Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
ToChas1232123:
By expecting a high rrr for Reduce-IT,
How do you quantify the timing of the separation
When you refer to Jelis ?
Do you believe Amarin can approximate the separation
based on their projections?
Just curious about your thoughts.
Thanking you in advance
All the best.
Now take the next step. Read and implement autophagy.
Read about autophagy. Make it happen in
Your own life.
You created a monster who is exerting his
first amendments rights. Keep responding to him...
I respectfully disagree. All the best
Be explicit Sir and straightforward. Thank you.
If you were born in the US and you did
all of this for free, everybody would
believe you are a pumper as why would do this for
free? Please please explain the rich Hungarian values...
Rafunrafun,
I do not believe you.
YES and he distorts information. I have stopped
replying to him. In part he is bitter since Amarin
did not accept him as an enrollee.
I do not think you blather as you are genuine..
Tasty:
You need to post more often please...
All the best as always to honest folks like yourself..
Me33:
Be humble. Ask Gabor for a lecture. He
Will educate you.Good luck to you.
Dear PennyPicksPro:
Because Amarin had successfully taken FDA
to court, they must make sure that they
are very thorough and not sloppy.
We, the investors get to buy this stock
on the cheap since many investors are on the
fence after the Adcom debacle.
Rest reassured that the Baker brothers have maintained
Their stake in Amarin.
Start planning how you want to cash out. Upon
Topline results or upon a buyout which could
go until second quarter 2019 when they may get a premium
Price.
You know Mendelian genetics randomization predicted that
Increasing hdl will not decrease cardiovascular risks. Yet bigpharma
Has wasted millions in CTEP inhibitors to increase hdl , which failed miserably.
This same genetics approach has predicted through calculation and observation that high level
Of triglyceride cause ischemia in coronary arteries. Yet big pharma
Ignored it in part because hdl level stays constant while triglyceride
Level varies day by day.
Elegant genetics randomization study have proved remnant cholesterol, a marker
For triglyceride caused both ischemia and low grade inflammation while ldl caused
Only ischemia without an inflammatory component.
Since all enrollees will be on optimized Statins all their ldl level will below 100. But the inflammatory component of the remnant cholesterol will Still be there. With 4 grams of EPA the main purpose is to reduce that low grade inflammation. We know from the results of the recent 6 years Cantos study that cardiovascular risks was significantly reduced by decreasing inflammation.
Further , with triglyceride level at below 150, Jelis study reduced risks by 19%.
This was in a Japanese populations , where they already consume a lot of fish. They only
took 1.8 grams of EPA. Thereafter Amarin increased the dose of epa to 4 grams and confirmed that there is a dose dependent benefits and therefore selected 4 grams of EPA for the ReduceIT study. Also Cherry study proved that EPA + Statin Reduce cause plaque regression by 50% compared to statins alone.
Taken together the science is proving that statins plus EPA at 4 grams should dramatically reduce risks of ischemia.
Six years and almost seven months have elapsed since the study started in
December 2011. The topline results will cause a paradigm shift in the prevention/ treatment
Of ischemia and other indications through the SE and TE subgroups.
All the best. Good luck. Be strong.
No until everything is complete... Be patient
me33, would you mind quoting where Dr Budoff
Stated rr is “ between 15 and 20%” ?. Thanks
Here is someone who can raise above pettiness
and mediocrity...
Hi Gabor:
Would like to know what Dr Budoff think of the relationship between
EPA/AA and Outcome study just read the design
And rationale of Evaporate study by Dr Budoff. I believe it is in the discussion
section.
All the best
Hi Tasty:
Great to hear from you as you have a good
sense of humor. Even if rrr was above 30
Percent there is no way study would have been
stopped at second interim to allow more events
For SE and TE.
They want holistic data...six years and seven months
and counting....
All the best.
Thanks for responding. I do not think
It is that crucial. Else Amarin
Would have looked into it.
Have a great week end.
And do not let Kiwi bully you
as you owe him nothing ...
Thanks a lot Chas. You know that
Japanese scientists rely on EPA/ AA
For us to reach your conclusion
In control do we need the AA level in those
11 or so countries for the Reduce IT study?
