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Antiviral therapy may halve risk of liver cancer after chronic hepatitis C infection
http://bmjopen.bmj.com/content/2/5/e001313
Abbott rises after saying drug cocktail cured 99 percent of hard-to treat hepatitis C patients
http://www.washingtonpost.com/business/abbott-rises-after-saying-drug-cocktail-cured-99-percent-of-hard-to-treat-hepatitis-c-patients/2012/10/15/05f4ff26-16e0-11e2-a346-f24efc680b8d_story.html
The ongoing impacts of hepatitis c - a systematic narrative review of the literature.
http://www.ncbi.nlm.nih.gov/pubmed/22900973
How cancer cells break free from tumors (These folks need to work with the HP)
http://web.mit.edu/newsoffice/2012/how-cancer-cells-break-free-from-tumors-1009.html
The researchers were surprised to find that adhesion tendencies of metastatic cells from different primary tumors were much more similar to each other than to those of the primary tumor from which they originally came. One pair of extracellular matrix molecules that metastatic tumors stuck to especially well was fibronectin and galectin-3, both made of proteins that contain or bind to sugars.
Preventing cancer spread
The findings offer potential new ways to block metastasis by focusing on a specific protein-protein or protein-sugar interaction, rather than a particular gene mutation, Reticker-Flynn says. “If those changes do confer a lot of metastatic potential, we can start thinking about how you target that interaction specifically,” he says.
18 Million U.S. Cancer Survivors Expected by 2022: Report
http://consumer.healthday.com/Article.asp?AID=665739
micre RNA's in Breast Cancer
http://www.genomeweb.com/blog/week-journal-molecular-diagnostics-20
Hypoxic enhancement of exosome release by breast cancer cells
Conclusions
These data provide evidence that hypoxia promotes the release of exosomes by breast cancer cells, and that this hypoxic response may be mediated by HIF-1alpha. Given an emerging role for tumour cell-derived exosomes in tumour progression, this has significant implications for understanding the hypoxic tumour phenotype, whereby hypoxic cancer cells may release more exosomes into their microenvironment to promote their own survival and invasion.
http://www.biomedcentral.com/1471-2407/12/421/abstract
Mayo Clinic: Melanoma Up to 2.5 Times Likelier to Strike Transplant, Lymphoma Patients
http://www.mayoclinic.org/news2012-rst/7116.html
Acoustic cell-sorting chip may lead to cell phone-sized medical labs
http://live.psu.edu/story/61681
AEMD : A Medical Device Strategy To Inhibit HER2+ Breast Cancer Progression
http://www.aethlonmedical.com/assets/001/5080.pdf
Biological markers increase clinical trial success rate of new breast cancer drugs
http://www.utm.utoronto.ca/main-news-research-news-general/biological-markers-increase-clinical-trial-success-rate-new-breast
Blood test that could be a stress-free alternative to mammograms
http://www2.le.ac.uk/news/blog/2012/october/blood-test-that-could-be-a-stress-free-alternative-to-mammograms
whirlybird
Thank you for your comments.
There seem to be so many new tests for identifying different diseases, coming out recently. Hopefully AEMD can find an ideal diagnostic product to match what it is proposing for the DARPA program. Although there are a lot of new tests being announced, definite treatment for many conditions still seems a long way off. I am referring to the conditions for which the HP is applicable. As mentioned a few times before, either the Govt., the insurance companies or the big pharmas have to at some time realize the potential of the HP and inculcate it with traditional medicine. That is something which may be hard for AEMD to do by itself. JJ has mentioned that AEMD has partnered with 2 big corporations or the DARPA program. I am curious to know which companies are these and the extent of the collaboration.
Look forward to your input on this board along with that of all the new members who have joined recently.
Mayo Clinic Physicians ID Reasons for High Cost of Cancer Drugs, Prescribe Solutions
http://www.mayoclinic.org/news2012-rst/7105.html
Bioengineers at UCSB Design Rapid Diagnostic Tests Inspired by Nature
http://www.ia.ucsb.edu/pa/display.aspx?pkey=2829
2012 World Clinical Trial Online Symposiums
http://www.targetmeeting.com//Modules/Symposia/SymposiaDetails.aspx?Id=10
Microparticles and Exosomes: Are They Part of Important Pathways in Sepsis Pathophysiology?
http://www.intechopen.com/books/severe-sepsis-and-septic-shock-understanding-a-serious-killer/microparticles-and-exosomes-are-they-part-of-important-pathways-in-sepsis-pathophysiology-
Extracellular RNA Communication informational webinar! (Oct 3rd)
Join us on October 3, 2012, from 11:00am-1:00pm (EDT) to hear from exRNA Communication program staff about new funding opportunities, and to have your questions answered live.
