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If everybody has a price….and I don't believe everybody does, but if everybody….you know; with "outstanding" results, this should be the most expensive acquisition in history.
It's a choice.
One could argue AF did his damndest to make her choose the road more travelled (i.e. sell the company -- as you suggest she might) and he also kept the price low, making it harder for her to turn down a reasonable offer; but I think she knows who she would add to her ship once they get the results they need. So I do not think selling out is in the bag. If the results come out as strong as some of us anticipate, I think 2 of those companies you speak about may have to merge and/or spin-off in order to afford NWBO. Linda also worked hard for the international infrastructure that now exists.
And I think perhaps a very possible text to text exists for similar mechanics in an accelerated approval situation under the new FDASIA guidance -- even if you completely put aside the international basis that existed in the ELI study.
Hi Flyboy.
IMHO, if any "code was cracked", credit goes to LongUSA and his earlier comments on AA -- particularly as it relates to FDASIA, and Evaluate -- for this article (See Message #11034 and #11116) and numerous other amazingly helpful links and highlights.
Well I purchased and read http://dij.sagepub.com/content/33/3/869.abstract
(All credit for finding it goes to Evaluate!)
Here is the relevant part of the abstract:
Guidelines for conducting interim analyses in clinical trials sponsored by the pharmaceutical industry have been recently published (1). Usually, the clinical trial will terminate or the design will change when the interim analysis shows outstanding efficacy results. There are situations, however, where the interim analysis shows outstanding efficacy results and yet the study continues, for example, when regulatory requirements in the United States and Europe differ concerning study duration.
That is an interesting point. Staccani, as you become wealthier, your ability to help these companies early without realizing an immediate (or any) profit will become something you will actually enjoy pursuing. The trick, as always, is picking the right ones. I must give a shout out to all the very early investors in NWBO. Thanks, you may be partially responsible for getting the world closer to a cure!
Terry,
I'm not certain Dolphins can carry rabies, but the 2007 NIH link you sent me on a rabies peptide smuggling in therapeutic material across the blood brain barrier has me foaming at the mouth. Is that good?
It is times like this that I wish my talents rested more towards the likes of Gary Larson exemplified by his Far Side Cartoons.
All the mice in the control groups died from JEV infection; in contrast, 80 percent of the mice that got the antiviral siRNA linked to the rabies peptide survived. These experiments demonstrate how the rabies peptide can be used to deliver antiviral siRNA across the blood-brain barrier and into nerve cells in the brain. Once inside brain nerve cells, the antiviral siRNA can silence key viral genes to control the infection. Furthermore, repeated administration of the RNA interference therapy did not trigger inflammation or antibodies to the peptide.
Currently, doctors use various methods to deliver therapeutic drugs directly into the brain. These methods involve invasive procedures that result in only localized delivery around the site of injection. The new research provides a safe and non-invasive method for delivering therapeutic molecules across the blood-brain barrier. It has the potential to be applied to the treatment of a variety of brain infections and diseases. The researchers are now trying to improve the efficacy of this delivery system and to make a stable form of siRNA that might yield even better results.
Article: "Transvascular delivery of small interfering RNA to the central nervous system," by N Manjunath et al. Nature DOI: 10.1038/nature05901 (2007
The thought occurs that temozolomide is a popular choice for treating brain cancer with radiotherapy, assuming it is, because of its low toxity but that something else may interfere as in the above case. Terry
Good Points. I'll try to distill the entire article for you later today.
Thanks for your take on it. Have a good vacation.
Hey LTT, did you read the "outstanding" article evaluate cited?
Here it is again.
http://dij.sagepub.com/content/33/3/869.abstract
I'd be interested in your input.
Have a nice weekend.
Have a good weekend.
One wonders. The phrase hidden in plain sight comes to mind.
Some other interesting info in there also. Ie, the statement about the intent to file for fast-track for DCVax-L. I don't remember that. Nice to see. Dok citing Evaluate
Hi Hodge.