Else we aresumming they are same as Japanese natives...
Chas:
Thanks for your contribution.
Since Reduce it increases the dose to close
To basal that of Japanese native on what basis do
You measure rrr to double???
Just curious
Have a great week end
All the best
Chas I second you. Kiwi needs to tell all
Of us FIVE times why Amarin rejected him
as an enrollees.
He is pre diabetic and he eats like a ....
Come on Kiwi and be candid....
I concur with you as I cannot see them
Rejecting a buyout offer.Hopefully in the thirtees..
Chas:
Thank you for responding. Once
we hit the jackpot number, how do you
Plan to cash out all ? Do you believe in
a potential acquisition thereafter?
All the best.
Thanks for your effort. How can you
factor the fact of enrollees in
Reduce-IT consume high level
Of carbohydrates which may lead
to insulin resistance? Also what about higher
Level of alcohol consumption which
may lead to higher level triglyceride
In the Reduce—IT enrollees?
Thanks again for trying.
Please please be patient Tasty
as we are almost. Also try out with
No alcohol consumption as it is not necessary.
Try fasting and see how your aldrenergic system
Kicks in . Watch md ...
Ditto!!!
No, follow your hunch and improve your
On your thesis why rrr may be even higher.
Just look at the elegant Mendelian genetics randomization by danish
scientists. Both Dr Budoff and Amarin believe in them...
You need to do due diligence. I reiterate
Low hdl is a bystander. It is not a causal effect.
If each time the hdl is low there is a heart attack
The ReduceIT investigators would have jumped on it.
They did not because they realized all it means
That the triglyceride level has been high for a long time.
So that is where the causal effect is: high triglyceride level.
It is too unfortunate you do not seek the truth but only
seek to fit your lame bet.
I reiterate that you read all the supporting papers
And INTEGRATE them all.
And RRR will not be 35 percent as our
Deity believe in but it will be above 15 percent
God bless that you seek the truth instead of supporting your
lame thesis...
Nothing new. Go back to my earlier post...
Kiwi:
Read
and re-read what Avi posted 5 years
Ago in Investor Village...
Until you read ALL the supporting studies that Amarin has in terms
of clinical, epidemiological and genetic studies it may
be impossible to convince you that low HDL
Only reflects that triglyceride level has been high
for a long term. It is just a bystander. If each time
HDL is low there is an increase in risks Reduce IT
Criteria would have included it as a target. They did not.
What is the risk for those with triglyceride between 150 and 200,
Where Reduce-IT has a number of participants?
Anyone has a listplacebo rate wherever statins are used
as controls in Outcome studies. Thanking you in advance.
Vubru and Tasty:
Go back to many CCs, say for example that of September 16, 2014
“
So far we have been tracking to that level of event.”
They can start with 5.2 percent placebo and assume
That Vascepa has a 0% efficiency and calculate the total
No of events.If total no of events is less then they can conclude
that Vascepa has indeed some efficiency...
BiWatch, an engineer wrote an article about that
In Seeking Alpha on October 9, 2014 and one of his possibilities
Was that ReduceIT will show 15 to 20 % efficacy in
Mid 2018. Those who have a statistics background can improve on his
model as we now more information.
Tasty and/or Gabor can follow up...
It is not a problem at all as in Reduce It there is a very
High risk participants. Low hdl is only a bystander as I referred
To my previous post.
No Kiwi, Outcome study using CTEP inhibitors proved
That increasing HDL does not reduce cardiovascular events
and the clinical trial outcome study failed.
When your hdl is low it is only telling you that for a long
time your triglyceride level has been high. There is no causal
effect between low HDL and cardiovascular events. That is why
In the ReDuce it study rationale below they do not specify a level
For hdl.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396348/#!po=40.1786
Tasty:
1. The subgroup of ACCORD-lipid (TG> 204 mg/dland HDL
< 34mg/dL) shows a reduction of CV events of 31%.
2. The subgroup of AIM-HIGH ( TG > 200 mg/dL and HDL < 32 mg/dL)
shows a reduction of 36% of CV events.
To Gabor: I just replied in details to your email in yahoo. Thanks