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Thanks Whatalane; That explains a lot of what has happened then. Although I don't recall what I ate prior to my last blood test. I do know that I've cut back on my consumption of red meat. I can't remember when I made Brisket last. I do eat some homemade Braseola and Cappacola but only in 1 - 2 oz portions. Yum, followed by several Fosters of course.....burp.. :0)
Funny one go seek; I use the following analogy; Like taking Vascepa to using Fuel Injector Cleaner...... In order to really clean the injectors I usually put a full bottle of Techron into 5 gals of gas vs. the 20 gals they recommend. I'm thinking that by limiting my calorie intake (diet & will power), I get a more profound effect from the 4 gms of V per day, than if I stuffed my face and went back for seconds and then take my V. I don't know, I may be wrong. How can you explain my drastic change (positive) in my cholesterol levels? The only thing I can think of is; I did make an observation, my blood work was done by two different labs each on separate occasions. Could the lab work vary that much? Can blood tests be peformed using different parameters? Are blood tests time & place dependent? I fasted both times and yet I had two different sets of results. My latest one was done in April 2014 had TGs = 113, my previous done in March 2014 had TGs = 208. ???
Thanks JL; that is why I would never take a statin. They have too many side effects. Doctors prescribe it willy-nilly and people are suckers for allowing their doctors to prescribe it for them because they don't know any better. I'll stick with Vascepa thank you.
Actually thats a 25 oz. curl. Fosters comes in a 25.3 oz can.....:0)
Time to get a new doctor.
Kiwi; the honor was mine to play. My great grandmother was a Wright which is a sept of the McIntyre clan. I'm about 1/8 th Scot, some Irish, mostly German. Still with the little amount of Celtic blood I do have I managed to pick up a thing or two.
Hi Black; no statins for this lad. If a doctor tries to prescribe stations to me. He'll have to get fitted with Orthopedic shirts. I don't believe in shutting down a vital organ like your liver just do my cholesterol reaches a certain level. I'm thinking my situation is unique. I'm currently going through a stressful time, although I feel really good, my appetite has definitely been curbed alot. Just losing weight has had an effect I'm thinking. GLTY
Hi Black; no statins for this lad. If a doctor tries to prescribe stations to me. He'll have to get fitted with Orthopedic shirts. I don't believe in shutting down a vital organ like your liver just do my cholesterol reaches a certain level. I'm thinking my situation is unique. I'm currently going through a stressful time, although I feel really good, my appetite has definitely been curbed alot. Just losing weight has had an effect I'm thinking. GLTY
I second that BIO: anything that could do what Vascepa has done for me in the past 9 months. This will be a blockbuster. Did I mention my Trigs went from 226 in Feb. 2013 to 113 on April 21, 2014? My LDL went from 143 to 103, my total cholesterol went from 246 to 178 during this time frame? Not to mention all the other side benefits such as, energy levels, weight loss, dry eye problem so long.... being 62 I have no joint pain either. Even my hands have stopped locking up on me....
I remember playing the pipes a number of years back for a group of Aussies and Kiwis who lived in Phoenix. They mentioned that they were honoring the fallen at Gallipoli. I never knew what the place was until I read about it afterwards. It's like Gettysburg or Khe San or Pearl Harbor to Americans. God bless their souls.
Good advice, thanks Whatalane. Problem may be he has a staff who probably screens all his mail? Doctors become prisoners of their own system. My PCP I think fired his assistant because she was kind of worthless. Who knows? There's turnover in any business. Chemistry plays a big part.
apologies Mr. Stock; son disconnected the router so I'm responding by cell phone. Here since $14, bought on way down, no money left.
