reels with the possibilities.
IF QM is given in conjunction with a vaccine, could it, would it extend the efficacy of the vaccine?
Sez who? You?
TSOI is the real deal. Watch.
Oh, could it be because 53% of the vol was shorted today?
52.78% of 82,854,679, to be exact. Whoohoo, let's go borrow a busload of shares and have some fun, you think?
New study: Vascular disease? Not a respiratory illness?
... drowned within the lungs? Not taking issue with you, but waaay more to learn about the debilitating effects of COVID-19.
In a study released by Indiana University School of Medicine this August, in partnership with COVID-19 nonprofit Survivor Corps, long haulers describe nearly 100 side effects, from fatigue and body aches to night sweats and neuropathy.
The study casts doubt on the idea that the COVID-19 is a respiratory illness that lasts only a few weeks, suggesting instead that it may be a vascular disease capable of wreaking havoc on the eyes, skin, heart and brain, long after the sore throat goes away. While some hospitals, such as Mount Sinai in New York, have launched recovery centers for post-COVID care, the Centers for Disease Control and Prevention has released little data on the longterm prognosis for those who survive.
TSOI long
So crazy it might just work.
Bitcoin partially backed with gold recovered from eWaste.
http://app.newmediawire.com/news/5efbb9018104f70ce8d76f44?source=twitter
Visit www.therefiningcompany.com to learn more about the company’s refinery and precious metal recovery business, and visit www.sperastablecoin.com to learn more about Spera, a stablecoin that we plan to partially back with gold recovered from eWaste refining.
How Much Gold is in a Computer? $9
Silver
Gold
Platinum
Palladium
Electronics Scrap
Then, again, Form 15: APT Systems Inc. Voluntarily Ceases to be Reporting Company
Now that the price of gold is rocketing, AUREX Trading and Recovery should be doing well:
@APTYsys
Shipping in 6700 pounds of circuit boards and telecom equipment to be properly sorted, recycled and refined to #recover the #gold. We will know how many ounces were hiding in about 4 weeks.
Never let it be said that the OTC isn't entertaining.
... most appealing pharmaceutical on the block.
https://www.reddit.com/r/pennystocks/comments/h956he/the_case_for_tsoi/
The case for $TSOI
Considering how widespread many of the diseases TSOI is currently making products for, any of the drugs could easily pull in nine-digits each year, even ten-digits, it's possibly the most appealing pharmaceutical on the block.
[More]
Patents by Inventor Howard J. Leonhardt
1994 - July 23, 2020
Wow.
https://patents.justia.com/inventor/howard-j-leonhardt
What if ...
A/O today, Sat Aug-08-2020, "Three vaccines are in phase 3 of human clinical trials, which ensure effectiveness but also safety."
> University of Oxford/AstraZeneca
> Moderna
> Chinese company CanSino Biologics
FDA: Any vaccine will need to be at least 50 percent effective to be approved: that is, prevent infections in at least 50 percent of the people who receive it.
Hmmm, wish them well, but seems to be a rather low hallelujah bar.
TSOI: Current clinical trial aims to assess in a 500 volunteer trial the efficacy of QuadraMune in reducing infection in individuals at high risk of COVID-19. [ClinicalTrials.gov Identifier: NCT04421391]; that is, to assess statistically significant increases in immune response activity within 5 days.
So, IF a vaccine(s) can identify, attack and neutralize a marauding COVID-19 virus with the tenacity of an OTC stock basher, great. There's a 50 percent (or hopefully greater) chance that'll happen.
IF QuadraMune can increase immune response to the degree that it neutralizes the COVID-19 virus naturally, the mind reels with the possibilities.
IF QM is given in conjunction with a vaccine, could it, would it extend the efficacy of the vaccine?
TSOI long
Spock...what would you expect the First Science Officer to write?
"Are You CovidMune? There's all kinds of weird stuff floating around up here."
https://areyoucovidmune.com/covidmune/
5 Hazards of Human Spaceflight
https://www.nasa.gov/hrp/5-hazards-of-human-spaceflight
Amazon has not renewed a bunch of contracts with logistics companies over the last year.
