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I wonder how much bigger is the reach of this article compared to MD's article to date.
What do those on this board who have blamed Peregrine for botching the phase II trial say to this? Do they have more credibility than The Motley Fool?
"In midstage studies, bavituximab led to a statistically significant improvement in media overall survival to 11.7 months from 7.3 months. Of course, this was after some controversy with a third-party laboratory that botched the results and made Peregrine retract its initial top-line figures. Bavituximab is currently being studied in a late-stage study known as SUNRISE, with results expected in December 2016."
http://www.fool.com/investing/general/2015/06/13/1-drug-will-make-or-break-these-3-biotech-stocks.aspx
With all the crazy stuff that has been going on with this stock who knows. Maybe that will happen.
Why would anybody pay more like 1.45 after hours when they could have easily paid 1.40 or less for most of the day?
It could be just somebody selling the shares to himself to paint the tape. If they want the price to open higher on Monday they would be having these trades at 1.45 or higher so that they can sell at the open if it opens higher. If somebody has a short position and they wanted to cover their position they would trade shares to themselves lower. Maybe I will try that one day.
What is the reach of her message. How many potential patients are going to read the message and not enroll because of it. It has been posted so many times on this board that the phase II trial was sabotaged and we got into phase III with fast track and two early lookins which not every trial gets.
How many investors have been reached and convinced? Judging by the pps not enough to make a difference.
Without looking at pbmd if you want to compare it to pphm you have to look at how many years it took both companies to reach phase II. Probably pbmd got there a lot sooner than pphm without leaving behind and carrying along a long trail of frustrated investors who were strung along for many many years with unfulfilled and broken promises.
12/31/15- 9.52
12/31/16- 62.48
At least they moved on long time ago from Bavi is a placebo. Now one new mantra is PPHM picked CSM who botched the trial so PPHM botched the trial.
BP yes man who is a fraud must mean that BP is a fraud too.
What will they do now with the 5.4 billion that those 'agencies' were given to combat ebola? So all that fear mongering was then to get those 6 billions to those agencies? Will there be an accounting of how all that money is being or will be spent? no corruption here.
>EBOLA:
Roughly $5.4 billion is provided across several agencies to combat the spread of the disease in the United States and around the world. The amount is less than the $6 billion Obama requested.<
http://www.washingtonpost.com/blogs/post-politics/wp/2014/12/09/whats-in-the-spending-bill-we-skim-it-so-you-dont-have-to/
The last time there was a partnership in the works with Abbvie the pps shut up to 5. Some of that was probably because of the preliminary positive data that was walked back because of the sabotage.
We don't know how much each, the partnership that was in the works and the positive data announcements, affected the pps but if there is a partnership in the works now it sure ain't doing anything for the pps.
Besides trading on insider information is illegal and if the SEC finds out you're in trouble. Ask Martha Stewart. So maybe because of the sabotage and pending lawsuit trial against CSM everybody is afraid to trade on insider information this time since the eyes of the SEC and FDA could be on PPHM.
You wear out very fast then. You are talking to people on this board who saw their PPHM shares decline by 80% or more over ten or more years. Talk about being worn out. Without the five for one stock split the pps is really 31 cents. I started buying about ten or eleven years ago when the pps was about two pre-split which would be ten now after the five for one split.
Ride this thing for another ten years or so and watch the pps sink to about twenty cents. Would that wear anybody out?
What's supposed to happen by next Tuesday?
I hope your efforts are successful.
But we are up against a huge problem.
Big Pharma controls the news on....Big Pharma.
RFK Jr has joined the fight against Big Pharma on vaccines and despite having the Kennedy name, the science, and evidence on his side he basically has gotten close to nowhere.
Big Pharma has complete control over the CDC who in turn puts vaccines on a recommended list which 90% plus of our kids get in school get or they won't be able to attend public school. Julie Gerbeding who was the CDC director from 2002-2007 ends heading the vaccine division at Merck right after her CDC gig. Any chance that Big Pharma has a similar incestuous relationship with the FDA?
Read the next two links and weep. It only took me some superficial research to find that vaccines are responsible for autism and so many other childhood illnesses. There was almost no autism and very little ADD before 1986 when Big Pharma lobbied congress to create the vaccines injure compensation fund which made Big Pharma not liable for any vaccines damages. Big Pharma started to add a lot more vaccines that are given to kids without any liability and the need to advertising them. Big Pharma has now 300 vaccines in the pipeline. You can search that if you find it hard to believe.