So, let's talk about Vascepa and why I'm still invested. I'm here because I believe in the science. There's always a why question until one gets to the root cause. Bottom line is, Vascepa has given me a new lease on life literally. Although I'm blessed with very good health, there's always an improvement one can make. Case in point; Feb. 2013 I began to take better care of myself. I got my first blood test in about 10 years. My Trigs were 226, total cholesterol was 246, LDL 143, after reading about Amarin is when I became more interested in reducing my cholesterol and living more healthy. After reading these message boards I became more educated. As I said I believe in the science. Even more so now because of all the 'trumped up" negativity. There is so much the medical community doesn't know. They are stuck in their own paradigms. My PCP for one and now my Psych doc. Although my PCP I think is coming around. Why? I just had my annual physical, my PCP is taking a more proactive approach with me as we've gotten to know each other better. After what a year and 4 months, my Trigs have gone down to 113, LDL 103, Total cholesterol dropped to 178. Not that lowering my cholesterol is not so important as reducing inflammation. It does prove to me that Vascepa has improved my quality of life. Not only physically, but mentally and emotionally. Its like reading a Tolstoy novel, I can tell you the basic story but its hard to describe all the nuances. Vascepa has improved my health naturally, without any side effects. What more could you ask. The people that bash the medication have no clue. Someday this will all change, slowly perhaps, don't know, can't tell you when but, it will happen. I don't want to miss the show....
?? Are you asking for a response? Are you a basher? I'll tell you why I'm here. If you tell me why you're here? Fair buff?
Canned sardines? I lov'em too but what about the sodium? The Louisiana hot sauce gets rid of tapeworm however.... :>)
The more I think about it, the more I want to send s letter to my doctor.. If he doesn't listen get another doctor. Of course it took me 6 weeks to get an appointment. However, I am willing to get another doc if it gets my point across.
Yes, that's what I was thinking. Funny way especially for someone in his field? Maybe a letter written personally to the doctor explaining the error of his way of thinking? If he refuses to listen. Then I will maintain my barrage.... I'll forward him James message...:>)
Hi Whatalane; I want your take on this; talked to my psychiatrist yesterday first time. Wanted to make sure of my meds. When I brought up the fact I was taking Vascepa (of course he had no clue), I asked him what his take was on taking Omega 3 Fatty acids. Of course I told him all about Vascepa which he essentially got glassy eyed (ignored what I was saying). He said that Fish oil supplements were not necessary. He said that eating Salmon or Tuna twice per week gives you more Omega 3 than any fish oil supplements. I told him I was taking 4 grams per day of EPA. He apparently wasn't listening. I find it hard to believe that by eating two servings of Salmon per week gives me the equivalent of 28 grams of EPA. IMHO not being a doctor this makes no sense. I think the doctor is wrong. He wasn't listening. How can eating Salmon give you enough EPA equivalent to Vascepa. With OM3 containing DHA/EPA, wouldn't the benefits be offset? Hence educating the medical community is paramount IMHO if V is to get any traction. Dr. Sears would be a good spokesman, we need someone to carry the banner.
You guys are talking like Vascepa is totally out of pocket for most patients prescribed Vascepa. I pay a co-pay of $120 for a 90 day supply. The rest Express Scripts picks up (United Health Care). I have no problem paying it, which ends up being $40 per month for my script. Now, if I use the Vascepa coupon (which I haven't yet....) My script goes down to $50 for 90 days.
What am I missing? It appears that some folks don't have as good a coverage as I do, but of course my premiums are $500 per month for medical insurance too. I have no clue as to those folks on Obamacare or paying the minimum premiums.
It's like those who can afford to eat Salmon 3-4 times per week compared to those who are on hot dogs 3-4 times per week. In order to reach a higher % of population obviously Vascepa wiil need Reduce-it and the medical community endorsement. Then of course the Cramers and Fartsteins will need to come around and embrace this science...
Bio: One would think logic would dictate. Why would AZN lau;nch Epanova when Lovaza sales are dropping and there is generic Lovaza hitting the market? Doesn't make sense to me. Although knowing what we know, why did AZN buy Omthera in the first place? That acquisition made no sense at all. Unless AZN had a whim and wanted to do a combo with Crestor & Epanova. Discussed numerous times already. IMHO, AZN has realized its mistake and will not continue to throw money down the drain.
Yes, same team.... certainly, still a long time holder of Amarin. Thought I'd throw a little humor out while the MMs play their little games with Amarin. Can't wait to see the KOWA effect. AZN PR on Epanova, PFizers continued courting of AZN shareholders. More studies which equates to more overwhelming proof that EPA is the coming tsunami we all know it to be.