Sorry for all my off-beat posts lately. I appointed myself comic relief through ASCO. I still fully believe in this technology. My experience is that people think better when they laugh a few times a day. Otherwise, the pre-ASCO stress starts to shut down circulation to the brain and extremities. This results in fear based decisions. Of course, all stocks are risky, but I think people make better decisions when they are relaxed.
I felt I needed to say that in order to place my silliness in context.
Flip
I
sometimes
wonder
why
you
type
on
the
left
hand
side
of
the
page.
I
sense
you
are
going
to
the
Hamptons
or
perhaps
Tahiti
and
hoping
you
will
not
have
too
many
imported
beers
when
a
PR
forces
you
to
respond.
:)
Hi Holly.
Here is a reminder of Les Goldman's latest email. The highlights are mine.
Les's email
May 15, 2014 NASDAQ:NWBO
Dear Austin,
In the ramp-up to the big annual ASCO conference 2 weeks from now, today we are beginning to present some early initial data from our ongoing DCVax-Direct Phase I/II clinical trial for all types of inoperable solid tumors.
Today's information provides a case study of a sarcoma patient with a large tumor mass plus multiple tumors metastasized to the lungs, who received 4 injections of DCVax-Direct over approximately 2 months, and saw the injected tumor collapse and some regression (shrinkage) of a metastasized tumor.
Such early indications in such a difficult and advanced stage of metastatic cancer are encouraging. Between now and ASCO we will be providing further updates, including other specific case information and overall information from the trial to date.
This is just a first glimpse of data, and it is still quite early, but the prospects are exciting.
And as we like to say, stay tuned.
Sincerely,
Leslie J. Goldman
Senior Vice President for Business Development
Let me see if I can sum up the efforts to answer that question thus far.
E = mc squared x Queen's Bishop to Knights in shining armor + Forescore and seven years ago / Time is Flowing Like a River - 2 cups of flour add four eggs beat well + The average number of Joe Biden Gaffes on any given Sunday = I acknowledge my limitations.
Sorry, I know you were looking for a serious answer.
Ah, but what uncut mineral hides in the rough, improves via "skilled artisans" and shines brighter by phase?"
Zen and the Art of Motorcycle Maintenance Quotes
It seems like patience and consequently Zen mastery seem to be a frequent theme or intimation over the past few days, I thought these quotes might be timely.
Zen and the Art of Motorcycle Maintenance Quotes
By Robert M. Persig
“The place to improve the world is first in one's own heart and head and hands, and then work outward from there.”
“When one person suffers from a delusion, it is called insanity. When many people suffer from a delusion it is called a Religion.”
“The truth knocks on the door and you say, "Go away, I'm looking for the truth," and so it goes away. Puzzling.”
“You look at where you're going and where you are and it never makes sense, but then you look back at where you've been and a pattern seems to emerge.”
“We’re in such a hurry most of the time we never get much chance to talk. The result is a kind of endless day-to-day shallowness, a monotony that leaves a person wondering years later where all the time went and sorry that it’s all gone. ”
“Is it hard?'
Not if you have the right attitudes. Its having the right attitudes thats hard.”
“Sometimes it's a little better to travel than to arrive”
“You are never dedicated to something you have complete confidence in. No one is fanatically shouting that the sun is going to rise tomorrow. They know it's going to rise tomorrow. When people are fanatically dedicated to political or religious faiths or any other kinds of dogmas or goals, it's always because these dogmas or goals are in doubt.”
“For every fact there is an infinity of hypotheses. ”
“If someone's ungrateful and you tell him he's ungrateful, okay, you've called him a name. You haven't solved anything.”
“In a car you're always in a compartment, and because you're used to it you don't realize that through that car window everything you see is just more TV. You're a passive observer and it is all moving by you boringly in a frame.
On a cycle the frame is gone. You're completely in contact with it all. You're in the scene, not just watching it anymore, and the sense of presence is overwhelming.”
“The law of gravity and gravity itself did not exist before Isaac Newton." ...and what that means is that that law of gravity exists nowhere except in people's heads! It 's a ghost!"