http://www.reuters.com/article/2009/12/21/us-merck-gerberding-idUSTRE5BK2K520091221
http://time.com/3714242/candidate-to-lead-fda-has-close-ties-to-big-pharma/
>Kennedy: "The trillion dollar pharmaceutical industry is now the largest advertiser on television ,radio and newspaper pages, spending from $3 billion to $5.4 billion annually over the past decade. Pharmaceutical companies target network news divisions for their advertising buys partially for message control and partially for the demographic; TV news audiences tend to be older affluent pharmaceutical customers .A network news division president told me two weeks ago he would fire a newscaster or program host whose reporting or programming choice lost his station an advertising pharmaceutical company. >
The above quoted paragraph is close to the top but I think it's good to read the whole thing to see how corrupt Big Pharma and the CDC and politics are. Unfortunately, the FDA who is supposed to approve Bavi is probably not much better than the CDC.
http://www.ageofautism.com/2015/04/-rfk-jr-speaks-out-on-vaccine-mandates-safety-at-new-jersey-state-capital-in-trenton.html#more
RFK Jr video
could it have been because of someone at PPHM working for the enemy?
Mary Boyd can negotiate all the agreements she wants or wanted.
But if ES et al refuse to do any agreements then there will be no agreements. Can she force the BOD into a partnership if they don't want one?
There was a deal on the table that didn't
go through because of the sabotage.
So it shouldn't be too hard to think that there will be another deal.
The biggest reason the pps is so low is because PPHM has been around for too long. When you are the new kid on the block you are going to fly on a mere promise. If that promise doesn't come to fruition (did I steal a line from SK?)the pps will tank. And that what has happened to PPHM more than once. Cotara, Bavi viral, now the Bavi phase II sabotage.
PPHM does not get rewarded for the numerous validations of the science like a new company would. People want PPHM to show them the money now. Like a partnership would. One IST alone would send the pps of a new small company flying. PPHM got five ISTs that have done zero, nada, zilch for its pps.
AVID would lift the pps of a small new company to new heights but has done nothing for PPHM pps. A management that communicates with his stock holders like a clam doesn't inspire any confidence. Until eight years ago there were no earnings calls until the stock holders exercised their right and forced PPHM to have earning calls. But they don't take any real questions. Just three questions from pre-approved callers.
PPHM doesn't even PR a lot of news that would help the pps. If it all sounds strange it must be because it is strange.
There is however such thing of succeeding in spite of yourself. Some of us have been thankful for all the buying opportunities. Just when you think you had your last one they surprise you with another one.
The bottom line is will Bavi succeeds? And all indications are that it will. So we have placed out bets. One can always sell and buy a stock like APPLE or GOOGLE who have already succeeded but offer a much less potential.
Probably written by AF.
That's because they want to surprise us.
>PPHM is the most undervalued stock on the NASDAQ.
I could not agree with you more on that. Stocks get rewarded for making through phase I and then phase II. We just got a glimpse of that with our phase II until the sabotage. We did not get rewarded for making into phase III and that has to be because most wrongly believe that PPHM was responsible for it like you said in your article.
In the end like many have said here what counts is whether bavi is approved and commercialized. I find it very interesting how management was able to salvage phase II and get approved for phase III with fast track. Maybe the FDA pay them back for the sabotage and gave them fast track knowing that PPHM had been victimized. Who knows.
By the way, I have been here for ten years and I blame ES a lot more than SK. ES is the one who pulls the strings. SK is just following his orders. But I think now that more and more people are finding out that PPHM had nothing to do with the phase II screw-up and the same people who stayed away will be overcome by greed and it looks like this has already started thanks to your article.
I sure hope so.
Let's not forget that every time SK speaks the pps goes lower. One day this will change and it could be next Monday.
You have done a much better job than SK promoting and defending the company. How would he look now after your article if it is the same boring and canned statements that he has said in the past?
1. a new management team
2. an improved old management team
3. a management team that is willing to do more than just put up a slide twenty-eight
4. a management team that doesn't say things like in the coming months, come to fruition unless it really happens
5......
Possibly PPHM's 121 patients clinical trial wasn't even quoted for by many Big CRO's because to small.
Great. How can I get an advance.
That shows how much he cares about the shareholders and the pps then.
With all of these ISTs,
does it ever cross the trial sponsors mind that they could partner with Peregrine and maybe buy them out before some body else does?
'They are not going to give it away for breadcrumbs and that is what BP expect. In this case 25 Billion $ would be breadcrumbs'
I think that they could have done a fair deal long time ago. It would go something like this: PPHM provides the patented drug for all these indications, the partner with the money funds all the trials and covers all of the costs.
The only think that is left to do how are they going to split the revenue in a fair way. Let's say 50-50 is fair as probably most would agree. Once this has been agreed upon it doesn't matter whether the total sales for all of the indications and regions amounts to 1 billion, 20 billion, 200 billion, 800 billion. The greater the revenue the more ecstatic both partners will be.