Let's not take this personally.
Amazon has abruptly canceled its contracts with three major delivery firms, a move that will put more than 2,000 people out of work ...
Inpax Shipping Solutions
Sheard-Loman Transport, said in a court filing ...
Letter Ride LLC
FedEx Ground won't renew delivery contract with Amazon
More?
TLSS: mid/long drive contract was extended until May 2021
AWARDED the shares means they have confidence in the company, the exact opposite of a company dumpin' and runnin'. Do we really need examples of the latter? Nahhh.
Traveled through Southeast Asia, but didn't make it to Vietnam. Burma, now Myanmar, was amazing; isolationist, 1948 time capsule. Anyway, population densities whether it's Hong Kong or NYC, are incredibly vulnerable. Ease of COVID-19 transmission is now just being understood, much faster, easier (air) than, say the 2009 H1N1 swine flu or even the 1918 Flu Pandemic, which killed 50K people worldwide. And now Vietnam is reporting a new, even faster strain. Time to think long and hard about supporting the immune system (QuadraMune).
Vietnam says the new strain of coronavirus behind its ominous COVID-19 spike is 3 times more contagious
> Each patient has been found to infect between five and six people on average, compared to a rate of 1.8 to 2.2 infections per patient as seen before, health minister Nguyen Thanh Long said Sunday.
> The strain is new to Vietnam, but has been seen in the British Isles and Bangladesh before.
> Vietnam has previously admitted that its health system could not cope with a mass outbreak.
The inventor of the Weed Eater wouldn't agree with you.
Patents don’t mean squat.
George Ballas
Or the inventor of Aspirin, Arthur Eichengruen, Bayer.
Or one of my favorites.
Therapeutic Solutions International Files Patent on Ability of QuadraMune Ingredient Pterostilbene to Reduce Inflammation while Stimulating Brain Protective Biological Pathways
> Mechanistic Studies Continuing on QuadraMune™ a COVID19 Candidate in Clinical Trial
> Company Continues Quest to Dominate Intellectual Property Regarding COVID-19 Associated Pathologies
Patents by Inventor Thomas E. Ichim
Read on. And on. Quite a list.
https://patents.justia.com/inventor/thomas-e-ichim
Q&A: Another dose of reality. Another reason to tune your immune system.
Dr. Osterholm: Americans will be living with the coronavirus for decades
> Dr. Michael Osterholm, epidemiologist at the University of Minnesota, recognized the coronavirus would become a pandemic as early as January
MarketWatch: One of the things I’m pretty interested in is the talk and the hope around a vaccine. Do you think we have misconceptions about what it means when we have a vaccine?
Michael Osterholm: Everyone is looking at the vaccine as being a light switch: on or off. And I look at it as a rheostat, that’s going to take a long time, from turning it on from its darkest position to a lightest position. If you’re anticipating a light switch, you’re going to be concerned, confused, and in some cases very disappointed in what it might look like in those first days to months with a vaccine.
[More]
https://www.marketwatch.com/story/osterholm-americans-will-be-living-with-the-coronavirus-for-decades-2020-07-30?siteid=yhoof2
Kodak's news; an agreement to produce generic drug ingredients, specifically the "building blocks used to produce generic drugs" should draw attention to U.S.-sourced nutraceuticals and TSOI; that is, light on the whole sector.
Kodak plans to produce two types of chemicals used to make pills and tablets: the initial building blocks, known as key starting materials and more refined substances called active pharmaceutical ingredients, known as API.
About 40 percent of the world’s supply of drug ingredients is used to produce generic medicines for Americans, but only 10 percent these materials are manufactured in the United States, according to DFC.
Hmmm, if the clinical trials prove the legitimacy of TSOI nutraceuticals, wow (understatement). Defense Production Act invites companies to apply for financing to support domestic production of drugs, personal protective equipment and other medical supplies such as vaccines or virus testing materials.
HOPE the FDA is watching.