Actually the longer Amarin stays around the more of an irritant it becomes to Big Pharma. Say what you want to about John Thero, but, IMHO he's a cost containment guy. Watch him do his magic and slow down the cash burn. Big race this weekend, can't tell you who's racing.
Still taking my Vascepa and feeling great......
Amarin is a pimple on an Elephants behind. PFE is looking for bigger fish. When the AZN aquisition is done then maybe Amarin will get a look. PFE is after AZN cancer stuff... IMHO
Robin, it shows a sign of AZN weakness which most likely should be used as fodder by Ian Reed to sway AZN shareholders to his point of view. Very poor execution by Soriot to buy Omthera to begin with. Question is; how will Soriot explain this one? Reed is no dummy. Look for more news coming. P wants AZN in a bad way.
I get it now, its OK to use swear words with asterisks as long as you don't use words like " nay sayers" which got my post removed by one of our beloved unbiased board moderators?
Go Amarin....you rock
Freak: Can you be a little more specific and supply some details as to why you think Amarin's (Startup Pharmaceutical) balance sheet is a joke? Let's see;
1) Amarin has the supply chain tied up for High Purity EPA
2) Amarin cash burn is approx. $70M per year, with their cash reserves somewhere around $190M.
3) You're forgetting KOWA coming on-line in May
4) Preliminary Reduce-it results we should see sometime in 2015 1st or 2nd Quarter by the latest.
5) Did I mention KOWA is coming on-line in May and is eventually going to form a partnership (IMHO)?
6) What about METFORMIN & EPA combo drug studies sponsored by KOWA?
7) Did I mention we will see increased sales through the summer? Currently $10M (Annual sales projected = $40M) per quarter and Quarter over Quarter sales will be increasing, thus off setting cash burn for Reduce-it.
I would like to see your analogy rather than just spewing "Amarin’s Balance sheet is trash". Prove to me it's trash with a logical argument. Thanks
Heck, what are these other options Ian Read is referring to? Why not just buy Amarin and beat AZN to the punch?
Since EPANOVA got approved today by the FDA don't you think AZN will want to do combo's using it's own CRESTOR or get into the Diabetes combo?
This will either heat up or Pfizer will get tired of this and go away and start it's own T2DM campaign.
It's only just beginning; Shareholders are starting to come over to Ian Read's side.
AstraZeneca Sets Out Pfizer Defense -- Update
Print
Today : Tuesday 6 May 2014
By Hester Plumridge
LONDON--AstraZeneca PLC set out its defense against takeover interest from Pfizer Inc., issuing new financial targets and highlighting the potential value of its drugs in development, four days after turning down a bid worth more than $106 billion from the U.S. drugs giant.
AstraZeneca, which said Pfizer's offer "substantially" undervalued its business, said Tuesday it was aiming to generate revenue of more than $45 billion by 2023.
The company also highlighted the potential value of its pipeline of cancer, asthma and diabetes drugs in development, forecasting the new drugs to generate peak annual sales of between $23 billion to $63 billion, depending on the proportion of its new drugs that might receive regulatory approval.
The company also set out new revenue targets for its five key growth areas by 2023: including annual revenues of $3.5 billion from its blood-thinning pill Brilinta; $8 billion in annual sales from its portfolio of diabetes drugs; $8 billion in respiratory drug sales; mid to high single digit revenue growth in emerging markets and low single digit revenue growth in Japan.
AstraZeneca is facing flat or declining revenues in coming years, as its best-selling drugs lose patent protection, but Chief Executive Pascal Soriot has focused on rebuilding the company's pipeline and returning it to growth.
Pfizer has been pursuing its British rival since November, but AstraZeneca has rejected the advances. Last week, AstraZeneca said Pfizer's most recent cash and stock proposal valued at GBP50, or $84, a share "substantially" undervalued the company.
AstraZeneca's announcement Tuesday comes a day after Pfizer sought to increase pressure on the British company to enter talks on creating the world's biggest pharmaceutical company. Pfizer also reported declining quarterly results that underscored why it is interested in a tie-up.