To join the webinar, please visit https://webmeeting.nih.gov/rnacommunicationwebinar/ on October 3 shortly before 11:00am (EDT). Please use the conference calling number 1-800-201-2375 and Participant Code: 471324 to call in.
Advances in Biodetection & Biosensors
http://selectbiosciences.com/conferences/index.aspx?conf=ABB2013
Isolating and concentrating cells from whole blood: an interview with Victor Ugaz
http://www.news-medical.net/news/20120921/Isolating-and-concentrating-cells-from-whole-blood-an-interview-with-Victor-Ugaz.aspx
New Sepsis Design Puzzle!
http://wyss.harvard.edu/viewpage/383/
Disease Detectives Catch Deadly African Virus Just As It Emerges
http://www.npr.org/blogs/health/2012/09/27/161912039/disease-detectives-catch-deadly-african-virus-just-as-it-emerges
A Physically Transient Form of Silicon Electronics
http://www.sciencemag.org/content/337/6102/1640
Oscillating microscopic beads could be key to biolab on a chip
http://web.mit.edu/newsoffice/2012/magnetic-beads-lab-on-a-chip-0925.html
University researchers develop blood test that accurately detects early stages of lung, breast cancer in humans
http://www.k-state.edu/media/newsreleases/sept12/cancertest92612.html
Positive data for hepatitis C drug lifts Achillion
http://www.businessweek.com/ap/2012-09-27/positive-data-for-hepatitis-c-drug-lifts-achillion
Bizarre tumor case may lead to custom cancer care
http://www.usatoday.com/news/nation/story/2012/09/26/bizarre-tumor-case-may-lead-to-custom-cancer-care/57846120/1
Truthteller
Thank you for the reminder. I have updated part of the the ibox.
Part of the problem, actually the main problem is that the ibox is extremely difficult to edit. I have used different browsers to do it also, both Mac and windows based, but still difficult. I plan to make some more changes on the ibox such that it can give a good idea about the company to new and interested investors.
CJD Dementia Diagnosis Often Delayed (from Med Page Today)
By Michael Smith, North American Correspondent, MedPage Today
Published: September 25, 2012
Reviewed by Robert Jasmer, MD; Associate Clinical Professor of Medicine, University of California, San Francisco and Dorothy Caputo, MA, BSN, RN, Nurse Planner
Action Points
Sporadic Creutzfeldt-Jakob disease (sCJD) is often confused with other forms of dementia, even when neurologists are making the diagnosis.
Point out that the most common individual misdiagnoses included viral encephalitis, paraneoplastic disorder, depression, vertigo, Alzheimer disease, stroke, and unspecified dementia.
Sporadic Creutzfeldt-Jakob disease (sCJD) is often confused with other forms of dementia, even when neurologists are making the diagnosis, researchers reported.
In a retrospective analysis of 97 patients with pathologically-proven sCJD, it took an average of 7.9 months to arrive at the correct diagnosis, according to Michael Geschwind, MD, PhD, of the University of California San Francisco, and colleagues.
On average, the physicians involved -- mainly neurologists and internists -- made 3.8 incorrect diagnoses before arriving at sCJD, the authors reported online in Archives of Neurology.
"CJD is rarely the first diagnosis made and it is usually confused with a wide range of other conditions," the authors noted.
On the other hand, they reported, in 17 patients the first diagnosis was correct -- and in those cases 16 of the diagnoses were made by neurologists and one by a specialist in rehabilitation medicine.
Sporadic CJD is caused by prion proteins that undergo conformational changes, resulting in an invariably fatal transmissible spongiform encephalopathy. Other animals also suffer spongiform encephalopathies, including the famous bovine form -- dubbed mad cow disease -- that can be transmitted to humans as new variant Creutzfeldt-Jakob, or nvCJD.
It is difficult to distinguish sCJD from other dementias, including some that may be reversible, Geschwind and colleagues noted. Their report comes just days after the American Academy of Neurology issued a diagnostic guideline aimed at reducing the difficulty of a diagnosis of sCJD.
To investigate the issue, Geschwind and colleagues looked at all the cases referred to the UCSF Memory and Aging Center rapidly progressive dementia and CJD clinical research program between August 2001 and February 2007.
Patients were eligible for the analysis if they had pathologically-proven sCJD and medical records sufficiently detailed to allow examination of the diagnostic course.
All told, the researchers had good records for 97 patients, who received a combined total of 373 diagnoses before their physicians settled on sCJD. On average, the disease course last 12 months and it took 7.9 months before the records said sCJD was "likely" or the patients was referred to the center (whichever came first).
Primary care physicians (40%) or neurologists (36%) were the first to assess 75% of patients, and most patients were first seen by a family doctor and then referred to a neurologist.
