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True. Though newbies don’t know.
I’m interested in seeing this kind of technology taken as far as it might be useful.
He’s setting up any delay as a fear run.
If they wanted to develop it in the manner you suggest, they’d invest. Your scenario is fake.
Nonsense.
Further validates the treatment. It’s all net.
So sorry to hear about the loss of his father. Prayers and all the best for him and his family and for his father.
That's rich coming from you Nemesis. :)
Well, if you’re a little crazy and already naked yourself, I could see how you’d have problems making a distinction such as that…
And you keep pretending to claim you’re a long too while you bashed every day… but of course your opinions suggesting otherwise are never far from such protestations… “but I’m a long! Don’t criticize me just because I don’t want to join a cult…”.
I think we all know how ridiculous not only your protestations are, but also your entire approach. Broad brush, no one can defend whatever you claim is indefensible…
But more importantly, just sell and move on. Why waste everyone’s time with your drivel? Invest in something you like… or is your investment a short position. If so, you owe it to everyone to be transparent and disclose rather than claiming the opposite, obviously untruthful notion, that you’re just a long like everyone else here… except you hate the company, the management and believe it’s going to fail, but then you hold on… and that would be idiotic. But what’s a short without claiming to do idiotic things just so he doesn’t have to disclose motive?
Actually, if Alzheimer’s is caused by bacteria, I see no reason why, someday, a dendritic cell vaccine might not be a possible way to help address parts of it… thanks for the inspiration. I had not been thinking of a cure to Alzheimer’s… very insightful!
https://www.nature.com/articles/s12276-023-01146-2#:~:text=They%20found%20that%20AD%20patients,Eubacterium%20rectale%20compared%20to%20controls
As with many diseases, Alzheimer’s is very complicated, so whatever the treatment, it might involve a range of different therapies, as here, probably not a silver bullet candidate. But still… great idea!
LOL.
I do not believe anyone has said it is going to be worth more than the U.S. economy, but have you seen how much they want to spend on scaling AI capacity? Those AI people are talking about the potential to scale GDP like never before… so if that happened, it would be nice if we also caught the ride.
You actually have to read what I wrote to comment intelligently. Got it?
They made a regulatory choice that this was an easier and better route. You happen to not be in the room with them and their advisors when that decision was made. Neither was I. But the reality is, it’s a completely reasonable way to proceed and doing it in order, rather than simultaneously is an easier bite, for numerous reasons that come to mind. But I’m not here to explain to you. I’m just an investor and observer.
Yes, I disagree with you on just about everything. But I also do not think they are working with MHRA because they believe the FDA is corrupt. I believe they are doing so because the MHRA is smaller and is anxious to show it is forward thinking and that is beneficial overall if they get a beneficial response there with all the other regulators, EU and Canada as well.
But just because people post garbage in chat everyday about their government, that doesn’t make it “true”. People s/it tall constantly on the internet and that reflects their basic assumptions, often their political bent, rarely is it deeply factual. And your post is currently true of the UK as well on Avastin. The UK is not some holy grail of a destination. They have made GBM a major national priority. That’s also helpful. But all that is circumstantially helpful, not a special sign of virtuosity that is absent elsewhere. Companies make decisions all the time to access special programs or opportunities. Some have even focused on Japan, but that did not make Japan “not corrupt” and everyone else corrupt. No. They just had a special program some cellular therapy companies thought, some mistakenly, might speed their access up.
You’re kind of silly here. No one said that either. You can read what I said without concluding that is what I said. I presume you just want to be argumentative. That’s your fun to have. I’m not interested.
You’re going in all kinds of false directions that have absolutely nothing to do with anything I said and no, I did not support this bizarre notion of “franchises”.
As for equity, that is more straightforward so long as the company can develop the drug with as many potential partners and alternative drugs as possible.
It’s pointless to chat further as you’re taking this in all kinds of directions that have absolutely nothing to do with your personal choices or with any suggestion about you personally. It’s not all about you, it is about the dynamics of these stocks and those generally who invest.
No one is saying anything like that. And yes, everyone wants the right deal. For most, that doesn’t give everything away up front so a few people who want their pop can move on. THAT would be a charity for big pharma and that’s not why any of us are here.