In an interview on Monday, Pfizer's Chief Executive Ian Read said the offer was "compelling" and urged the U.K.-based company to enter talks.
"I'm hoping they will come back into discussions, but we are reviewing our options," he said.
Mr. Read agreed that Pfizer's options include walking away from a potential deal and even looking for a different one, though he argued that a combination would benefit both companies and their shareholders.
He added that his talks with AstraZeneca shareholders suggest they are open to doing a deal and want to discuss the terms further.
Mainstreet: Yahoo message board is so quiet it's scary. Not much pumping going on over there. So many bashers on ignore though unlike IHub, where you're ability to ignore is limited.
Here's to Kowa coming on board in a week.... tomorrow is May 1st. A really important holiday in Russia, that's where dancing around the May Pole originated....
Thanks.
Hi go seek: I'm viewing this YouTube on my cell phone. Is there a date for this video? If only the FDA would get its you know what out of you know where and watch this. He talks about JELIS.
Case in point; AZN buys Omthera. No approved drug, no revs. So, PFE perceives some weakness in AZN, so, hence the big fish is eaten by the bigger fish. Plus the tax implications. Isn't our Gubmint and country a great place to invest?
No stems or seeds that you don't need Acapulco Gold is Bad A$$ weed.... Cheech & Chong.
If only Amarin could address the chronic pain market, we'd have caviar and champagne every night....
Jesse: You're correct except the study has two Cohorts A & B
Cohort A - Low Dose Metformin Eicosapentaenoate 1500 mg or Metformin HCl 500 mg and Vascepa 1000 mg and
Cohort B - High Dose Metformin Eicosapentaenoate 3000 mg or Metformin HCl 1000 mg and Vascepa 2000 mg
Still if Cohort B is administered TP-101 twice daily, then it should be sufficient. The JELIS study used 1.8 grams of EPA per day with significant results.
I'll second that comment; BioBill you are a genius.... Why not the Japanese? Heck we gave them management theory and they stuck it up you know where? Think of Ford, GM & Chrysler back in the late 70's. Our automakers were too slow to react or thought they had the market's tied up. Little did they know Japanese made cars captured huge market share because the American autos were poorly designed, gas guzzling machines.
Go Kowabunga....
Agree; says alot about Vascepa, if your going to do a study and you want the best product, why not use the "best in class." I like Rosenman's comments, if this study works Thetis doesn't need to do an outcomes study to be able to market this Metformin EPA drug. Just have it available and they will come..... I have several friends who are diabetics. They could use this drug. I forgot to include this part on my justification letter. That Vascepa is beneficial for diabetics for leveling Glucose levels. Even though I don't have diabetes, it is becoming more prevalent in older Americans.
Sorry sts: I have to throw the BS flag on that;
Kowa Company Limited has been around for some time.
http://www.kowa.co.jp/eng/company/division.htm
They have several Divisions under the Kowa name. Looks like eight divisions total. Pharmaceuticals is just one division.
RobinF, sts; The Kowa/ Amarin deal has been going on for months. It doesn't take a rocket scientist to figure that one. Companies take weeks and weeks of talks and preparation for deals like this to come off. The advertisement itself also has a lead time. What's fantastic is the spokesman Kurt Warner and his wife. This couple is very well respected in AZ (AZ Cardinals & St Louis Rams, Superbowl MVP twice!!). It's amazing what a sports figure can do for your image. The Warners have a very good following around the country and are very religious, which a lot of folks can relate to. Very positive for Kowa to get the Warner's involved with this partnership.
It just struck me as coincidental that the words "Supportive Resources" and the statins comment were used in the same paragragh. I don't know, call it a hunch. That's why most of us are here isn't it, a hunch?
Kowa has been around for over 100 years, they are no one's fool.
The fact that Kowa has Livalo (Pitvastatin) and is willing to do a deal with Vascepa, albeit at Kowa's expense speaks volumes. The psychology Kowa is putting on the street say's "hey we understand the limitations and the side effects of statins" we want to help those who suffer from these side effects and at the same time give folks alternative therapies which will enrich their lives."