Mind has no matter or energy but they can't escape its predominance over everything they do. Logic exists in the mind. numbers exist only in the mind. I don't get upset when scientists say that ghosts exist in the mind. it's that only that gets me. science is only in your mind too, it's just that that doesn't make it bad. or ghosts either."
Laws of nature are human inventions, like ghosts. Law of logic, of mathematics are also human inventions, like ghosts."
...we see what we see because these ghosts show it to us, ghosts of Moses and Christ and the Buddha, and Plato, and Descartes, and Rousseau and Jefferson and Lincoln, on and on and on. Isaac Newton is a very good ghost. One of the best. Your common sense is nothing more than the voices of thousands and thousands of these ghosts from the past.”
“We take a handful of sand from the endless landscape of awareness around us and call that handful of sand the world.”
“The test of the machine is the satisfaction it gives you. There isn't any other test. If the machine produces tranquility it's right. If it disturbs you it's wrong until either the machine or your mind is changed.”
“The Buddha, the Godhead, resides quite as comfortably in the circuits of a digital computer or the gears of a cycle transmission as he does at the top of the mountain, or in the petals of a flower. To think otherwise is to demean the Buddha - which is to demean oneself.”
“Peace of mind produces right values, right values produce right thoughts. Right thoughts produce right actions and right actions produce work which will be a material reflection for others to see of the serenity at the center of it all.”
“But to tear down a factory or to revolt against a government or to avoid repair of a motorcycle because it is a system is to attack effects rather than causes; and as long as the attack is upon effects only, no change is possible. The true system, the real system, is our present construction of systematic thought itself, rationality itself, and if a factory is torn down but the rationality which produced it is left standing, then that rationality will simply produce another factory. If a revolution destroys a systematic government, but the systematic patterns of thought that produced that government are left intact, then those patterns will repeat themselves in the succeeding government. There’s so much talk about the system. And so little understanding.”
“The real cycle you're working on is a cycle called yourself.”
“…the doctrinal differences between Hinduism and Buddhism and Taoism are not anywhere near as important as doctrinal differences among Christianity and Islam and Judaism. Holy wars are not fought over them because verbalized statements about reality are never presumed to be reality itself.”
“The real purpose of the scientific method is to make sure nature hasn’t misled you into thinking you know something you actually don’t know.”
“It's the sides of the mountain which sustain life, not the top.”
“I argued that physical discomfort is important only when the mood is wrong. Then you fasten on to whatever thing is uncomfortable and call that the cause. But if the mood is right, then physical discomfort doesn't mean much.”
“The pencil is mightier than the pen.”
“(What makes his world so hard to see clearly is not its strangeness but its usualness). Familiarity can blind you too.”
“Who really can face the future? All you can do is project from the past, even when the past shows that such projections are often wrong. And who really can forget the past? What else is there to know?”
“When analytic thought, the knife, is applied to experience, something is always killed in the process.”
“Absence of Quality is the essence of squareness. ”
“We have artists with no scientific knowledge and scientists with no
artistic knowledge and both with no spiritual sense of gravity at all,
and the result is not just bad, it is ghastly.”
“And what is good, Phaedrus,
And what is not good—Need we ask anyone to tell us these things?”
“Other people can talk about how to expand the destiny of mankind. I just want to talk about how to fix a motorcycle. I think that what I have to say has more lasting value.”
Hi Dok, I agree with your caveats and other thoughts. I highlighted them in bold below, just to re-emphasize -- plus I added a couple additional thoughts.
Yeah, that prednisone is magic isn't it! Seems to be the treatment for many symptoms and even the cure for many symptoms in a broad range including auto-immune problems. I know two people that got treated successfully with prednisone, one was for a rare auto-immune disorder called Giant Cell Arteritis. But be prepared to change personalities on prednisone. It will make you a bull. I don't mean sexually, I just mean super aggressive in general. So you would want to warn anybody around you first.
