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From 10k -Our Target Indications
We have developed compounds with potential application to two broad categories and several specific indications. including:
Central Nervous System Diseases
Alzheimer’s, Parkinson’s, Rett syndrome, Depression , Epilepsy , Neuropathic Pain
Cancer
Malignant Melanoma, Prostate Cancer, Pancreatic Cancer
TOP
It's a boring and quick cc until i heard that and wake me up. " Highest enrollment in Australia ever for an Alzheimer's trial."
Nice post Nidan and I agree -" No one wants AVXL to go forward w/an irresponsible, one size fits all, release program."
It reminds me of Dr. M statement several years ago " We’re trying to gather as much data as possible so we can do this properly,” Dr. Missling said. “You can make the case that some developers have rushed into these studies after interpreting early results the wrong way. They said the glass was half-full when it was really half-empty.
For us, it’s very important not to do that. We won’t go ahead with this until we are completely comfortable with what we see.”
and after several yrs they went ahead and continue the trial, to me it's a very good signal. can't wait for the trial results and GL to all us.
TOP123
Thank you, you are so kind to response to my post. I did my research and I got my target number shares for now and will buy more and use my wife's RVU once next milestone achieve.
This is a good read at least for me from " Joshua D. Goldman, PhD, CFA who is a Partner and Director of Research at Taylor Wealth Management Partners and he prefers to avoid companies with only one drug candidate and told me, "An investor should favor companies that have a core technology which is already proven safe and potentially hints at being effective i.e. a therapy based on this core intellectual property has already made it beyond phase I and hopefully phase II clinical trials. This should increase the chance that other drugs based upon the same core intellectual property are also safe. If there are many drugs in the pipeline based on the same platform, than an investor has thereby increasing the likelihood of success."
And thank you also all long who contribute on this wonderful board.
Nice post and thank you Steady..Falcon if you have time would you please comment on the article below, love to hear from your perspective.. Thanks in advance.
https://phys.org/news/2019-12-insights-major-disease-pathways.html
Indeed really smart CEO, I read somewhere this - He graduated summa cum laude from the Ludwig Maximilian's University in Munich which, in case anyone wants to know, is ranked ( #1 ) the best University in Germany. (Google "Best Universities in Germany). In my opinion, he is "the real deal."
TOP123
Correct Xena, Doctors do all the time for the sake of their patients, the only challenge is the insurance will not pay for it and or Physician justify it which requires paper works/call/fax, that's what i heard from my wife who is a Physician.
GL to all of us long.
" Everyone should always fact check everything they read." yes after all this is internet, but its tell you who you are base on your opinion/post in life. personally I want to be honest on everything I say or do, again that's me and proud of it.
Is this early Christmas gift or have to wait longer, planning to add position here soon. GL all
Nice 2.90 - maybe we see 3.00 at the close..
Yea right!!!!LOL
falcon as always thank your for your great post..
" Avxl is a scam." Wow that is a very big statement Doc.
Squeal - That's my thinking, CM is planning way in advance..
I got my target number shares and waiting mode now like everyone else, will double my position when the next milestone accomplish. GL
Talon - Simply reducing the buildup of plaque will not do it, Biogen as we all know that did not demonstrate to satisfied FDA between reduction in the plaque and positive changes in the mental function of patients.
Thanks Benny.. what do you think about this, maybe nothing..
ANAVEX 2-73 (Cat. No. 5058) has been withdrawn from sale for commercial reasons.
-- https://www.tocris.com/products/anavex-2-73_5058#product-details
By the way you are 81 yrs old, wow wish you many many years to come. God bless you with health and wealth.
TOP
New investor here but love it Anavex 2-73 firing on all cylinders.
" Anavex’ candidate is Anavex 2-73, a sigma-1 receptor (S1R) transmembrane protein activator that is thought to be involved in regulating homeostasis in cells, keeping them in a healthy, steady state
>>>>> by reducing factors such as oxidative stress, protein misfolding, mitochondrial dysfunction and inflammation – all of which are seen in the brains of Alzheimer’s patients.
GL to all of us and have a good day!!
Don't be excited, in a second it will be in the .05'- 0.06, crazy and manipulator MM.
I don't care much on P there is not much scientific ref for its validity but for B and K tremendous amount of potential/s but whats wrong with BP and IPIX management why they get along and give us a break.
He said if I remember correctly that UC will be at the end of this yr now mid 2020.
The only thing remain of LEO if he still have integrity and honor is to keep his word is not to do RS which he promise us long that will never do.
My goodness .05 with a promising drug/s
I did cut half of my holding since .10-.12 still have over 500k shares.
Above is my IMO as a frustrated long
Benny - Thank you -Not a lot compare to most here, pick up 17k shares will add more this week.
