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FFS,
If we assume for a minute that your theory is correct and a word got out that RI is doomed. Why the selling stopped then? Why the stock doesn't continue to hit new lows as the rumor spreads out and more people become aware of what's coming?
The answer is nobody knows anything. Fear of unknown and lock of knowledge drove the stock price down. From what I can tell majority of investors see a chance of RI success as 50/50. I see it at ~85%. Therefore I remain invested and see this binary gamble as a risk worth taking.
The resolution is approaching fast. We are weeks if not days away from it.
I also believe patients have the right to access their medical records. Amarin can't stop that.
FFS,
Comparing multi-billion Novartis with big product portfolio (mostly in cancer) and pipeline to Amarin is like comparing apples to oranges on a basis that they are both fruits.
FFS,
I would disagree with your statement "we live in a messed up world where nobody cares about integrity or honesty". Many people do care about those qualities.
Back to Amarin. At this point only very few people at DMC know how RI performed up until second interim analysis. I strongly doubt they leaked any info for two main reasons: First, they know any leak will be quickly circled back to them and they will face harsh penalties that likely include jail time, ruined careers and reputation, financial penalties, etc. I'm also sure all of this was made very clear to them when they signed non-disclosure and confidentiality agreements. Second, if they did leak info after 2nd IA a year ago, the sell off would started much earlier and we wouldn't have January rally.
Now here are three main reasons for the current pps:
Dilution and insiders selling.
Funds portfolio adjustment to reduce risk exposure.
Fish oil Meta Analysis.
None of the above changes anything about EPA sience and RI chances of success. IMO recent sell off created a unique opportunity to accumulate shares at nice discount so close to a binary event.
Now to be clear although it's possible I'm not betting on some crazy efficacy results but IMO results will be substantial enough to generate huge interest and demand for AMRN stock with imminent BO in the end.
That sounds creepy now.
JL,
This is getting a bit ridiculous so let me clarify a few things.
I have never stated that patients figuring out they are in placibo arm and taking action was my major concern. However, it's a possibility that should not be ignored.
Regarding V smell when you break a capsule and let it spoil. I'll leave it up to the board. I personally was able to pick up a distinct smell. I believe someone on this board also mentioned just recently that he noticed a district smell in V bottle because one capsule broke while V was delivered via mail.
I believe what JT was referring to when he discussed difference between V and placibo was bottles, labels, and the way capsules look. He mentioned nothing about V smell if you let it spoil.
Regarding blood work. While my private insurance coverage gets worse and more expensive every year and I had several different ones (MetLife, Blue Cross Blue Shield, Cigna) in the past 18 years, it always allows free annual blood test.
In order to get it. I fill out a form online that lists some random physician who I never met in my life. I print it out and take it to my local LabCorp. Btw in your fact check exercise you were calling Quest...
I have never had appointment with a cardiologist. The last time I had physician appointment was many years ago when I was accepted to grad school and needed immunization paperwork from my physician. But I do my blood work every year through my insurance.
I hope this helps to clarify my previous statements and put an end to this discussion.
Agree 100%.
There's not enough data available to make a precise estimate. The range is too wide. My guestimate is based on Jelis results and Jelis differences with RI (inclusion criteria, lower EPA doze, higher statin doze, lower LDL, etc) and all other trials and data available. The recent interview with Dr. Budoff only reinforced my view on upcoming RI results.
There is a different between educated guess and lottery pick. Don't you think so?
It wasn't criticism, just observations. Btw I don't think JL needs a puppet to jump in his defense on every occasion.
Where you pulled that 66 year old bs from?
The trial protocol states 45 or older.
https://clinicaltrials.gov/ct2/show/NCT01492361
Next time do some DD before jumping in with bs arguments.
Marzan,
Really? I disagree and I think Amarin would disagree too since they referenced all those trials with other Trigs lowering drugs in their presentations.
While I would agree with you that V is the best option. I disagree that nothing else works. Maybe not as good with bad side effects, but other meds and supplements can lower trigs too.
JL,
You should stop labeling people you disagree with. That's not nice.
Yes, you can easily distinguish mineral oil from fish oil EPA. Just break one of your V capsules and leave it on the countertop for a day. I can guarantee you, it won't smell like mineral oil. But of course you can also run expensive lab test as you suggested.
I was able to get free annual blood test with every insurance I had in the past 18 years. Just print a page and walk in to your local LabCorp. No appointment needed.
The argument was about placibo arm not V arm. So EPA/AA ratio won't necessarily help in determining if patients in placibo arm are playing by the rules.
Perhaps you can learn from HDG. He always replies with facts, not with highly opinionated statements.
You forgot to list years. lol
OmegaVia EPA 500 will make a difference.
Eliminating red meat and processed food will change things too.