You can have clauses like if the partner refuses to fund all of the trials that were agreed upon or market the approved drug in all of the markets that it was agreed upon the contract is null and void. That is a heck a lot better than just talking and talking for years. Like they say talk is cheap.
Look at VRTX. They got a partner with a phase three trial and a few phase two trials. A market cap of 27 billion, $2 per share loss. I don't think they have an approved drug yet. If they did and they are still losing over $2 per share and still losing about $500 million a year they would eventually go out of business.
"Nice volume and price surge late.
Surprise on Monday!"
Cannot even begin to tell you how many times I have heard that over the years and then nothing ever happened. Hope to be wrong this time.
Maybe PPHM doesn't want to partner with anybody because they may end up partnering with whoever was behind the dose switching. So it might be smart on their part to wait until they know who it was.
I would agree that management credibility is a factor. You can only string along people for so long before they stop believing you. And they have done that with the "we're in talks" statements over the years.
But I think there are also outside forces with perhaps connections inside and outside the company messing with this stock. Take the DIOS deal announcement about ten minutes before the close a number of years ago. The deal put the market cap barely over the Russel 2000 limit. Every place had a closing price that put us over the limit to stay in the Russell index. But then jazzbeerman found out I believe at NASDAQ that the last sale of the day was a 200 share trade at a price that barely kicked us out of the Russell. There were a few trades of 10,0000 shares or more right before the 200 share trade which would have kept us in the Russell.
How in the world can somebody time a trade of 200 shares to be the last trade of the day unless whoever placed it had connections with the market makers and/or NASDAQ? We got kicked out of the Russell which forced all of the index funds to sell PPHM. Somebody must have made a bundle shorting the stock knowing full well that we would get kicked out of the Russell.
Then take the put that was bought way of the money for $20,000 and then somehow after months the price drops big time and the put was way in the money and whoever bought it made about one million in profit. How in the world would whoever bought the put know that there would be no news or catalysts that would keep the price the same or stay above the put strike price? This suggests that the put buyer knew there would be no such news or catalyst and probably shorted the stock too. You can guess how the put buyer would know.
These are two things that it's very hard to believe would happen but actually did. Now the trial label switching is way bigger than those two shenanigans. Somebody has it in for PPHM and you can guess who or why.
So I think management and nefarious outside forces have everything to do with the current pps.
Out of twenty catalysts will it be years before a major catalyst happens? Getting really tired of all these carrot sticks.
Question
I started buying this stock about ten years ago and have been buying more. I had to check out for a couple of years after the 80% drop due to the trial dose switching.
I though I read a while back that we had a partner ready to start phase III with. If that is true, I can understand why that partner fled. But why doesn't that partner come back after it became known that it was an outsider who did the label switching?
we need to root for our old PPHM.
Bavi copycat
"In the past three weeks, the company has signed contracts with two of the biggest players in the pharmaceuticals industry which could lead to hundreds of millions of pounds flowing into the firm's unique research on cancer immunotherapy – using the body's own immune system to fight tumour cells."
http://www.independent.co.uk/news/science/exclusive-cancer--a-cure-just-got-closer-thanks-to-a-tiny-british-company--and-the-result-could-change-lives-of-millions-8707590.html
I agree.
Many overlook that PPHM stock never got any support from management until that conference call at the end of June or early July. We should all remember the well deserved criticism management got for that until the turnaround. The stock has been worth a lot more that it has been trading at until now. If management had been supporting the pps for years, we would be sitting at a much higher pps now.
Many of us took advantage of the depressed pps and bought more. With the options, I now have about ten times more shares than I did after the stock split. If the stock instead of going down to 50 cents had gone up to say ten dollars after the stock split, I might have maybe one fifth the number of shares I have now.
PPHM is still way undervalued. I say $100 a share or ten billion market cap is cheap. I think we should get multiples of that.
I base this on the worth of other biotechs. VRTX, for example, has a market cap of 13 billion. I like PPHM's pipeline much better than theirs.
I bought 150 contracts January calls 5 strike
Two good points. Either they want to cover or get in low. Another point: would they even
bother if they didn't have a stake in PPHM. Do they write articles or messages about stocks they have no stake in.
PPHM is way undervalued. The pps was about 3.20 after the reverse split. We're not even there yet even after all the positive data that has come out since. It's now clear that management wanted to get their options cheaper and cheaper. They did all they could to lower and suppress the pps. Now we got the signal that they want to make tons of money on the way up. The climb is barely getting started.
The calls are very expensive now. Just this past Monday I bought 200 contracts of the 2.50 January 2013 for .34. Now it's up to 1.05.
I am almost in the money. I plan on exercising them. I will have to pay $50,000 for 20,000 shares. I think they pps will be around ten in January.
Can you buy the calls on margin?