And I would certainly agree that there is no way anybody should mess with something that powerful without monitoring by an MD.
But I hope you are agreeing that just getting out of that physical environment that is so rich in possible antigen culprits would be a good test that should be on it's own for a while before adding any other meds or supplements.
I was thinking more along the lines of a temporary medically prescribed prednisone pack, if die-off symptoms start increasing (Benadryl would not likely be enough). Again, only under close monitoring by a physician. I guess what I am saying is that SwampRabbit should be prepared for a temporary set-back and not give up if he makes a commitment to try a long trip to some drier climate.
And when you say good long trip, I think we are talking about at least a couple months. If it is mold, there may be a die-off period (perhaps weeks), that can release even more toxins and also cause more allergic responses during the mold death throes .
So if SwampRabbit tries this, it might be most effective if monitored and perhaps coordinated by an expert. There may be some supplemental treatment that will mitigate symptoms during the transition and/or speed/improve recovery.
Be well my friend. We will all keep a sharp eye out for possible therapies.
-- Flip.
You think that's funny….
http://www.pbs.org/wgbh/pages/frontline/united-states-of-secrets/#part-one---the-program
http://www.pbs.org/wgbh/pages/frontline/united-states-of-secrets/#part-two---privacy-lost
Original air dates: May 13, May 20 2014
To Herror is uman.
"rhum."
Really?
Does it taste as good with an h? Good thing I'm drinking Campagne right now:)
Spot on!
Here's the issue I see with that tactic. With only one or two P.R.'s, the ability for a small group of tyrannical bashers with large microphones to spin and dismiss excellent findings is quite likely -- at least for a given period of time. Moreover, if you want Brian Williams, Charlie Rose and Gwen Ifill to hang out in your booth, you do not keep it a secret until the event.
I know my posts of late are less cerebral, but we must get ready to rumble!!!
Phase III is not going to blow up. It might be in great shape, or there might be a delay. --Dok
Scotty: "Captain, the shields are down to 18%, I don't think we can take another hit"
Captian Kirk: "Keep her together Scotty, I don't care if you have to use duct tape and bailing wire!"
Mr. Sulu: "Captian, F-stein is requesting our terms of surrender, shall I put him on screen."
Captain Kirk: "Tell him to stand-by."
Lieutenant Uhura: "F-Stein is firing more photon torpedoes."
Captain Kirk: "Evasive Maneuvers."
U.S.S Enterprise shakes from glancing blow.
Scotty: "Our shields are completely down!"
Mr. Sulu: "Captain?"
Captain Kirk: "Hold your fire, wait, wait, wait, zzzzzzz"
Lieutenant Uhura: "Captain?"
Captain Kirk: "zzzz, hmm what's that??? oh, wait….Now Mr. Spock!"
Spock uncloaks and with 6 rapid bursts, blasts TheStreet-ons.
Captain Kirk: "Put F-stein on screen Mr. Sulu."
F-Stein: "What, How, What??"
Mr. Spock: "I believe that's What, Where, When, Why, How and Whom."
Thanks, and to your question….I dunno.
I do know that AF is not our CEO, nor is he our Senior Vice President of Business Development. I pray that will remain the case.
because I don't think next week will bring us the status of L. That news will probably be still to come - after ASCO.
No doubt they need to follow through with their 5/15/14 P.R.. They cannot be ruled by AF's whims. Basically if they do this, NWBO might as well start paying him the CEO and Public Relation's salaries.
Chin up Afford, Les and company hold the cards, and timing is critical. IMHO.
New CNBC Numbers:
Institutions 50 Holders
Mutual Funds 17 Holders
Other Major Holders 24 Holders
Total: 91
What is a store halt? Are other stocks behaving the same way this morning?
Remember the abstract title that was submitted in early February?
Local and systemic antitumor effects of activated autologous dendritic cells for intratumoral injection.
I thought a cardboard box was the best toy until I saw that Lab with his bucket.
Thanks Sentiment, but I would not feel comfortable with that.