You're sensitive. It's just the reality. That's the reality. Most want this to soar to infinity asap. Regardless of their desire to sell or whatever. My point is rather that upon achieving commercialization, the more thoughtful and better route to develop the platform doesn't entail selling it all out to the first buyer, necessarily. Chill out.
I agree on the franchise deals. I don’t agree on exclusivity. The exclusivity for any BP will come with regard to doing combinations with their drug, but not for a particular cancer, as that could delay promising development with other drugs if that company’s drug doesn’t turn out to be a phenomenal combination. But just don’t see them giving a total exclusive, say, for some cancer and Merck, for instance, just because they have Keytruda, and no trial validating that the combination is the best possible option for patients. This in the point of owning your own IP. If they sign such deals, there is a good likelihood that those companies and others will either develop competing DC technology with other players or they will simply wait out expiration of certain patents.
I do think there will be lucrative opportunities to work with other companies, but surrendering exclusivity deals up front seems like the worst possible move for developing DCVax to its full potential in the long-run. A lot of people are looking forward to cashing out as soon as they can, and I understand. It has been really a very long and challenging ride for those of us who do not actively trade. But I think they need to focus on developing the platform broadly. I do agree that this franchise notion sounds like people speculating on interesting concepts that in practice are highly unlikely to be relevant.
But clearly they can give exclusive to Merck, for instance, for combinations with Keytruda while reserving their own rights to develop trials, real world “trials” and marketing with Keytruda for the company as well, just in case Merck turns out to be slow on moving forward. But I think Merck’s patent situation could be highly motivating depending on the results from the UCLA trial, which I believe will be very good.
It belongs to NWBO. No ambiguity. Combinations will likely be under the combination patent which included NWBO and UCLA and is filed pursuant to their original agreement for development of new technologies sprouting from UCLA’s work. But not ambiguous at all, regardless of what some of the shorts would want to say.
They are not inventing new vaccines every time the inject a patient in an approved clinical trial. Let’s not be ridiculous even if some shorts put forth such ridiculous notions daily.
I don’t agree. Once available, many will know about it and all those doctors that signed the paper and their clinical centers, which are key research centers in competition with others that, if they do not offer it, will be perceived as behind.
Not necessarily. Small bios at this stage pending approval often get squeezed. That it happen d during a period when interest rates rose precipitously and there were other sectors capturing a large amount of investment capital, AI, it’s not entirely surprising. But, there are clearly people piling on and like kids at a playground trying to vandalize and break the equipment for sport, we face a daily barrage of such persons throwing everything they have at squeezing this down as much as possible while they trade or own other stocks and swing trade in and out of this based on news and their own induced swings.
Not necessarily. The fact is shorts and funds attack firms that have a large and tightly holding group of investors because they want a deal. They squeeze to put pressure on those people to sign deals at the price point they want. The fact is, not selling out cheap is a virtue, not a vice.
No worries. :)
Don’t waste your time. You’re not credible and no, I’m not going to waste my time rebutting your garbage when I have the JAMA article, Nature article, UPenn article and others saying credible things that are far more reasonable and written by experts. You’re just a nuisance poster anonymously posting garbage on this bulletin board to manipulate the share price. Not credible, won’t disclose your position, just lying day after day, and then you expect people to take you seriously. Give us all a break and fine somewhere else to post this noise.
Absolutely right HB4CT! I would not mean to slander innocent creatures, but the reality is, in the wrong place, they do do a lot of damage and it is good not to ignore them when you have them. But you’re right. God’s creatures, great and small, are not really comparable to these artificial trolls we face.
I’m usually the one calling for you to do it, except there is one key difference… everything I mentioned is referenced and cited to up and down this page and they are the baseline studies for this drug. So pretending 1) you’re an expert here; and then 2) complaining, where are the links, is completely and as utterly disingenuous as you are and can be every day, as well as ludicrously singleminded in your efforts to basically be anti-science while pretending that’s all you really want…
You must’ve studied at the Tobacco Institute. Thank you for smoking..