TSOI has never made the claim and, um, you know it.
COVID-19 cure
ClinicalTrials.gov Identifier: NCT04421391
So Amazon Prime delivers a carb for my pressure washer.
Nice touch, Amazon. Emails a pic to verify delivery.
Driver PO'd; rethinking relationship with Amazon.
I'm beginning to think TLSS is better off without Amazon, at least with the discounted rates offered. John Merc's diversification strategy (Business 101) - Walmart+ - is the right idea.
https://www.businessinsider.com/amazon-truckers-low-rates-no-work-2019-6
"As long as you pay me market value, I'm good. I don't need astronomical numbers," Leckliter told Business Insider. "But they were lower than that and it was considerable."
According to a recent report from FreightWaves, Amazon's rates in the spot market — which is when retailers and manufacturers buy trucking capacity as they need it, rather than through a contract — are on average 18.4% lower than rates posted on DAT, one of the largest broker boards in the country.
"It was just not gonna work for me," Leckliter said. "It was not as profitable as working with a different broker who is going to pay market value."
https://www.freightwaves.com/news/freightwaves-research-amazons-new-online-freight-platform-is-viewed-negatively-by-8-of-10-carriers-and-freight-brokers
FreightWaves research: Amazon’s new online freight platform is viewed negatively by 8 of 10 carriers and freight brokers
Miro spinning heads again; Howdy Doody, Linda Blair (Exorcist), countless shareholders. If he wanted a shell, why would he buy a company that's $1.8 million dollars in debt?
When a company wants to buy a shell, it could pay anywhere between $100,000 to $1,000,000 for the entity, with the price increasing if the shell is perceived to be an unusually clean one, with minimal likelihood of undocumented liabilities.
Feels like news soon, but who knows. Complete confidence in John Merc & Co.; doing it right, not wham bam, thank you shareholders, unlike too many OTC companies.
Walmart to build $220M distribution center - 3 million-square-foot distribution center on 250 acres at the State Ports Authority’s (SC) industrial campus.
Love ya Amazon, but here comes Walmart+.
... will supply several regional distribution centers, supporting approximately 850 Walmart stores and Sam’s Clubs across South Carolina and beyond.
Splitting a barrel of Guinness with cashclan? TLSS? No split in sight. Do you think an insider such as Puritan Partners LLC >10% Owner with "10,800,000 Shares Directly Owned" would hang around for a R/S?
Tiger Money, thanks for the detailed review of QuadraMune.
Hope you keep 'em coming.
Inflammation results interesting. If anybody knows any sports trainers, ... opinions welcome.
That's ridiculous. Flintstone vitamins have never been in a clinical trial.
In a perfect world, COVID-19 would have marker(s) - their own little, unique tags (SKU's) - and the immune system would zoom in and destroy them. Apparently the immune system is going into overdrive with deadly repercussions.
Humbling to be an amateur virologist but at least we're trying to wrap our heads around this.
Thanks for the articles. Similar: Coronavirus victim autopsies show ‘dramatic’ blood clots throughout body, doctor says
https://www.nydailynews.com/coronavirus/ny-coronavirus-blood-clots-throughout-body-doctor-20200711-mqlgvgwynfhnpoocr3yg5nvrfy-story.html
To research:
Rapkiewicz’s study, which was published in The Lancet journal EClinicalMedicine, found that clotting was “a prominent feature in multiple organs” suggesting that it “plays a role very early in the disease process.”
Cents, since you're drilling down on Covid-19 as many of us are, very interesting, sobering interview/article with Dr. Larry Brilliant.
The Doctor Who Helped Defeat Smallpox Explains What's Coming
If I would not be excommunicated from the world of science, I would call this an evil virus, but I can’t do that because I can’t impugn motives to it.
https://www.wired.com/story/larry-brilliant-on-how-well-are-we-fighting-covid-19/
C'mon, there's nothing that compels them to flip for chump change, relatively speaking. They're risk takers who have obviously analyzed the bejesus out of risk and have demonstrated belief in their own DD.