Long term holder here besides i like LT cap gain vs ST.
GL to of us
Hello Long- first time post here, I did a lot of reading last week and able to pick up good number of shares @2.33-2.36. I am late this morning as I transfer funds but will add again later.
Thank you all long for sharing your dd.
Science looks solid and promising. There are a lot of familiar poster here.
GL to all long.
Exactly! same here own very large shares, LEO did an excellent job on this company many years ago but in the past 3 yrs its been disappointment, LEO PLEASE RESIGN AND TURN OVER THIS COMPANY to a seasoned and credible experience pharma executive to bring this company to the next level.
Leo you failed to delivered in the past 3 yrs. please do the right thing. AGAIN hired someone else to do the job.( nice to have LW but New CEO is what we need )
IMO, frustrated long but still hopeful.
Voted - FOR
TheDane- B-derm or oral? maybe or maybe not-
Perrigo
Corporate Headquarters
The Sharp Building
Hogan Place
Dublin 2, Ireland
Telephone: +353 1 709 4000
Registered in Ireland
Registration Number 529592
North American Base of Operations
515 Eastern Avenue
Allegan, Michigan 49010
Telephone: +1 269 673 8451
https://www.perrigodocs.com/contact.aspx
CMC- Very Interesting, did AMGEN mentioned Kevetrin in their patent before?
Agreed Dane - how about this
" Anything that regulates the p53 pathway has an importance in tumor development – and potentially for therapy,” says senior author Tamara Terzian, PhD, investigator at the CU Cancer Center and assistant professor at the Gates Center for Regenerative Medicine on the University of Colorado Anschutz Medical Campus."
Agreed! my questions is are they working part time, full time or overtime? must be good money since they are here 24x7x365 and oncall duty LOL..
CallMECrazy and others thanks for all the informative post lately..let's not forget Leo's PR .
“After completing our Phase 1 Kevetrin study, we were invited by one of the world’s largest pharmaceutical companies to meet at their world headquarters and discuss our results,” said Leo Ehrlich, Chief Executive Officer at Innovation Pharmaceuticals. “In attendance were the company’s CEO and senior scientists flown in from around the country. The main takeaways from the meeting were twofold. In order to enter into a development deal with them we needed to show p53 modulation in the tumor and develop a Kevetrin formulation as an oral dose. In our Phase 2a trial in ovarian cancer, intra-tumor p53 modulation was observed. Our goal now is to initiate a clinical trial of oral Kevetrin as soon as is feasible. Should clear efficacy be demonstrated, oral Kevetrin—as one of the few p53-modulating drugs in human trials, and in pill or tablet form—could emerge as a frontline treatment for cancer.”
Great news indeed!!! LOL
Just came from 8 days Alaska Cruise with the family and then this good news... Able to pick more today at the low..Thanks and GL fellow long..
Jav - I am not there with you! I am still believe in our science and its potential but as I said I am very frustrated that He can't close any deal.
Leo is a number guy by profession, as posted here before by BioH and others that as saying " beggars can't be choosers" do small deal for validation, cash infusion and shareholder confidence then next deal/s that's where he can play hardball.
You mentioned Dr B., If you look his past history he move to different company after few years but this time I am glad He still with us.
Obviously we don't know what development activity on the background, BUT PLEASE DO THE RIGHT THING.
TOP123
Dang! Can you relieve yourself as CEO and get someone with credible record in pharma industry that done closing deal/s.
We are shouting to the whole world that we have 2 potential platform in our pipeline and I believe we do have but how come almost every single day deal occur in pharma world and we can't get deal/s done.
very frustrated long investor but still believe in our pipeline potential.
TOP123
It's nice to know that ...
" Dr. Farraye is a consultant for Braintree Laboratories, Janssen Biotech, Inc., Merck & Co. Inc., Pfizer Inc., and Takeda Pharmaceuticals, USA, Inc.
He also is a stockholder and on the advisory board for Innovation Pharmaceuticals and is on the data safety management board for Eli Lilly and Company and Theravance Biopharma.
GL Fellow long
Fress - it's right timing bought last week for few thousand shares will hold for long term. whats your take on biosynthesis of IML** are you still on it? whats your current analysis? TIA
Wow like it... "The end goal is to disrupt the market by creating a world-class, affordable small molecule in tablet form as a new treatment option with clear advantages over today’s commonly used biologics for patients with extensive IBD, such as Ulcerative Colitis (UC)."
Glad I did pick a few yesterday..GL fellow long.
Nick - Is that just a guess or you have a source that tells you that.. TIA
Farrell - got mine 25k @.25 in addition to my already overloaded shares.
GL to us.
Several stink bids are in!!!