1) all trials have exclusion factors, the notion that this set of exclusion factors are unique is ridiculous;
2) the phase 3 shows immense survival results across the board and when factoring in the sickest in the trial, yes, you still get a survival benefit that is substantial and no other trial of its sort has had any results even close for decades;
3) once you add in an adjuvant stimulant for the immune system you get even crazier good results broadly and across tumor types, and including recurrent patients.
4) it really only takes a guy with Google to post garbage on chat boards trying to undermine the work of the top minds in the field for decades, but Google and some rhetorical nonsense that ignores everything to claim to paint a negative picture, doesn’t make the criticisms valid.
5) you concede this good percentage of patients living 5 years plus and we know many who have lived far in excess and for those patients that was not necessarily the end, just the end of the study, and try to paint it in a “bad light”, which is what makes what you post not just ridiculous but ludicrous. Only people who have skin in the game either as shorts or competitors or jealous researchers would spend so much time throwing sand in everyone else’s eyes. No one legitimately otherwise has such an interest in being this annoyingly a one-note Johnny…
That plus when you don’t see them, it’s like letting the termites eat your home and putting down carpets so you don’t have to see them. They are destroying the company’s narrative and one is blind to it. But I get why so many wish not to see them or to bother with them. It’s vexatious and ruins perfectly good moments otherwise. And if one is truly patient, not worrying about such activity is definitely the way to go.
True and very good answer. I can’t argue with that. I want them to speed up too. I do believe it will get out more once it is approved for GBM, but the nature of things is that medicine is conservative and money opens the doors. It’s real and disappointing.
But also the reality is that the trials are not necessary to get this made available and even covered once they have real world data. So those trials may be a fake-out in the new regulatory environment, in terms of really making it available. But marketing and investment in expanding production, and investment in doing combination validation trials (rather than old fashioned clinical trials) to show the medical establishment what is now possible… those things are absolutely valuable for expediting.
I am excited for this platform and believe we will see great things ahead, despite the vicissitudes of the markets and the play of the swing traders in the stock because it is a thinly traded penny stock.
Thanks ExT. Just an early morning rant when u saw what the board offered on first view.
He is an anonymous poster like us all, but he refuses to identify his position and it makes no sense that he spends so much time and energy here, doing what he does as a random bystander. Same with all of them. The reality is, they count on newbies to read their garbage and see a message board choked with negative posts and to move on without ever learning the full story here, and that explains their desperation, because of what they said was true, the would not need to so relentlessly do what they do.
These guys think it’s not obvious if they create new ID’s to maintain the fiction that there is this huge crowd against this company. It’s a distinct set of individuals, traders and funds…
Thanks Vator! I can’t wait to hear what they report.
Thanks so much Papa9x! I hope you’re well!
As I said vague and also not data from this trial and proves the survival rate is spectacular. Look, top doctors who are treating these patients daily say so. Your fake opinions are worthless.
No sir. And that is a vague rebuttal. I gave facts and studies, you gave spin.
Very few patients to zero line that long without recurrence and don’t waste your time answering for “other people”…
The treatment is currently outstanding. And utilizes natural immune responses that have been shown in side studies by UCLA to have the ability to be enhanced with an adjuvant. It is normal for yes, vaccines to be further studied with the addition of adjuvants and no, yes, the MHRA just like the FDA will look at an amazing Phase 3 AND the other side trial data as well to see what is actually happening. They will not be reading your posts here, thankfully.
Are you kidding? Patients are living 20+ years without recurrence. In the phase 3 with the drug alone it doubled patients living beyond 5 years and that just the end of the study. Doesn’t mean they were “dead”.
With poly-iclc as an adjuvant stimulant you had one arm 100% of the patients are out beyond 9 years 3/4ths out 10 and again, that’s just when the study ended, not when they DIED.
In another arm, approximately 50-% were out beyond 5 years and again, that’s because that is when they stopped counting months survival to PRINT a study.
At Brown University, they said t is very rare to have patients to live beyond expectations but they had a number of patients out 12 years.
University of Pennsylvania did a side study related to a new method of scanning and confirmed the survival improvements. For most cancers, a large study only shows a short improvement because you have all of the patients, and while many improve, some do not and some improve a lot. To say 3 months only for a GBM study using only DCVax-L when no other systemic treatment in decades has done anything like it is ridiculous.
You clearly have no clue what you’re talking about.