I'm taking a page from BioBills book. Makes pefect sense to me. Sure Kowa is taking a chance with Vascepa, you bet. But, they are willing to take that risk, without a little risk where is there spice in life? A company who sells a statin is finally seeing the benefits of combining Vascepa with their product as an alternative to anything out there. AZN, GSK, PFE better get on board or be left at the station. Kowa is all about taking market share from these "Big boys"
sts: This statement says it all..... I'll do a BioBill and read between the lines.
"Up to 75% of Americans stop taking statins, the most commonly prescribed therapy, within the first year, demonstrating the clear need for more education and supportive resources."
You're forgetting "supportive resources" what the heck are those?
The ad may have been a plug for Livalo, but, the wording could mean any number of things. They've left the door open and could plug-in Vascaepa as a supportive resource. Especially if there's a combo being planned. Reducing the amount of statins people take is key. If what you guys say about the side effects. If those can be reduced then we have a winnah.....
Cool sts: sounds like your a tinkerer like most. Have you ever thought about jury rigging your own SCBA? Like take a Gas mask and attach a CPAP air line to it? Air is amazing, unlike liquid you don't need a whole lot of energy to push air. It can travel long distances without losing a lot of energy. I bought a CPAP machine from Goodwill for $4. I don't have sleep apnea, I was using it for another application. CPAP machines don't push a lot of air, however you could put the CPAP machine in a clean environment (outside your shop) and run the airline to your mask. Just a thought.
Also thanks to you and BioChica, great ideas, if you want to get something done do it yourself. I'll have my doc write me another script and I'll take it to Target and fill my Vascepa Script there. Good suggestion. I think I know what to say. I'm sure Express Scripts would rather I not take any medications.
Now as far as Lovaza is concerned; Doesn't it raise your LDL-C and it also has an A-FIB warning on its label?
The other drugs Express Scripts suggested were Feno-Fibrates and Niacin, no comment these are detrimental and have way too many side effects.
Got to touch all bases; Statins..... statins to me are poison, anything that shuts down your liver function to me is deleterious, plus the adverse side effects, joint pain etc.. Looks like I pull up some old messages and read thoroughly.
Thanks again, Nuke
Express Scripts is in a full court press:
Has anyone had to write a justification letter to their Prescriber or PCP before explaining why they need to be on Vascepa? I have a pretty good idea what I want to say but if anyone has a version of their justification letter please post it. Thanks.
Express Scripts is delaying or denying my script for Vascepa. I'm currentlty taking Vascepa off-label.
sets; sounds like you need what firefighters wear. It's called a self contained breathing apparatus (SCBA). Goodness what is it you do? Paint cars? Rebuilding batteries? Fake nail technician?
Hi sts; yes, I see your point, when Generic Lovaza comes out then it will be a push for sure to try and switch branded Lovaza users and perhaps even Vascepa users. Doesn't Lovaza have an A-fib warning? I don't think it will be too difficult to justify Vascepa, since it doesn't raise my LDL-C, which I've explained to my care providers. Like anything new, you must continually remind your PCP and staff about Vascepa and it's benefits. I'm no doctor but, I've read enough on these boards to know when I hear the truth, I'm more determined than ever.
I had a "major" psychological event that came to a head the week of April 1st. That if I hadn't been taking Vascepa at the time, the event could have been much worse. I truly believe that V saved me from further harm. I'm okay now as my PCP prescribed some medication, I've backed off some now as I think I just needed that little extra boost in my Seratonin levels. I'm able to sleep through the night now without Xanax. I owe a lot to Vascepa. If you Google "Diets for Bipolar Depression", you will see that physicians recommend fish oil supplements. Well, I have feel I have the best in class supplement money can buy in Vascepa. I don't drink or smoke or go to Starbucks everyday so, I can afford my $120 co-pay for 360 capsules (90 day script) of Vascepa. I feel like the most interesting man in the world commercials when I say, "when I take any drugs I want it to be Vascepa" a couple Dos Equis woudln't be bad either....