At some point every in Amarin history happened prior to ADCOM. You need to be specific.
Raf,
I think many but not all signed up for the trial to get a free treatment. And just like Kiwi some will go one step farther which is breaking a capsule to find out if they are in V arm. If they are, I'm sure they will continue to take V every day as they suppose to. But if they realize that they ended up in placibo arm, they are likely to stop taking pills. That is fine with me as it will be same scenario as in Jelis. However, if they are concerned about their trigs and start do something about it like taking other meds, fish oil supplements, or even change their diet and start exercising. That's what concerns me.
I don't think it will be a major issue in RI, but it's certainly possible and potential might skew the final results in a wrong direction.
Maybe not a wrong question but a wrong person.
Again I doubt Amarin can prohibit sick patients from taking a simple blood test outside of the trial for whatever purposes.
If Kiwi was selected for the trial, he would be breaking and melting capsules the day he got his hands on them. I'm sure Kiwi is not the only one.
Amarin did not hire reps prior to ADCOM. Amarin hired them after V approval and had to let them go after ADCOM ambush to preserve cash.
I don't think there's a provision in the trial protocol prohibiting patients from taking a blood test.
Now if you were a patient. Wouldn't you be interested in finding out if you are taking for years a real drug or mineral oil. Especially since it's so easy to do. Just break a capsule.
Now if you do a free blood test (that doesn't even need to go to your doctor unless you specify so) and see your trigs are high. A blood test report will definitely highlight all abnormal readings.
So if you were a patient what would you do?
They don't get to see blood test results through the trial. But nothing stops them from taking a free annual blood test through their insurances.
Kiwi,
First, I'm not sure if that correlation (100Tgs drop = 14%-16% RRR) is accurate.
Second, this is assuming the Tgs in placibo arm won't change. IMO there's a good chance the mean Tgs in placibo arm might slightly increase over time as people aren't taking any additional meds or supplements to lower them. They are taking pills filled with mineral oil.
Third, you are ignoring inflammation benefits of V in addition to Tgs lowering properties.
Hiring process takes time. Sometimes several months. RI results will be out before they hire a single person.
Come on raf!
That's easy.
More statin > lower LDL > RI is doomed.
I hope a beefed-up dude with a long ... doesn't emerge from that bathroom to teach us all one last lesson.
JT already started AMRN won't PR data lock. The 4 day clock will start ticking when JT gets the results.
You obviously have no idea on how things work. In addition to base salary you need to account for bonuses and overheads that are substantial.
I ordered yesterday from Amazon and it was shipped yesterday.
Looks like it.
Good info. Thanks for sharing. I'll try PharmaEPA next time.
It's nice to see the company is preparing for success, but not more than that. I'm sure they will schedule interviews and even identify good candidates, but they won't make offers until they know RI results. Within a month IMO.
I remember a company (AVEO) that hired salespeople to sell their new drug that was about to be approved. They even bought cars for those salespeople. But eventually failed to secure FDA approval.
My major concern with taking OmegaVia is oxidation. I have no idea if it was stored property before it got to me. It's 90 degrees out and the OmegaVia I just bought will be sitting in UPS tracks for 2 days. I'm sure it might do some damage.
The reason I'm concerned with oxidation is because I believe it linked to prostate cancer. I don't care about healthy heart if I get a prostate cancer instead. lol
Regarding the price. If you have insurance and a prescription for V, the 3 months supply will cost you $9 with a coupon. Hard to beat that.
My trigs dropped to 84. I doubt docs will prescribe me V and insurance will cover. So OmegaVia EPA 500 is my only alternative.
Just placed an order of OmegaVia EPA 500 via Amazon prime. Delivery scheduled for Thursday.
AMRN call will make him shine.
JT discussed the process in Q2 ER CC.
"Some investors have theorized that someone must know the results. No. Nobody yet knows the results. As a reminder, patients and clinical sites do not know whether each patient is administered placebo or Vascepa. The capsules are not marked and indistinguishable and lab tests for the study are performed at a centralized facility and not reported back to the clinical sites. Such lab also doesn't know which patients are on Vascepa and which patients are on placebo."
So if a patient decides to take a lab test outside of the trial. Let's say through his insurance wellness program (once a year free lab test). He can certainly do that. And if he sees something he doesn't like, something like abnormally high trigs, he can certainly do something about it. Like change his diet, start exercising, or perhaps start taking OmegaVia EPA 500.
GEMP just got a nice 24% haircut after hours. FDA wants more safety data.
Or order Epadel from Japan where it's sold OTC.
Meta Analysis has always been a secondary research that can be used to support primary research findings.
No graduate thesis or PhD work would ever pass if it's based on Meta analysis only or as a primary research method.
He took many millions off the table right after V approval. This on top of his nice garanteed salary. I'm sure his wife is not complaining.