Most of the misdiagnoses fell into a few categories -- neurodegenerative, autoimmune/paraneoplastic, infectious, and toxic/metabolic disorders, Geschwind and colleagues found. The most common individual misdiagnoses included viral encephalitis, paraneoplastic disorder, depression, vertigo, Alzheimer disease, stroke, and unspecified dementia.
With regard to viral encephalitis as the most common individual diagnosis, the authors suggested that "the multifocality, acuity, and rapidity of symptoms seen in sCJD" was a possible reason for the miscall.
Of the 222 doctors who made a diagnostic error, 95 were neurologists and 51 were internists, the researchers reported.
The diagnosis of sCJD has become more difficult, rather than easier, in recent years because of the increasing awareness of other forms of rapidly progressing dementia, commented Richard Caselli, MD, of the Mayo Clinic in Scottsdale, Ariz.
The long "diagnostic journey" faced by patients is complicated by the non-specific nature of the early symptoms, which often suggest a "more common and less lethal" disease, Caselli noted in an accompanying editorial.
Even neurologists, he argued, can be forgiven for missing the diagnosis in the hope that a reversible cause of the dementia can be found.
The study had support from the National Institute on Aging, the National Institute of Neurological Disorders and Stroke, the Michael J. Homer Family Fund, the National Center for Research Resources University of California, San Francisco Clinical and Translational Science Institute, and the John Douglas French Alzheimer's Foundation.
The journal said Geschwind and Caselli reported no financial conflicts of interest.
The Wnt Homepage
http://www.stanford.edu/group/nusselab/cgi-bin/wnt/
Active Wnt proteins are secreted on exosomes.
Author(s) Gross JC, Chaudhary V, Bartscherer K, Boutros M
Institution 1] German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Heidelberg University, Department for Cell and Molecular Biology, Medical Faculty Mannheim, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany [2].
Source Nat Cell Biol 2012 Sep 16.
Abstract Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions. Recent studies have identified several factors that are required for the secretion of Wnt proteins; however, how Wnts travel in the extracellular space remains a largely unresolved question. Here we show that Wnts are secreted on exosomes both during Drosophila development and in human cells. We demonstrate that exosomes carry Wnts on their surface to induce Wnt signalling activity in target cells. Together with the cargo receptor Evi/WIs, Wnts are transported through endosomal compartments onto exosomes, a process that requires the R-SNARE Ykt6. Our study demonstrates an evolutionarily conserved functional role of extracellular vesicular transport of Wnt proteins.
Language ENG
Pub Type(s) JOURNAL ARTICLE
Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells (Mad Cow Disease!)
http://nar.oxfordjournals.org/content/early/2012/09/08/nar.gks832.full
In summary, our results strongly support the hypothesis that exosomes released from prion-infected neuronal cells have a distinct miRNA signature that may be utilized for the identification of prion infection. This signature comprises significant increases in let-7 b, let-7i, miR-128 a, miR-21, miR-222, miR-29 b, miR-342-3 p and miR-424 with decreased miR-146 a detection and agrees to some extent to previously reported miRNA changes detected in brains of terminally infected mouse and primate models of prion disease, and sporadic CJD samples (17,18).
Evaluation of our exosomal miRNA signature in circulating exosomes derived from clinical plasma samples from sporadic and variant forms of human prion disease and in animal models infected with different prion strains will be the subject of our further studies. Importantly, it has been shown the miRNAs deregulated in prion-infected exosomes identified in this study have also been detected in circulating exosomes isolated from human serum samples (14), and that neither have currently been detected in disease-associated exosomes in the current literature and a search of ExoCarta database (58), suggesting that this miRNA signature has significant and specific diagnostic potential. However, it should be noted that our study also identified other ncRNAs and mRNA fragments (Supplementary Figure S1) that may also be deregulated in exosomes released from prion-infected neuronal cells. Furthermore, it has been identified that extracellular miRNA released from cells into plasma can associate in two populations, both dependent and independent of exosomes either bound to AGO2 (59–61) or high-density lipoproteins (62). Therefore, targeted exosomal purification strategies for enrichment of circulating miRNA biomarkers may be required to increase biomarker sensitivity (14,15,23). This research also has potential diagnostic implications for other neurodegenerative diseases in which exosomes have been identified to play a role including Alzheimer’s disease (63–65), amyotrophic lateral sclerosis (66) and Parkinson’s disease (67).
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Caltech Biologists Gain New Insight into Migrating Cells
http://mr.caltech.edu/press_releases/13559
2) Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. (Also, see the previous post. Some major pharma has to realize that there would be more value in removing the entire exosome which harbors many other micrornas, enzymes and other factors!!)
http://www.ncbi.nlm.nih.gov/pubmed/22684891